Digital Commons Network^™

Stimulus-Driven Cerebrospinal Fluid Dynamics Is Impaired In Glaucoma Patients, Ji Won Bang, Carlos Parra, Kevin Yu, Hyun Seo Lee, Gadi Wollstein, Joel Schuman, Kevin Chan

Wills Eye Hospital Papers

Cerebrospinal fluid (CSF), partly driven by sensory stimulation, is crucial for maintaining homeostasis and clearing metabolic waste. Whether such stimulus-driven CSF flow is disrupted in age-related neurodegenerative diseases of the visual system remains unclear. This study examined the CSF flow during visual stimulation in glaucoma patients and healthy older adults using functional magnetic resonance imaging. In glaucoma, CSF inflow becomes progressively decoupled from the visually evoked blood-oxygenation-level-dependent (BOLD) response. Specifically, the characteristic stimulus-locked CSF patterns, which decrease after stimulus onset and increase after offset, diminish with disease severity. Mediation analysis suggests this flattened CSF pattern is driven by a flatter …

The Texas Business Court: Year One, Jack B. Disorbo

St. Mary's Law Journal

No abstract provided.

Environmental Factors Associated With Heatwaves Affecting The Growth Of Harmful Algal Bloom Species Pyrodinium Bahamense, Ketzia Garcia, Camiyah Blanchard, Lydia Ruggles, Lauren D' Amore, Margaret Mars Brisbin

Making Waves REU

• Pyrodiniumbahamenseis a harmful algal bloomdinoflagellate that forms blooms in subtropical and tropical estuarine waters, includingalong Florida's coasts
• The species formsintense harmful algal blooms in theOld Tampa Bayand Indian River Lagoon regions, producing toxins that cause paralytic shellfishpoisoning (PSP)
• Marine heatwaves (MHW), periods of time where ocean temperatures rise 1–3°C or more above the normal, have intensified over the years
• Marine heatwaves may influence microbial interactions and harmful algal blooms (HABS)

Acoustic Analysis Of Prosodic Speech Pause In Autistic And Neurotypical Adults, Rachel Johnson

Theses and Dissertations

The purpose of this study is to examine prosodic speech pause across two groups: neurotypical and autistic young adults. Conversational speech samples were collected from 11 neurotypical and 11 autistic young adults between the ages of 18 and 26. Speech samples were subsequently transcribed and analyzed using Praat Software. The boundaries of between- and within-utterance pauses were identified, as well as acoustically determining if the pause was filled, silent, or a combination of both. Results found a significant difference in the frequency of pauses as a function of location, pause type, and neurological status. As expected, combination pauses were the …

Preliminary Evaluation Of Remote Sensing Evapotranspiration Models For Field-Scale Agricultural Water Management In Arid Central Iran, Somayeh Sima, Iman Raissi Dehkordi, Mohammadhosein Taghikhani, Neamat Karimi

Civil and Environmental Engineering Faculty Publications

Accurate estimation of actual evapotranspiration (ET_a) is crucial for effective water resource management and optimizing agricultural yields. While satellite-based surface energy balance ET_a models are widely adopted, their field-scale accuracy in under-researched regions, such as Iran, remains a critical knowledge gap. This study assesses five prominent models—PySEBAL, PyMETRIC, SSEBop, PyTSEB, and ETLook (from FAO’s WaPOR v.2, L1 product)—for daily ET_a estimation over an alfalfa field in the arid central part of Iran. Models were adjusted for the field using in situ weather data and Landsat-8 images, and validated against the scintillometer data. Results showed SSEBop provided …

An Eye For An Eye And A Smile For A Smile: Examining Aggressive And Supportive Behavioral Alignment Among Taiwanese Adolescence Who Play Video Games, Nicholas Bowman, Chrissy Cook, Chingching Chang

Media Studies - All Scholarship

The social dynamics of video games, especially those played online, are one of the primary motivators for gaming. Unfortunately, while there are numerous benefits to online gaming, there is also potentially harmful toxic and aggressive behavior. Prior research has investigated toxicity, but most studies rely on convenience samples, typically from WEIRD populations. The current study extends this scholarship with a nationally representative sample of Taiwanese adolescents who are frequent gamers, (a) quantifying their experiences with aggressive and supportive behaviors in games and (b) investigating personological-level variables that might explain reciprocating (referred to as “behavioral alignment”). Key findings were (1) aggressive …

Turning The Tables: Using Texas’S Stowers Doctrine To Rein In Delay, Deny, Defend Tactics, Ethan Evans

St. Mary's Law Journal

No abstract provided.

Wcu Digital Commons Submission Guidelines, Julia Doelling

Policy Library

No abstract provided.

