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Dental Age–Based Assessment Of Retromolar Morphology In Skeletal Class Iii Patients: Implications For Mandibular Third Molar Development, Thuy-Trang Thi Ho, Tu Manh Nguyen, Loc Minh Lu, Fang-Yu Fan, Ying-Sui Sun, Yang-Che Wu, Sheng-Wei Feng, Chien-Fu Tseng, Pao-Chang Chiang, I-Ta Lee

Journal of Dental Sciences

Background/purpose: In skeletal Class III malocclusion, evaluation of mandibular third molar development is clinically important for orthodontic treatment planning, particularly in relation to posterior space conditions. This study aimed to assess the association between dental age of mandibular third molars and retromolar morphological characteristics in skeletal Class III patients.

Materials and methods: This retrospective cross-sectional study included panoramic radiographs from 157 patients diagnosed with skeletal Class III malocclusion based on clinical examination and lateral cephalometric analysis. Mandibular third molar development was evaluated using Demirjian mineralization stages (D–H), representing stages from crown completion to root maturation. Retromolar morphology was evaluated …

Endothelin-1 Drives Cyclooxygenase-2 And Prostaglandin E2 Expression In Osteoblasts Through Mitogen-Activated Protein Kinase And Activator Protein-1 Signaling During Periodontal Inflammation, Fang-Yu Fan, Thi Thuy Tien Vo, Hsuan Kuo, Chien-Fu Tseng, Wei-Ning Lin, Chia-Yu Wu, Yang-Che Wu, Chuen-Mao Yang, Li-Der Hsiao, I-Ta Lee

Journal of Dental Sciences

Background/purpose: Endothelin-1 (ET-1) has been implicated in inflammatory tissue responses, but its role in osteoblast-mediated inflammation during periodontal inflammation remains unclear. This study investigated whether ET-1 induces cyclooxygenase-2 (COX-2) expression and prostaglandin E₂ (PGE₂) release in osteoblasts and explored the underlying signaling mechanisms.

Materials and methods: Murine osteoblast-like MC3T3-E1 cells were stimulated with ET-1. COX-2 protein and mRNA expression, promoter activity, and PGE₂ release were assessed by Western blotting, real-time RT-PCR, luciferase reporter assay, and ELISA, respectively. Pharmacological inhibitors and siRNA knockdown were used to examine the roles of ET_A/ET_B receptors, G_{q …}

Cephalometric And Soft Tissue Determinants Of Esthetic Outcomes After Single-Jaw Mandibular Setback Surgery In Skeletal Class Iii Patients: A Retrospective Study, Chun-Te Ho, You-Ru Chen, Tsui-Hsien Huang, Jnug-Chun Yeh, Tzu-Yu Peng, Chia-Tze Kao

Journal of Dental Sciences

Background/purpose: Orthognathic surgery is an effective treatment for skeletal Class III malocclusion; however, the relative influence of skeletal and soft tissue variables on postoperative esthetic outcomes remains unclear. This study aimed to evaluate the relationships among cephalometric parameters, soft tissue changes, and esthetic outcomes following single-jaw mandibular setback surgery.

Materials and methods: A retrospective study was performed on 258 adult patients with skeletal Class III malocclusion subspinale-nasion-supramentale (ANB) angle < 0° who were treated between 2016 and 2021. Patients were divided into three groups: bilateral vertical ramus osteotomy (BVRO) group (n = 99), genioplasty alone group (n = 30), and BVRO plus genioplasty group. (n = 129). Cephalometric and …

Isoliquiritigenin Represses The Pro-Fibrotic Tgf-Β/Smad2 Signaling And Nuclear Enriched Abundant Transcript 1 (Neat1) In Oral Submucous Fibrosis, Chi-Shan Tseng, Shih-Min Wang, Yi-Wen Liao, Her-Hsiung Huang, Cheng-Chia Yu, Yicyuan Chen

Journal of Dental Sciences

Background/purpose: Isoliquiritigenin (ISL) has shown anti-fibrotic potential in several organ systems, but its effects on oral submucous fibrosis (OSF) remain unclear. This study investigated whether ISL attenuates myofibroblast activities in buccal mucosal fibroblasts (BMFs) from OSF patients by modulating TGF-β/Smad2 signaling and the long non-coding RNA NEAT1.

