Digital Commons Network^™

Modality-Agnostic, Patient-Specific Digital Twins Modeling Temporally Varying Digestive Motion, Jorge Tapias Gomez, Nishant Nadkarni, Lando S Bosma, Jue Jiang, Ergys D Subashi, James M Balter, Neelam Tyagi, Harini Veeraraghavan

Faculty, Staff and Student Publications

No abstract provided.

Twin And Cotwin Predictors Of Fetal Demise After Laser Photocoagulation Therapy In Advanced Stage Twin-Twin Transfusion Syndrome: A Fetal Heart Society Research Collaborative Study, Shiraz A Maskatia, Fu-Sheng Chou, Betul Yilmaz, Lisa Howley, Vidhya Annavajjhala, Lindsay Freud, Allison Divanovic, Laxmi Ghimire, Anita J Moon-Grady

Faculty, Staff and Student Publications

Background: Current models to predict outcomes in advanced twin-twin transfusion syndrome are limited. We hypothesized that twin and cotwin echocardiographic factors would improve model performance for donor and recipient demise following laser photocoagulation therapy.

Methods: We performed a multicenter retrospective cohort study of stage 3 to 4 twin-twin transfusion syndrome referred for laser photocoagulation therapy. Fetal echocardiograms were analyzed at a core laboratory. We used multivariable logistic regression models to select variables used for generalized linear mixed-effects modeling. Separate models were developed for donor and recipient demise, using both twin and cotwin variables. Models were assessed by area under the …

Haze Processing Of Atmospheric Particles During Wintertime In The Indo-Gangetic Plains, Susan Mathai, Amna Ijaz, Tania Gautam, Zezhen Cheng, Nurun Nahar Lata, Harsh Bhotika, David Tseng, Rosalie K. Chu, Lynn Mazzoleni, Claudio Mazzoleni, Swarup China

Michigan Tech Publications

The impacts of haze on visibility, air quality, and climate are not well quantified due to a lack of understanding of the evolution of the mixing state and phase state of atmospheric particles during haze processing. The variability of the mixing state of atmospheric particles contributes significantly to uncertainties associated with the estimated aerosol radiative forcing. We collected particle samples in January 2018 from the highly polluted Indo-Gangetic plain during hazy conditions to study haze-processed particles. Single particle analysis using multi-modal micro-spectroscopy techniques revealed an abundance (40–70% by number) of potassium-rich sulfate particles from biomass-burning influenced smoke. Tilted view imaging …

Multiple Myeloma Risk Linked To Dna Damage Response Genes, Michael Conry, Irina Ostrovnaya, Yelena Kemel, Saloni Sinha, Linda B. Baughn, Brian Avery, Kylee Maclachlan, Victoria Groner, Lauren Banaszak, Aaron Norman, Nicholas J. Boddicker, Alyssa I. Clay-Gilmour Ph.D., Shaji Kumar, Ellen Kim, Sita Dandiker, Mitul Waghmare, Susan Slager, Douglas Sborov, Judy Garber, Elizabeth E. Brown, Michelle Hildebrandt, Et. Al.

Faculty Publications

Background DNA damage response genes (DDRG), implicated in several cancers as both predisposing risk factors as well as biomarkers for aggressiveness, have not been fully explored in multiple myeloma (MM).

Methods Herein, we analyzed disease associations of pathogenic variations in nine putative candidate genes using 3 446 MM cases and 323 233 cancer-free controls.

Results Increased MM risk was found to be associated with inherited rare pathogenic mutations in TP53, ATM, CHEK2, KDM1A, and ARID1A, with an enrichment of these variants among individuals with early onset or family history of MM. Individuals with TP53 or ATM germline mutations are also …

Neuronal Subtype Governs Amyloid Structure, Cellular Response, And Cognitive Outcome In Genetically Targeted App Mouse Models, Gabriella A Perez, Zoe Lai, George A Edwards Iii, Jacob M Dundee, Shannon N Leahy, Chuangye Qi, Yanyan Qi, Ye-Jin Park, Tzu-Chiao Lu, M Danish Uddin, Rong Zhao, Hui Zheng, Hongjie Li, Joanna L Jankowsky

