Digital Commons Network^™

Defining Rna Oligonucleotides That Reverse Deleterious Phase Transitions Of Rna-Binding Proteins With Prion-Like Domains., Lin Guo, Jacob Mann, Jocelyn Mauna, Katie Copley, Hejia Wang, Jack Rubien, Cristian Bergmann, Jenny Carey, Jessica Merjane, Marilyn Ngo, Jiazhen Xu, Hana Odeh, Jiabei Lin, Bo Lim Lee, Laura Ganser, Emma Robinson, Kevin Kim, Anastasia Murthy, Tapas Paul, Bede Portz, Amanda Gleixner, Zamia Diaz, Ashleigh Smirnov, George Padilla, Ellen Lavorando, Carolann Espy, Yulei Shang, Eric Huang, Alessandra Chesi, Nicolas Fawzi, Sua Myong, Christopher Donnelly, James Shorter

Department of Biochemistry and Molecular Biology Faculty Papers

RNA-binding proteins (RBPs) with prion-like domains (PrLDs), such as FUS and TDP-43, condense into functional liquids, which can transform into pathological fibrils that underpin fatal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). Here, we define short RNAs that prevent FUS fibrillization by promoting liquid phases and distinct short RNAs that prevent and reverse FUS condensation and fibrillization. These activities require interactions with multiple RNA-binding domains of FUS and are encoded by RNA sequence, length, and structure. We define a short RNA that dissolves cytoplasmic FUS aggregates, restores nuclear FUS, and mitigates FUS toxicity in optogenetic models and ALS …

ユーピの４２ミニビデオシリーズの１ページロードマップ, Yoshihiko Ariizumi

Learning, Teaching, & Researching Optimization

「ユーピメソッド：人生変革のロードマップ」へようこそ。本資料は、あなたが天との確かなパートナーシップを築き、自らの人生というかけがえのない物語を主体的に、そして力強く紡いでいくための道標として作成されました。全42本（各２～４分）のビデオから抽出されたエッセンスと具体的な実践ガイドが、あなたの歩みを力強く支えます。ともすると混沌とした経験を知恵へと昇華させ、神の子供としての無限の可能性を開花させる「聖なる旅路」を、共に始めましょう。

Review Of Injustice At The Intersections: Race, Gender, Class, And Criminal, Yudu Li

Open Educational Resources - Reviews

No abstract provided.

Method And System For Distributed Timekeeping And Synchronization Using Coprime Cyclic Hyperdimensional Vectors, Steven Kirkland

Defensive Publications Series

Disclosed is a protocol and architecture for distributed timekeeping that replaces scalar binary counters (e.g., Unix timestamps) with Hyperdimensional (HD) State Vectors. The system, termed the "Universal Time-Locked Protocol (UTLP) Vector Time," generates a global time state via the superposition of multiple coprime cyclic attractors (virtual oscillators), creating a high-dimensional "temporal texture" that evolves deterministically.

Unlike scalar clocks which require absolute synchronization, this vector-based approach enables "Fuzzy Synchronization," where distributed nodes correct drift via similarity-based gradient descent rather than hard resets. To accommodate low-bandwidth networks (e.g., BLE, 802.15.4), the system utilizes "Generative Compression," transmitting only the phase indices (a "Harmonic …

Novel Repurposing Of Empagliflozin-Loaded Buccal Composite (Chitosan/Silk Fibroin/Poly(Lactic Acid)) Nanofibers For Alzheimer’S Disease Management Via Modulation Of Aβ–Ager–P-Tau Pathway, Samar A. Salim

Nanotechnology Research Centre

Background/Objectives: Empagliflozin (EMPA) was repurposed for Alzheimer’s disease (AD) treatment via buccal delivery, exploiting novel nanofibers (NFs) integrating chitosan (Cs), silk fibroin (Fb), and poly(lactic acid) (PLA). Methods: EMPA-loaded Cs/Fb/PLA NFs were electrospun in different formulations to optimize the formulation parameters. The optimized formulation was then investigated for its enhanced in vivo effect. Results: Optimized nanofiber diameters ranged from 459 ± 173 to 668 ± 148 nm, possessing bead-free morphology confirmed by SEM and satisfactory mechanical properties. EMPA was successfully well-dispersed in the polymer matrix as evidenced by FTIR, XRD, and drug content. The optimized NFs displayed a hydrophilic surface …

Masthead

Washington Journal of Law, Technology & Arts

No abstract provided.

