Digital Commons Network^™

Circulating Tumor Dna Refines Risk Stratification Of Neoadjuvant Therapy-Resistant Breast Tumors, Mark Jesus M Magbanua, Nayelis A Manon, Denise M Wolf, Samuel Rivero-Hinojosa, Ziad Ahmed, Rosalyn W Sayaman, Antony Tin, Derrick Renner, Ekaterina Kalashnikova, Lamorna Brown-Swigart, Gillian L Hirst, Christina Yau, Wen Li, Claudine Isaacs, Rebecca A Shatsky, Amy S Clark, Alexandra Zimmer, Amy L Delson, Angel Rodriguez, Minetta C Liu, Paula R Pohlmann, Laura J Esserman, Hope S Rugo, Angela Demichele, Laura Van 'T Veer

Faculty, Staff and Student Publications

Early-stage breast cancers resistant to neoadjuvant therapy (NAT), characterized by high residual cancer burden (RCB) after treatment, have an increased risk of metastatic recurrence. Here, we show that circulating tumor DNA (ctDNA) detected using a tumor-informed test (1) can improve risk stratification of patients with NAT-resistant tumors (RCB-II/RCB-III) and (2) predict response to NAT. Stratification using ctDNA status at pretreatment or post-NAT and ctDNA dynamics identified NAT-resistant tumors with a significantly decreased risk of metastatic recurrence. ctDNA clearance as early as week 3 across receptor subtypes predicted favorable responses to NAT, including immunotherapies. Interestingly, less than a fifth of patients …

Single Cell Spatial Profiling Of The Matrisome Identifies Region-Specific Adhesion And Signaling Networks In Glioblastoma, Arpan De, Santiago A Forero, Ali Pirani, John E Morales, Marisol De La Fuente-Granada, Sumod Sebastian, Jason T Huse, Leomar Y Ballester, Jeffrey S Weinberg, Frederick F Lang, Kadir C Akdemir, Joseph H Mccarty

Faculty, Staff and Student Publications

The human brain contains a milieu of extracellular matrix (ECM) components that promote normal development and physiology. ECM signaling pathways are often dysregulated in brain pathologies including the malignant cancer glioblastoma (GBM). Here, we used single-cell spatial transcriptomic platforms to map the expression of nearly 400 ECM genes in matching non-cancerous brain and GBM samples. At least four different GBM cell populations have been identified that show unique ECM expression profiles and spatial enrichment in distinct intratumor regions. Spatial mapping demonstrates largely non-overlapping expression signatures of ECM components in GBM stromal cell types, particularly in vascular endothelial cells and microglia/macrophages. …

A Review Of Bioactive Compounds Of Caesalpinia Sappan: Pre- And Post-Harvest Effect, Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly

Jurnal Kultivasi

Sappanwood (Caesalpinia sappan L.) is a shrub or small tree that thrives in tropical regions and has been widely distributed across various areas. It has long been used as a natural dye in textiles, cosmetics, and herbal beverages due to its content of various bioactive compounds. This literature review discusses the secondary metabolites in sappanwood, their health benefits, and strategies to enhance product quality through pre-harvest and post-harvest treatments. This literature review was conducted by searching for relevant journals on Google Scholar using relevant keywords. Sappanwood contains diverse secondary metabolites, including flavonoids, phenolics, anthraquinones, triterpenoids, steroids, alkaloids, and tannins, with …

Towards Fair Sequential Resource Allocation: Algorithmic Designs, Interventions, And Evaluations, Ashwin Kumar

McKelvey School of Engineering Graduate Student Theses & Dissertations

This thesis develops a comprehensive framework for fair sequential resource allocation in multi-agent systems where a centralized allocator coordinates actions under global feasibility constraints, while satisfying preferences of different agents. Ranging from ridesharing platforms and homelessness intervention programs to power grid management, such systems play a critical role in shaping access to essential resources. Yet, existing approaches to resource allocation often prioritize aggregate utility, leading to systematic inequities across individuals and groups, particularly in sequential settings where decisions unfold over time. To address this challenge, we introduce the Distributed Evaluation, Centralized Allocation (DECA) framework, which unifies a broad class of …

Role Of Nano Edible Coating, Packaging, And Storage Temperature In Maintaining Color, Moisture Content, And Phenolic Compounds Of Straw Mushroom, Kiki Nuratni Sitompul, Syariful Mubarok, Kusumiyati