2020-Current year OA Pubs

Pathological heterogeneity is increasingly appreciated in Alzheimer’s disease, yet we do not know how distinct aggregate conformations arise or influence cognitive outcomes. In an amyloid mouse model, we found that different brain regions formed structurally distinct Aβ deposits, prompting us to test whether neuronal subtypes shape aggregate conformation. To address this, we created transgenic mice expressing the same APP construct in either glutamatergic or GABAergic neurons. APP expression in GABAergic neurons resulted in diffuse plaques with high Aβ42/Aβ40 ratios and minimal gliosis, while glutamatergic expression produced neuritic plaques with activated glia. Despite similar Aβ levels, only mice with neuritic plaques …

Durability Of The Benefit Of Vagus Nerve Stimulation In Markedly Treatment-Resistant Major Depression: A Recover Trial Report, Charles R Conway, Christopher L Kriedt, Charles F Zorumski, Hunter Brown, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Greater levels of treatment resistance in major depressive disorder (MDD) are associated with lower rates of initial benefit and higher rates of relapse (lower durability).

OBJECTIVE: Characterize depressive symptoms, function, and quality of life (QoL) over 24 months of adjunctive vagus nerve stimulation (VNS) in participants with markedly treatment-resistant depression.

DESIGN: Prospective, open-label, single-arm, long-term extension study (RECOVER) conducted from September 2019 to April 2025.

SETTING: Outpatient.

PARTICIPANTS: Adults with moderate-severe MDD with ≥ 4 failed antidepressant trials in the current episode, randomized to blinded, adjunctive VNS for 12 months, who subsequently received open-label, adjunctive VNS for 12 additional …

A Caregiver’S Perspective Of Caring For Children With Intellectual Disabilities, Lajoy Johnson Law

Walden Dissertations and Doctoral Studies

Current estimates reported by the National Institute of Health suggest that between 1.4 and 2.2 million children in the United States have some form of intellectual disability. These children need caregivers, yet in the literature there is a lack of studies focusing on the experiences of caregivers raising children with intellectual disabilities. Further, there is a lack of public policies and programs for Washington, D.C. caregivers. The purpose of this general qualitative study was to explore the lived experiences of these caregivers in Washington, D.C. and to identify what policies, programs, and services are needed to support them. Guided by …

Female Military Sexual Trauma Survivors’ Experiences With Seeking Treatment From The Veterans Health Administration, Sherry Sophia Bolden Rivers

Walden Dissertations and Doctoral Studies

The Veterans Health Administration (VHA) provides free healthcare related to those who have experienced military sexual trauma (MST); however, many female veterans either go without or delay accessing such care. This generic qualitative study was conducted to answer the research question about the reasons behind female veterans’ decisions to seek or not seek VHA services following the experiences of MST. The framework for this study was Wollstonecraft’s feminist theory. An additional question was how, if at all, the stigma of MST and the military’s male-dominated culture play a role in the reporting of these incidents. Data were collected through semistructured …

Factors Affecting The Level Of Grief Experienced By Men Whose Female Partner Died In The United States, Keona C. Lee

Walden Dissertations and Doctoral Studies

Grief is an emotional reaction to the loss of a loved one through death. Although grief is a universal human experience, its perspective is unique, and research has often ignored the varied experiences of racial/ethnic and cultural groups, particularly men of color in the United States. The purpose of this quantitative study was to measure the level of grief experienced by men whose female partner died and to determine whether ethnicity, having a prior mental health diagnosis, social support, and traumatic or anticipated loss significantly impacted their level of grief. The study was guided by the social-ecological model to explain …

Community College And School Administrators’ Perspectives On Communication And Collaboration In The Formation Of Partnerships, Shannon Stukes Williams

Walden Dissertations and Doctoral Studies

Challenges have limited the opportunities for educational institutions to support student transitions and success. The problem addressed through this study was the challenge to establish effective partnerships between community colleges and public K–12 schools in a rural county in a southern state. Grounded in Hartford’s small group theory, the purpose of this basic qualitative study was to examine community college and K–12 administrators’ perspectives on the role of collaboration and communication, as well as the knowledge and skills needed for faculty, staff, and officials to create and sustain partnerships. Semistructured interviews were conducted with 18 community college and K–12 administrators. …

Exploring The Impact Of Antidiscrimination Laws On Child-Welfare Workers Working With Lgbtq Foster Youth, Heather Kesterson

