Digital Commons Network^™

Tubulin Regulates Stability And Localization Of Stmn2 By Binding Preferentially To Its Soluble Form, Xiang Deng, Gary A Bradshaw, Marian Kalocsay, Timothy Mitchison

Faculty, Staff and Student Publications

The small, tubulin-binding protein STMN2 is highly expressed in neurons and is implicated in amyotrophic lateral sclerosis. STMN2 degrades rapidly and accumulates at axotomy sites, suggesting fast turnover is crucial for its neuroprotective function. We show that STMN2 was primarily degraded by the ubiquitin-proteasome system. Its membrane-targeting N-terminal domain promoted fast turnover, whereas its tubulin-binding domain promoted stabilization. Proximity labeling and imaging showed that tubulin binding reduced STMN2 targeting to trans-Golgi network membranes. Pull-down assays showed that tubulin binds preferentially to soluble over membrane-bound STMN2. Our observations suggest that STMN2 interconverts between a soluble, tubulin-bound form and a membrane-bound, tubulin-free …

Better Floors, Better Health: A Theory Of Change For An Improved Household Flooring Intervention In Rural Communities In Kwale And Bungoma Counties, Kenya, Stella Kepha, Hugo Legge, Katherine E. Halliday, Victoria Ochwal, Lynne Elson, Jacinta Mwongeli, William E. Oswald, Beatrice Kakoi, James Wambua, Charles Mwandawiro, Ulrike Fillinger, Rachel Pullan, Doris Njomo

All Peer-Reviewed Publications

Background: Household flooring is increasingly being investigated as a determinant of health, however the pathways through which flooring may impact health and wellbeing are not yet well understood. The SABABU study is a cluster-randomised controlled trial evaluating the impact of an improved flooring intervention on soil-transmitted helminthiasis, tungiasis, and enteric infections in Bungoma and Kwale counties, Kenya. This paper presents the findings from a theory of change development process that was undertaken as part of the formative research phase of the SABABU project. Methods: A co-creation workshop (n = 1), stakeholder meetings (n = 2), and community meetings (n = …

Exploring The Microbiomes Of Camel Ticks To Infer Vector Competence: Insights From Tissue-Level Symbiont-Pathogen Relationships, Rua Khogali, Armanda Bastos, Dennis Getange, Joel L. Bargul, Shewit Kalayou, Nehemiah Ongeso, Joost Theo Petra Verhoeven, James Kabii, John Ngiela, Daniel Masiga, Jandouwe Villinger

All Peer-Reviewed Publications

Ticks are blood-feeding ectoparasites that harbor diverse pathogens and endosymbionts. Their microbial communities vary based on tick species, stage, sex, geographical location, surrounding environment, and tissue type. Understanding tick microbiota at the tissue level is crucial for unraveling how microbiomes are distributed in tick tissues and influence pathogen transmission. We used V1-V2 16 S rRNA gene sequencing to analyze tissue-specific bacterial compositions (hemolymph, saliva, salivary glands, and midgut) of Amblyomma gemma, Rhipicephalus pulchellus, Hyalomma dromedarii, and Hyalomma rufipes ticks collected from camels in Marsabit County, northern Kenya. The V1-V2 region of the 16 S rRNA gene effectively differentiated 43 Rickettsia …

Maximizing Horizontal Transmission Through Mating: Increased Mating Frequency And Mating Competitiveness Associated With Microsporidia Mb-Infected Anopheles Arabiensis Males, Tracy Maina, Aclaine Shisia, Joseph Gichuhi, Joel L. Bargul, Jeremy K. Herren, Tullu Bukhari