Jurnal Kultivasi

Straw mushrooms are among the most sought-after edible mushrooms, but their harvest is highly perishable due to their high respiration and transpiration rates, leading to a decline in quality during storage. The application of nano edible coating can cover the surface of straw mushrooms and maintain their freshness, while packaging and storage at low temperatures can maintain quality by inhibiting respiration and enzymatic activity. This study aims to evaluate the effects of nano edible coating, packaging types, and different storage temperatures on the color, moisture content, and phenolic compounds of straw mushrooms. The study was conducted at the Horticulture Laboratory, …

Comparative Analysis Of Color, Texture, And Water Content In Three Shallot Cultivars At Different Harvest Ages, Rahma Wati Lestari, Kusumiyati, Syariful Mubarok

Jurnal Kultivasi

Shallots are a major horticultural commodity with high economic value. The quality of shallots is determined not only by the quantity of the harvest but also by physical characteristics such as bulb color, texture, and water content. This study aims to evaluate the differences in these physical parameters in three popular local cultivars: Brebes, Sumenep, and Tuktuk, harvested at 56, 63, and 70 days after planting (DAP), respectively. This research uses a Randomized Block Design consisting of 9 treatment combinations and analyzed using the SmartstatXL application. Color measurements are conducted using the CIELAB method and converted to CIELCH and RGB …

515-517 West 171st Street Llc V. Sequin

All Decisions

A landlord initiated a licensee holdover proceeding. The tenant, son of the former rent-controlled tenant, moved for summary judgment on his succession defense, claiming he primarily resided with his deceased father. The court granted the tenant's motion, finding sufficient evidence of co-residency for the statutory period, even considering the father's time in a nursing home before death. The landlord failed to raise material issues of fact, and the petition was dismissed, establishing the tenant's right to succeed to the rent-controlled tenancy.

Camidanlumab Tesirine For Relapsed Or Refractory Classic Hodgkin Lymphoma: A Phase 2 Study, Alex F Herrera, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

Outcomes in classic Hodgkin lymphoma (cHL) have steadily improved; however, additional therapies are needed for patients who relapse or do not respond to novel agents. Here, we report the efficacy and safety of camidanlumab tesirine (Cami), an anti-CD25 antibody-drug conjugate, in patients with relapsed/refractory cHL after brentuximab vedotin/programmed cell death protein 1 inhibitor therapies from the phase 2 ADCT-301-201 study. Eligible patients were adults with cHL who had received ≥3 previous lines of systemic therapy (or ≥2 if ineligible for hematopoietic stem cell transplant). Patients received 45 μg/kg Cami (IV, once every 3 weeks) in cycles 1 to 2, followed …

Deep Profiling Of Human T Cells Defines Compartmentalized Clones And Phenotypic Trajectories Across Blood And Tonsils, Suhas Sureshchandra, Elizabeth Levendosky, Allyssa Daugherty, Samuel J H Murphy, Chandrani Thakur, Naresha Saligrama, Et Al.

2020-Current year OA Pubs

98% of T cells reside in tissues, yet nearly all human T cell analyses are performed on peripheral blood. We performed single-cell sequencing of 5.7 million T cells from autologous blood and tonsils of ten donors. We identified distinct patterns of clonal expansion associated with tonsil-restricted phenotypes. Clonal sharing between blood and tonsils was lower than previous estimates and increased with age. Identical T cell receptor (TCR) sequences exhibited limited concordance in their phenotypes across compartments. Furthermore, location dictated the frequencies, clonal dominance, and phenotypes of antigen-specific T cells. Using immune organoids, we showed that antigen exposure drives functionally distinct …

Nktr-255 Enhances Complete Response Following Cd19 Car T-Cell Therapy In Patients With Relapsed/Refractory Large B-Cell Lymphoma, Sairah Ahmed, John Dipersio, Et Al.

2020-Current year OA Pubs

No abstract provided.

Biological Parenthood Rates Among Men With Sickle Cell Disease, Anyssa N Young, Sarah R Hayford, Sapuni S Chandrasena, Sara Conroy, Tanvi P Karkare, Barbara L Kroner, Allison King, Robert M Cronin, Luca Badolato, Leena Nahata, Susan E Creary

2020-Current year OA Pubs

No abstract provided.