Walden Dissertations and Doctoral Studies

Lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth are overrepresented in the foster care system and have unique needs compared to their peers. In the state of Virginia, there is an antidiscrimination policy that protects LGBTQ foster youth; however, it is unclear how this impacts child welfare workers. Past literature has explored the needs of LGBTQ youth, the experiences of foster parents, and policy implications, but not the impact of antidiscrimination laws on child welfare workers. The purpose of this generic qualitative study was to explore the understanding of child welfare workers’ knowledge, integration, training, and implications of Virginia’s antidiscrimination …

Association Between Monoclonal Gammopathy Of Undetermined Significance And Cardiovascular Disease Risk: A Veterans Health Administration Study, Tzeyu L Michaud, Mei Wang, Daphne R Friedman, Lawrence Liu, Theodore S Thomas, Kristen M Sanfilippo, Graham A Colditz, Martin W Schoen, Su-Hsin Chang

2020-Current year OA Pubs

BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) is associated with an increased risk of cardiovascular disease (CVD). However, its potential to provide additional prognostic information beyond traditional CVD risk assessments remains unknown. This study aimed to examine the association between MGUS and incident CVD and to determine whether MGUS status offers additional prognostic value beyond the established atherosclerotic cardiovascular disease risk calculation.

METHODS: We conducted a retrospective, matched observational study using 2010 to 2021 Veterans Health Administration data. MGUS status, confirmed through a validated natural language processing algorithm, were 1:5 matched to individuals without MGUS. The outcome of interest was …

Neuronal Subtype Governs Amyloid Structure, Cellular Response, And Cognitive Outcome In Genetically Targeted App Mouse Models, Jacob M Dundee, Shannon N Leahy, Chuangye Qi, Yanyan Qi, Ye-Jin Park, Tzu-Chiao Lu, M Danish Uddin, Rong Zhao, Hui Zheng, Hongjie Li, Joanna L Jankowsky

Faculty, Staff and Students Publications

Pathological heterogeneity is increasingly appreciated in Alzheimer’s disease, yet we do not know how distinct aggregate conformations arise or influence cognitive outcomes. In an amyloid mouse model, we found that different brain regions formed structurally distinct Aβ deposits, prompting us to test whether neuronal subtypes shape aggregate conformation. To address this, we created transgenic mice expressing the same APP construct in either glutamatergic or GABAergic neurons. APP expression in GABAergic neurons resulted in diffuse plaques with high Aβ42/Aβ40 ratios and minimal gliosis, while glutamatergic expression produced neuritic plaques with activated glia. Despite similar Aβ levels, only mice with neuritic plaques …

Erratum For Nachman Et Al., “Increased Fungal Burden In The Gastrointestinal Tract Of Brain-Dead Organ Donors”, Javier Nieto, Madeline M Bresson, Clare M Robertson, Maggie N Seale, Nora M Villafuerte, Zhe Lyu, Eva C Preisner, Heather A Danhof, Sara C Di Rienzi, Yolanda T Becker, Robert A Britton

Faculty, Staff and Students Publications

No abstract provided.

Postoperative Lymph Is A Proximal Source Of Ctdna For Detection Of Recurrence In Hpv-Independent Head And Neck Cancer, Seka Lazare, Noah Earland, Peter Harris, Ricardo Ramirez, Benjamin Wahle, Sid Puram, Doug Adkins, Wade Thorstad, Rebecca Chernock, Aadel A Chaudhuri, Et Al.

2020-Current year OA Pubs

PURPOSE: Relapse is a major cause of failure in human papillomavirus-independent head and neck squamous cell carcinoma. Clinicopathologic criteria for adjuvant treatment remain imprecise and have not changed for decades. We investigated whether ctDNA in lymphatic exudate collected via surgical drains ("lymph") 24 hours after surgery identified molecular residual disease (MRD) and compared its performance with time-matched plasma.

