Digital Commons Network^™

Integrating Metabolomics And Physicochemical Analysis In Black Soldier Fly Bioconversion Of Schizochytrium Residue: A Pathway To High-Value Ω-3 Products, Yaru Zhang, Jing Liu, Yan Xiao, He Yang, Yanzhou Zhang, Chrysantus Mbi Tanga, Dawei Huang, Jinhua Xiao

All Peer-Reviewed Publications

The global microalgae processing industry generates substantial residues rich in ω-3 fatty acids, presenting both a waste management challenge and an untapped resource for innovative food biotechnology. This study investigated the potential of bioconversion of Schizochytrium residue (SCR) by black soldier fly larvae (BSFL) to enrich ω-3 fatty acids and evaluated the industrial applicability of the resulting BSFL products. SCR supplementation enhanced larval growth performance (7.5 % increased weight, 19.9 % higher bioconversion rate) and protein quality, while enabling exclusive accumulation of EPA and DHA in BSFL. The total ω-3 content increased from 1.18 % to 17.37 %, achieving a …

Infochemicals For The Management Of Thysanoptera, Nanadagopal Bakthavatsalam, Kesavan Subaharan, Anjenappa Raghavendra, Sevgan Subramaniam

All Peer-Reviewed Publications

Infochemicals, classified as pheromone, kairomone, allomone, synomone and apneumone, play significant role in insect communication. Unlike Lepidoptera, Thysanoptera utilize male produced aggregation pheromone for their communication. Neryl (S)-2-methybutanoate, (R) lavandulyl acetate, (+) R-lavandulyl 3 methyl-butenoate, dodecyl acetate and tetradecyl acetate are the compounds identified as aggregation pheromones for several species. Pheromone lures placed in blue or yellow or white sticky traps are effective in capturing adults of Frankliniella, Thrips, Megalurothips and Odonothrips. Decyl acetate and dodecyl acetate along with other volatile chemicals have been identified as alarm pheromones for many Thysanoptera. Push-Pull technology using alarm pheromone and aggregation pheromone or …

Assessment Of Stroke Priority Status On Door-To-Reversal Time And Outcomes In Anticoagulant Associated Intracranial Hemorrhage, Kayla Mitzel, Jonathan Kline, Thomas J. Wolfel, Erika Dittmar, Nina Cruz, Felipe De Los Rios La Rosa, Heidi Clarke

Nursing & Health Sciences Research Journal

Background: The emergent reversal of anticoagulation in the setting of intracranial hemorrhage (ICH) is critical, and it is essential that comprehensive stroke centers adhere to the American Heart Association (AHA) metrics for door-to-reversal within the designated 90 minutes. The objective of this review is to evaluate individuals classified as stroke alert priority 1 and non-stroke alert and compare AHA metrics for door-to-reversal times and clinical outcomes when diagnosed with ICH.

Methods: Single-center observational, retrospective review that compared stroke alert priority 1 individuals to non-stroke alert individuals who were diagnosed with an ICH and taking an anticoagulant prior to admission. The …

When Thermal Risk Indices Work And When They Don't: A Case Study Of Two Maize Insect Pests, Komi Mensah Agboka, Frank Thomas Ndjomatchoua, Luca Rossini, Ritter A. Guimapi, Elfatih M. Abdel-Rahman

All Peer-Reviewed Publications

The biological life cycle of terrestrial arthropods, using temperature as the primary driving factor has a large interest for insect pests in agriculture, forestry, urban ecosystems, as constitutes the basics for the development of mathematical models for decision making. A recent study proposed a physiologically-based risk index (RI) which finds large applications in the definition of risk maps; however, further case studies are needed to better explore its strengths and limitations. This study aims to extend this knowledge by presenting an application of the RI on two economically significant pests: the fall armyworm Spodoptera frugiperda and the stem borer Busseola …

