Digital Commons Network^™

Ga4gh Phenopacket-Driven Characterization Of Genotype-Phenotype Correlations In Mendelian Disorders., Lauren Rekerle, Daniel Danis, Filip Rehburg, Adam S L Graefe, Viktor Bily, Andrés Caballero-Oteyza, Pilar Cacheiro, Leonardo Chimirri, Jessica X Chong, Evan Connelly, Bert B A De Vries, Alexander J M Dingemans, Michael H Duyzend, Tomas Freiberger, Petra Gehle, Tudor Groza, Peter Hansen, Julius O B Jacobsen, Adam Klocperk, Markus S Ladewig, Michael I Love, Allison J Marcello, Alexander Mordhorst, Monica C Munoz-Torres, Justin Reese, Catharina Schuetz, Damian Smedley, Timmy Strauss, Ondrej Vladyka, David Zocche, Sylvia Thun, Christopher J Mungall, Melissa A Haendel, Peter N Robinson

Faculty Research 2026

Comprehensively characterizing genotype-phenotype correlations (GPCs) in Mendelian disease would create new opportunities for improving clinical management and understanding disease biology. However, heterogeneous approaches to data sharing, reuse, and analysis have hindered progress in the field. We developed Genotype-Phenotype Statistical Evaluation of Associations (GPSEA), a software package that leverages the Global Alliance for Genomics and Health (GA4GH) Phenopacket Schema to represent case-level clinical and genetic data about individuals. GPSEA applies an independent filtering strategy to boost statistical power to detect categorical GPCs represented by Human Phenotype Ontology terms. GPSEA additionally enables visualization and analysis of continuous phenotypes, clinical severity scores, and …

N.D., G.D., M.D., And Clark County Department Of Family Services V. Kevin John D., 142 Nev. Adv. Op. 2 (Jan. 08, 2026), Natalie D'Ambrosio

Nevada Supreme Court Summaries

N.D., G.D., M.D., and Clark County DFS v. Kevin John D. held that dismissal of a NRS 432B petition is a final, appealable judgment under NRAP 3A(b)(1); NRAP 3A(b)(7) does not bar such appeals, and In re A.B. is partially overruled.

Deutsche Bank Nat’L Tr. Co. V. Collegium Fund Llc Ser. 16, 142 Nev. Adv. Op. 1 (January 8, 2026), Ashley Arita

Nevada Supreme Court Summaries

If a homeowner makes payments to their homeowner’s association (HOA) sufficient to pay off their superpriority lien, those payments convert it to a subpriority lien.

Usa V. Christopher Texidor

2026 Decisions

USDC for the Middle District of Pennsylvania

Usa V. Ryan Mendoza

2026 Decisions

USDC for the Western District of Pennsylvania

D. Blankenship V. Financial Industry Regulatory Authority

2026 Decisions

USDC for the Eastern District of Pennsylvania

Usa V. Abdur Islam

2026 Decisions

USDC for the Eastern District of Pennsylvania

Rheology-Guided Spinnability In Emulsion Forcespinning Of Water-In-Oil Nanofibers: Influence Of Surfactants And Internal Phase Concentration, Saptasree Bose, Alexandra Salinas, Evelyn Torres, Jose Ramirez, Elizabeth Gamez, Michelle A. Calabrese, Karen Lozano, Victoria Padilla

Mechanical Engineering Faculty Publications

This study explores the emulsion Forcespinning (FS) approach for fabricating nanofibers with a hydrophilic phase encapsulated within a hydrophobic polymer matrix. Key factors influencing fiber production and morphology, including the concentration of the internal water phase and the presence of ionic and nonionic surfactants, were systematically investigated. Additionally, the centrifugal spinnability of the emulsions was assessed using environmentally controlled dripping-onto-substrate (DoS) rheometry, correlating the observed extensional flow behavior and emulsion extensibility with fiber spinnability. The nanofibers were characterized by scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) spectroscopy. These findings offer critical …

Hotty Toddy Tailgate: Oxford School Turns Hallways Into Mini Grove, Marvis Herring

University of Mississippi News

OXFORD, Miss. – The vibrant, manicured grass, towering magnolia trees, Ole Miss tents with finger foods, a Walk of Champions archway and even restrooms labeled "Hotty Toddy Potty" helped recreate the iconic Grove inside Della Davidson Elementary School on Thursday (Jan. 8).

