Digital Commons Network^™

New Resource: Psyctests, Joanne Romano

TMC Library Newsletter (2015-)

APA PsycTESTS is now available through the TMC Library. Each record includes detailed test information, permissions for use, and—when available—full-text tests and supporting documentation.

Introducing Consensus Library, Joanne Romano

TMC Library Newsletter (2015-)

No abstract provided.

Martin Luther King Jr. Day Holiday Hours, Beatriz Varman

TMC Library Newsletter (2015-)

No abstract provided.

An Empirical Comparison Of K-Nearest-Neighbors And Logistic Regression Classification Models, Jackson Cushing

Graduate Studies Theses and Dissertations 2026

This thesis presents an empirical comparison of two classification methods: Logistic Regression and K Nearest Neighbors (KNN). The primary objective of this research is to evaluate the strengths and limitations of each method when applied to real-world datasets. Several publicly available datasets on diabetes, breast cancer, heart attack risk, and cardiovascular disease, were analyzed. For each dataset, K Nearest Neighbors models were implemented in the same way logistic regression had already been applied. The results demonstrate that while logistic regression offers interpretable parameter estimates and performs well when the underlying predictor and outcome relationship is approximately linear, however KNN can …

Machine Learning Modeling Of In-Situ Effective Thermal Conductivities And Ablation Behaviors Of Ceramic Matrix Composites Under Hydrogen Combustion Environments For Gas Turbine Engines, Jayanta Bhusan Deb

Graduate Studies Theses and Dissertations 2026

Through the integration of experimental characterization, machine learning, deep learning, numerical modeling, and physics-informed artificial intelligence, this dissertation explores the thermal performance of polymer-derived ceramic matrix composites (CMCs) for hydrogen combustion environments. The polymer infiltration and pyrolysis (PIP) process was used to create Yttria-stabilized zirconia (YSZ)-fiber-reinforced ceramic matrix composites, which were then experimentally assessed under hydrogen torch and hydrogen combustion conditions typical of next-generation gas turbine and aerospace propulsion systems. Front- and back-surface temperature measurements were used to continually monitor thermal reactions, and post-test microstructural characterization and numerical simulations were carried out to evaluate material integrity and heat-transfer behavior. To …

Assessment Of Major Adverse Cardiovascular Event Across Diverse Racial Groups Of Psoriasis Patients On Biologic Therapy: A Retrospective Cohort Study, Chunghwan Ro, Ana Ormaza Vera, Waleed Adawi, Clinton W. Enos

Department Dermatology Faculty Publications

Psoriasis is associated with an increased risk of major adverse cardiovascular events (MACE), and biologic therapy may reduce this risk by targeting systemic inflammation. However, limited data exist on whether long term MACE risk differs by biologic class or across racial groups. We conducted a retrospective cohort study to assess the risk of primary MACE in psoriasis patients receiving biological therapies, stratified by biological class, compared with biologic-naïve psoriasis patients. Whether MACE risk among biologic-treated patients varied by race was further examined. After 1:1 propensity score matching, 36 330 biologic-treated patients were compared with 36 330 non-biologic-treated patients. Incident MACE …

The Development And Initial Validation Of A Measure Of Professional Mentoring Engagement Among School Counselors, Emily Kitching

Theses and Dissertations

This study describes the development and initial validation of the Mentoring Engagement Scale (MES), a self-report instrument designed to measure a person’s level of engagement in professional mentoring. Despite emerging evidence that professional mentoring may serve as a protective factor against the burnout and stress associated with school counselors’ roles and responsibilities, existing measures of mentoring are limited by weak documentation of development procedures, mixed psychometric support, and limited practical applicability. In two phases, the present study aimed to (1) evaluate content validity and systematically refine items grounded in Kahn’s (1990) theory of engagement and (2) investigate the preliminary psychometric …

Implementation Of Tg-351 Reference Dosimetry For A 6 Mv Photon Beam In An Mr-Guided Radiotherapy System, Nicholas A. Castellano Jr.