Glycoside Hydrolase-Mediated Glucomannan Catabolism In Segatella Copri, A Target Of Microbiota-Directed Foods For Malnourished Children, Cyrus Zhou, Matthew C Hibberd, Evan M Lee, Suzanne Henrissat, Marie A Crane, Jiye Cheng, Michael J Barratt, Jeffrey I Gordon, Et Al.

2020-Current year OA Pubs

Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation produced superior ponderal and linear growth compared to a standard ready-to-use supplementary food. Subsequent analyses disclosed several candidate bioactive polysaccharides in the MDCF and their bacterial targets, notably strains of

Association Of Pet4 Response With Outcomes Of Bv-Chp Vs Chop In The Echelon-2 Trial In Cd30+ Peripheral T-Cell Lymphoma, Swaminathan Iyer, Neha Mehta-Shah, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

In the phase 3 ECHELON-2 trial, brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (BV-CHP) significantly improved progression-free survival (PFS) and overall survival (OS) compared with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in patients with CD30+ peripheral T-cell lymphoma, benefits that were maintained at 5 years. Interim positron emission tomography (PET) scan can be used to assess prognosis and risk-stratify patients. The prognostic value of interim PET was assessed in this post hoc exploratory analysis from ECHELON-2, evaluating interim 18F-fluorodeoxyglucose PET scans after cycle 4 (PET4) and end-of-treatment-based response, and correlated with PFS per investigator and OS. PET4 response was determined by …

Beyond Static Models - A Framework For Evaluating Dynamic Ml Approaches In Heart Failure Risk Prediction, Mohammad Arif Ul Islam

Theses

Heart failure remains a pressing global health challenge, affecting approximately 64 million people and incurring annual healthcare costs of $108 billion, driven by high readmission rates and delayed interventions. Current risk prediction models predominantly rely on static machine learning approaches, utilizing fixed datasets that fail to adapt to the evolving nature of patient health. This limitation results in outdated risk assessments, hindering timely clinical responses and worsening patient outcomes and resource efficiencies. This research addresses a fundamental methodological gap by developing and validating a chunk-based ensemble framework that enables researchers to evaluate dynamic machine learning potential using readily available static …

Analysis Of Source–Sink Organ Dynamics In Kaffir Lime (Citrus Hystrix Dc.) At Different Plant Ages, Siti Auliya Rahma, Rahmat Budiarto, Syariful Mubarok

Jurnal Kultivasi

Kaffir lime (Citrus hystrix DC.) is a leafy spice commodity widely used as a culinary ingredient, in bio-pharmaceuticals, and as a raw material for essential oil production. Despite its high demand, leaf productivity remains relatively low, highlighting the need for improved cultivation practices. A better understanding of source–sink dynamics is essential, as leaf production is strongly influenced by the balance between assimilate-producing and assimilate-consuming organs. Therefore, this study aimed to evaluate the source-sink capacity of kaffir lime plants of different ages as a preliminary step toward identifying cultivation strategies to enhance leaf production. The experiment was conducted at Bale Tatanen …

Mind Over Injury: Exploring Mental Imagery As A Game Changer In Athlete Rehabilitation, Maria Angelina Budelman, Jeff Cherubini

International Journal of Exercise Science: Conference Proceedings

GNYACSM Original Research

Mind Over Injury: Mental Imagery for Recovery

MARIA ANGELINA BUDELMAN, JEFF CHERUBINI Alumni Hall; Kinesiology; Manhattan University; Bronx, New York

Category: Undergraduate

Advisor / Mentor: Cherubini, Jeff ([email protected])

ABSTRACT According to the National Collegiate Athletic Association (NCAA), approximately five million injuries occur annually among collegiate athletes, many of which are associated with increased risks of negative mental health outcomes. As participation in collegiate athletics continues to grow, likely, both physical and psychological demands on athletes will also increase. Mental imagery (MI), the intentional practice of visualizing movements through the mind’s cognitive, emotional, and sensory processes, has been …

Combining Home Exercise, Fitbit Tracking, And Virtual Reality Mindfulness To Reduce Stress And Improve Cardiometabolic Health: A Physical Therapy Student Research Experience, Sharon A. Martino, Kelly Warren, John Calisi, Anthony Dicrescento, Mehran Mohamad, Gabrielle Lewin, Stefanie Gera, Ashley Youseffi, Steven Gengo