Alford Family Carries Ole Miss Legacy Forward At Fiesta Bowl, Clara Turnage

University of Mississippi News

OXFORD, Miss. – The last time the University of Mississippi won a football national championship, in 1960, offensive lineman Warner Alford was on the field. As the Rebels prepare for a semifinal that could send them back to the title game, Alford's son and daughter-in-law will be there, too – wearing his letterman sweater.

Dean Leslie Named One Of The National Jurist’S Most Influential People In Legal Education, Benjamin N. Cardozo School Of Law

Cardozo Law News Archive

Dean Melanie Leslie was named one of The National Jurist's 25 Most Influential People in Legal Education for 2026 in recognition of her leadership at Cardozo School of Law. The announcement highlights her role in advancing social justice, innovation, institutional growth, and leadership development in legal education.

In Re: Michael Robinson

2026 Decisions

USDC for the Middle District of Pennsylvania

Hotty Toddy Drone Show Hits The Jackpot In Vegas, Clara Turnage

University of Mississippi News

OXFORD, Miss. – What happens at Ole Miss doesn't stay at Ole Miss. In fact, the Rebels' stellar football season was a subject that lit up the sky in Las Vegas with 600 drones during a dazzling display.

Zoliflodacin Versus Ceftriaxone Plus Azithromycin For Treatment Of Uncomplicated Urogenital Gonorrhoea: An International, Randomised, Controlled, Open-Label, Phase 3, Non-Inferiority Clinical Trial, Alison Luckey, Manica Balasegaram, Lindley A. Barbee, Teresa A. Batteiger, Helen Broadhurst, Stephanie E. Cohen, Sinead Delany-Moretlwe, Henry J.C. De Vries, Jodie A. Dionne, Katherine Gill, Chris Kenyon, Rossaphorn Kittiyaowamarn, Drew Lewis, John P. Mueller, Vimla Naicker, Seamus O'Brien, John P. O'Donnell, Nittaya Phanuphak, Elizabeth Spooner, Subasree Srinivasan, Stephanie N. Taylor, Magnus Unemo, Zinhle Zwane, Edward W. Hook, Zoliflodacin Phase 3 Study Group

School of Medicine Faculty Publications

Background Development of new treatments for gonorrhoea is a global public health priority. We aimed to evaluate the efficacy and safety of zoliflodacin versus ceftriaxone plus azithromycin in patients with uncomplicated urogenital gonorrhoea. Methods In this phase 3, multinational, randomised, controlled, open-label, non-inferiority clinical trial, participants aged 12 years and older with clinical suspicion of uncomplicated urogenital gonorrhoea were eligible for inclusion. The trial was done in 17 outpatient clinics in Belgium, the Netherlands, South Africa, Thailand, and the USA. Participating countries with high disease prevalence were identified for participation in the study. Sites selected for participation were led by …

Defining Rna Oligonucleotides That Reverse Deleterious Phase Transitions Of Rna-Binding Proteins With Prion-Like Domains., Lin Guo, Jacob Mann, Jocelyn Mauna, Katie Copley, Hejia Wang, Jack Rubien, Cristian Bergmann, Jenny Carey, Jessica Merjane, Marilyn Ngo, Jiazhen Xu, Hana Odeh, Jiabei Lin, Bo Lim Lee, Laura Ganser, Emma Robinson, Kevin Kim, Anastasia Murthy, Tapas Paul, Bede Portz, Amanda Gleixner, Zamia Diaz, Ashleigh Smirnov, George Padilla, Ellen Lavorando, Carolann Espy, Yulei Shang, Eric Huang, Alessandra Chesi, Nicolas Fawzi, Sua Myong, Christopher Donnelly, James Shorter