All Peer-Reviewed Publications

Background: Microsporidia MB is a naturally occurring symbiont in Anopheles arabiensis mosquitoes that inhibits the development of Plasmodium. It is transmitted both vertically and horizontally, enabling its spread within mosquito populations. Currently, mating is the only known mechanism for horizontal transmission. Understanding the factors that influence Microsporidia MB transmission during mating is crucial for developing a malaria transmission-blocking strategy based on this symbiont. Methods: The effect of mosquito age on Microsporidia MB transmission was determined through mating bioassays between infected and uninfected Anopheles arabiensis males and females in three age groups: 3–4 days, 7–8 days, and 10–11 days. Mating bioassays …

Did Copyright Fail Music Artists?, Rachel Landy

Articles

Music soundtracks our lives, supports over two million domestic jobs annually, and is listened to more than ever before. The record industry is thriving, having made over $17 billion in 2024. Yet, many professional artists are barely surviving. Artists signed to record deals lament royalty payments that amount to a fraction of a penny for each stream of their songs. So where is all the money going, and who, or what, is to blame? Public rhetoric and existing legislative proposals implicate copyright as a guilty party. But are those concerns justified?

This Article unpacks the music supply chain. It builds …

Armando’S Case: Diagnostic Emergent Literacy Assessment For Children With Complex Communication Needs, Bronwyn A. Harris, Tonya R. Moore, Ashley E. Pennell

Journal of Case Learning & Exceptional Learners

This practice-based case study is designed to offer a tutorial on how to adapt an informal, diagnostic emergent literacy assessment to meet the needs of students like six-year-old Armando, a Latino, multilingual learner with autism spectrum disorder (ASD) and complex communication needs (CCN) in an inclusive kindergarten classroom. Armando’s informal literacy assessment adaptations and outcomes are discussed, including descriptions of his emergent literacy skills observed through his engagement in literacy stations, small group reading instruction in his classroom, and his use of alternative and augmentative communication (AAC) in both instructional and assessment settings. This case study illustrates how traditional literacy …

Involvement Of Students With Extensive Support Needs In Pbis: Middle School Educator And Administrator Perspectives, Virginia L. Walker, Megan E. Carpenter, Sheldon Loman

Journal of Case Learning & Exceptional Learners

School-wide positive behavioral interventions and supports (PBIS) is a widely adopted multi-tiered system of behavioral supports designed to promote a safe, predictable, and inclusive school environment for all students. Despite the positive outcomes associated with PBIS, students with extensive support needs (ESN) may have limited access to and involvement in all aspects of PBIS. In this article, we describe the perspectives of three staff members––an administrator, general education teacher, and special education teacher––who participated in interviews about the involvement of students with ESN in PBIS. These staff members provided insightful information about how students with ESN were involved in PBIS …

"Forgive Our Living And Our Dead": Colonial Warfare In The Philippines, Mattie Fitzpatrick

History

In March of 1906, American troops massacred over 1,000 Filipino civilians on Bud Dajo mountain. American service members were commended for this incident. My research examines this massacre to ask why wars of insurgency are specifically subject to abuses of power, particularly during the American-Philippines War and the ensuing colonial warfare between 1898 and 1906 under the colonization of the US. My research will focus on the circumstances created to excuse US soldiers after atrocities were committed and the colonial attitudes of the time in addition to the brutal methods used by the American government in Philippines. American colonial administrators …

Breaking Barriers For Student Success: Leading In Challenging Times, Lisa Marie Dewey

Dissertations

This study explores how Diversity, Equity, and Inclusion (DEI) directors in one Midwestern state understand and lead equity initiatives in K–12 public education. The purpose of the study was to examine how DEI leaders make sense of their roles and the challenges of sustaining equity work within complex and often politicized systems. Using a basic qualitative methodology, the research examined how personal identity, sociopolitical context, and organizational structures shape DEI leadership. Critical Race Theory (CRT) framed the study, centering race, power, and systemic inequity in participants’ experiences.

Seven DEI directors participated in semi-structured interviews. Three key themes emerged. First, participants’ …

Front And Back Matter

The Foundation Review

No abstract provided.