International Journal of Exercise Science: Conference Proceedings

GNYACSM Original Research Abstract

Combining Home Exercise, Fitbit Tracking, and Virtual Reality Mindfulness to

Reduce Stress and Improve Cardiometabolic Health: A Physical Therapy Student

Research Experience

SHARON A MARTINO, KELLY A WARREN, ANTHONY DICRESCENTO, JOHN CALISI, MEHRAN

MOHAMMAD, STEFANIE GERA, ASHLEY YOUSEFFI, GABRIELLE LEWIN, STEVEN GENGO

Rehabilitation Research and Movement Performance Laboratory; Stony Brook University; Stony

Brook, NEW YORK

Category: Graduate

Advisor / Mentor: Martino, Sharon ([email protected])

ABSTRACT

Student engagement in research is critical to developing evidence-based practice and critical thinking skills in PT education.

Student-driven research fosters independence, collaboration, and a deeper understanding of the scientific process,

preparing future …

Turning Aquatic Wearable Research Into Coaching Insight: Quantifying Fatigue To Improve Technique, Jack Grotke, Gerald Rashkovsky, Dhruv Seshadri

International Journal of Exercise Science: Conference Proceedings

Shoulder fatigue is a key contributor to performance decline and injury risk in swimmers, highlighting the need for objective monitoring tools; yet, despite their widespread use in land-based sports, wearable sensors remain underutilized in aquatic environments. PURPOSE: To examine how wearable muscle oxygenation (SmO₂%) sensors can quantify local fatigue during performance, predict fatigue-induced kinematic breakdowns, and inform evidence-based training strategies. METHODS: This IRB-approved study (Lehigh University #2113291-4) recruited fourteen (n=14) Division I butterfly swimmers randomized into Exercise (EX) or Control (CON) groups. All athletes maintained standard training routines, while EX completed a targeted exercise—two sets to …

Subject Specific Autoencoders Reveal Terminal Stage Gait Variability In The Bruce Protocol, Ali Boolani, Azarang Asadi

International Journal of Exercise Science: Conference Proceedings

General fatigue impacts both physiological and neuromuscular systems, leading to mechanical consequences in the musculoskeletal system that manifest as alterations and variability in gait patterns. The Bruce Protocol ends at maximal exertion, providing a window to study fatigue-linked gait deviations. Purpose: To investigate whether step-by-step gait during the terminal stages of the Bruce Protocol departs from a subject’s normal pattern. Methods: 24 Division I athletes completed the Bruce Protocol while spatiotemporal gait parameters were captured with OptoGait. Features included normalized parameters plus within- and between-limb variability metrics. Redundant features were removed using hierarchical clustering. A deep autoencoder was trained on …

Menstrual Phase Effects On Performance Readiness In Division I Women’S Basketball: A Longitudinal Multi-Modal Study, Hayley E. Whitney, Addie Micir, Rupa Ravi, Dhruv Seshadri

International Journal of Exercise Science: Conference Proceedings

Hormonal changes across the menstrual cycle influence cardiovascular, neuromuscular, and recovery responses, potentially altering athletic readiness and injury risk. Despite this, cycle phases are rarely integrated into athlete monitoring. PURPOSE: To examine menstrual phase–related differences in physiological and psychological readiness in Division I women’s basketball players. METHODS: Thirteen NCAA Division I athletes (IRB #2113291-6) were tracked daily from October 2024 to April 2025. Subjective measures include energy, soreness, sleep quality, and stress. Workload metrics were collected with the Beyond Pulse platform, and biometric data (recovery score, sleep index, resting heart rate, heart rate variability) were obtained from the Ultrahuman Ring …

Differential Associations Between Physical Activity Subtypes And Psychological Health In Sedentary Urban College Students, Rosselyn A. Charris, Bray Ilori, Galila Werber-Zion

International Journal of Exercise Science: Conference Proceedings

College students often report high levels of stress and anxiety, which can negatively impact academic performance and overall well-being. Physical activity (PA) is widely recognized for its mental health benefits; however, PA encompasses various domains. Subtypes such as Leisure-Time Physical Activity (LTPA), Occupational Physical Activity (OPA), Transportation Physical Activity (TPA), and Domestic Physical Activity (DPA) may not yield the same psychological outcomes. Understanding how specific PA domains relate to mental health may offer insight into how daily routines influence psychological well-being in urban college students. PURPOSE: This study aimed to determine whether distinct types of PA are differentially associated with …