Secretory Iga Dysfunction Underlies Poor Prognosis In Fusobacterium-Infected Colorectal Cancer, Ilseok Choi, Kyung-A Kim, Sang Cheol Kim, Donghwan Park, Ki Taek Nam, Jun Hyung Cha, Seungbyn Baek, Junha Cha, Hye-Yeong Jo, Minsun Jung, Melody Y Zeng, Irina Matei, Susan Bullman, Joong Bae Ahn, Yoon Dae Han, Han Sang Kim, Insuk Lee

Faculty, Staff and Student Publications

Fusobacterium nucleatum (Fn) is commonly enriched in colorectal cancer (CRC) and associated with poor outcomes, though its mechanisms remain unclear. Our study investigated how Fn affects the tumor microenvironment through single-cell transcriptomic analyses of 42 CRC patient tissues, comparing Fn-positive and Fn-negative tumors. We discovered that Fn impairs IgA plasma cell development and secretory IgA (sIgA) production by disrupting communication with tumor-associated macrophages. Additional experiments in germ-free mice, together with our re-analysis of a publicly available single-cell RNA-seq data set from a CRC mouse model with an intact gut microbiome–both models having been orally gavaged with Fn–jointly validated the causal …

Smags-Lasso: A Novel Feature Selection Method For Sensitivity Maximization In Early Cancer Detection, Hamid Khoshfekr Rudsari, Sara Khorami-Sarvestani, Johannes F Fahrmann, James P Long, Samir Hanash, Kim-Anh Do, Ehsan Irajizad

Faculty, Staff and Student Publications

Background: Sensitivity and specificity are foundational metrics for cancer detection tools. However, most machine learning algorithms prioritize overall accuracy during optimization, which fails to align with clinical priorities of early detection. We aim to develop a feature selection machine learning algorithm while maximizing sensitivity at a given specificity.

Methods: We developed SMAGS-LASSO, a machine learning algorithm that combines our developed Sensitivity Maximization at a Given Specificity (SMAGS) framework with L1 regularization for feature selection. This approach simultaneously optimizes sensitivity at user-defined specificity thresholds while performing feature selection. SMAGS-LASSO utilizes a custom loss function with L1 regularization and multiple parallel optimization …

Registration Is A Powerful Rotation-Invariance Learner For 3d Anomaly Detection, Yuyang Yu, Zhengwei Chen, Xuemiao Xu, Lei Zhang, Haoxin Yang, Yongwei Nie, Shengfeng He

Research Collection School Of Computing and Information Systems

3D anomaly detection in point-cloud data is critical for industrial quality control, aiming to identify structural defects with high reliability. However, current memory bank-based methods often suffer from inconsistent feature transformations and limited discriminative capacity, particularly in capturing local geometric details and achieving rotation invariance. These limitations become more pronounced when registration fails, leading to unreliable detection results. We argue that point-cloud registration plays an essential role not only in aligning geometric structures but also in guiding feature extraction toward rotation-invariant and locally discriminative representations. To this end, we propose a registration-induced, rotation-invariant feature extraction framework that integrates the objectives …

Sheetpedia: A 300k-Spreadsheet Corpus For Spreadsheet Intelligence And Llm Fine-Tuning, Zailong Tian, Zhuoheng Han, Houfeng Wang, Lizi Liao

Research Collection School Of Computing and Information Systems

Spreadsheets are widely used for data analysis and reporting, yet their complex structure and formula logic pose significant challenges for AI systems. We introduce Sheetpedia, a large-scale corpus of over 290,000 diverse spreadsheets (from 324,000+ workbooks) compiled from enterprise email archives and online forums. We detail a rigorous collection and preprocessing pipeline (integrating the Enron email spreadsheet archive and the Fuse web corpus, plus a new crawl of Excel forums) to standardize formats, filter languages, and remove duplicates. Sheetpedia provides extensive coverage of real formulas and annotations – addressing a gap left by prior table datasets (e.g. web tables used …