Death Of Substantiality: Why The Legal System Should Rethink The Application And Weight Of This Fair-Use Factor In The Context Of Social Media, Lindsey Vickers

Washington Journal of Law, Technology & Arts

The fair use test for exemption for liability from copyright infringement was codified in the 1970s and has not been updated since—despite major technological changes in the interim. While three of the test’s four prongs are still useful when applied to short-form media that now dominates worldwide media consumption, the factor that considers the substantiality of the portion used relative to the total work is obsolete. The current dysfunctionality of this prong in social media settings is not the only reason it should be reassessed by courts and Congress. The prong and its analysis are a bit of a Frankenstein. …

Fluid Agency In Ai Systems: A Case For Functional Equivalence In Copyright, Patent, And Tort, Anirban Mukherjee, Hannah H. Chang

Washington Journal of Law, Technology & Arts

Modern artificial intelligence (AI) systems lack human-like consciousness or culpability, yet they exhibit fluid agency: behavior that is (i) stochastic (probabilistic and path-dependent), (ii) dynamic (co-evolving with user interaction), and (iii) adaptive (able to reorient across contexts). Fluid agency generates valuable outputs but collapses attribution, irreducibly entangling human and machine inputs. This fundamental unmappability fractures doctrines that assume traceable provenance—authorship, inventorship, and liability—yielding ownership gaps and moral “crumple zones.”

This Article argues that only functional equivalence stabilizes doctrine. Where provenance is indeterminate, legal frameworks must treat human and AI contributions as equivalent for allocating rights and responsibility—not as a claim …

Fiscal Sponsorship In Truly Independent Film: Entity And Model Choice And Legal Risks, Samuel Johnson

Washington Journal of Law, Technology & Arts

This article examines fiscal sponsorship as a legal and financing structure for “truly independent” films—low-budget, non-commercial projects created by filmmakers without access to studio financing, tax incentives, or traditional investors. Neither standalone nonprofit incorporation nor purely for-profit entity structures adequately address the unique needs of such projects. After surveying the development of fiscal sponsorship as a means of funding projects that meet an exempt purpose, relevant IRS guidance, and current prevailing practices and organizational structures in independent film, the article contends that a Model C (“regranting”) fiscal sponsorship paired with a single-member limited liability company (SMLLC) offers the optimal balance …

Table Of Contents

Washington Journal of Law, Technology & Arts

No abstract provided.

Omar Folk V. Usa

2026 Decisions

USDC for the Middle District of Pennsylvania

Board Of Directors Meeting Minutes (January 8, 2026), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on January 8, 2026.

Department Of Audit, Annual Report 2025, Tennessee. Comptroller Of The Treasury.

Annual Reports

No abstract provided.

Department Of Audit, Annual Report 2025, Tennessee. Comptroller Of The Treasury.

Annual Reports

No abstract provided.

Oer Review For Business & Society – Ai Generated Oer Supplements And Open Pedagogy Assignment: Undergraduate Perspectives On Responsible Business, Cynthia E. Clark Ph.D

Open Educational Resources Publications

This review examines the integration of open educational resources and open pedagogy in Business & Society (MG 313), where students engaged in both AI‑supported research and authorship to create the open textbook Undergraduate Perspectives on Responsible Business. The project combined open access materials, AI‑generated readable adaptations of scholarly articles, and a redesigned Position Paper assignment that invited students to contribute their work to a public Pressbooks publication. These activities strengthened student engagement, improved comprehension of responsible business perspectives, and expanded access to course materials. The iterative use of OER, alongside guest instruction and library support, fostered deeper student ownership …

Analysis Of The Determinants Of Cash Holdings And The Implications For Local Government Spending Effectiveness In West Java, Ismail Marzuki Randos, Nia Suciyati

Journal of Accounting Auditing and Business

Cash management is fundamental to sustaining uninterrupted local service delivery and supporting credible budget execution. In West Java, municipal cash holdings exhibited fluctuations over 2019–2023, with only a limited number of districts/cities consistently maintaining cash holdings ratios above the operational sufficiency threshold. This study examines (i) the determinants of cash holdings Capacity and (ii) the relationship between cash holdings and expenditure effectiveness. Cash Holdings Capacity is classified as sufficient when the cash holdings ratio exceeds 100%, whereas Expenditure Effectiveness is classified as effective when the effectiveness ratio exceeds 90%. The quantitative analysis applies binary logistic regression to 27 districts/cities in …

Transmission Of Geopolitical Shocks To Firm Behavior: A Synthesis And Integrative Model, Daniel S. Andrews, Harald Puhr, April Knill