EXPERIMENTAL DESIGN: Using an ultra-sensitive tumor-informed sequencing approach, tumor variants were called in lymph and plasma to classify patients as ctDNA positive or ctDNA negative, trained in an initial cohort of 36 patients, and replicated in an independent cohort of 37 patients. …

Mass Spectrometry Footprinting Reveals How Kinetic Stabilizers Counteract Transthyretin Dynamics Altered By Pathogenic Mutations, Francisca Pinheiro, Ravi Kant, Saketh Chemuru, Nathalia Varejão, Adrián Velázquez-Campoy, David Reverter, Irantzu Pallarès, Michael L Gross, Salvador Ventura

2020-Current year OA Pubs

The aggregation of transthyretin (TTR) results in life-threatening transthyretin amyloidosis. Familial forms of the disease arise from point mutations that destabilize the TTR tetramer, leading to its dissociation and/or monomer unfolding and subsequent formation of amyloid fibrils. Small molecules that kinetically stabilize the native tetramer effectively inhibit this aggregation. Although over 300 X-ray crystal structures of TTR have been determined, these data refer to a static structure and do not capture the conformational effects of mutations and ligand binding. Here, we demonstrate that hydrogen-deuterium exchange (HDX) and fast photochemical oxidation of proteins (FPOP) coupled with mass spectrometry (MS) offer critical …

Polymer Conformational Entropy As The Driver Of Complex Coacervation, Tommaso Inzani, Giovanni Nava, Marco Buscaglia, Andrea Soranno, Alessandro Gori, Greta Bergamaschi, Samir Suweis, Amos Maritan, Tommaso Bellini

2020-Current year OA Pubs

Understanding the mechanisms leading to complex coacervation is a fundamental challenge in biomolecular sciences. Here, we explored the condensation transition and pretransitional behavior of an archetypal system consisting of polyuridylic acid chains (PolyU) and short cationic peptides in buffered aqueous solutions. By combining static and dynamic light scattering with confocal microscopy, we determined the location of the transition and the partitioning of PolyU and peptides between the coexisting phases as a function of the total peptides/PolyU ratio. We find that upon adding peptides in the system, the size of PolyU coils in the single-phase region is progressively reduced by peptide-mediated …

Knowledge And Perception Of Human Milk Donation Among Pregnant, Lactating, And Postpartum Women In Rochester, Ny, And Near Hmbana Milk Banks, Samantha Allen

Theses

Human milk banks provide pasteurized donor milk for premature infants whose mothers are unable to produce sufficient amounts of milk, offering critical nutritional and immunological benefits for this high-risk population.1–4 Although 28 HMBANA-accredited milk banks operate in the United States, none are located within 4.5 hours of Rochester, NY. This study examined the knowledge and perceptions of human milk bank donation among pregnant, lactating, and postpartum women in Rochester, NY, and in communities near HMBANA-affiliated milk banks, and assessed if there is a correlation regarding the proximity of milk banks.  A cross-sectional study design was used, and participants completed a …

Feasibility Of Echocardiography And Speckle-Tracking-Derived Right Ventricular Parameters For A Prediction Model Of Early Bronchopulmonary-Dysplasia In Preterm Infants (Report-Bpd Study): An Observational Cohort Study, W. S. Muhsen, J. Hosking, E. Nestaas, J. M. Latour

School of Nursing and Midwifery

Background: Bronchopulmonary dysplasia (BPD) is a common morbidity affecting preterm infants’ underdeveloped lungs, leading to long-term growth and neurodevelopmental issues. Despite its significance, no clinical prediction model exists for neonatologists. Aim: To assess the feasibility of study procedures and provide descriptive data to guide a large multicentre study for developing a BPD-prediction model. Methods: This was a single-centre feasibility observational cohort study conducted at a neonatal intensive care unit. Forty preterm infants born before 32 weeks of gestation were recruited within 18 months. Two echocardiographic scans on days 5 and 9 after birth were planned for each infant. Feasibility targets …

Merging Terrestrial And Satellite Gravity Data For Africa: A Possibility To Fill-In The Data Gaps, Hussein A. Abd-Elmotaal, Norbert Kuhtreiber

Mansoura Engineering Journal

The major challenge that the IAG Sub-Commission on gravity and geoid in Africa faces is the significantly large gravity data gaps. It is essential to properly tackle this issue for all geodetic applications in Africa due to the large interpolation errors occur at these large gaps. Simple interpolation (using any type of interpolation technique) of the gravity data does not add new information at the large data gaps, and the solution is free there. Global Earth gravity models offer themselves as a possible way to fill-in such large data gaps, provided that they approximate the African gravity field to an …

