Digital Commons Network^™

Amidst The Struggles, Nyc Actors Say The Pursuit Of Their Craft Is Always Worth It, Allison Dubrow

Capstones

Despite high ticket prices and safety concerns, Broadway has had a record-breaking season, surpassing pre-pandemic box office revenue largely due to star-driven productions. While the industry is financially thriving, many NYC actors struggle to make a livable wage and rely on non-acting jobs to support themselves. The uncertainty of auditions and booking work makes sustaining an acting career especially difficult in such a competitive city. This project highlights the contrast between Broadway’s success and the resilience it takes for actors to survive and pursue their craft in New York City.

Two Major Ontario Hospital Labs Bought Research Dogs From U.S. Breeder With Troubled Pastdogs Bred For Scientific And Medical Testing Suffer Abuse As The Scientific Industry Increasingly Turns To Alternatives For Research., Allison Hunter, Mary Beech, Sami Marshak, Kate Morano

Capstones

The purpose-bred dog breeding industry for research is little known. Each year, thousands of dogs are bred for scientific and medical testing, supplied to research facilities by a handful of major commercial breeders. But gaps in enforcement and regulation have allowed abuses to persist, even as the industry increasingly turns to alternatives to animal testing. Animal rights advocates have been decrying the treatment of these dogs. A federal Inspector General report found lax oversight of the industry, raising further concerns about how dogs are treated. This story was reported in collaboration with the Investigative Journalism Bureau, based in Toronto, and …

Relief, At A Cost: New Bill Forces Landlords To Offer Ac, But Leaves Tenants With The Bill, Niamh Mcauliffe

Capstones

As summers in New York City are getting hotter and hotter every year due to climate change, lack of home air conditioning is a serious issue. A newly passed City Council bill would require landlords to provide air conditioning upon tenant request. While advocates see the legislation as a necessary step to protect tenants from the dangers of extreme heat, there are still unresolved questions around energy affordability, costs and implementation.

https://docs.google.com/document/d/1XgVilwyn6ncwVbslr1UcdP6p-3OwGQAseHXMY3EYCeY/edit?usp=sharing

The Glow Up Guide: Chicago Edition : Housing + Stability After Foster Care, Lucila M. Baptiste

Capstones

For my practicum, I examined what “independence” looks like for young people aging out of foster care and how the transition to adulthood is shaped by housing instability, rising living costs, and uneven access to support. Using an engagement journalism approach, I centered lived experience and community-informed reporting to document the challenges young people face as systems shift responsibilities onto them often quickly and with limited safety nets.

This practicum pairs narrative reporting with a practical, service-oriented resource component designed to be useful beyond the classroom. The project draws on interviews, field reporting, and collaboration with people closest to the …

El Camino Al Exilio Para Una Estudiante De Nicaragua Que Huyó De Ortega, Leyrian Colon Santiago

Capstones

A inicios de 2018, Lucía tenía bien estructurado como serían sus próximos dos años en la escuela de medicina. En las mañanas, se enfocaría en las clases teóricas y en las tardes, haría sus rotaciones como practicante en algún hospital de Nicaragua. Y cuando le sobrara tiempo, visitaría a su familia a las afueras de la capital, Managua.

Lo que Lucía jamás pensó fue que ser una estudiante universitaria que protestó pacíficamente contra el gobierno de su país la empujaría al exilio a sus 23 años de edad.

Actualmente Lucía, quien pidió que su nombre real no fuese publicado por …

Beyond Precision: Ambiomic Survivorship In Childhood And Aya Cancer., Juan Antonio Ortega-García, Omar Shakeel, Nicole Wood, Antonio Pérez-Martínez, Jose Luís Fuster-Soler, Mark D. Miller

Manuscripts, Articles, Book Chapters and Other Papers

Background: Survival among children and adolescents and young adults (AYA) with cancer has improved substantially over recent decades; however, dominant survivorship models remain reactive-activated post-treatment and anchored to static exposure- and organ-based screening. This design underuses the anticipatory window at diagnosis and overlooks environmental and social determinants that modulate outcomes across the life course. Methods: We narratively reviewed international frameworks including the Children's Oncology Group (COG), the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG), the Pan-European Network for Care of Survivors after Childhood and Adolescent Cancer (PanCare) and the National Comprehensive Cancer Network (NCCN), and synthesized evidence …

Rwu Law Alumni Holiday Reception 12-03-2025, Roger Williams University School Of Law

School of Law Conferences, Lectures & Events

No abstract provided.