The Ai Contributor: A New Thought Partner In Systems Change, Jewlya Lynn, Rachel Reichenbach

The Foundation Review

Many foundations are making long-term commitments to advancing systemic change, continually adapting and refining their approaches along the way. An emerging and often underutilized tool in their systems change toolkit is generative artificial intelligence (AI).

AI is enhancing practices across philanthropy, often focused on increasing efficiencies and scaling or streamlining human tasks. What if we instead focus on what AI can do that is distinctly different from what a human can offer? In the world of systemic change, we continue to struggle with the complexity and intractability of systems and finding moments when systems can be shifted. AI can be …

Once Upon A Time: A Kinesthetic Approach To Teaching Evidence, Peter C. Alexander, Cheryl T. Page, Hannah G. Chapman

Southern Illinois University Law Journal

This Article describes and evaluates a kinesthetic, simulation-based approach to teaching Evidence at Southern Illinois University Simmons Law School. Departing from the traditional Langdellian, case-method model, one section of Evidence requires students to memorize and apply the Federal Rules of Evidence through a series of five scaffolded mini-trials built around fractured fairy tales and nursery rhymes. Drawing on the MacCrate Report, Bloom’s taxonomy, and Vygotsky’s theory of scaffolding, we situate this pedagogy within the broader movement toward experiential legal education and argue that Evidence—because of its centrality to litigation practice—is an ideal doctrinal course in which to integrate trial advocacy …

The Messenger, Vol. 52, No. 2

The Messenger (archival - 1870-)

No abstract provided.

Comparative Assessment Of Lower Limb Neuromusculoskeletal Activation And Joint Kinematics In Normal And Impaired Gait, Jack Ryan Schule

Theses and Dissertations

This thesis evaluates whether accessible and affordable technologies can provide clinically significant, quantifiable gait analysis comparable to traditional marker-based motion capture systems. Modern high-end systems offer excellent accuracy but remain financially and logistically inaccessible to many clinicians and researchers. To address this gap, a framework was developed using markerless pose estimation using the model, MediaPipe, inertial measurement units (IMUs) processed through an Extended Kalman Filter (EKF), and surface electromyography (sEMG) to measure joint kinematics and neuromuscular activity during gait. An experiment was performed where data was collected from participants with both normal gait and pathologies including: Osgood–Schlatter disease, Plica Band …

Validating A Creative Teaching Inventory: A Mixed Method Approach To Construct Validity, Todd Kettler, Beatrice Ruiz Buentello, Nilay Ayse Gunel, Madelyn Chance, Laila Y. Sanguras

Teaching and Learning Faculty Publications

Creative pedagogies are increasingly important as the demand for a creative workforce grows. However, there are limited measures of creative pedagogy. One such measure is The Inventory of Teaching Practices in Higher Education. Only one study has been published examining its factor structure when used with undergraduate students. The present study aims to further investigate its construct validity using a convergent mixed methods design. We recruited students (n = 268) from a private university in Texas and administered a modified version of the inventory, with items from each factor presented together followed by two open ended items asking …

Exploring 2d Geometric Shape Classification Using Ai-Driven Feature Tables In Mathematics, Yasemin Gunpinar, Woonhee Sung

Education Faculty Publications and Presentations

This study explored the effectiveness of an AI-integrated instructional task designed to enhance preservice teachers' understanding of the features and hierarchical relationships of 2D geometric shapes. Originally developed and tested in online K-12 professional development settings, this intervention was adapted for in-person preservice teacher education context in this study. Data were collected from 17 preservice teachers through demographic surveys, pre- and posttests using the Van Hiele geometry framework, hierarchical diagram tasks, feature table creation during the intervention, and postintervention reflections. Findings indicated a statistically significant improvement in the accuracy and complexity of postintervention hierarchical diagrams, along with a descriptively higher …