Materials and methods: Primary normal BMFs and fibrotic BMFs (fBMFs) were isolated from human buccal mucosa, and cell viability, collagen gel contraction, migration, and wound closure were examined after ISL treatment with or without arecoline. TGF-β1 secretion was quantified, while protein expression of phosphorylated Smad2, COL1A1, and α-SMA was analyzed, and …

Dual-Layer Biphasic Calcium Phosphates/Tantalum Pentoxide Coating On Titanium For Concurrent Biocorrosion Resistance And Enhanced Biocompatibility, Ying-Sui Sun, Kai-Yi Lin, Wei-Cheng Chen, Her-Hsiung Huang

Journal of Dental Sciences

Background/purpose: Titanium (Ti) dental implants must resist biocorrosion while maintaining biocompatibility. This study developed a dual-layer biphasic calcium phosphates/tantalum pentoxide (BCPs/Ta₂O₅) coating on Ti to improve both biocorrosion resistance and biological performance.

Materials and methods: A dense Ta₂O₅ inner layer was fabricated via a hydrolysis–condensation process to act as a corrosion barrier. Subsequently, a porous BCPs outer layer was deposited by electrochemical cathodic deposition to provide a bioactive interface. Surface morphology, functional groups, crystalline structure, wettability, surface free energy, coating thickness and nanostructure, protein adsorption, and in vitro bioactivity were characterized. Biocorrosion behavior was evaluated using polarization curve measurements in …

Developing Anti-Inflammatory Mineral Trioxide Aggregate As Dental Implant Crown Cement To Reduce Peri-Implantitis Incidence, Yung-Fu Hsu, Sea-Fue Wang, Yi-Le Liao, Chih-Sheng Lin, Ssu-Chi Chen, Sheng-Yang Lee, Wei-Chun Lin

Journal of Dental Sciences

背景/目的：牙周組織周圍的牙科樹脂黏固劑殘留是植體周圍炎的原因之一。嚴重病例可能導致植體鬆動或脫落。因此，本研究旨在對礦物三氧化物聚集體（MTA）進行改性，使其成為一種抗發炎的牙科植體冠黏固劑（ICC）。

材料與方法：本研究評估了去離子水溶液（Daq）、羥基磷灰石溶液（Haq）和氯化鈣溶液（Caq）對ICC凝固時間、抗壓強度、黏結強度和生物相容性的影響。以單因子變異數分析（ANOVA）檢定各實驗組間的差異（ P < 0.05）。

結果：表面微觀結構分析表明，添加Haq和Caq有助於ICC顆粒間的結合。表面元素分析表明，添加Haq增加了Ca離子含量。凝固時間結果表明，與Daq相比，Caq和Haq分別使最終凝固時間縮短了46.5%和34.7%（ P < 0.05）。 Caq的抗壓強度分別比Daq和Haq高35.1%和13.4%（ P < 0.05）。三種ICC組的黏接強度結果表明，樹脂黏接劑的效果相同（ P > 0.05）。生物相容性和清除活性測試表明，ICC優於樹脂黏接劑。

結論： ICC與Caq合併使用可縮短凝固時間、提高抗壓強度、增強生物相容性並降低發炎發生的可能性。因此，ICC與Caq聯合使用可作為牙科樹脂黏固劑的替代方案。

Antisense Oligonucleotides-Mediated Rescue Of The Amelx Splicing Defects, Eui-Sic Cho, Youn Jung Kim, Figen Seymen, Mine Koruyucu, Jan C.-C. Hu, James P. Simmer, Jung-Wook Kim

Journal of Dental Sciences

Background/purpose: Amelogenesis imperfecta (AI) is a group of rare, inherited disorders characterized by abnormal enamel formation. While identifying the genes and mutations that cause the disease is important, understanding its molecular pathogenesis is essential to developing precision and personalized medicine, which aim to stop disease onset, slow its progression, and provide a range of treatment options. Previously, we identified mutations that affect the conserved alternative splicing of the AMELX gene, leading to the inclusion of normally skipped exon 4 and resulting in a characteristic AI phenotype.