(Un)Intended Consequences Of Race In Medicine: The Ethics Of Race-Based Medical Practice And The Perpetuation Of Structural Racism, Allegra Merriweather

Electronic Theses and Dissertations

This dissertation proposes that race-based medicine acts as a form of structural racism that is ethically indefensible. While it may be claimed to be a neutral diagnostic tool, the medical use of race as a biological proxy only further enforces the very hierarchies it purports to remediate, reinscribing inequity from conception to death. Building off Jacques Ellul’s work on Technique, we interpret race-based medicine as a self-perpetuating system that values procedural expediency over moral accountability. In nine chapters, the analysis follows the ways this technique is manifested in genetics and assisted reproduction, where commodified racial selection preserves social hierarchies; in …

Utilizing The Visia Camera For Analyzing 5-Fluorouracil Treatment Efficacy For Actinic Keratosis, Emily Woolhiser, Leena Jamal, Jessica Kirk, Bertha Baum, Robert Dellavalle

Student Publications

The VISIA camera is a device that captures images of the skin, offering a detailed look at skin health by detecting changes that are often missed during physical exams and by the naked eye. It can help identify changes in UV damage, pigmentation, texture, fine lines, and redness. In dermatology, it has become a useful tool to build targeted treatment plans and follow patient progress over time. We present a case of a male patient diagnosed with diffuse scalp actinic keratoses who was treated with topical 5-fluorouracil (5-FU). VISIA images were taken before treatment, at one week, and again three …

Daily Intake Of A Lycopene-Rich Juice Is Associated With Reductions In Inflammatory Markers But Not Increases In Skin Carotenoids In A Pilot Study Among Participants With Obesity, Stephanie B Jilcott Pitts, Qiang Wu, Melissa N Laska, Elizabeth Gates, Megumi H Seese, Katelyn E Senkus, Santiago Carrero Longlax, Alexandra Portillo-Varela, Andrew R Dinardo, Nancy E Moran

Faculty, Staff and Students Publications

Background

Obesity is associated with systemic inflammation, increasing chronic disease risk. Carotenoids possess anti-inflammatory properties, yet the short-term impact of carotenoid-rich juice intake on inflammation in individuals with obesity remains unclear. Therefore, the purpose of this paper was to examine: (1) participant adherence to a 3-week lycopene-rich juice intervention; (2) variance and effect sizes of responses to the dietary intervention; (3) changes in skin and plasma carotenoids, and inflammatory markers among adults with obesity.

Methods

Twenty-five participants with body mass index (BMI) > 30 kg/m2 were recruited and completed the study. Participants drank 4 ounces (118.3 mL) of study-provided tomato juice, …

A Systematic Characterization Of Fibroblast Subtypes And Heterogeneity, Xiuli Zhu, Hongen Kang, Zhongming Zhao, Peilin Jia

Faculty, Staff and Student Publications

Fibroblasts are essential components in development, disease, and treatment response, yet their diversity and function remain incompletely understood. Here, we constructed a comprehensive fibroblast landscape by integrating large-scale single-cell and single-nucleus RNA sequencing datasets spanning 60 major human organs and tissues across various developmental stages and biological conditions. We identified 16 fibroblast subtypes and systematically characterized their tissue specificities, transcriptional heterogeneity, and cell states. Further analyses revealed distinct fibroblast subtypes associated with pluripotency and senescence across tissues. Leveraging the well-defined fibroblast atlas, we demonstrated that different fibroblast subtypes were associated with various complex traits such as anthropometric and immune diseases. …

Evaluating The Accuracy Of Point Of Care Testing Compared To Standard Laboratory Testing Among Inborn Infants In The Neonatal Intensive Care Unit, Isha Parikh, Sepideh Saroukhani, Matthew Rysavy, Brian Chang, Mar Romero-Lopez, Lindsay F Holzapfel

Faculty, Staff and Student Publications

Objective: Point-of-care (POC) testing offers expedited results with lower blood volume requirements than central laboratory (CL) tests, particularly for low-birth-weight infants.

Methods: A retrospective cohort included 118 patients with paired POC and CL tests within one hour in the first 14 postnatal days. Differences and agreement were assessed using linear mixed-effect models that account for within and between-subject variations.