Navigating Federal Work-Study: How Informational And Structural Barriers Shape First-Year Student Participation, Sooji Kim

Journal of Student Financial Aid

Understanding the complex nature of institutional and student behaviors regarding the federal work-study program (FWS) is critical to bolstering federal and institutional efforts to implement tangible policy interventions and practical improvements to the program. However, there is scant literature about the mechanisms of students’ FWS decision-making processes. To better understand the “why” of students’ decisions and behaviors around the FWS program, this study explores the determinants of imperfect FWS aid take-up among lower-income, first-year college students. Drawing upon multidisciplinary views on students’ work decisions while in college, a survey was developed and administered at a large public four-year university in …

Forging Pathways: How Low-Income Stem Students Navigate College On A Free Tuition Program, Taylor Wilby, Sarah Madsen, Nathan F. Alleman

Journal of Student Financial Aid

In light of the ever-increasing cost of tuition, colleges and universities are turning to free tuition programs to make college more affordable – especially for those students demonstrating the most financial need. Concurrently, students from low-income backgrounds continue to enroll in Science, Technology, Engineering, and Mathematics (STEM) majors, navigating rigorous fields of study and anticipating highly lucrative career opportunities following graduation. This project, therefore, sought to answer the following question: How and in what ways is the college-going navigation of low-income STEM students influenced by a free tuition pathway in a selective, affluent university? Utilizing a qualitative, symbolic interactionist …

Refusing To Run Away From The Hard Part: Notes On Reflexivity Towards Abolitionist Pedagogy & Teaching, Julissa O. Muñiz, Casey P. Wong

Feminist Pedagogy

In this critical commentary, we enter into conversation with educators who have practiced abolition, culturally sustaining pedagogy, and critical pedagogies, and consider what it means to sustain a learning community experiencing harm in real time. We assess a case involving a teacher-student interaction at a private minimum security women’s state prison in Texas. Following one of the author's critical reflections, we think about the importance of abolitionist educators giving benefit of the doubt, grasping at the roots of harm, and controlling their affective responses. We argue that community is a practice and a discipline that must be continuously sustained and …

Beta Boule Program, Zeta Phi Beta Sorority Incorporated

Josie Green Washington Papers

A program for the Zeta Phi Beta Sorority 32nd National Boule.

Pilots’ Perceived Cognitive Functions: The Effect Of Mental Workload And Mindfulness On Prospective Memory Performance, Zehra Nur Kurtoğlu, Pınar Ünsal Bayrakçı

International Journal of Aviation, Aeronautics, and Aerospace

Errors related to human factors remain a leading cause of aviation accidents, with many of these incidents being attributed to pilot performance. A key aspect of pilot performance might be prospective memory (PM), the ability to remember and execute future tasks at the appropriate time. The dynamic and high-demand environment of the cockpit presents significant challenges for pilots' PM, particularly due to high mental workload and the constant need for multitasking. This study investigates the impact of perceived mental workload as consisting of cognitive, emotional, temporal, and performance demands dimensions, and mindfulness on pilots' PM performance. A mindfulness scale specific …

32nd National Boule & 42nd Anniversary Conclave, Zeta Phi Beta Sorority Incorporated, Phi Beta Sigma Fraternity Incorporated

Josie Green Washington Papers

A sorority/fraternity program for the 32nd National Boule for the Zeta Phi Beta Sorority Incorporated and the 43rd Anniversary Conclave for the Phi Beta Sigma Fraternity Incorporated. This copy belongs to Josie Green Washington.

Boule Chapter Directory Archonette, Zeta Phi Beta Sorority Incorporated

Josie Green Washington Papers

A chapter directory titled "1947 Boule Archonette".

Uncovering 14 Generations: An Interview With Pauletta Hansel On Appalachia, Genealogy, And Her Forthcoming Hybrid Collection, Pauletta Hansel, Megan Hutchinson

Critical Humanities

No abstract provided.

A Lyrical Life: An Interview With Doug Van Gundy On Teaching, Writing, And The Influence Of Music, Doug Van Gundy, Megan Hutchinson

Critical Humanities

Interview

"Can You Hear The Earth Shift?" And "An Act Of Nature", John C. Mannone

Critical Humanities

No abstract provided.