Integrating Muscle Oxygen Monitoring Into Achilles Rehabilitation: Teaching Physiological Awareness Through Wearable Technology, Charles Rulon, Joe Amitrano, Marco Giuliani, Kevin Cahill, Dhruv Seshadri

International Journal of Exercise Science: Conference Proceedings

Rehabilitation following Achilles tendon rupture remains highly variable, with progression often guided by subjective observations rather than objective physiological metrics. Wearable near-infrared spectroscopy (NIRS) technology provides a means to quantify local muscle recovery and educate both clinicians and patients on the physiology of healing. PURPOSE: To evaluate the use of the Moxy muscle oxygen sensor in monitoring gastrocnemius muscle oxygen saturation (SmO₂) during rehabilitation after Achilles tendon repair and to translate these data into actionable insights for clinical and athlete education. METHODS: A 23-year-old male NCAA Division I football lineman (IRB #2113291-6) underwent right Achilles tendon repair on …

The Mode Of Physical Activity Does Not Affect Post-Prandial Blood Glucose Attenuation When Metabolically Matched, Tanathia Camacho, Adam E. Mohan, Thinh Le Mr., Levi Vazquez, Douglas J. Oberlin Ii

International Journal of Exercise Science: Conference Proceedings

PURPOSE:

Postprandial hyperglycemia contributes to the development of chronic diseases such as diabetes mellitus. While post-meal physical activity (PA) is known to reduce blood glucose (BG), it remains unclear whether certain modes of PA are more effective than others when matched for energy expenditure. This study aims to compare the BG-attenuating effects of two energetically equivalent postprandial modes of PA.

METHODS:

Eleven healthy adults completed three randomized sessions, consisting of a 75g oral glucose challenge and either walking, stepping, or rest. Each session’s PA lasted 15 minutes and occurred between 45–60 minutes post-ingestion, when BG typically peaks. During PA both …

Effects Of Differential Interset Temperature Application On Resistance Exercise Performance And Psychophysiology Responses, Adam E. Mohan, Alec Piñero, Ryan Burke, Jackson Mandart, Alysson Enes, Paul A. Swinton, Erik Hummer, Gerard Mcmahon, Brad J. Schoenfeld

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

Previous research has explored exposing distal extremities to cold temperatures as a strategy to enhance exercise performance (ExPer). While some studies have found acute ergogenic benefits to indices such as repetitions-to-failure and muscle activity, overall findings remain equivocal. No studies to date have evaluated interset palm cooling (IPC) effects across a full-body (FB) resistance training (RT) protocol. Thus, it remains unclear whether IPC may aid in physiological or performance-oriented outcomes in an ecologically valid context. PURPOSE: This study’s primary purpose was to evaluate the effects of IPC during a FB RT protocol on volume load (VL). The secondary …

Effects Of An Acute Dietary Capsaicin Intervention On Ambulatory Blood Pressure With Sex And Condition Differences: Preliminary Findings, Hashim B. Ghias, Kyle Heise, Valerie Chervinskaya, Melissa Severino, Isabella Harelick S. Harelick, Meredith Georger, Zoe Fallon, Ben Melnick, Kira Pegues, Elisa Fioraso, Erin Davis, Siena Goebel, Will Quin, Jillian Lang, Elena Shostak, Justin Deblauw, Stephen Ives

International Journal of Exercise Science: Conference Proceedings

Cardiovascular disease (CVD) is the foremost cause of death in the United States and worldwide; thus, understanding novel interventions (e.g., diet) to reduce CVD risk is of critical importance. Ambulatory BP monitoring allows assessment of cardiovascular responses under real-world conditions and may be superior to in-office BP in terms of CVD risk prediction. PURPOSE: This study examined the effects of an acute dietary capsaicin intervention on 24-hour peripheral BP and pulse pressure (PP), with attention to sex-specific responses, given prior evidence of sex differences in vascular function. METHODS: In a double-blind, randomized, placebo-controlled design, 70 healthy adults (36 females, 34 …

Correlations Between Bioelectrical Impedance And Subjective Measures During Recovery From A 100-Mile Trail Ultramarathon, Colin M. Bayait, Thomas Rosky, Rapolas Mastauskas, Samantha Colon, Aiden Miranda, Michael G. Wortley