Results: Compared to CL, POC testing underestimated sodium (6.0 mEq/L), potassium (0.1 mEq/L), chloride (5.1 mEq/L), and glucose (2.3 mg/dL), and overestimated hemoglobin (0.08 g/dL) and hematocrit (0.8%). Differences (CL- POC) varied by postnatal age and sample type, with larger differences …

The Impact Of Patient-Generated Health Data From Mobile Health Technologies On Health Care Management And Clinical Decision-Making: Narrative Scoping Review, Ava Keeling, John Downey, Matthew Halkes, Yinghui Wei

School of Nursing and Midwifery

Background: Long-term health conditions and multimorbidity are increasing globally, placing an unsustainable pressure on health care systems. Mobile health (mHealth) technologies enable the collection of patient-generated health data outside clinical settings, offering the potential to support personalized care and inform clinical decision-making. However, the ways in which mHealth patient data are being used in clinical practice remain unclear. Objective: This study aimed to map and synthesize the existing literature on how patient-generated mHealth data are reportedly being used and influencing clinical decision-making for adults with long-term conditions in an outpatient care setting. Methods: A narrative scoping review was conducted on …

Consciousness Studies In Community: Allan Leslie Combs’S Enduring Vision, Debby Flickinger Phd, Rebecca A. Damien Phd

Journal of Conscious Evolution

Consciousness studies can be found in many different disciplines. Allan Leslie Combs held an inclusive view of consciousness that was not limited to any one branch, and he inspired us to explore consciousness through many doorways. Together the authors share narratives about teaching and learning with Combs while reviewing key areas shaped by his legacy, including gatherings, archetypes, psychology, and synchronicity. Our shared intention is to honor Leslie’s legacy through a narrative that comes from the heart as well as the mind.

Keywords: consciousness studies, gatherings, archetypes, synchronicity, Allan Leslie Combs

Single-Nucleus Multiomics Reveals The Disrupted Regulatory Programs In Three Brain Regions Of Sporadic Early-Onset Alzheimer’S Disease, Andi Liu, Citu Citu, Nitesh Enduru, Xian Chen, Chia-Hao Tung, Tirthankar Sinha, Sofia E Sepulveda, Astrid M Manuel, Damian Gorski, Brisa S Fernandes, Meifang Yu, Paul E Schulz, Lukas M Simon, Claudio Soto, Zhongming Zhao

Faculty, Staff and Student Publications

Sporadic early-onset Alzheimer’s disease (sEOAD) represents a substantial but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type–specific transcriptomic changes and linked candidate cis-regulatory elements (cCREs) across brain regions. We prioritized eight conservative transcription factors in glial cells in multiple brain regions, including RFX4 in astrocytes and IKZF1 in microglia, which are implicated in regulating sEOAD-associated genes. Moreover, we identified the top 25 altered intercellular signaling between glial cells …

Accepting Vs Understanding, Transgender Aliens And Alienation, Reyna G. Aliah

English

Trans people have been the subject of intense discrimination in recent years, suffering dehumanization from right-wing and conservative groups. This dehumanization (and the fear resulting from it) parallels common attitudes in science fiction about actual aliens. Orson Scott Card’s Hierarchy of Foreignness classifies individuals and species into five categories, depending on their sentience; whether they are from the same city, nation, or planet; and whether communication is possible. This paper examines how transgender people can be classified according to this system on a societal level, with said class depending on the lens used to view them as well as the …

Playing By Feel: Gender, Emotion, And Social Norms In Overwatch Role Choice, Cristo Leon, Angela Arroyo, James Lipuma

STEM for Success Resources

This paper explores how emotion, gameplay context, and social norms shape role choice in both digital and institutional systems. Using Overwatch as a case study, it examines gendered experiences of physiological excitement and decision-making during play. Women often describe heightened emotional engagement where victory represents both personal achievement and resistance to cultural expectations. Such emotions influence situational choices, including whether to play as a Tank, DPS, or Support, and which hero to select based on perceived risk or visibility. Drawing on feminist game studies and transdisciplinary communication, the authors argue that role preference is determined not only by game mechanics …

Biophysical Characterization And Structural Insights Into The Complex Between The Extracytoplasmic Function Sigma Factor, Pupi, With The Antisigma Domain Of The Sigma Regulator, Pupr, From Pseudomonas Capeferrum, Tajnin Sultana, Robin N. Kutsi, Alexander Tischer, Siri Froiland, Elizabeth L. Gertz, Jaime L. Jensen, Matthew Auton, Sangita C. Sinha, Christopher L. Colbert