Benthic Infaunal Responses To Shoreline Restoration, Jessica Lauren Cline

Theses and Dissertations

In the age of increasing urban coastal sprawl, natural shorelines are being replaced by hard armoring structures, which result in the loss of valuable ecosystem services. Hybrid living shorelines, areas that include limited and less intensive armoring strategies paired with the integration of plants and other natural materials, present an opportunity to marry the need for more aggressive stabilization with the continued preservation of ecosystem functions and biological communities. This project uses benthic infauna to evaluate the success of a living shoreline installation in Palm Bay, Florida. The deployment features experimental treatments of breakwaters and red mangroves to explore how …

Annual Daf Report 2025, H. Daniel Heist, Danielle Vance-Mcmullen, Jeff Williams, Genevieve G. Shaker, Rachel M. Sumsion

Research, Reports, and Publications

We’re pleased to publish the inaugural edition of the Annual DAF Report produced by the Donor Advised Fund Research Collaborative (DAFRC).

For nearly two decades, the National Philanthropic Trust compiled and published data on donor advised funds (DAFs), creating a foundational source of data for the nonprofit sector. Starting with this 2025 edition, the Annual DAF Report will be independently produced by the DAFRC.

This report draws on Internal Revenue Service (IRS) Form 990, Schedule D data for fiscal year (FY) 2024 to provide aggregate data on the number of DAF accounts, contributions to DAFs, grants from DAFs, DAF assets, …

Executive Summaries

The Foundation Review

No abstract provided.

Editorial, Julia Coffman

The Foundation Review

No abstract provided.

Archetypes Of Ai Adoption: A Snapshot In Time Of Philanthropic Practice, Grace Lyn Higdon, Linda Raftree

The Foundation Review

The authors identified four archetypes describing philanthropic funders’ approach to AI: The Curious, The Doers, The Dreamers, The Skeptics.

The authors did not find major differences found across foundations based on their geographic location, though there were differences found based on their mission and values. Feminist and social justice funders in the Global South demonstrated more skepticism than others.

Even in seemingly benign or straightforward applications, AI systems demonstrate unpredictable behavior, leading to most foundations proceeding with caution.

The rapid pace of AI has meant that formal AI policies are rare, though foundations align on some common “red lines” that …

Deepening Our Understanding Of Resilience: How Evaluation Can Contribute, Michael Quinn Patton

The Foundation Review

Resilience is the capacity to experience a significant shock and adapt as needed to survive and move forward. The current age is one of constant system shocks economically, environmentally, and politically. Resilience becomes essential for navigating these and other risks.

Individuals, organizations, communities, and ecosystems manifest different degrees and types of resilience requiring appropriately matched evaluation responses. In considering new directions for philanthropic evaluation, this article offers for the first time an overarching framework of four different responses to system shocks and disruptions. This leads to four different evaluation criteria: continuity, adaptation, innovation, and capitulation.

In addition to the long-term …

Collective Learning In Philanthropy: Ai, Trust, And The Future Of Grant Reporting, Rachel Kimber, Valerie Ehrlich, Blanch Vance, Abigail Osei

The Foundation Review

Grant reporting has largely devolved from a learning tool to a bureaucratic exercise that reinforces power asymmetries and burdens nonprofits. As philanthropy confronts mounting crises demanding equity and transparency, reporting must transform into a space for collective sensemaking.

This paper explores how Artificial Intelligence (AI), paired with Oral and Alternate Reporting (OAR) methods, can build equitable, human-centered reporting systems. We propose the E⁴ framework — Efficiency, Effectiveness, Expansiveness, and Equity — for intentionally leveraging AI in service of more equitable reporting practices.

Traditional reporting often sidelines the expertise of nonprofit staff and communities most affected by funded programs. Drawing …

Philanthropy As Risk Capital: Shaping Trust And Learning At The Speed Of Ai, Nina Sabarre, Clara Bennett, Laura Chavez-Varela

The Foundation Review

As artificial intelligence rapidly reshapes society, philanthropy is increasingly called to act as "risk capital" for the public good. But risk alone is not enough. Without rigorous, field-wide learning, philanthropy's bold bets may remain isolated and short-sighted, failing to catalyze the systemic change this moment demands.