Department of Biochemistry and Molecular Biology Faculty Papers

RNA-binding proteins (RBPs) with prion-like domains (PrLDs), such as FUS and TDP-43, condense into functional liquids, which can transform into pathological fibrils that underpin fatal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). Here, we define short RNAs that prevent FUS fibrillization by promoting liquid phases and distinct short RNAs that prevent and reverse FUS condensation and fibrillization. These activities require interactions with multiple RNA-binding domains of FUS and are encoded by RNA sequence, length, and structure. We define a short RNA that dissolves cytoplasmic FUS aggregates, restores nuclear FUS, and mitigates FUS toxicity in optogenetic models and ALS …

ユーピの４２ミニビデオシリーズの１ページロードマップ, Yoshihiko Ariizumi

Learning, Teaching, & Researching Optimization

「ユーピメソッド：人生変革のロードマップ」へようこそ。本資料は、あなたが天との確かなパートナーシップを築き、自らの人生というかけがえのない物語を主体的に、そして力強く紡いでいくための道標として作成されました。全42本（各２～４分）のビデオから抽出されたエッセンスと具体的な実践ガイドが、あなたの歩みを力強く支えます。ともすると混沌とした経験を知恵へと昇華させ、神の子供としての無限の可能性を開花させる「聖なる旅路」を、共に始めましょう。

Review Of Injustice At The Intersections: Race, Gender, Class, And Criminal, Yudu Li

Open Educational Resources - Reviews

No abstract provided.

Method And System For Distributed Timekeeping And Synchronization Using Coprime Cyclic Hyperdimensional Vectors, Steven Kirkland

Defensive Publications Series

Disclosed is a protocol and architecture for distributed timekeeping that replaces scalar binary counters (e.g., Unix timestamps) with Hyperdimensional (HD) State Vectors. The system, termed the "Universal Time-Locked Protocol (UTLP) Vector Time," generates a global time state via the superposition of multiple coprime cyclic attractors (virtual oscillators), creating a high-dimensional "temporal texture" that evolves deterministically.

Unlike scalar clocks which require absolute synchronization, this vector-based approach enables "Fuzzy Synchronization," where distributed nodes correct drift via similarity-based gradient descent rather than hard resets. To accommodate low-bandwidth networks (e.g., BLE, 802.15.4), the system utilizes "Generative Compression," transmitting only the phase indices (a "Harmonic …

Novel Repurposing Of Empagliflozin-Loaded Buccal Composite (Chitosan/Silk Fibroin/Poly(Lactic Acid)) Nanofibers For Alzheimer’S Disease Management Via Modulation Of Aβ–Ager–P-Tau Pathway, Samar A. Salim

Nanotechnology Research Centre

Background/Objectives: Empagliflozin (EMPA) was repurposed for Alzheimer’s disease (AD) treatment via buccal delivery, exploiting novel nanofibers (NFs) integrating chitosan (Cs), silk fibroin (Fb), and poly(lactic acid) (PLA). Methods: EMPA-loaded Cs/Fb/PLA NFs were electrospun in different formulations to optimize the formulation parameters. The optimized formulation was then investigated for its enhanced in vivo effect. Results: Optimized nanofiber diameters ranged from 459 ± 173 to 668 ± 148 nm, possessing bead-free morphology confirmed by SEM and satisfactory mechanical properties. EMPA was successfully well-dispersed in the polymer matrix as evidenced by FTIR, XRD, and drug content. The optimized NFs displayed a hydrophilic surface …

Masthead

Washington Journal of Law, Technology & Arts

No abstract provided.