APC Fund Awardees

Gram-negative bacteria utilize siderophores to scavenge for environmental iron. Pseudomonas capeferrum produces the siderophores pseudobactin BN7/8, which trigger cell surface signaling (CSS). Iron import CSS pathways consist of an outer membrane TonBdependent transporter, an inner membrane sigma regulator, and a cytoplasmic sigma factor that activates transcription of target genes. The P. capeferrum sigma regulator, PupR, has an N-terminal antisigma domain (ASD). Previously, the PupR ASD was purified as a dimer in the absence of its cognate sigma factor, PupI. Here we use pulldown assays to demonstrate that His6-PupIFL interacts with the PupR ASD as well as with homodimer-disrupting mutants. We …

A Comparison Of Tenecteplase To Alteplase For Treatment Of Acute Ischemic Stroke Using Epic Cosmos Database, Marco Gonzalez Castellon

Theses & Dissertations

Ischemic stroke is highly prevalent and an important cause of morbidity, mortality, and long-term disability in the in the United States. The incidence and prevalence of stroke is expected to increase in the next few years due to several factors including aging of the U. S. population, improved treatment, and socioeconomic factors. In 1996, the FDA approved rtPA for the treatment of ischemic stroke patients. Patients had a greater likelihood of recovering successfully. However, rtPA has significant limitations, such as an elevated risk of intracranial hemorrhage, administration difficulties, and limited effectiveness. In March 2025, the FDA approved the use of …

Posterior Anatomic Limit For Mandibular Molar Distalization In Subjects With Different Growth Patterns, Genders, And Growth Status, Rehana Bashir

Theses & Dissertations

The objective of this study is to identify the anatomical limits for mandibular molar distalization, a technique frequently employed in orthodontics to address various malocclusions. Mandibular molar distalization plays a critical role in the management of crowding, and correction of the molar relationship.

It is imperative to assess the posterior anatomical space (PAS) in the mandibular retromolar area prior to distalization or uprighting the mandibular molars to avoid periodontal issues (dehiscence, orthodontically induced root resorption, and tooth mobility) and achieve successful treatment outcomes.

A clinical question that, however, isn't well understood is whether the amount of mandibular molar distalization is …

Mechanistic Insight Of Neuropilin-2 Expression During The Progression Of Prostate Cancer, Sanika Bodas

Theses & Dissertations

Advanced prostate cancer represents a particularly aggressive and challenging form of prostate cancer (PCa) that shows resistance to both traditional therapies, such as androgen deprivation therapy, and newer treatment modalities like hormone therapies and immunotherapies. For patients diagnosed with advanced stages of PCa, treatment options are limited, and chemotherapy is often the last line of defense. Unfortunately, chemotherapy can severely diminish the quality of life, particularly in older patients, due to its harsh side effects, including fatigue, immune suppression, and overall physical decline. Despite these challenges, researchers and clinicians remain focused on developing more effective and targeted treatments for patients …

Assessment Of Polymeric Chloroquine Formulations For Targeted Therapy Of Ulcerative Colitis And Metastatic Colorectal Cancer, Neha Kumari

Theses & Dissertations

Effective targeted drug delivery is a critical unmet need in the management of both ulcerative colitis and metastatic colorectal cancer, where conventional systemic therapies may be hindered by suboptimal efficacy and significant side effects. This thesis explores the development and preclinical assessment of polymeric chloroquine (PCQ)-based nanotherapeutics, leveraging stimuli-responsive designs for disease-specific delivery and action.

For ulcerative colitis, a reactive oxygen species (ROS)-responsive nanogel system was engineered to release PCQ, a macromolecular derivative of hydroxychloroquine, specifically in the inflamed areas within the colon. Nanogels with well-defined size and positive surface charge were synthesized via reversible fragmentation chain transfer (RAFT) polymerization …

Development And Characterization Of Non-Viral Delivery Systems For Pulmonary Delivery Of Nucleic Acid Therapeutics, Kasturi Siddhanta

Theses & Dissertations

The development of non-viral delivery systems for pulmonary delivery of nucleic acid therapeutics is driven by the need for safer and more accessible approaches to treat lung diseases, while avoiding the systemic side effects and immune responses associated with viral vectors. Such systems encompass both non-invasive inhalation-based platforms, and systemically administered platforms designed to achieve localized lung delivery. These strategies aim to enable high drug concentrations at the site of action, rapid onset of therapeutic effect, and greater therapeutic efficacy than existing treatments. Designing effective pulmonary delivery systems requires precise optimization of particle properties—including size, morphology, surface characteristics, cell-specific targeting, …

Evaluating Joint Control Teaching Procedures For Teaching Yes-No Responding With Tact And Intraverbal Questions For Children With Autism, Desiree J. Dawson