Identifying Over- And Underfunded Diseases By Comparing National Institutes Of Health Funding For Skin Disease Research With Us Skin Disease Burden According To 2021 Global Burden Of Disease Data: Cross-Sectional Analysis, Aileen Park, Emily Woolhiser, Hannah Riva, Leo Wan, Haaris Kadri, Elizabeth Lamberty, Parks Juels, Sandra Jaroonwanichkul, Madison Reed, Catherine Hegedus, Dana Chen, Danielle Duffle, Jessica Kirk, Sydney Christensen, Emma Shelby, Robert Dellavalle

Student Publications

Background: Understanding the burden of various skin diseases can help guide funding allocation for skin disease research. A 2015 cross-sectional study found a partial correlation between US skin disease burden according to the 2010 Global Burden of Disease (GBD) study and National Institutes of Health (NIH) funding in 2012-2013.

Objective: This study aims to identify trends, correlations, and disparities in US skin disease burden and NIH research funding allocation using the latest data from the GBD 2021 and NIH funding data from the fiscal years 2021-2022.

Methods: A cross-sectional analysis was conducted to compare the disability-adjusted life years for 15 …

State Prior Authorization Prohibitions And Buprenorphine Retention Among Privately Insured Patients, Ju-Chen Hu, Shashi N. Kapadia, Hao Zhang, Ali Jalali, Kristen Underhill, Christina Andrews Ph.D., Yuhua Bao

Faculty Publications

Importance  Buprenorphine is the most commonly prescribed medication for opioid use disorder, but rates of retention in treatment remain low. Prior authorization (PA) has been identified as a barrier to the administration of buprenorphine, and patients may need multiple PAs to continue treatment; thus, many states have passed laws to prohibit the use of PA for buprenorphine in private insurance.

Objective  To examine the association between PA prohibitions and buprenorphine treatment retention overall and by branded vs generic drug status.

Design, Setting, and Participants  This cross-sectional study used a difference-in-differences design and private insurance claims data from 49 states and …

Lessons In Surrender: Living With Chronic Illness, Danielle Wyenberg

Faculty Work Comprehensive List

"My experience with chronic illness has pushed me to lean on my community, stripped away layers of pride and certainty, and forced me to find a much greater peace with human limits and mortality."

Posting about hope in difficult circumstances ­­­­­­­­from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Lessons in Surrender

Tectonic Implications Of Transitional Melting Regimes From Petrological, Geochronological, And Compositional Characterization Of The Ophiolitic Seventymile Terrane, Alaska, Usa, Erin Todd, Johnathan Saul Caine, Michael Bizimis, Andrew R.C. Kylander-Clark, Robert Reece Hammond, Alicja Wypych

Faculty Publications

New geochemical, U-Pb geochronology, and Sr-Nd-Hf isotope data provide evidence for the tectonic evolution of the Seventymile terrane in interior Alaska, USA. Ultramafic and mafic rocks of the Seventymile terrane are thought to represent components of a dismembered ophiolite and provide unique constraints on regional terrane evolution and accretion. The Seventymile ophiolite represents fragments of the Devonian to Permian Slide Mountain Ocean (SMO) that separated allochthonous and parautochthonous continental fragments of western North America. It now occurs as multiple thrust sheets containing Permian mafic and ultramafic rocks overlying and/or possibly imbricated with amphibolite-facies supracrustal rocks of allochthonous Yukon-Tanana terrane and …

Spatial2gwas: A Database For Linking Spatial Transcriptomic Regions With Gwas Traits, Xiaobo Zhou

Faculty, Staff and Student Publications

Spatial heterogeneity of gene expression within tissue regions has a critical influence on biological functions, thereby affecting disease pathogenesis. However, systematic associations between spatially resolved transcriptomes and phenotypes, especially in complex diseases, remain underexplored. Here, we developed spatial2GWAS (http://www.spatial2gwas.cn), a comprehensive resource linking spatial transcriptomic (ST) regions with GWAS traits. In the database, we collected 1196 ST slices (human and mouse) from five technologies and 812 GWAS traits spanning 18 phenotype categories and identified 29 701 ST slice-GWAS trait pairs containing 47 492 significant regions. Functional analyses reveal distinct patterns of cell type composition, gene expression, GO/KEGG pathway activation, and …

Knockrbp: An Integrated Multi-Omics Database Of Functional Perturbation Profiles For Rna-Binding Proteins, Xiaobo Zhou, Yungang Xu