When Less Language Is More: Language-Reasoning Disentanglement Makes Llms Better Multilingual Reasoners, Weixiang Zhao, Jiahe Guo, Yang Deng, Tongtong Wu, Wenxuan Zhang, Yulin Hu, Xingyu Sui, Yanyan Zhao, Wanxiang Che, Bing Qin, Tat-Seng Chua, Ting Liu

Research Collection School Of Computing and Information Systems

Multilingual reasoning remains a significant challenge for large language models (LLMs), with performance disproportionately favoring high-resource languages. Drawing inspiration from cognitive neuroscience, which suggests that human reasoning functions largely independently of language processing, we hypothesize that LLMs similarly encode reasoning and language as separable components that can be disentangled to enhance multilingual reasoning. To evaluate this, we perform a causal intervention by ablating language-specific representations at inference time. Experiments on 10 open-weight LLMs spanning 11 typologically diverse languages show that this language-specific ablation consistently boosts multilingual reasoning performance. Layer-wise analyses further confirm that language and reasoning representations can be effectively …

Strategic Interactions And Gender Cues: Evidence From Social Preference Games, Hernán Bejarano, Matias Busso, Juan Francisco Santos

ESI Working Papers

This paper studies trust, reciprocity, and bargaining using a large-scale online experiment conducted in six Latin American countries. Participants played trust and ultimatum games under randomly assigned conditions in which the gender of their counterpart was either disclosed or withheld. On average, disclosing counterpart gender does not yield statistically detectable effects in either game. However, statistically significant differences emerge by participants' own gender: on average men exhibit higher levels of trust, reciprocity, and generosity in bargaining than women. When disaggregating by participant-counterpart gender pairings, point estimates differ in sign across groups but are generally imprecisely estimated, and differences between interacting …

Studies Of Trispyrazolylborate Molybdenum-Oxo Compounds And Related Reactions, Miranda Sanders

Graduate Theses and Dissertations

This dissertation details the design, development, and synthesis of a molybdenum-dioxo complex bearing a trispyrazolylborate ligand. The system was tested for its efficiency as a catalyst for deoxydehydration with a small substrate scope. Deoxydehydration reactions with 1-phenyl-1,2-ethanediol, diethytartrate, and 1,2-octanediol show low yields with catalytic turnover only found for diethyltartrate. Electrochemical studies show well behaved PCET behavior with two distinct electron transfer events in the presence of a proton donor. Studies of two molybdenum-dioxo complexes bearing dianionic pincer ligands were conducted to expand further on systems that have been extensively studied in our lab. Deoxydehydration of glycerol by a molybdenum-dioxo …

Perception Of Drinking Water Quality Among Arkansas Residents, Kolade Olawale Olatunde

Graduate Theses and Dissertations

Objective: Perceptions of drinking water quality influence public trust, water consumption behaviors, and the willingness to invest in infrastructure improvements. Despite the importance of safe drinking water, regional and socio-economic disparities impact how residents perceive their tap water and their readiness to pay for enhancements. While past research indicates that negative views of tap water quality have resulted in behavioral changes, the connection between perception and actual household water usage remains ambiguous. This study aims to investigate how perceptions of drinking water quality differ across regions in Arkansas and how residents are willing to invest in quality improvements. Method: A …

Fungicidal Management Of Spring Dead Spot Using Improved Modeling And Application Strategies, Michael Vincent Battaglia

Graduate Theses and Dissertations

Spring dead spot (SDS) is a destructive disease of bermudagrass (Cynodon Rich. spp.) in parts of the world that experience winter dormancy. Fungicides are often necessary to properly manage SDS, and significant research has been conducted to improve fungicidal effectiveness. Several studies were conducted with the objectives of improving fungicide application timing, method of fungicide application, and long-term fungicidal efficiency. In the fungicide application study, a cooling degree-day (CDD) model based on soil temperatures was developed. The CDD model showed that isofetamid was highly effective against SDS during a wide application window in autumn, while tebuconazole was inconsistently effective and …