Theses and Dissertations

Magnetic resonance guided radiation therapy (MRgRT) combines magnetic resonance imaging (MRI) and radiation therapy to enable the visualization of anatomy in real time during treatment. The presence of a magnetic field in MRgRT affects charged particle radiation and detector responses, necessitating changes to traditional reference dosimetry procedures. The American Association of Physicists in Medicine (AAPM) Task Group 351 (TG-351) provides a formalism for reference dosimetry in MRgRT. In this study, the TG 351 formalism is used to perform reference dosimetry for a 6 MV flattening filter-free (FFF) photon beam from a Viewray MRIdian MR-Linac radiation therapy system. Beam quality determination, …

De Novo Protein Binding To Zinc Oxide Through Biomineralization Pathways, Jean-Mark A. Francis

Theses and Dissertations

De novo proteins are structurally distinct from proteins found in nature and thus capable of having their amino acid sequence modified to accomplish tasks such as increasing protein-nanoparticle binding without unfolding or decomposing. Zinc Oxide nanoparticles are functionally distinct from their bulk counterparts and are widely used as semiconductors in a variety of fields such as medicine and agriculture. With demand for these nanoparticles increasing, environmentally sustainable methods of Zinc Oxide nanoparticle synthesis are being investigated as an eco-friendly alternative to currently utilized but environmentally hazardous chemical and physical techniques. This research investigates the binding characteristics between Zinc Oxide nanoparticles …

Dodgeballs And Dragons: Gamified Live Theatre In The Service Of Community Betterment, Teddy Mcpherson

Theses and Dissertations

This thesis qualifies and documents a new genre of interdisciplinary, interactive theatre called Dodgeballs and Dragons. It covers a brief history of Dungeons and Dragons and Theatre of the Oppressed (the two foundational works for the new genre) as well as previous uses of D&D as a form of theatrical entertainment. After establishing the precedence used to create this product, the rest of the thesis breaks down how to write, lead, and play these shows on a regular basis. The document culminates in collected data providing concrete evidence for the future of the form and its many applications.

Conceptual Concerns Regarding The Content Validity Of The Construct Of Gender Dysphoria In The Diagnostic And Statistical Manual Of Mental Disorders, Fifth Edition, Text Revision, Waverley Vesely

Theses and Dissertations

The diagnostic classification of gender dysphoria in the DSM-5-TR elicits a number of clinical, political, and philosophical concerns, ranging from those that are diagnostic and taxonomical in nature to those that fall within the domains of ontology, phenomenology, and hermeneutics. Part of the reason for the complexity of studying the diagnostic and nosological validity of gender dysphoria as an extant diagnostic classification is that, unlike many disorders, gender dysphoria is inextricably tethered to identity. While the recent change from gender identity disorder to gender dysphoria has nominally removed the status of disorder, in practice, both clinicians and the general population …

The Relationship Between Symptom Catastrophizing And Sociocultural Factors Among Adults With Persistent Sympathetic Activation Syndromes, Whitney M. Redemer

Theses and Dissertations

Persistent Sympathetic Activation (PSA) has emerged as a potential unifying mechanism underlying a range of complex chronic health conditions yet remains poorly characterized within biomedical and psychosocial research. Limited research has delineated how PSA manifests across diverse populations or how diagnostic and sociocultural factors shape lived experiences of this phenomenon; thus, the objective of the present study was to examine whether diagnostic certainty – operationalized as provider-confirmed versus self-suspected PSA-related diagnoses – is associated with symptom catastrophizing, and whether this relationship varies as a function of sociocultural factors. Drawing on data from a larger study aimed at characterizing the lived …

Foreign-National Families, Education, And Parenting: Unpacking The Influence Of Cultural Transitions On Child-Rearing And Expectations, Yuqi Zhang

Theses and Dissertations

This qualitative study examines how highly skilled foreign-national parents navigate parenting and educational decision-making within the context of cultural transition in the United States. While existing research on foreign-national parenting has largely focused on socioeconomically disadvantaged populations, less is known about families who possess substantial educational and professional capital. Despite these advantages, these parents encounter unique challenges related to institutional navigation, identity negotiation, and social constraints. Guided by Bronfenbrenner’s bioecological theory, Coleman’s social capital theory, Berry’s acculturation framework, and Yosso’s community cultural wealth model, this study explores how cultural background and migration experiences shape highly skilled foreign-national families’ parenting beliefs …

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell

Faculty, Staff and Student Publications

Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and …

Where Perspectives Meet: A Comparative Case Study Of How Participatory Practices Shape Deliberation During District-Level Educational Change, Gregory Vincent Massara

Electronic Theses & Dissertations (2024 - present)

Public education in the United States is socially and politically constructed, and ongoing reforms increasingly require collaborative engagement among diverse stakeholders amid heightened divisiveness. This mixed methods comparative case study examined how educational stakeholders make sense of one another’s perspectives during district-level collaborative work and the conditions that may foster conscientization, the critical reflection on one’s positionality. Two school districts developing a Profile of a Graduate (POG) and one engaged in deliberation about the relationship between public and charter schools within its community serve as comparative cases. The study triangulated meeting observations, a post-deliberation survey of stakeholders (N = 43), …

