Biomedical Commons^™

Synthesis, Characterization And Antibacterial Properties Of Silver(I) N-(4-Pyridyl) Benzamide Complexes With Varying Conterions, Mauro J. Ruiz

Open Access Theses & Dissertations

Organic semiconductor materials composed of - stacking aromatic compounds have been under intense investigation for their potential uses in flexible electronics and other advanced technologies. Herein we report a new family of seven - stacking compounds of Silver(I) N-(4-pyridyl) Benzamide with varying counterions, namely [Ag(NPBA)2]X, where NPBA is N-(4-pyridyl) Benzamine, X = NO3- (1), ClO4- (2), CF3SO3- (3), PF6- (4), BF4- (5), CH3PhSO3- (6), and PhSO3- (7), which form extended - stacking networks in one-dimensional (1D), 2D and 3D directions in the crystalline solid-state via the phenyl moiety, with average inter-ring distances of 3.823 Å. Interestingly, the counterions that contain …

Image Analysis For Lung Cancer Diagnosis And Superresolution Localization Microscopy, Xia Huang

Open Access Theses & Dissertations

With the development of imaging analysis techniques, flurry of applications associated with it has been hatched. In this paper, image analysis on both organ and cellular levels will be demonstrated. For organ level images, a deep learning based computer aided lung cancer diagnosis based on computer tomography images is studied. Deep learning techniques have been extensively used in computerized pulmonary nodule analysis recent years. Many reported studies still utilized hybrid methods for diagnosis, in which convolutional neural networks (CNNs) are used only as one part of the pipeline, and the whole system still needs either traditional image processing modules or …

Bioprinted Mcf7 Breast Cancer Cells, An In Vitro Model For Drug Discovery, Aleli Campbell

Open Access Theses & Dissertations

Current breast cancer treatments are successful in eradicating this disease in the majority of patients, though there are quite a few cases where relapse or recurrence follow, which may lead to continued cancer therapy or death. Thermal inkjet bioprinting (BP) is a novel technique that is used to bioprint biomaterials or diverse cellular organisms to engineer tissue or organ models in vitro. In this Dissertation, we investigated the molecular effect of BP MCF7 breast cancer cells (BCC), cell survival of the cells when exposed to FDA approved systemic therapy alone and in combination with radiation and lastly, the ability of …

Platelet Biology And Thrombosis: Juul E-Cigarette Exposure And 5ht2a Receptor Drug Discovery, Jean Emmanuel Montes Ramirez

Open Access Theses & Dissertations

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Computer-Aided Classification Of Impulse Oscillometric Measures Of Respiratory Small Airways Function In Children, Nancy Selene Avila

Open Access Theses & Dissertations

Computer-aided classification of respiratory small airways dysfunction is not an easy task. There is a need to develop more robust classifiers, specifically for children as the classification studies performed to date have the following limitations: 1) they include features derived from tests that are not suitable for children and 2) they cannot distinguish between mild and severe small airway dysfunction.

This Dissertation describes the classification algorithms with high discriminative capacity to distinguish different levels of respiratory small airways function in children (Asthma, Small Airways Impairment, Possible Small Airways Impairment, and Normal lung function). This ability came from innovative feature selection, …

Raman Computational And Experimental Studies On Label-Free Biological Investigations, John Ciubuc

Open Access Theses & Dissertations

Raman spectroscopy is an optical technique that allows for label-free biological investigations to take place. This approach presents both new perspectives and a means for visualizing investigations. This thesis confronts two biological cases: dopamine (DA) detection at physiological levels and assessment of renal osteodystrophy (ROD). We employed surface-enhanced Raman spectroscopy on silver nanoparticles recording DA concentrations as low as 10−11 molar. Quantum chemical density functional calculations were carried out using Gaussian-09 analytical suite software. Good agreement between the simulated and experimentally determined results indicates the existence of distinct DA molecular forms, such as uncharged DA±, anionic DA−, and dopaminequinone. Disappearance …

Microstructural Evaluation Of Aluminium Alloy A365 T6 In Machining Operation, Bankole I. Oladapo, S. Abolfazl Zahedi, Francis T. Omigbodun, Edwin A. Oshin, Victor A. Adebiyi, Olaoluwa B. Malachi

Electrical & Computer Engineering Faculty Publications

The optimum cutting parameters such as cutting depth, feed rate, cutting speed and magnitude of the cutting force for A356 T6 was determined concerning the microstructural detail of the material. Novel test analyses were carried out, which include mechanical evaluation of the materials for density, glass transition temperature, tensile and compression stress, frequency analysis and optimisation as well as the functional analytic behaviour of the samples. The further analytical structure of the particle was performed, evaluating the surface luminance structure and the profile structure. The cross-sectional filter profile of the sample was extracted, and analyses of Firestone curve for the …