A Phenomenological Exploration Of Black International Graduate Students’ Experiences In Building A Sense Of Belonging And Community At A Predominantly White Southern University, Hilda Solange George

Graduate Theses and Dissertations

Black international graduate students’ experiences navigating and developing a sense of belonging and community at higher educational institutions in the United States and particularly at predominantly white institutions have received minimal attention in scholarly inquiries, despite their cultural, intellectual, and financial contributions to host institutions and the country. To fill this gap in the existing literature, this hermeneutical phenomenological study aimed to gain a nuanced and in-depth understanding of Black international graduate students' perceptions of their sense of belonging and community at a predominantly white southern university (PWSU) in the United States. Guided by the research questions and the Black …

Effects Of Injectable Trace Mineral Timing On Calf Performance And Health Indicators, Marie E. Goulais

Graduate Theses and Dissertations

One hundred and fourteen calves (average BW= 224kg ± 89kg) were utilized to evaluate the effects of injectable trace mineral (ITM) administration on calf performance and health when administered pre-weaning and at weaning. Calves were blocked by sex, stratified by age, and randomly assigned to one of the following treatment groups: 1) no ITM injection (CON), 2) ITM administered 28 d before weaning (PW), or 3) ITM administration at weaning (WEAN). Calves were vaccinated against respiratory pathogens on D-28 and D0. At weaning, cattle were transported to a local auction market, held overnight and returned the following morning. Body weight …

Optimizing Cobb Mx X 500 Broiler Diets Through The Investigation Of Lysine And Energy Synergies, Soybean Processing “Add-Backs” Ingredients, And Soybean Genotype Amino Acid Selection, Savannah Caroline Wells

Graduate Theses and Dissertations

This dissertation explored strategies to optimize Cobb MX x 500 broiler chicken nutrition by investigating lysine and energy synergies, the utilization of soybean processing by-products (“add-backs”), and soybean genotype selection for enhanced amino acid composition. Three independent but complementary research objectives were pursued to improve feed efficiency, sustainability, and cost-effectiveness in modern broiler production. The first objective assessed the interactive effects of dietary lysine and metabolizable energy (ME) on the performance and carcass traits of Cobb MX × 500 broilers. Using a central composite design, nine dietary treatments were formulated across multiple feeding phases. Results demonstrated that broiler performance responded …

Understanding Outer Solar System Ice Composition Through Impact Processes: Simulations And Hydrates, Jill Rebecca Mcdonald

Graduate Theses and Dissertations

This work concerns solar system ices, particularly water ice and clathrate hydrates. Water ice is abundant as a mineral in the outer parts of the solar system, providing source material for the formation of clathrates. We explored constituents through a combination of numerical modeling and laboratory experiments. Understanding the differences and similarities between these materials can shed light on planetary habitability, composition, and evolution. Chapter one contains relevant background information. This chapter introduces the ices that will be studied and gives insight into the locations of interest within our solar system. It also explains the mechanics of impact cratering processes …

Novel Approaches To Disinfecting Poultry Processing Wastewater For Reuse, Seth Olorunmijuwonlo Adesope

Graduate Theses and Dissertations

Water is an essential resource used in poultry processing, generating large volumes of foodborne pathogen-rich wastewater posing treats to public health. Treating poultry processing wastewater (PPW) is crucial for safe water reuse and sustainable development. Conventional disinfection methods like aerobic digestion and chlorination, although effective, impose considerable operational cost and generate harmful by-products. Integrated recycling systems such as advanced oxidation processes (AOPs) which destroy micro-organisms through the generation of reactive oxygen species (ROS) present a promising opportunity for enhancing resources and sustainability. This study investigated the use of photo-electrochemical (PEC), specifically by combining electrochemical (EC) and photochemical (PC; Photosensitizer and …

Transcriptomic And Contractile Adaptations In Skeletal Muscle In A Rodent Model Of Anorexia Nervosa, Oscar Armando Vicen