Materials and methods: HEK293 cells were grown on cell culture dishes …

Biomechanical Effects Of Titanium Alloy Removable Partial Denture Framework Designs Fabricated By Selective Laser Melting In Mandibular Kennedy Class Ii Partial Edentulism: A Finite Element Study, Min-Chieh Chang, Ping-Ching Wu, Wei-Shao Lin, Yung-Chung Chen

Journal of Dental Sciences

Background/purpose: The biomechanical effects of framework design and material interactions in mandibular free-end saddle removable partial dentures remain unclear. This study evaluated framework variables using finite element analysis.

Materials and methods: A mandibular Kennedy Class II model was digitized to create a cobalt-chromium (CoCr) and sixteen Ti-6Al-4V (Ti64) frameworks varying by major connector dimension, clasp configuration, and lingual reciprocal assembly (LRA). Periodontal ligament (PDL) and mucosa layers were incorporated. Contacts were defined, and materials were assumed homogeneous and isotropic. Vertical and oblique loads were applied, and von Mises stresses were analyzed. Model validation was performed using digital image correlation. …

N-Acetylcysteine Restores Osteogenesis In Human Periodontal Ligament Stem Cells By Attenuating Hif-1Α-Driven Oxidative Stress And Glycolytic Reprogramming, Xiaochi Chang, Yanghao Zhao, Yang Wang, Chang Shu, Yi Feng, Yichong Sun, Guangxun Zhu, Jianxia Hou

Journal of Dental Sciences

Background/purpose: Periodontitis-associated hypoxia signaling and oxidative stress severely impair the regenerative capacity of human periodontal ligament stem cells (hPDLSCs). This study investigated whether antioxidant intervention rescues hPDLSC osteogenesis under CoCl₂-induced HIF-1α stabilization by modulating PI3K/Akt/HIF-1α/HO-1 signaling and glycolytic reprogramming.

Materials and methods: Primary hPDLSCs isolated from healthy premolars were characterized by flow cytometry and multilineage differentiation. To simulate periodontitis-associated stress, a CoCl₂-induced HIF-1α-stabilizing condition was established. Cells were treated with the antioxidant N-acetylcysteine (NAC), the glycolysis inhibitor 2-deoxy-D-glucose (2-DG), or the PI3K inhibitor LY294002. Redox balance (DCFH-DA, MDA, GPX activity), glycolysis-related markers (HK2, GLUT1, lactate), and osteogenic-related markers …

Optical Properties Of Conventional And High-Translucency Zirconia Ceramics And Their Effects On Resin Cement Polymerization, Chia-Ling Li, Ping-Ju Chen, Jui-Che Lin, Shu-Fen Chuang

Journal of Dental Sciences

Background/purpose: Adequate polymerization of resin luting cements is essential for durable bonding in zirconia restorations. However, variations in zirconia microstructure and composition may influence translucency and light transmittance, thereby affecting resin cement polymerization. This study aimed to investigate the optical properties of conventional and high-translucency zirconia ceramics and their effects on resin cement polymerization.

Materials and methods: Six zirconia ceramics were evaluated: CerconBase, CerconHT, and VitaHT (3Y-TZP); VitaST (4Y-PSZ); and CerconXT and VitaXT (5Y-PSZ). Disk specimens (0.5 and 1.0 mm thick) were fabricated and sintered. Grain size and elemental compositions were analyzed using scanning electron microscopy and energy-dispersive X-ray …

Spatially Resolved Transcriptomics Identifies Epithelial-Specific Oncogenic Signaling Networks In Ameloblastoma, Chih-Huang Tseng, Shohei Yoshimoto, Kai-Feng Hung, Pei-Hsuan Lu, Yi-Ping Wang, Julia Yu-Fong Chang

Journal of Dental Sciences

Background/purpose: Ameloblastoma is a benign odontogenic tumor characterized by locally aggressive growth and a high recurrence rate. Although recurrent mutations such as BRAF V600E have been identified, the epithelial-specific molecular mechanisms underlying tumor initiation and invasion remain incompletely defined. Previous transcriptomic studies have been limited by stromal contamination and lack of spatial resolution.