Death Of Substantiality: Why The Legal System Should Rethink The Application And Weight Of This Fair-Use Factor In The Context Of Social Media, Lindsey Vickers

Washington Journal of Law, Technology & Arts

The fair use test for exemption for liability from copyright infringement was codified in the 1970s and has not been updated since—despite major technological changes in the interim. While three of the test’s four prongs are still useful when applied to short-form media that now dominates worldwide media consumption, the factor that considers the substantiality of the portion used relative to the total work is obsolete. The current dysfunctionality of this prong in social media settings is not the only reason it should be reassessed by courts and Congress. The prong and its analysis are a bit of a Frankenstein. …

Fluid Agency In Ai Systems: A Case For Functional Equivalence In Copyright, Patent, And Tort, Anirban Mukherjee, Hannah H. Chang

Washington Journal of Law, Technology & Arts

Modern artificial intelligence (AI) systems lack human-like consciousness or culpability, yet they exhibit fluid agency: behavior that is (i) stochastic (probabilistic and path-dependent), (ii) dynamic (co-evolving with user interaction), and (iii) adaptive (able to reorient across contexts). Fluid agency generates valuable outputs but collapses attribution, irreducibly entangling human and machine inputs. This fundamental unmappability fractures doctrines that assume traceable provenance—authorship, inventorship, and liability—yielding ownership gaps and moral “crumple zones.”

This Article argues that only functional equivalence stabilizes doctrine. Where provenance is indeterminate, legal frameworks must treat human and AI contributions as equivalent for allocating rights and responsibility—not as a claim …

Fiscal Sponsorship In Truly Independent Film: Entity And Model Choice And Legal Risks, Samuel Johnson

Washington Journal of Law, Technology & Arts

This article examines fiscal sponsorship as a legal and financing structure for “truly independent” films—low-budget, non-commercial projects created by filmmakers without access to studio financing, tax incentives, or traditional investors. Neither standalone nonprofit incorporation nor purely for-profit entity structures adequately address the unique needs of such projects. After surveying the development of fiscal sponsorship as a means of funding projects that meet an exempt purpose, relevant IRS guidance, and current prevailing practices and organizational structures in independent film, the article contends that a Model C (“regranting”) fiscal sponsorship paired with a single-member limited liability company (SMLLC) offers the optimal balance …

Table Of Contents

Washington Journal of Law, Technology & Arts

No abstract provided.

Omar Folk V. Usa

2026 Decisions

USDC for the Middle District of Pennsylvania

Board Of Directors Meeting Minutes (January 8, 2026), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on January 8, 2026.

Department Of Audit, Annual Report 2025, Tennessee. Comptroller Of The Treasury.

Annual Reports

No abstract provided.

Department Of Audit, Annual Report 2025, Tennessee. Comptroller Of The Treasury.

Annual Reports

No abstract provided.

Oer Review For Business & Society – Ai Generated Oer Supplements And Open Pedagogy Assignment: Undergraduate Perspectives On Responsible Business, Cynthia E. Clark Ph.D

Open Educational Resources Publications

This review examines the integration of open educational resources and open pedagogy in Business & Society (MG 313), where students engaged in both AI‑supported research and authorship to create the open textbook Undergraduate Perspectives on Responsible Business. The project combined open access materials, AI‑generated readable adaptations of scholarly articles, and a redesigned Position Paper assignment that invited students to contribute their work to a public Pressbooks publication. These activities strengthened student engagement, improved comprehension of responsible business perspectives, and expanded access to course materials. The iterative use of OER, alongside guest instruction and library support, fostered deeper student ownership …

Analysis Of The Determinants Of Cash Holdings And The Implications For Local Government Spending Effectiveness In West Java, Ismail Marzuki Randos, Nia Suciyati

Journal of Accounting Auditing and Business

Cash management is fundamental to sustaining uninterrupted local service delivery and supporting credible budget execution. In West Java, municipal cash holdings exhibited fluctuations over 2019–2023, with only a limited number of districts/cities consistently maintaining cash holdings ratios above the operational sufficiency threshold. This study examines (i) the determinants of cash holdings Capacity and (ii) the relationship between cash holdings and expenditure effectiveness. Cash Holdings Capacity is classified as sufficient when the cash holdings ratio exceeds 100%, whereas Expenditure Effectiveness is classified as effective when the effectiveness ratio exceeds 90%. The quantitative analysis applies binary logistic regression to 27 districts/cities in …