Graduate Theses and Dissertations

BACKGROUND: Anorexia Nervosa (AN) is a psychiatric disorder marked by severe chronic caloric restriction and is primarily diagnosed through psychological and behavioral symptoms. AN has the highest mortality of any psychiatric disorder with an increased risk of all-cause mortality. Many individuals with a history of AN experience incomplete recovery despite intervention treatment. Skeletal muscle molecular mechanisms under chronic energy deprivation remain poorly understood. PURPOSE: To investigate transcriptomic profiles of the gastrocnemius muscle following one month of a rodent model of AN. This study analyzed whether the molecular changes correlate with collected muscular force data to provide a comprehensive understanding of …

National Hero And Water Deity: The Worship Of Triệu Việt Vương In The Red River Delta, Vietnam, Huong Thi Nguyen

Graduate Theses and Dissertations

In my dissertation, the theory of collective memory will be deployed to address many questions regarding retaining, recovering, and re-creating the worship of King Triệu Việt Vương. He was a legendary, historical king of Vietnam who supposedly lived in the 6th century. His achievements were connected to the people living in the Red River Delta in their fight against the Liang invasion. The villagers who lived near or in this area also honored him for his spiritual power. They built a small temple/ shrine right by the riverbank to worship this King. The Vietnamese dynasties, Ly (in the 11th century), …

Ring-Opening And Monofunctionalization Study On Spiro Cyclic Aminals And N, O-Acetals System Via Nitrogen-Centered Radical Intermediates, Chujun Zhou

Graduate Theses and Dissertations

The nitrogen-centered radical has been drawing increasing attention among researchers. Radical polarity is one of the key factors in studying nitrogen-centered radicals’ reactivity, and the functional groups attached to the nitrogen atom are of vital importance. Among different types of nitrogen-centered radicals, aminium radical and metal aminium radical are electrophilic due to the positive charge on the intermediate. The sulfonamide radical, amidyl radical, and cyanide amine radical are also electrophilic since the nitrogen is adjacent to electron electron-withdrawing group. The neutral amino radical, iminyl radical, masked nitrogen radical are nucleophilic because of the electron-donating groups. After classifying the nitrogen-centered radical, …

Reading Between Lines: Mapping El Orinoco Ilustrado, Guillermo Pupo Pernet

Graduate Theses and Dissertations

This dissertation examines El Orinoco Ilustrado (EOI) by Joseph Gumilla as a layered textual and cartographic artifact central to the production of colonial knowledge in the Orinoco River basin. Moving beyond surface narratives of evangelization and exploration, it interrogates the sombras and silencios implanted in the Jesuit chronicle. Through an intradisciplinary approach combining literary analysis, archival research, and visual studies, the study reveals how EOI helped construct imperial visions of space, race, and resource extraction in eighteenth-century Spanish America. The dissertation is structured around six chapters. Chapter One outlines a theoretical framework. Chapter Two provides a longue durée historical context, …

A Prognostic Classification System For Extent Of Resection In Idh-Mutant Grade 2 Glioma: An International, Multicentre, Retrospective Cohort Study With External Validation By The Rano Resect Group, Philipp Karschnia, Jacob S Young, Maarten M J Wijnenga, Tommaso Sciortino, Nico Teske, Alba Corell, Arthur Wagner, Gilbert Youssef, Yae Won Park, Levin Häni, Stephanie T Jünger, Antonio Dono, Felix Ehret, Eduardo E Mendoza Mireles, Nicolas Neidert, Francesco Bruno, Chad A Tuchek, Thijs Van Der Vaart, Marco Rossi, Marco Conti Nibali, Lorenzo Gay, Alfred Gramelt, Nitin Tandon, Sung Soo Ahn, Jong Hee Chang, Michael Weller, Arnaud J P E Vincent, Roland Goldbrunner, Daniel P Cahill, Raymond Y Huang, Andreas Raabe, Bernhard Meyer, Juergen Beck, Annette M Molinaro, Susan M Chang, Michael A Vogelbaum, Roberta Rudà, Einar O Vik-Mo, Jorg Dietrich, Yoshua Esquenazi, Stefan J Grau, Patrick Y Wen, Asgeir S Jakola, Oliver Schnell, Lorenzo Bello, Martin J Van Den Bent, Shawn Hervey-Jumper, Mitchel S Berger, Joerg-Christian Tonn

Faculty, Staff and Student Publications

Background: The efficacy of resection in IDH-mutant grade 2 gliomas remain controversial since terminology for the extent of resection has been inconsistently applied across studies. We aimed to establish a standardised classification for the extent of resection and assess the association between supramaximal resection and survival across molecular subtypes.