Faculty, Staff and Student Publications

RNA-binding proteins (RBPs) regulate diverse post-transcriptional processes, yet their functional impacts across multiple molecular layers remain incompletely characterized. KnockRBP (https://knockrbp.xu-bioinfo.com) is presented as a comprehensive, multi-omics database systematically cataloging regulatory changes resulting from genetic perturbation of RBPs. The resource integrates 1453 datasets from GEO, ENA, and ENCORE, encompassing RNA-seq, Ribo-seq, microRNA (miRNA)-seq, and 3'RACE-seq across 639 RBPs, 182 cell lines, and 61 diseases. Regulatory outcomes covered include alternative splicing, alternative polyadenylation, RNA editing, transcript abundance, translation efficiency, and miRNA expression, with all events processed through standardized analytical pipelines and annotated with open reading frame consequences, predicted loss-of-function impacts, and established …

Assessing The Effectiveness Of The One Paleopathology Workshop, Julianne R. Stamer, Mario Apata Mamani, Bernardo Arriaza, Robin Bendrey, Kelly Blevins, Tessa Campbell, Nicole Gottdenker, Rebecca Gowland, Haagen Klaus, Carina Marques

Anthropology Faculty Publications

Background and objectives: One Paleopathology is a novel concept in Paleopathology that extends the One Health paradigm into the past. A workshop at the University of Durham, UK, was held prior to the 2024 International Society for Evolution, Medicine, and Public Health (ISEMPH) meeting, firstly to define and expand the concept of One Paleopathology and secondly to generate transdisciplinary research and outreach under this framework. This article presents a logic model to evaluate how effectively the workshop met its goals.

Methodology: Two surveys were conducted, one immediately following the workshop and at the 1-year mark. These surveys assess the direct …

Surgical Strategies For Unilateral Pulmonary Artery Agenesis: A Case Series, Amr Abolwafa, Alaa Al-Lawati, Hamood Nasar Al-Kindi, Sunny Zacharias, Pranav Subbaraya Kandachar, Madan Mohan Maddali

Sultan Qaboos University Medical Journal

Unilateral pulmonary artery agenesis, typically affecting the right pulmonary artery, is a rare condition that may lead to congestive heart failure or pulmonary hypertension in infants and early surgical intervention improves outcomes. We report 5 cases from Muscat, Oman, of unilateral pulmonary artery agenesis who underwent surgical correction between November 2019 and August 2023, at an average age of 4.4 months. Most presented with cyanosis or respiratory distress and all had pulmonary hypertension confirmed by imaging. Surgical approaches included Gore-Tex conduit placement, autologous pericardial reconstruction and patent ductus arteriosus unifocalisation. All patients successfully restored pulmonary blood flow with no perioperative …

Correction: Sadagopan Et Al Reduced Computed Tomography Scan Speed Improves Alignment Errors For Patients Undergoing Thoracic Stereotactic Body Radiation Therapy, Ramaswamy Sadagopan, Rachael M Martin-Paulpeter, Christopher R Peeler, Xiaochun Wang, Paige Nitsch, Julianne M Pollard-Larkin

Faculty, Staff and Student Publications

In the original publication [...].

Thermal Performance And Specific Energy Consumption Of Traditional Tobacco Curing Barns In Tanzania, Seuri S. Kilakoi, Baraka Kichonge, Thomas Kivevele, Mtaki T. Maagi, Jacob B. Lisuma

Tanzania Journal of Science

Traditional tobacco curing barns remain the dominant technology in Tanzania due to their low construction cost and accessibility, particularly in major producing regions such as Tabora. However, their thermal inefficiency results in excessive firewood use and environmental degradation. This study presents a field-based performance evaluation of a traditional flue-curing barn at the Tobacco Research Institute of Tanzania. Environmental parameters and fuel consumption were monitored at 15- minute intervals throughout the yellowing, leaf drying, and stem drying stages. The curing process handled 429 kg of fresh tobacco using 1,016 kg of firewood, equivalent to 16,256 MJ of energy input. The specific …

Messages From The Provost, Georgia Southern University

Messages from the Provost

• Message from the Provost

• Designing Confidence: GS Students Reimagine the Career Closet — and Discover Their Own Potential

• Top 2% Scientists: Leading Minds in Science

Rogue Waves In Extended Gross-Pitaevskii Models With A Lee-Huang-Yang Correction, Sathyanarayanan Chandramouli, S. I. Mistakidis, G. C. Katsimiga, D. J. Ratliff, D. J. Frantzeskakis, P. G. Kevrekidis