International Journal of Exercise Science: Conference Proceedings

A 100-mile trail ultramarathon does significant damage to the musculoskeletal system. While subjective measures are commonly used to assess recovery from these events, objective measurements such as bioelectrical impedance (BEI) may offer validation and potentially insights into physiological changes happening during the recovery process. PURPOSE: The purpose of this study was to examine correlations between BEI data and subjective survey responses collected daily for one week before and after a 100-mile ultramarathon. METHODS: One participant (male, 47 years) completed daily assessments for one week before and after a 100-mile ultramarathon. All assessments were performed at 8:00 a.m., and …

Effects Of Load, Walking Direction, And Lifting Straps On Upper Limb Muscle Activation During The Farmer’S Walk., Areej Hassan, Chase Morrissey, Merylyn Acosta, Zaghloul Ahmed

International Journal of Exercise Science: Conference Proceedings

The Farmer’s Walk is a functional loaded gait exercise that integrates strength, balance, and postural control. It is frequently integrated into rehabilitation programs due to its functional relevance and ability to challenge total body strength, core stability, and dynamic control. PURPOSE: While its effects on postural stability and grip endurance have been documented, the neuromuscular activation patterns of upper limb muscles during loaded gait remain poorly understood. METHODS: Surface EMG was recorded from six muscles: supraspinatus, biceps brachii, triceps brachii, extensor digitorum, flexor carpi radialis, and flexor carpi ulnaris during forward and backward walking with loads equal to 50%, 75%, …

The Effects Of Dietary Capsaicin On Movement-Induced Hyperemia, Isabella S. Harelick, Valerie Chervinskaya, Kyle Heise, Melissa Severino, Meredith Georger, Zoe Fallon, Elisa Fioraso, Ben Melnick, Kira Pegues, Hashim Ghias, Justin Deblauw, Erin Davis, Siena Goebel, Will Quinn, Jillian Lang, Elena Shostak, Stephen Ives Facsm

International Journal of Exercise Science: Conference Proceedings

Cardiovascular disease (CVD) is the leading cause of death in the United States and affects men and women differently, highlighting the importance of understanding vascular regulation across both sexes. Regular consumption of dietary capsaicin (found in spicy peppers) has been associated with reduced CVD risk, potentially through improvements in vascular function. However, the mechanisms by which dietary capsaicin influences vascular health are not well understood. Passive limb movement-induced hyperemia (PLM) is a non-invasive technique used to assess vascular health. During PLM, a limb (typically the leg) is moved passively—without muscle contraction—by an external force, such as a researcher or mechanical …

Pre-Frailty Is Associated With Reduced Percent-Predicted Cardiorespiratory Fitness In Patients With Heart Failure, Kellie N. Hoehing, Alexander Chui, Rochelle Goldsmith, Carol Garber Facsm, Afsana Rahman

International Journal of Exercise Science: Conference Proceedings

Frailty and pre-frailty affect over half of patients with heart failure (HF) and are linked to less favorable outcomes, independent of age and New York Heart Association (NYHA) functional class. Pre-frailty, a transitional and potentially reversible state, is more prevalent than overt frailty but remains less studied. Cardiopulmonary exercise testing (CPET) is the gold standard for assessing functional capacity (VO2peak) and prognosis in HF, but the relationship between pre-frailty and CPET metrics remains unclear. PURPOSE: Determine whether pre-frailty status is independently associated with lower percent predicted cardiorespiratory fitness (%VO2peak) among individuals with HF compared to those classified as robust. METHODS: …

Surgical Management Of A Grade-Ii Anterior Talofibular Ligament Tear With Ehlers-Danlos Syndrome: A Case Report, Jake Finkelstein, Jessie Hirsch, Ofra A. Pottorf, Alex Rothstein

International Journal of Exercise Science: Conference Proceedings

CASE HISTORY: A 21-year-old female with hypermobile Ehlers-Danlos Syndrome (hEDS) sustained a right ankle inversion injury while stepping off a curb, resulting in acute pain, swelling, and inability to weightbear. Initial conservative treatment including rest, ice, and traditional physical therapy (PT) was initiated but failed to relieve symptoms. Magnetic Resonance Imaging (MRI) revealed a Grade-II ATFL tear with chronic instability. After three months of unsuccessful conservative management and persistent pain and instability, surgical intervention was pursued. PHYSICAL EXAM: Examination revealed marked tenderness over the anterior talofibular ligament (ATFL), restricted motion in all directions, decreased strength (2+/5) and positive anterior drawer …