Materials and methods: An integrative transcriptomic strategy was applied, combining bulk RNA sequencing of fresh ameloblastoma and dental follicular tissues, RNA sequencing of primary cultured ameloblastoma epithelial cells and dental follicular epithelial cells, and spatial transcriptomic profiling of formalin-fixed, paraffin-embedded ameloblastoma specimens.

Results: Differential expression and functional …

Quantitative Cbct Assessment Of Anterior Loop Safety Margins Using Canine-Guided Osteotomy Designs For Chin Bone Harvesting., Han-Sheng Chen, Kun-Jung Hsu, Hsiu-Yueh Liu, Hui-Na Lee, Chun-Ming Chen

Journal of Dental Sciences

Background/purpose: Chin bone harvesting is a common intraoral grafting procedure but carries a risk of neurosensory complications involving the mental foramen (MF), anterior loop (AL), and mandibular incisive canal (MIC). Present study quantitatively evaluated whether the mandibular canine can serve as a safer and more reproducible landmark for chin bone harvesting.

Materials and methods: Cone-beam computed tomography (CBCT) scans from 40 adults were analyzed. The mandibular canine distal angle (CDA) and canine long axis (CLA) were used as reference lines. Measurements included AL-MF length, distances from the CLA to the MF and AL, interMF distance (IntMF), interAL distance (IntAL), interCLA …

Performance Of Chatgpt-4, Gemini, And Deepseek-V3 On English-Translated Questions From The Taiwan National Dental Technician Licensing Examination Over A Three-Week Period, Yi-Pang Lee, Ching-Yi Huang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Large language models (LLMs) have shown potential in answering professional examination questions. This study evaluated the performance of ChatGPT-4, Gemini, and DeepSeek-V3 in answering English-translated questions from the 2023 Taiwan National Dental Technician Licensing Examination (TNDTLE) over a three-week period.

Materials and methods: A total of 194 English-translated, text-based multiple-choice questions were selected from the 2023 TNDTLE. ChatGPT-4, Gemini, and DeepSeek-V3 were used to answer the same set of English-translated questions at four time points: baseline and one-, two-, and three-week follow-ups. Accuracy rates (ARs) were calculated and compared to evaluate changes over time and differences among the three …

A Comprehensive Analysis And Sex-Related Differences In Root And Root Canal Anatomy In The Taiwanese Population, Ho-Sheng Chiang, Wei-Cheng Lee, Ying-Wu Chen, Ling-Yu Kung, Kuei-Yuan Chen, Ren-Yeong Huang, Yi-Shing Shieh, Yu-Chiao Wu

Journal of Dental Sciences

Background/purpose: Root canal morphology exhibits substantial anatomical variation influenced by ethnicity and sex, which may complicate endodontic treatment if unrecognized. This study aimed to comprehensively evaluate root and root canal configurations in a Taiwanese population using cone-beam computed tomography (CBCT) and to investigate sex-related differences in canal anatomy.

Materials and methods: CBCT scans from 802 patients treated between 2022 and 2024 were retrospectively analyzed. A total of 18,578 teeth met the inclusion criteria. Root canal configurations were assessed for every root using Vertucci’s classification, and C-shaped canals were further categorized based on morphology. Sex-related differences were analyzed using chi-square tests. …

Performance Of Chatgpt-4, Gemini, And Deepseek-V3 In Answering The Prompt-Engineered Questions From The Taiwan National Dental Technician Licensing Examination Over A Three-Week Period, Yi-Pang Lee, Ching-Yi Huang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Large language models (LLMs) have shown promise in answering professional examination questions. This study evaluated the performance of ChatGPT-4, Gemini, and DeepSeek-V3 in answering prompt-engineered questions selected from the 2023 Taiwan National Dental Technician Licensing Examination (TNDTLE) over a three-week period.