Physics Faculty Research & Creative Works

We explore the existence and dynamical generation of rogue waves (RWs) within a one-dimensional quantum droplet-bearing environment. RWs are computed by deploying a space-time fixed point scheme to the relevant extended Gross-Pitaevskii equation (eGPE). Parametric regions where the ensuing RWs are different from their counterparts in the nonlinear Schrödinger equation are identified. To corroborate the controllable generation—relevant to ultracold atom experiments—of these rogue patterns, we exploit two different protocols. The first is based on interfering dam break flows emanating from Riemann initial conditions, and the second refers to the gradient catastrophe of a spatially localized waveform. A multitude of possible …

Comparing The Cognitive And Physiological Effects Of Traditional And Virtual Reality Exercise In Overweight/Obese Adults: A Pilot Study, Emma Kelsey, Greta Ness, Grayce Bjugan, Darci Wiseman, Terence Moriarty

Faculty Publications

Research suggests that overweight/obese adults (BMI ≥ 25 kg/m²) have an elevated risk of cognitive decline. Although exercise is recommended to improve both physical and cognitive health, adherence is often low in this population. Virtual reality (VR) is an emerging strategy that may enhance exercise engagement. This pilot study compared the effects of traditional (TRAD) cycling and VR-based exercise on cognitive performance and prefrontal cortex (PFC) oxygenation (O2Hb). Eleven adults (M = 6, F = 5; BMI: 31.1 ± 2.8 kg/m²; VO2max: 30.4 ± 5.7 mL/kg/min) completed a VO2max test and two 16 min moderate-intensity cycling …

The New Hampshire Voluntary Paid Family And Medical Leave Program: Did The Program Increase Coverage?, Kristin Smith

Carsey Publications

In this brief, author Kristin Smith evaluates whether the New Hampshire Voluntary Paid Family and Medical Leave (PFML) program increased paid family and medical leave coverage. The NH Voluntary Paid Leave program launched at the start of 2023. Granite State Poll data show no change in the share of workers with medical, parental, or fam­ily medical leave benefits between December 2022 (pre-program) and December 2024. Specifically, about 3 percent of New Hampshire workers were enrolled in the NH PFML program by June 2025. In the first two- and one-half years of the program, it did little at the state level …

A Phase 1, First-In-Human, Dose Escalation Study Of Jnj-80038114, A Psmaxcd3 Bispecific Antibody, In Participants With Metastatic Castration-Resistant Prostate Cancer, Andrew Hudson, Anuradha Jayaram, Benjamin Garmezy, Nicholas Zorko, Kevin Zarrabi, Ligi Mathews, Brent Rupnow, Mengjie Li, Debopriya Ghosh, Karen Urtishak, Peter Francis, Sherry Wang, Edward Attiyeh, Johann De Bono

Department of Medical Oncology Faculty Papers

PURPOSE: Prostate-specific membrane antigen (PSMA) has been identified as a therapeutic target for metastatic castration-resistant prostate cancer (mCRPC). The recent success of radioligands targeting PSMA spurred development of new PSMA-targeting agents including immunotherapy. JNJ-80038114 is a bispecific antibody that binds PSMA on tumor cells and CD3 on T cells to induce anti-tumor activity.

METHODS: This was a phase 1, open-label, multicenter study of JNJ-80038114 in participants with mCRPC and ≥ 1 prior systemic therapy. JNJ-80038114 was administered subcutaneously every 3 weeks (Q3W), starting at 0.1 mg. The primary endpoint was safety. Secondary endpoints included pharmacokinetics (PK), immunogenicity, and prostate-specific antigen …

Music Therapy Versus Cognitive Behavioral Therapy Via Telehealth For Anxiety In Survivors Of Cancer: A Randomized Clinical Trial, Kevin T. Liou, Joke Bradt, M. Beatriz Currier, Raymond Baser, Katherine Panageas, Jodi Macleod, Desiree Walker, Susan Q. Li, Ana Maria Lopez, Kelly Mcconnell, Jun J. Mao

Department of Medical Oncology Faculty Papers

PURPOSE: Anxiety is prevalent, disruptive, and undertreated among survivors of cancer. Cognitive behavioral therapy (CBT) is the first-line treatment, but not all individuals have access, respond to treatment, or prefer this option because of stigma. Music therapy is effective for short-term anxiety reduction, but it is unknown whether it is noninferior to first-line CBT for long-term anxiety reduction.