1995-2005: A Decade Of Innovation In Low Temperature Plasma And Its Applications, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Scientific breakthroughs tend to come in spurts when unique societal, economical, and political circumstances conspire (knowingly or unknowingly) and create an environment ripe for creativity. The field of low temperature plasma (LTP) recently experienced such an upheaval, which this paper attempts to relate in some details. There have been “roadmap” papers published before, which look towards the future of the field, but all roads start somewhere and even “new” roads are often paved over older roads that were discovered and traveled by early pioneers. With the sharp decrease in funding for fusion research in the USA in the early 1990s …

Effectiveness Of Physiological Alarm Management Strategies To Prevent Alarm Fatigue, Amy Clemens

Walden Dissertations and Doctoral Studies

There is limited clinical research on the effectiveness of alarm management strategies and nursing behaviors related to alarms in clinical settings. As many as 76% of physiological monitor alarms are overlooked as clinically insignificant by nursing staff. Excessive alarms may impact patient outcomes and cause cognitive overload for nurses that can result in medical errors and missed patient resuscitations. The purpose of this systematic review was to rate alarm management studies on level of evidence for interventions, nursing responses to alarms, and impact on alarm fatigue behavior. The nursing role effectiveness model guided this project. Twenty-seven studies were reviewed to …

Modifikasi Alat Medis Stetoskop Untuk Monitoring Suara Jantung Menggunakan Tampilan Gui Matlab, Dessy Irmawati, Ridho Prasakti

Elinvo (Electronics, Informatics, and Vocational Education)

Heart sounds are very important for the initial diagnosis of a disease. This article aims to modify the stethoscope's medical device by adding a Low Pass Filter (LPF) and a condenser sensor so that data can be recorded in a digital device. The stages of tool development begin with analysis, design, development and testing. At the analysis stage, it was stated that a conventional medical stethoscope can only be done by a medical expert directly, where data cannot be stored for detailed analysis purposes, the device is not equipped with LPF which can limit the frequency in a certain range, …

Extraction Of Vital Signs Using Real Time Video Analysis For Neonatal Monitoring, Bhushan Lohani

Electrical Engineering Theses

Video data is now commonly used for analysis in surveillance, security, medical and many other fields. The development of low cost but high-quality portable cameras has contributed significantly to this trend. One such trend includes non-invasive vital statistics monitoring of infants in Neonatal Intensive Care Units (NICU). National Center for Health Statistics Publications has reported a high infant death rate (23,215 in 2014). This statistic has drawn the interest of health system professionals. Due to occurrence of conditions like bradycardia, apnea and hypoxia, these preterm infants are kept in an NICU for constant monitoring. One of the problems faced at …

Modeling And Simulation Methodologies For Spinal Cord Stimulation., Saliya Kumara Kirigeeganage

Electronic Theses and Dissertations

The use of neural prostheses to improve health of paraplegics has been a prime interest of neuroscientists over the last few decades. Scientists have performed experiments with spinal cord stimulation (SCS) to enable voluntary motor function of paralyzed patients. However, the experimentation on the human spinal cord is not a trivial task. Therefore, modeling and simulation techniques play a significant role in understanding the underlying concepts and mechanics of the spinal cord stimulation. In this work, simulation and modeling techniques related to spinal cord stimulation were investigated. The initial work was intended to visualize the electric field distribution patterns in …

Il-12 Gene Electrotransfer Triggers A Change In Immune Response Within Mouse Tumors, Guilan Shi, Chelsea Edelblute, Sezgi Arpag, Cathryn Lundberg, Richard Heller

Bioelectrics Publications

Metastatic melanoma is an aggressive skin cancer with a relatively low survival rate. Immune-based therapies have shown promise in the treatment of melanoma, but overall complete response rates are still low. Previous studies have demonstrated the potential of plasmid IL-12 (pIL-12) delivered by gene electrotransfer (GET) to be an effective immunotherapy for melanoma. However, events occurring in the tumor microenvironment following delivery have not been delineated. Therefore, utilizing a B16F10 mouse melanoma model, we evaluated changes in the tumor microenvironment following delivery of pIL-12 using different GET parameters or injection of plasmid alone. The results revealed a unique immune cell …

Frameworks To Investigate Robustness And Disease Characterization/Prediction Utility Of Time-Varying Functional Connectivity State Profiles Of The Human Brain At Rest, Anees Abrol

Electrical and Computer Engineering ETDs

Neuroimaging technologies aim at delineating the highly complex structural and functional organization of the human brain. In recent years, several unimodal as well as multimodal analyses of structural MRI (sMRI) and functional MRI (fMRI) neuroimaging modalities, leveraging advanced signal processing and machine learning based feature extraction algorithms, have opened new avenues in diagnosis of complex brain syndromes and neurocognitive disorders. Generically regarding these neuroimaging modalities as filtered, complimentary insights of brain’s anatomical and functional organization, multimodal data fusion efforts could enable more comprehensive mapping of brain structure and function.