Materials and methods: A total of 194 Chinese-language text-based multiple-choice questions were selected from the 2023 TNDTLE. The three LLMs answered these questions using a standardized prompt referring to 17 dental technology textbooks. Accuracy rates (ARs) were recorded at baseline and after one, two, and three weeks. Comparisons of ARs over time, among three LLMs, between basic and …

Ensemble Learning For Predicting Periapical Lesions From Dental Radiographs, Fang-Yuan Liao, Ming-Jyun Jian, Abdullah Sarini, Yulianto Jesica, Yen-Kun Lin, Hsun-Yu Huang

Journal of Dental Sciences

Background/purpose: Diagnosing periapical cysts and granulomas using periapical radiographs is challenging due to subtle radiographic differences. This study aimed to develop a machine learning–based diagnostic framework to improve lesion classification through ensemble learning and dentin standardization.

Materials and methods: Five models—Support Vector Classifier (SVC), Nu-SVC, K-Nearest Neighbors (KNN) and Decision Tree—were trained on 144 pre-treatment periapical radiographs (70 cysts and 74 granulomas). Dentin standardization normalized grayscale values to ensure feature consistency. A weighted soft voting strategy was employed to integrate predictions, with model weights derived from individual diagnostic performance. Model performance was evaluated via five-fold cross-validation. Statistical significance among models …

2-O-Methylmagnolol Suppresses Oral Squamous Cell Carcinoma Progression By Targeting C-Myc Signaling, Chi-Yuan Chen, Tzong-Ming Shieh, Chin-Chuan Chen, Yann-Lii Leu, Yu-De Chu, Miaw-Jene Liou, Yi-Tsen Liu, Hsin-Wei Lin, Kai-Yin Chen, Cheng-Chia Yu, Tong-Hong Wang

Journal of Dental Sciences

Background/purpose: Oral squamous cell carcinoma (OSCC) is characterized by aggressive growth and frequent recurrence, highlighting the need for novel targeted therapies. Magnolol, a bioactive compound derived from Magnolia officinalis, exhibits anti-tumor activity. In this study, we synthesized a methoxylated derivative, 2-O-methylmagnolol (MM1), and evaluated the anti-OSCC efficacy and underlying mechanisms of magnolol and MM1.

Materials and methods: Human OSCC cell lines (SAS and OECM1) were treated with magnolol or MM1. Cell proliferation, migration, and invasion were analyzed using functional assays. Cell-cycle distribution and apoptosis were assessed by flow cytometry and DiOC₆/PI staining. Protein expression of c-MYC and downstream regulators …

Role Of Three-Phase Bone Scintigraphy And Fluorodeoxyglucose Positron Emission Tomography In Monitoring Hyperbaric Oxygen Therapy Combined With Conservative Surgery For Refractory Osteomyelitis, Yu Nakai, Ken-Ichiro Sakata, Masayuki Shinohara, Yusuke Nakamura, Keisuke Nakamura, Tougo Tanabe, Taku Kimura, Takuya Asaka, Jun Sato, Yoshimasa Kitagawa

Journal of Dental Sciences

Background/purpose: The anti-inflammatory effect of hyperbaric oxygen therapy (HBOT) on osteomyelitis of the jaw has not been sufficiently quantified. In this study, we aimed to quantitatively evaluate the effects of HBOT and postoperative disease status in patients with jaw osteomyelitis treated with minimally invasive surgery combined with HBOT using nuclear medicine imaging.