Evaluation Of Organ-Specific Relative Biological Effectiveness Of Proton Therapy Using Radiation-Induced Pneumonitis As An Endpoint, Li Liao, Ting Xu, Mei Chen, Tingshi Su, Narayan Sahoo, Xiaorong Zhu, Steven J Frank, Quynh-Nhu Nguyen, Zhongxing Liao, Xiaodong Zhang

Faculty, Staff and Student Publications

Background and purpose: Proton therapy has become widely used for non-small cell lung cancer (NSCLC) due to its ability to spare normal tissue. However, the commonly assumed relative biological effectiveness (RBE) of 1.1 may underestimate the therapy's true biological effects on lung, potentially leading to a higher than expected incidence of radiation-induced pneumonitis (RP). In this retrospective study, we evaluated the variability of organ-specific RBE of proton therapy using RP grade 2 or higher (RP2+) as an endpoint.

Materials and methods: Data from 270 NSCLC patients across two clinical trials were analyzed, with 134 given photon therapy and 136 given …

Trial Interviews To Explore Glycogen Storage Disease Type Ia Patient Experiences Following Gene Therapy, Diane M Turner-Bowker, Jessica Butler, Shayna Egan, David A Weinstein, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, Rebecca Riba-Wolman, John J Mitchell, Christina Theodore-Oklota

Faculty, Staff and Student Publications

Background: Glycogen storage disease type Ia (GSDIa) is a rare, inherited, autosomal recessive deficiency of glucose-6-phosphatase (G6Pase), an enzyme necessary in glycogenolysis and gluconeogenesis. To maintain normal blood glucose levels and ensure survival, individuals living with GSDIa must frequently consume complex carbohydrates (eg, uncooked cornstarch). Dietary management can result in chronic complications and significant patient burden. DTX401 (pariglasgene brecaparvovec) is an investigational adeno-associated virus serotype 8 vector (AAV8)-based gene therapy designed to restore endogenous glucose production.

Objectives: Patient experience interviews were conducted as part of an open-label, phase 1/2 dose-escalation trial (NCT03517085) evaluating the safety and efficacy of …

Dietetic Guidance For Nutritional Management Of People With Phenylketonuria Receiving Sepiapterin, Anita Macdonald, Kirsten Ahring, Alexa Bledsoe, Hiroki Fujimoto, Sara Giorda, Christian Kogelmann, Jessica Kopesky, Laura Nagy, Sara O'Neill, Alex Pinto, Soraia Poloni, Paige Roberts, Annemiek M J Van Wegberg, Suzanne Hollander

Faculty, Staff and Student Publications

Background/objectives: Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism. If untreated, elevated blood phenylalanine (Phe) levels lead to neurological and behavioral impairments. Phe levels can be managed through a lifelong Phe-restricted diet; however, this can be challenging to maintain. Sepiapterin is an adjunct therapy for PKU that has shown efficacy in reducing blood Phe levels in both tetrahydrobiopterin (BH4)-responsive and BH4-non-responsive people with PKU in clinical trials. Practical guidance is needed for dietitians and other healthcare professionals supporting the dietary management of people with PKU who are initiating or receiving sepiapterin.

Methods: A group of international dietitians participated …

Applications And Challenges Of Utilizing Digital Pathology And Ai-Enabled Workflows In Clinical Trials, Manu Sebastian, Harsh Batra, Monika Lamba Saini, Staci Kearney, Lorcan Sherry, Serge Alexanian, Michael Cohen, William Weber, Joe Lennerz, Anil V Parwani

Faculty, Staff and Student Publications

This is a comprehensive review on current utilization and challenges of digital pathology adoption in clinical trials and aims to provide a broad view on its impact on pathology review processes in clinical trials. It provides an overview of current pathology review practices in clinical trials and unique advantages digital pathology adoption can offer. The key areas including existing workflows, use case scenarios in different disease areas in clinical trials, including but not limited to patient identification and pre-screening, and regulatory aspects have been described with relevance. In addition, the review delves into the integration of genomics, AI, image analysis, …

Infliximab For Grade Iii Or Iv Immune Checkpoint Inhibitor Nephritis Clinical And Translational Evidence, Nada Youssef, Masroor Habeeb, Hong Chen, Zainab Alhamal, Omar Mamlouk, Heather Lin, Valda Page, Amanda Tchakarov, Sreyashi Basu, Adi Diab, Padmanee Sharma, Ala Abudayyeh