Methods: In this international, multicentre, retrospective study, patients aged 18 years and older with newly diagnosed grade 2 IDH-mutant glioma were identified from institutional databases across 16 centres in the USA, Europe, and Asia between between Sept 1, 1993, and May 10, 2024. We used Cox proportional hazard regressions to analyse …

Peripheral Blood Gene Expression Profiling And Prognostic Significance For The Course Of Interstitial Lung Disease In Patients With Systemic Sclerosis, Shervin Assassi, Christopher P Denton, Matthias Zwick, Ramona Schmid, Carina Ittrich, Tobias Litzenburger, Sudha Visvanathan

Faculty, Staff and Student Publications

Objective: We used data from the placebo arm of the Safety and Efficacy of Nintedanib in Systemic Sclerosis (SENSCIS) trial to determine the prognostic/predictive significance of peripheral blood cell (PBC) transcript modules for the course of forced vital capacity (FVC) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) with and without mycophenolate mofetil (MMF) treatment.

Methods: Patients had SSc-ILD with first non-Raynaud symptom within 7 years. MMF treatment was permitted if taken at a stable dose for ≥6 months. PBC RNA samples were taken at baseline. Global RNA sequencing was performed, followed by a modular analysis using 62 curated …

2025-12-01 Message From The President, Morehead State University. Office Of The President.

Staff Congress Records

A message sent by the Office of the President to the campus community on December 1, 2025, regarding upcoming events on campus, construction progress, Board of Regents meeting, and awards.

Breakwater Phase Iii: Results For Encorafenib And Cetuximab Plus Mfolfox6 In First-Line Braf V600e-Mutant Metastatic Colorectal Cancer, Scott Kopetz, Josep Tabernero, Elena Élez

Faculty, Staff and Student Publications

The BREAKWATER Phase III study investigated encorafenib and cetuximab plus mFOLFOX6 versus chemotherapy with or without bevacizumab for the treatment of patients with previously untreated BRAF V600E – mutant metastatic colorectal cancer. The study showed significantly improved objective response rate by blinded independent central review, and significantly longer progression-free survival by blinded independent central review and overall survival in patients treated with first-line encorafenib and cetuximab plus mFOLFOX6 compared with chemotherapy with or without bevacizumab. The safety profiles were consistent with those known for each agent. These results led to the approval of encorafenib and cetuximab plus mFOLFOX6 for the …

Benzodioxane-Benzamides Targeting Bacterial Cell Division Protein Ftsz Potentially Disrupt Slma-Mediated Nucleoid Occlusion And Reversible Biomolecular Condensation, Marta Sobrinos-Sanguino, Inés Barros-Medina, Lorenzo Suigo, Alessia Lanzini, Ermanno Valoti, William Margolin, Valentina Straniero, Begoña Monterroso, Silvia Zorrilla

Faculty, Staff and Student Publications

New strategies are urgently needed against antimicrobial resistance, a major health threat, and the different mechanisms regulating the bacterial cell division machinery offer multiple opportunities for developing novel therapeutics. FtsZ, an essential protein of this process, is targeted by multiple small molecules, and benzodioxane-benzamides (BDOBs) are among the most potent inhibitors in several bacterial species. BDOBs mechanisms are however poorly understood, particularly their impact on FtsZ's interplay with partners and ability to assemble phase-separated biomolecular condensates potentially involved in stress sensing. We show that certain BDOBs shielded FtsZ against depolymerization induced by the nucleoprotein complexes of SlmA, which inhibit Z-ring …