METHODS: This comparative effectiveness trial randomly assigned English- or Spanish-speaking survivors of cancer to seven weekly telehealth sessions of music therapy or CBT. The coprimary end points were changes in the Hospital Anxiety and Depression Scale (HADS) anxiety score at weeks 8 …

Synthesis Study Of Evapotranspiration Evolution In The Mekong Delta Induced By Land Use And Land Cover Changes In The Decades Of 1990–2020, Emiliana Valentini, Serena Sapio, Son V. Nghiem, Seung Hee Kim, Sara Liburdi, Andrea Taramelli

Institute for ECHO Articles and Research

Evapotranspiration (ET) plays a key role in the water cycle and balance, and its estimation is of paramount importance in hydrological studies. This variable is also strongly influenced by the land use and land cover (LULC). This study use a synthesis approach to analyse the relationship between ET variation and LULC transformation in the period 1990–2020. The study area represents a major agricultural region in the Mekong Delta of Vietnam between the Mekong and Bassac rivers. The multivariate dataset was ingested into the hydrological model Soil and Water Assessment Tool to examine the multidecadal ET evolution across the study region. …

Powering Up Clinical Practice: Mastering Clinical Literature Search Techniques – 2026 Jan Hslic Workshop, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This HSLIC workshop introduces practical clinical literature search techniques, focusing on how to translate clinical questions into structured database searches and efficiently navigate core resources. Topics include identifying key concepts, using Boolean operators, truncation, wildcards, phrase searching, proximity operators, subject headings (MeSH/Emtree), building multi-concept search strategies, and accessing full text through HSLIC tools and service.

Intravenous Thrombolysis In Patients On Direct Oral Anticoagulants: Analysis Of The Get With The Guidelines Stroke Registry, Shadi Yaghi, Opeolu Adeoye, Et Al.

2020-Current year OA Pubs

BACKGROUND: Intravenous thrombolysis for acute ischemic stroke (AIS) is a proven effective treatment. Whether thrombolysis in patients with AIS with recent direct oral anticoagulant (DOAC) use is safe and efficacious is not well established. We aimed to compare outcomes of patients with AIS and recent DOAC use who received thrombolysis to those otherwise eligible but excluded due to recent DOAC use.

METHODS: This study included patients for the GWTG (Get With The Guidelines) registry with a diagnosis of AIS within 4.5 hours from last known normal, on a DOAC, and either (1) received intravenous thrombolysis, or (2) were excluded from …

What Is The Psychological And Cognitive Impact Of Returning Alzheimer Disease Dementia Research Results To Healthy Research Participants? A Delayed-Start Randomised Clinical Trial Protocol For The Weshare Study (Washington University Study Of Having Alzheimer Disease), Sarah M Hartz, Spondita Goswami, Amy Oliver, Alissa Evans, Sacha Jackson, Erin Linnenbringer, Krista M Moulder, John C Morris, Jessica Mozersky

2020-Current year OA Pubs

INTRODUCTION: Returning research results that indicate risk of Alzheimer disease (AD) dementia-a disease for which no meaningful treatments or cure exist-to cognitively normal participants is controversial. AD is thought to begin many years before clinical signs and symptoms begin. During this time, individuals are cognitively normal but have biomarkers that indicate pathophysiological changes in the brain. With this study, we aim to evaluate the impact of returning research results on cognitively normal participants recruited from a longitudinal observational cohort on ageing at the Knight Alzheimer Disease Research Centre (Knight ADRC) at Washington University in St. Louis.

METHODS AND ANALYSIS: Our …

The Igvf Catalog-From Genetic Variation To Function, Daofeng Li, Shane Liu, Wenjin Zhang, Juan F Macias-Velasco, Tianjie Liu, Sarah Cody, Lucinda Antonacci-Fulton, Ting Wang, Et Al.

2020-Current year OA Pubs

Genomic variation between individuals is essential for understanding how differences in the genome sequence affect molecular and cellular processes. The Impact of Genomic Variation on Function (IGVF) Consortium aims to uncover the relationships among genomic variation, genome function, and phenotypes by combining experimental techniques, such as single-cell mapping and genomic perturbation assays, with computational approaches such as machine learning-based predictive modeling. The IGVF Data and Administrative Coordinating Centers collect, analyze, and disseminate data and results from across the consortium through an open-source platform called the IGVF Catalog. This resource includes, but is not limited to, data on the effects of …

Large-Scale Cubesat Chassis, Matthew D. Evans, Robert A. Bettinger

AFIT Patents

The present invention relates to large-scale CubeSat chassis and methods of making and using same. The disclosed CubeSat comprises specific structural features that can yield up to at least a 27 U CubeSat that has comparable or even better performance and benefits than that of smaller CubeSats. Such volume increase coupled with the structural integrity of Applicants' CubeSats opens up a wide range of CubeSat performance increases including, but not limited to, larger payloads, more diverse payloads and larger CubeSat fuel capacities. Such increased payload capabilities includes, for example, increased focal length capabilities and such improved maneuverability results in, for …