Faculty, Staff and Student Publications

Introduction: Acute interstitial nephritis (AIN) is a common presentation of immune checkpoint inhibitor (ICI) toxicity. Increased tumor necrosis factor (TNF)-α expression has been observed in ICI-induced AIN (ICI-AIN). In this study, we compared treatment with glucocorticoids plus infliximab to glucocorticoids only in stage III or IV ICI-AIN. We conducted retrospective NanoString analysis of ICI-exposed kidney samples to identify associated gene signatures and possible association with TNF-α expression.

Methods: We reviewed the records of patients who received ICI, developed acute kidney injury (AKI), and underwent kidney biopsy at MD Anderson Cancer Center from January 2022 to October 2024. Fifty-five patients had …

Reconsidering The Definition Of Triple-Negative Breast Cancer In The Immune Checkpoint Inhibitor Era: An Optimal Cut-Off Value For Hormone Receptor Percentage Of Her2-Negative Invasive Breast Cancer, Takeo Fujii, Toshiaki Iwase, Yu Shen, Jami Fukui, Naoto T Ueno

Faculty, Staff and Student Publications

The optimal cut-off values of estrogen receptor (ER) and progesterone receptor (PgR) expression to define the positivity of ER and PgR have been under discussion for over a decade but remain controversial. The American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) and the St. Gallen International Expert Consensus recommended that breast cancers with ≥1% of ER or PgR expression should be considered hormone receptor (HR)-positive tumors but ER/PR expression of 1% to 10% should be reported as HR-low positive; however, among HER2-negative disease, data on the overall benefit of adjuvant endocrine therapies for patients with HR-low positive disease is …

T Cells Modulate The Development And Maintenance Of Painful Paclitaxel-Induced Peripheral Neuropathy In Rnu Rats, Ahmed Olalekan Bakare, Gerard Limerick, Vasudha Goel, Ratan K Banik, Lei Zheng, Andrew J Shepherd, Kristine Glunde, Qin Zheng, Eellan Sivanesan

Faculty, Staff and Student Publications

The role of T cells in chemotherapy-induced peripheral neuropathy (CIPN) is complex and shaped by biological and experimental factors, including sex, hormonal status, genetic background, and cancer model. This complexity has contributed to inconsistent findings among studies, limiting therapeutic progress. In this study, we investigate how T cells contribute to painful paclitaxel (PTX)-induced peripheral neuropathy (PIPN). Adult male T cell-competent (RNU+/−) and T cell-deficient (RNU−/−) rats were subcutaneously inoculated with tumor cells and subsequently treated with intraperitoneal PTX (8 mg/kg total dose). Reflexive (mechanical, heat, cold) and non-reflexive (burrowing, gait) pain behaviors were assessed from baseline through week 6. Immunohistochemistry …

Protective Behavioral Strategies On Alcohol And Cannabis Co-Use Occasions, Sabrina Todaro

Open Access Dissertations

Simultaneous use of alcohol and cannabis, or co-use (i.e., the use of both substances so that effects overlap), is an increasingly significant public health concern among young adults between the ages of 18 and 25 in the U.S. (SAMHSA 2025; Terry-McElrath & Patrick, 2018). Protective behavioral strategies (PBS; i.e., tactics used to modify or limit substance use related harm; Pearson, 2013) have been robustly linked to fewer negative outcomes (e.g., lower use quantity, frequency, and consequences) for alcohol- and cannabis-only occasions (Bravo et al., 2016; Bravo et al., 2017; Bravo et al., 2019; Pearson, 2013; Pedersen et al., 2016; Pedersen …

The Influence Of Limb Dominance On Neural Activation Patterns While Performing Different Motor Control Tasks, Kevin A. Hooks

Graduate Studies Theses and Dissertations 2026

Humans interact with our environment in many ways. One of the most outward-facing aspects of this is limb dominance. The neural underpinnings of limb dominance remain in question today. The objective of this research was to use different methods to analyze neural activation while subjects performed upper extremity motor tasks while recording electroencephalography (EEG). The first experiment used decoding methods to examine whether neural signals collected from the contralateral limb could be used to train a classifier to test on the ipsilateral limb during a reach-to-grasp or reach-to-touch task. It was determined above chance level that within-subject action and direction …