Molecular And Immunological Features Associated With Long-Term Benefits In Metastatic Nsclc Patients Undergoing Immune Checkpoint Blockade, Pedro Rocha, Rafael Bach, Laura Masfarré, Sharia Hernandez, Nil Navarro-Gorro, Adrià Rossell, Xavier Villanueva, Mario Giner, Ignacio Sanchéz, Miguel Galindo, Raúl Del Rey-Vergara, Albert Iñañez, Beatriz Sanchéz-Espiridion, Wei Lu, Ariadna Acedo-Terrades, Pau Berenguer-Molins, Albert Sánchez-Font, Roberto Chalela, Victor Curull, Álvaro Taus, Max Hardy-Werbin, Mark Sausen, Andrew Georgiadis, James White, Jennifer B Jackson, Laura Moliner, Sergi Clavé, Beatriz Bellosillo, Ana Rovira, Ignacio Wistuba, Luisa M Solis Soto, Júlia Perera-Bel, Edurne Arriola

Faculty, Staff and Student Publications

Introduction: Immunotherapy is firmly established as a treatment regimen in various solid tumors, driven by its exceptional benefits in a selected group of patients. Despite widespread adoption of immune checkpoint blockade (ICB) across diverse solid tumors, the quest for a clinically informative biomarker for long-term benefit remains unmet.

Methods: A total of 49 patients with metastatic NSCLC treated with ICB were included. Long-term (LTR) and short-term responders (STR) were defined as those with a response to ICB lasting more than 24 months or less than 6 months, respectively. Longitudinal blood specimens were collected before ICB treatment initiation and early-on treatment. …

Caspase 3-Specific Cleavage Of Ubiquitin-Specific Peptidase 48 Enhances Drug-Induced Apoptosis In Aml, Zhanglin Zhang, Xiang Lin, Yaling Yang, Xuemei Wang, Yi Wang, Xianbao Huang, Miao Hong, Wei Gao, Hua He, M James You, Yi Yang, Guangyao Kong

Faculty, Staff and Student Publications

Dysfunction or dysregulation of deubiquitination is closely related to the initiation and development of multiple cancers. Targeted regulation of deubiquitination has been recognized as an important strategy in tumor therapy. However, the mechanism by which drugs regulate deubiquitinase is not clear. Here, we identified ubiquitin-specific peptidase 48 (USP48), a member of the ubiquitin-specific protease family highly expressed in various tumors, as a specific substrate for the activated caspase-3. During drug induced apoptosis of AML cells, activated caspase-3 cleaves USP48 through recognizing the conservative motif DEQD located at 611-614 sites of human USP48. Subsequent analysis showed that the cleavage USP48 N-terminal …

Impact Of Peripheral Circadian Misalignment And Alcohol On The Resiliency Of Intestinal Barrier And Microbiota, Laura Tran, Maliha Shaikh, Phillip A Engen, Ankur Naqib, Dulce M Frausto, Vivian Ramirez, Malia Gasteier, Zlata Bogin, Kristi Lawrence, Lijuan Zhang, Shiwen Song, Stefan J Green, Faraz Bishehsari, Christopher B Forsyth, Ali Keshavarzian, Garth R Swanson

Faculty, Staff and Student Publications

Circadian organization is involved in many gastrointestinal tract (GIT) functions such as the maintenance of intestinal barrier integrity. There is compelling evidence that perturbation of the circadian clock decreases intestinal epithelial cells' resiliency to alcohol-induced injury. One of the most common causes of circadian misalignment is wrong-time eating (largest meal at dinner) in modern societies. Yet, few studies have examined the importance of peripheral circadian rhythms of the GIT to alcohol consumption. Eating patterns during physiologic rest time, defined as wrong-time eating (WTE), misalign the peripheral circadian clock of the GIT and the body's central clock. This study aims to …