Theses & Dissertations

Responding to yes and no questions is a general language skill that allows individuals to efficiently interact with their verbal community. Few behavior analytic studies have sought teaching this skill in general, with even fewer studies seeking to teach this skill when it pertains to a tact or intraverbal context. All behavior analytic studies to date seeking to teach this skill have used direct prompting and reinforcement of the yes and no responses, but there is little guidance for what can be done if this teaching strategy is not producing desired acquisition. The current experiments examined a teaching procedure informed …

Role Of Nadph Oxidase 4 In Murine Cancer-Associated Fibroblast, Faith M. Gomez

Theses & Dissertations

Breast cancer is the second leading cause of cancer deaths in women in the United States. Frontline hormone therapies for breast cancer prove ineffective in triple negative breast cancer tumors wherein the hormones estrogen, progesterone, and HER2 are downregulated or absent; therefore, patients diagnosed with triple negative breast cancer are primarily limited to chemotherapies which carry a higher failure and resistance rate. Here we target cancer associated fibroblasts as potential drivers of chemoresistance in triple negative breast cancer. We investigated the mechanism by which Nox4 regulates the YAP/TAZ pathway in modulating DTX sensitivity and sought to determine if targeting Nox4 …

Development Of Self-Assembled Polymeric Polyplexes For Microrna Delivery: Toward Treatment Of Alcohol-Associated Liver Disease, Marjina Akter Kalpana

Theses & Dissertations

Self-assembled polymeric polyplexes have the potential to serve as an RNA interference (RNAi) delivery platform for the combined inhibition of CXCR4 and miR-155 in the treatment of alcohol-associated liver disease (AALD). A central challenge in RNA delivery is balancing the extracellular stability of polyplexes, cellular uptake, and intracellular release of RNA cargo. We developed polymeric polyplexes using the CXCR4-antagonist polymer PAMD, designed to target CXCR4 on activated hepatic stellate cells (HSCs) and deliver therapeutic miRNA to activated Kupffer cells (KCs) in fibrotic liver. We improved the polyplexes by cholesterol modification of PAMD and by PEGylation of PAMD-Ch. The cholesterol modification …

2025 Winter Series Animal Tracks Identification Challenge, Alison Coleman

UNH Cooperative Extension

No abstract provided.

Comparison Of Cervical Spine Injury Clinical Prediction Rules For Children After Blunt Trauma, Lois K. Lee, Fahd A. Ahmad, Lorin R. Brown, Monica Harding, Lawrence Cook, Kathleen Adelgais, Rebecca K. Burger, Alexander Rogers, Leah Tzimenatos, Lauren C. Riney, Daniel Rubalcava, Caleb E. Ward, Kenneth Yen, Julie C. Leonard

2020-Current year OA Pubs

No abstract provided.

Integrating Traditional Ecological Knowledge And Environmental Science For Sustainable Lake Conservation: Danu Kerthi In Bali, Ni Kadek Surpi, Si Luh Nyoman Seriadi, Ni Wayan Jemiwi Jero

Journal of Environmental Science and Sustainable Development

This study investigates how the Danu Kerthi philosophy operates as a framework that integrates Traditional Ecological Knowledge (TEK) with environmental science to support sustainable lake conservation in three upstream lakes in Bali: Beratan, Buyan, and Tamblingan. While previous scholarship has largely focused on the normative and symbolic dimensions of Sad Kerthi, empirical evidence on its ecological effectiveness remains limited. To address this gap, the study adopts a multi-site qualitative design involving participatory observation, document analysis, and semi-structured interviews with 30 participants representing traditional leaders, Hindu priests, tourism managers, village officials, and local residents. Thematic analysis shows that Danu Kerthi continues …

Baseline Exposure-Response Assessment Of Metals From Dried Blood Spots And Personal Household Air Pollution Concentrations Among Pregnant Women In Rwanda: Household Air Pollution Intervention Network Trial, Adolphe Ndikubwimana, Lisa De Las Fuentes, Victor G Dávila-Román, Et Al.

2020-Current year OA Pubs

BACKGROUND: Exposure to metals from the combustion of biomass via inhalation may result in negative health outcomes affecting a variety of organs and systems. Pregnant women cooking with biomass fuels may be exposed to metals, such as lead (Pb) and cadmium (Cd), and have unique risks for adverse health effects with potential impacts on the growing fetus. We assessed the associations between household air pollution and metals detected in dried blood spots from pregnant women at baseline in Rwanda.

METHODS: We analyzed data from 781 pregnant women aged 18-35 years who resided in rural households using biomass fuel and who …