An Experimental Investigation On The Influence Of Emotion On Craving And Alcohol Consumption Among Women, Melissa C. Rothstein

Open Access Dissertations

A burgeoning literature suggests that alcohol use, rates of binge drinking, rates of alcohol use disorder, and experiences of alcohol-related consequences are increasing among women in comparison to men (Adams et al., 2022; Baraona et al., 1991; Peltier et al., 2019; White, 2020). As such, alcohol use among women is a growing public health concern, but historically, most existing research, including interventions, has focused on men (Agabio et al., 2017; Holzhauer et al., 2020; Maxwell et al., 2022; Verplaetse et al., 2021; White, 2020). Although there is a large literature on the role of negative emotion in alcohol use (Austin …

Cultivating Workplace Happiness In Technology Workers, Cherie A. Herrin

Graduate Studies Theses and Dissertations 2026

Technology workers are central to the innovation and performance of modern organizations and retaining them is a persistent challenge for modern organizations. One important aspect of retention in many contexts is Workplace Happiness, which has been argued to improve worker performance and reduce turnover; however, there is little empirical evidence of the effectiveness of these interventions for technology workers. This dissertation develops a model in which two affective states, Workplace Happiness and Workplace Distress, mediate the relationships between six socio-technical work conditions and two behavioral outcomes: Turnover Intent and Work Execution (i.e., self-rated work performance and quality). A systematic literature …

Optimizing Markov Chain Monte Carlo Algorithms For Fairness, Scalability, And Interpretability In Electoral Redistricting, Madhukara Kekulandara

Open Access Dissertations

Gerrymandering undermines democratic representation by manipulating electoral district boundaries to dilute the political influence of targeted communities. While Markov Chain Monte Carlo (MCMC) based redistricting algorithms have become a standard computational tool for detecting partisan gerrymandering, their effectiveness in addressing racial gerrymandering and their scalability on modern computing systems remain limited. This dissertation advances the theory and practice of algorithmic redistricting by optimizing MCMC-based approaches across three dimensions: racial fairness, computational efficiency, and interpretability.

First, this work introduces the Partial Map MCMC algorithm, a novel redistricting method designed specifically to address racial gerrymandering under the legal framework of Section 2 …

Integrated Corridor Management Framework For Severe Freeway Incidents, Sanjida Afroz Iqra

Graduate Studies Theses and Dissertations 2026

Traffic incidents are a major source of non-recurrent congestion on urban freeways, generating substantial mobility, safety, and economic impacts. Severe incidents that block multiple or all travel lanes are particularly disruptive because they degrade freeway operations and propagate congestion onto surrounding arterials. Effective Integrated Corridor Management (ICM) requires the ability to identify severe incidents, estimate their network-wide impacts, and anticipate the traffic conditions and driver behaviors that contribute to instability. This dissertation develops a data-driven ICM framework to address these challenges using real-world incident, crash, detector, and connected vehicle data from major Central Florida corridors, including I-4 and SR-417. The …

Investigating The Anti-Apoptotic Properties Of The N-Terminus Of The Chlamydia Trachomatis Effector Tarp, Kasey S. Jordan

Graduate Studies Theses and Dissertations 2026

As the most prevalent bacterial STI in the United States and leading cause of infection-related blindness worldwide, the obligate intracellular bacteria, Chlamydia trachomatis (Ct), poses a significant threat to public health. As an obligate intracellular bacteria, invasion of the host cell is a crucial step in Chlamydia’s developmental cycle. To drive invasion, Ct injects prepackaged effectors into the host cell using a T3SS. An early Chlamydial effector, translocated actin recruiting phosphoprotein, or Tarp, interacts with host cell actin to promote invasion, mediated via Tarp’s C-terminal region. Although the function of Tarp’s C-terminus is well defined, the Tarp’s N-terminus …

Homoplasy Of Maxillary Orthognathism In Derived Homo, Jared Jordan

Graduate Studies Theses and Dissertations 2026

The evolution of the orthognathic condition in the genus Homo represents a monumental transition toward the facial morphology of modern humans from that of earlier hominins, but the phylogenetic positioning of this transformation remains poorly understood. This study investigated temporal trends in maxillary and mandibular prognathism in the genus Homo, and whether maxillary and mandibular shortening in East Asian H. erectus and later East Asian Middle Pleistocene Homo (e.g., Homo longi) represent independent derivations of orthognathic morphology, thereby making orthognathism a homoplasy in the genus Homo. Using a sample of roughly 109 cranial and mandibular specimens spanning …