Faculty Publications

This study examines the transmission of geopolitical shocks to firm behavior. While previous research has primarily focused on the direct relation between shocks and firm behavior, we provide a more nuanced understanding by conceptualizing geopolitical shocks as disruptions that evolve through explicit and implicit channels to influence firm behavior. Based on a systematic review of 159 articles, we identify the key mechanisms that transmit the impacts of a geopolitical shock. Our findings reveal that geopolitical shocks manifest in institutions and their lower-level mechanisms, and such transmission is neither uniform nor random. Furthermore, we categorize firm behavior into distinct response modalities. …

Floral Park Properties Llc V. Hartman

All Decisions

In a holdover proceeding, the tenant moved to dismiss for the landlord's failure to serve the required Good Cause Eviction Law (GCEL) notice with the petition. The landlord cross-moved to amend the petition. The court, interpreting RPL § 217 and § 231-c, found that the GCEL notice is akin to a predicate notice requiring strict compliance. Failure to include the GCEL notice with the petition is an incurable and fatal defect. Consequently, the tenant's motion to dismiss was granted, the landlord's cross-motion to amend was denied, and the proceeding was dismissed without prejudice.

Ford V. Ford

All Decisions

The landlord, as trustee, commenced a holdover proceeding to evict the tenant from a cooperative apartment, alleging she was a licensee. After a trial, the court granted the tenant's oral motion for judgment as a matter of law and dismissed the petition. The court found that the tenant, who had been in exclusive possession since 1986, was a tenant at will entitled to a 30-day notice under RPL 228, which the landlord failed to serve. The court also ruled that judicial estoppel did not apply, as the prior related proceeding was voluntarily discontinued without a judgment.

84-16 Beach Channel Llc V. Job

All Decisions

The tenant moved to dismiss a residential holdover petition, arguing that the landlord failed to properly plead compliance with the Good Cause Eviction Law (GCEL) or include the required GCEL Notice. The landlord cross-moved to amend the petition to add the GCEL Notice. The court granted the tenant's motion to dismiss without prejudice, finding that the failure to timely serve the information required by RPAPL §§ 741(5)(a) and (5)(b) cannot be cured by amendment. The landlord's cross-motion to amend was denied.

Usa V. William Baskerville

2026 Decisions

USDC for the District of New Jersey

Temperature Dependent High Frequency Performance Of A 62% Algan Channel Hemt, Jiahao Chen, Abdullah Al Mamun Mazumder, Parthasarathy Seshadri, Dheekshinn Nandakumar, Ruixin Bai, Rafael Andrew Choudhury, M. Asif Khan, Chirag Gupta

Faculty Publications

This article reports on the temperature dependent performance of a HEMT with an Al_0.62Ga_0.38N channel layer and an Al_0.84Ga_0.16N barrier layer grown by metal–organic chemical vapor deposition. The device in this report was measured at room temperature and elevated temperatures of 100–150 °C. The sheet resistance increased from 3.5 kΩ/sq (25 °C) to 5.4 kΩ/sq (150 °C), while the contact resistance remained nominally similar. For a device with 160 nm gate length and 2 µm source-to-drain length, excellent electrical characteristics have been achieved when the device was operated at 150 °C with …

General Education Subcommittee Agenda, January 8, 2026, Utah State University

Educational Policies Committee

• Call to Order
• Approval of Minutes - December 4, 2025
• Course Approvals/Removals/Syllabi Approvals
• New Business
• Depth Courses and Engineering Discussion
• Additional Items
• Adjourn: 9:30 am

Biogeochemical Cycling Of Dissolved Zinc And Zinc Isotopes In The Arctic Ocean, Elise Langer, Dylan J. Halbeisen, Ruifeng Zhang, Seth G. John, Tim M. Conway

Making Waves REU

• Dissolved Zinc (dZn) is an essential micronutrient that supports primary productivity in the ocean (Morel & Price, 2003).
• Dissolved zinc isotope ratios (δ⁶⁶Zn) help us understand the sources, sinks, and internal cycling of dZn (Bermin et al. 2006; Conway and John, 2014, Horner et al. 2021).
• The background deep ocean has a largely homogenous δ⁶⁶Zn composition of +0.45‰ (Conway and John, 2014), thus deviations away from +0.45±0.05‰ suggest dZn input, loss, or alteration (Fig. 1).
• We hypothesize that margin sediments and freshwater input deliver isotopically light dZn to the coastal Arctic (Jensen et al. 2019).
• Near the North Pole, We …