Materials and methods: The study included 11 patients who underwent sequestrectomy or saucerization and preoperative HBOT in our department between 2008 and 2015. The underlying etiologies were dental infection-related osteomyelitis (four cases; hereinafter ODONT group), osteoradionecrosis (four cases; hereinafter ORN group), or medication-related osteonecrosis of the jaw (three …

C-X-C Motif Chemokine Ligand 13 And The C-X-C Motif Chemokine Receptor 5–C-Jun N-Terminal Kinase–Nuclear Factor Kappa B–Matrix Metalloproteinase 9 Axis In Oral Squamous Cell Carcinoma Metastasis, Ju-Fang Liu, Kuan-Chou Lin, Po-Chih Hsu, Tsung-Ming Chang, Peng Chen, Ying-Sui Sun

Journal of Dental Sciences

Background/purpose: Metastasis is the leading cause of treatment failure in oral squamous cell carcinoma (OSCC). This study investigated the role of C-X-C motif chemokine ligand 13 (CXCL13) in OSCC metastasis and the underlying signaling mechanism.

Materials and methods: Integrative transcriptomic analysis was performed using three independent OSCC datasets to identify metastasis-associated genes. CXCL13 expression was examined in OSCC tissues and highly migratory sublines. The effects of CXCL13 on cell migration were evaluated in vitro. Pathway analysis, pharmacological inhibitors, and receptor silencing were used to investigate the downstream signaling pathway. An orthotopic tongue xenograft model was used to evaluate the effect …

Synergistic Effects Of Biodegradable Magnesium Alloy And Erythromycin On Osteogenic Activity, Kridtapat Sirisereephap, Kitipong Pasanaphong, Thanaphum Osathanon, Patcharapit Promoppatum, Tomoki Maekawa, Viritpon Srimaneepong, Meircurius Dwi Condro Surboyo, Kamolporn Wattanasirmkit

Journal of Dental Sciences

Background/purpose: Biodegradable magnesium (Mg)–based alloys are emerging as promising alternatives to non-resorbable titanium for bone regeneration because of their favorable mechanical properties and biodegradability. However, the interaction between Mg alloys and immunomodulatory agents in promoting osteogenesis remains poorly understood. This study aimed to evaluate the osteogenic effects of an Mg alloy on pre-osteoblasts and to investigate whether erythromycin enhances Mg-induced osteogenic differentiation through regulation of developmental endothelial locus-1 (DEL-1).

Materials and methods: WE43 Mg alloy disks were immersed in culture medium to produce Mg alloy-conditioned medium at concentrations of 25%, 50%, 75%, and 100%. MC3T3-E1 cells were treated with conditioned …

Modulation Of Osteoclast Differentiation By Epigallocatechin-3-Gallate (Egcg)/Type I Collagen–Coated Titanium Implant Surface In Vitro, Her-Hsiung Huang, Yu-Ying Cheng, Chia-Fei Liu, Wei-Cheng Chen

Journal of Dental Sciences

Background/purpose: Implant osseointegration depends not only on osteogenesis but also on coordinated bone remodeling. Our previous study demonstrated that epigallocatechin-3-gallate (EGCG)/type I collagen–coated titanium (Ti) surfaces enhance angiogenesis and osteogenic differentiation in vitro. However, their influence on osteoclast differentiation remains unclear. This study evaluated the modulatory effects of this coating on osteoclast responses in vitro.

Materials and methods: Sandblasted and acid-etched (SLA) Ti surfaces followed by alkaline treatment (SLAA) were prepared. Type I collagen was immobilized onto SLAA surfaces using the natural crosslinker EGCG (10 or 50 μg/mL). Surface morphology, roughness, hydrophilicity, and functional groups were characterized. RAW 264.7 macrophages …

Development Of A Risk Scoring System For Predicting Post-Extraction Medication-Related Osteonecrosis Of Jaws: A Derivation And Validation Cohort Study, Ling-Ying Wei, Ching-Ming Chiu, Sang-Heng Kok, Hung-Ying Lin, Wei-Yih Chiu, Hao-Hong Chang, Shih-Jung Cheng, Jang-Jaer Lee

Journal of Dental Sciences

Background/purpose: Although risk factors for medication-related osteonecrosis of the jaw (MRONJ) are known, clinical assessment prior to dental extraction remains largely subjective. We aimed to develop and externally validate a simple clinical risk scoring system to predict post-extraction MRONJ in osteoporotic patients receiving antiresorptive therapy (ART) and support evidence-based clinical decision-making.