This article draws on three sources of learning at Omidyar Network—an evaluation of The Tech We Want initiative, external strategy consultations with 29 stakeholders, and early learnings from a generative AI portfolio—to identify how philanthropy can uniquely "de-risk" AI innovation for collective benefit.

Through trust-based partnerships, ecosystem infrastructure support, and narrative change, these learning …

When Shift Happens: Navigating Toward A Framework For Responsible Philanthropic Exits, Laila Bell, Stephanie Teleki, Jaime Vazquez

The Foundation Review

Philanthropy can be a powerful force for social change, with influence extending far beyond the funding period. When foundations decide to cease funding in a specific area, how they exit can significantly impact the field they are leaving in both the short- and long-term. A poorly executed exit risks blindsiding grant partners and communities, damaging key relationships, undermining progress, and potentially leaving the field worse off than it was found. In contrast, a responsible exit can help the work continue long after the foundation ceases its funding.

What defines a responsible exit? In this article, learning leaders at three different …

Base Building Evaluation: Three Opportunities To Improve Its Use And Relevance, Katie Fox, Margaret A. Post

The Foundation Review

The concept of base building comes from the traditions of electoral and labor organizing, where organizers focus on drawing leadership from a specific constituency or geography. Base building is foundational to organizing efforts. It involves the recruitment, training, and leadership development of people who are often most directly impacted by the issues and causes that organizing focuses on.

In recent years, base building has seen increased interest and investment from the philanthropic sector as funders recognize base building as critical to community-led change. As funders expand their investment in base building, they increasingly seek information and data about base building …

Tfr 17.3 Full Issue

The Foundation Review

No abstract provided.

Beyond Transactions: Building Relational Partnerships Between Evaluators And Foundations, Lauren Beriont, Cassie Bruny, Madison N. Garcia, Ebonie Guyton, Chelsey Hurt, Leah Josephson, Kate Mallula, Mary Mattson, Rory Neuner, Ramona Perry, Andrea Prado Tuma, Sarah Smith, Kim Van Der Woerd, Sofia Vitalis

The Foundation Review

The co-authors have framed this article as an emergent learning journal of sorts, summarizing observations, findings, and key takeaways; walking the reader through the process, key tensions, and classic myths they identified; and highlighting principles they uncovered that underlie and lay the groundwork for imagining more equitable ways for evaluation consultants and foundations to act in relationships.

Case Study: Using Ai To Design More Effective, Efficient, And Equity Focused Grant Application Review Processes, Emily Yu, Bryan Speelman

The Foundation Review

Grants fuel millions of organizations and advance social innovation across sectors. In the United States, foundations and corporations respectively awarded $103.5B and $36.5B to nonprofits in 2023 alone (Childress, 2024; Lilly Family School of Philanthropy, 2024).

By extension, grant applications play a critical role in how grant recipients are identified and selected. While many funders are eager for more streamlined and equitable processes to review grant applications, the process remains primarily a manual and time consuming one (Hewlett Foundation, 2021). These factors leave some funders implementing grant application processes potentially at odds with their impact goals. Examples include restricting who …

Effect Of Capillary And Viscous Forces On Carbon Dioxide Desorption In Porous Adsorbent Layers, Caroline Isabel Mcclung

Theses and Dissertations

Temperature swing adsorption-based (TSA) carbon dioxide (CO₂) separation processes, which involve an alternating flow of gases and liquids in adsorbent-coated microchannels, have been shown to yield superior and environmentally friendly performance than the existing processes. This technique begins by sending the impure gas mixture through hydrophobic silicalite adsorbent-coated microchannels, which results in the adsorption of CO₂. Subsequently, hot water heat transfer fluid (HTF) flows through the same channels, displaces the purified gas stream, heats the adsorbent, desorbs the CO₂, and removes that desorbed CO₂ from the channel. This stage is followed by cooling …