Gh Alters Lymphatic Vessels In Female Mice And Stat5 Phosphorylation In Human Lymphatic Endothelial Cells, Christopher Walsh, Emily Scott, Elise Wagner, Jerome Walsh, Shashank Reddy, Arshad Ahmad, Reetobrata Basu, Eva Sevick-Muraca, Rich Brody, Uday Sandbhor, Sebastian Neggers, John J Kopchick

The Brown Foundation: Institute of Molecular Medicine

Disruption of lymphatic function underlies a broad spectrum of inflammatory and metabolic disorders, yet the hormonal pathways that regulate lymphatic biology remain poorly defined. GH, which is implicated in similar disease states, has an unclear role in lymphatic homeostasis. To address this gap, we investigated how chronic alterations in GH signaling alter lymphatic structure and function. Using transgenic mouse lines with increased, decreased, or absent GH action, we quantified the effect of GH on lymphatic pumping rate and lymphangiogenic remodeling during wound healing using near-infrared fluorescent imaging. We also measured markers of lymphatic endothelial cells using Western blot and immunohistochemistry …

Eeg Pressure Injuries, Paula Ebert

Nursing Grand Rounds

EEG Pressure Injuries. Paula Ebert, MS, RN, CNS, ACCNS-AG, CCRN, SCRN

Objectives:

• Understand the clinical impact of pressure injuries related to EEG
• Understand the implemented changes to reduce pressure injuries related to EEG
• Understand the multidisciplinary approach to addressing the problem

Longitudinal Observation Of Children With Achondroplasia: Findings From A Global Natural History Study (Achieve), Klane K White, Cesar G Fontecha, Janet M Legare, Wolfgang Högler, Daniel G Hoernschemeyer, Dirk Schnabel, Sheila Unger, Carlos Alberto Bacino, Paul Hofman, Yongguo Yu, Huamei Ma, Chunxiu Gong, Xiaoping Luo, T Andrew Burrow, Geneviève Baujat, Stefano Mora, Melissa Fiscaletti, Carol Zhao, Michael A Makara, Aimee D Shu, Ravi Savarirayan

Faculty, Staff and Students Publications

Introduction: The ACHieve study assessed growth velocity, body proportionality, and clinical events in children with achondroplasia not receiving growth-promoting therapy.

Methods: ACHieve was a global, longitudinal, prospective, observational study. Children ≤8 years old with achondroplasia were enrolled and evaluated every 6 months for anthropometric parameters and clinical events.

Results: ACHieve enrolled 259 children in 15 countries, including 83 from China. Median follow-up was 21 months; median age of diagnosis was approximately 52 weeks in China and 2 weeks elsewhere. Growth parameters were similar regardless of region. Mean annualized growth velocity was 9.3 cm/year for males and 10.4 cm/year for females …

Generative Synthesis Of Historical Precedents For Automated Procedural Guidance, Pooja Agrawal, Tanmay Kayande, Akash Dambhare, Deep Raithatha, Mohith P

Defensive Publications Series

Knowledge workers in enterprise environments can face challenges when resolving complex inquiries, as they may need to manually parse and synthesize information from multiple historical precedents. Existing retrieval systems may identify relevant cases but can leave the cognitive burden of synthesis to the user. Systems are described that can automate the synthesis of insights. For example, a system may use a semantic similarity model to retrieve a set of procedurally analogous historical cases from a data repository. A generative synthesis module could then compile data from these retrieved cases into a structured prompt for a large language model. The model …

Remote Procedure Call Performance Service For Performance Testing, Reda Nassif Haddad

Defensive Publications Series

A new remote procedure call (gRPC) performance service is proposed herein, referred to as a gRPC-Perf service, which can enable a network operator to understand gRPC limitations for any gRPC service that the network operator intends to use between any two points in a network. The gRPC-Perf service may also be useful for troubleshooting gRPC performance issues (e.g., whether an issue is a client issue or a network issue based on direction of traffic).

Agentic Framework Integrating Rag For Policy Queries And Autonomous Trend Analysis, Tanmay Kayande, Deep Raithatha, Akash Dambhare, Mohith P, Pooja Agrawal

Defensive Publications Series

Tools that just pull up whole, complicated company policy documents often don't help people find the specific answers they need. This new technology is a system for understanding and analyzing policies that works in two ways.

A "Reactive" Mode acts like a Q&A tool. It uses advanced technology (retrieval-augmented generation) to break down policies into small, searchable pieces. This allows the system to give direct answers with citations and even run simulations to show what happens in different situations based on the rules.

A "Proactive" Mode is an automated agent that constantly checks support data to spot trends and see …