Materials and methods: This retrospective cohort study used a derivation cohort (N = 1,067 extractions, 2003‒2022) to develop a 5- to 16-point risk score system based on five predictors (age ≥ 75, ART duration ≥ 24 months, bisphosphonate use, drug interruption < 3 months, and extraction site). The model was validated in an independent cohort (N = 928 extractions, 2022–2024) using a pre-defined ≥12 cut-off. Performance metrics included the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).

Results: MRONJ prevalence was lower in the validation …

Prevalences Of Vitamin B12 Deficiency, Pernicious Anemia, Macrocytosis, And Hyperhomocysteinemia In 532 Serum Gastric Parietal Cell Antibody-Positive Oral Mucosal Disease Patients, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous studies found the serum gastric parietal cell antibody (GPCA) positivity in 12.3% to 26.7% of atrophic glossitis (AG), burning mouth syndrome (BMS), and oral lichen planus (OLP) patients. This study assessed whether GPCA-positive oral mucosal disease (GPCA⁺OMD) patients (including 284 AG, 109 BMS, and 139 OLP patients) had significantly higher frequencies of microcytosis, macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than healthy control subjects (HCSs) or GPCA-negative OMD (GPCAˉOMD) patients.

Materials and methods: The mean corpuscular volume, blood Hb, and serum iron, vitamin B12, homocysteine, and GPCA levels were measured and compared …

Dynamic Navigation-Assisted Implant Placement For The Jaw-In-A-Day Mandibular Reconstruction, Ni Lin, Min-Yi Sung, Yu-Cheng Cheng

Journal of Dental Sciences

No abstract provided.

Impact Of Immediate Restoration On Bone Remodeling In The Esthetic Zone: A Randomized Clinical Trial, Hao-Dong Wang, Xin-Hai Lin, Yi-Wen Wu, Hong-Run Zhou, Tai Zhao Wei, Xi Chen, Yi-Qun Tang, Ya-Qin Zhu, Long Jiang

Journal of Dental Sciences

Background/purpose: Traumatic loss of anterior teeth creates esthetic challenges and often requires immediate rehabilitation. Although immediate implant placement and restoration (IIPR) shortens treatment time, strict primary stability limits its use. A native-crown restoration supported by fiber-reinforced composite (FRC) splints may broaden the indications of immediate restoration, but its effectiveness remains unclear. This randomized controlled trial aimed to evaluate the effects of the novel immediate restoration following IIP on peri-implant bone remodeling in anterior esthetic zone trauma during osseointegration.

Materials and methods: Twenty participants undergoing IIP in the anterior maxilla were randomized into two groups. In the experimental group, immediate restorations …

Influence Of All-On-4 Implant Angles On Stability And Crestal Bone - A Finite Element Optimization Analysis,, Jing-Jie Chen, Chen-Sheng Chen

Journal of Dental Sciences

No abstract provided.

Poly-Ε-Caprolactone/Multi-Wall Carbon Nanotube Composites As Osteoinductive Scaffolds For Alveolar Bone Regeneration,, Chien-Yang Yeh, Firdiansyah Rasyid

Journal of Dental Sciences

No abstract provided.

Comparative Effects Of Plasma Activation And Monomer Infiltration On The Surface Characteristics And Wettability Of 3d-Printed Permanent Crown Resin,, Pyi Phyo Win, Szu-Yu Lai

Journal of Dental Sciences

No abstract provided.

Integrated Analysis Of Single-Cell And Bulk Rna-Sequence Data Reveal Plasma Dendritic Cell-Related Diagnostic Model For Sjögren's Syndrome Based On Machine Learning,, Jinhao Zhang, Chunye Zhang

Journal of Dental Sciences

No abstract provided.

Risk Factors For Surgical-Site Infections In Oral Cancer Patients With Microvascular Free Flap Reconstruction–A Retrospective Study In A Single Medical Center In Taiwan, Pei-Yin Chen, Yu-Wei Chiu

Journal of Dental Sciences

No abstract provided.