Large scale functional organization of the brain is often studied by …

X-Search: An Open Access Interface For Cross-Cohort Exploration Of The National Sleep Research Resource, Licong Cui, Ningzhou Zeng, Matthew Kim, Remo Mueller, Emily Ruth Hankosky, Susan Redline, Guo-Qiang Zhang

Computer Science Faculty Publications

Background: The National Sleep Research Resource (NSRR) is a large-scale, openly shared, data repository of de-identified, highly curated clinical sleep data from multiple NIH-funded epidemiological studies. Although many data repositories allow users to browse their content, few support fine-grained, cross-cohort query and exploration at study-subject level. We introduce a cross-cohort query and exploration system, called X-search, to enable researchers to query patient cohort counts across a growing number of completed, NIH-funded studies in NSRR and explore the feasibility or likelihood of reusing the data for research studies.

Methods: X-search has been designed as a general framework with two loosely-coupled components: …

Dual-Display Laparoscopic Laser Speckle Contrast Imaging For Real-Time Surgical Assistance, Jaepyeong Cha, Corey Zheng, Lung Wai Lau

Pediatrics Faculty Publications

Laser speckle contrast imaging (LSCI) utilizes the speckle pattern of a laser to determine the blood flow in tissues. The current approaches for its use in a clinical setting require a camera system with a laser source on a separate optical axis making it unsuitable for minimally invasive surgery (MIS). With blood flow visualization, bowel viability, for example, can be determined. Thus, LSCI can be a valuable tool in gastrointestinal surgery. In this work, we develop the first-of-its-kind dual-display laparoscopic vision system integrating LSCI with a commercially available 10mm rigid laparoscope where the laser has the same optical axis as …

Classification Of Intensity-Modulated Proton Therapy Plans, Louise Gabrielle Lima '19, Alice Liu '19

Student Publications & Research

Proton Radiotherapy

Proton radiotherapy is a form of radiation treatment that uses energized protons to break DNA, leading to cell death and killing cancers.

Direct Crystal Formation From Micronized Bone And Lactic Acid: The Writing On The Wall For Calcium-Containing Crystal Pathogenesis In Osteoarthritis?, Anna A. Bulysheva, Nardos Sori, Michael P. Francis

Bioelectrics Publications

Introduction

Pathological calcium-containing crystals accumulating in the joints, synovial fluid, and soft tissues are noted in most elderly patients, yet arthritic crystal formation remains idiopathic. Interestingly, elevated lactic acid and bone erosion are frequently among the comorbidities and clinical features of patients with highest incidence of crystal arthropathies. This work shows that bone particulates (modeling bone erosion) dissolve in lactic acid and directly generate crystals, possibly presenting a mechanism for crystal accumulation in osteoarthritis.

Methods and results

Micronized human bone (average particle size of 160 μm x 79 μm ) completely dissolved in lactic acid in 48 hours, and in …

Emerging Roles Of The Membrane Potential: Action Beyond The Action Potential, Lina Abdul Kadir, Michael Stacey, Richard Barrett-Jolley

Bioelectrics Publications

Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of action potentials in excitable tissue, muscle, and nerve. However, as ion channel research shifts beyond these tissues, it became clear that the RMP is a feature of virtually all cells studied. The RMP is maintained by the cell's compliment of ion channels. Transcriptome sequencing is increasingly revealing that equally rich compliments of ion channels exist in both excitable and non-excitable tissue. In this review, we discuss a range of critical roles …

Hyperspectral Imaging For Characterizing Single Plasmonic Nanostructure And Single-Cell Analysis, Nishir Sanatkumar Mehta

LSU Master's Theses

Orientation of plasmonic nanostructures is an important feature in many nanoscale applications such as photovoltaics, catalyst, biosensors DNA interactions, protein detections, hotspot of surface-enhanced Raman spectroscopy (SERS), and fluorescence resonant energy transfer (FRET) experiments. Silver nanocubes with significant spectral signatures between 400-700 nm are observed in this experimental research. Whereas study of single cells will enable the analysis of cell-to-cell variations within a heterogeneous population. These variations are important for further analysis and understanding of disease propagation, drug development, stem cell differentiation, embryos development, and how cells respond to each other and their environment. Adipose-derived mesenchymal stem cells possess the …