Biomedical Commons^™

Muscle Activity-Driven Green-Oriented Random Number Generation Mechanism To Secure Wbsn Wearable Device Communications, Yuanlong Cao, Guanghe Zhang, Fanghua Liu, Ilsun You, Guanglou Zheng, Oluwarotimi W. Samuel, Shixiong Chen

Research outputs 2014 to 2021

Wireless body sensor networks (WBSNs) mostly consist of low-cost sensor nodes and implanted devices which generally have extremely limited capability of computations and energy capabilities. Hence, traditional security protocols and privacy enhancing technologies are not applicable to the WBSNs since their computations and cryptographic primitives are normally exceedingly complicated. Nowadays, mobile wearable and wireless muscle-computer interfaces have been integrated with the WBSN sensors for various applications such as rehabilitation, sports, entertainment, and healthcare. In this paper, we propose MGRNG, a novel muscle activity-driven green-oriented random number generation mechanism which uses the human muscle activity as green energy resource to generate …

Power Mobility Sensor Data Collection Verified Through Standardized Pediatric Assessments, Ayshka Elise Rodriguez-Velez

UNF Graduate Theses and Dissertations

The collaboration between the School of Engineering and the Department of Physical Therapy at the University of North Florida has introduced the possibility of creating a new environment for pediatric physical therapy assessments. There are currently no methods for remotely monitoring children with impairments. However, with embedded sensor technology in the form of power mobility and accepted therapy assessment tools, remote monitoring can become a possibility. As a part of this work, a ride-on toy car was developed as a remote monitoring device and a case study with a child with a mobility impairment was used as a proof of …

Self-Image Multimedia Technologies For Feedforward Observational Learning, Nkiruka M. A. Uzuegbunam

Theses and Dissertations--Electrical and Computer Engineering

This dissertation investigates the development and use of self-images in augmented reality systems for learning and learning-based activities. This work focuses on self- modeling, a particular form of learning, actively employed in various settings for therapy or teaching. In particular, this work aims to develop novel multimedia systems to support the display and rendering of augmented self-images. It aims to use interactivity (via games) as a means of obtaining imagery for use in creating augmented self-images. Two multimedia systems are developed, discussed and analyzed. The proposed systems are validated in terms of their technical innovation and their clinical efficacy in …

Effects Of Protein-Coated Nanofibers On Conformation Of Gingival Fibroblast Spheroids: Potential Utility For Connective Tissue Regeneration, Gili Kaufman, Ryan A. Whitescarver, Laiz Nunes, Xavier-Lewis Palmer, Drago Skrtic, Wojtek Tutak

Engineering Technology Faculty Publications

Deep wounds in the gingiva caused bytrauma or surgery require a rapid and robust healing of connective tissues. Wepropose utilizing gas-brushed nanofibers coated with collagen and fibrin for that purpose. Our hypotheses are that protein-coated nanofibers will: (i) attract and mobilize cells in various spatial orientations, and (ii) regulate the expression levels ofspecific extracellular matrix (ECM)-associated proteins, determining the initial conformational nature ofdense and soft connective tissues. Gingival fibroblast monolayers and3D spheroids were cultured onECMsubstrate and covered with gas-blown poly-(DL-lactide-co-glycolide)(PLGA) nanofibers (uncoated/coated with collagen and fibrin). Cell attraction and rearrangement was followed byF-actin staining and confocal microscopy. Thicknesses ofthe cell …

Formulation Of Nanoparticle Systems For Drug Delivery Application In Biomedical Sciences, Victor Alfredo Rodriguez

Open Access Theses & Dissertations

Antibiotic-resistant strains of bacteria may result in serious infections which are difficult to treat. In addition, the poor antibiotic pipeline has also contributed to the crisis. Recently, the complex of furosemide and silver (Ag-FSE) has been reported as a potential antibacterial agent. However, its poor aqueous solubility is limiting its activity as an effective antibacterial agent. The purpose of this study was to encapsulate Ag-FSE into chitosan nanoparticles (CSNPs) and evaluate antibacterial efficacy. Ag-FSE CSNPs were prepared using ionic gelation technique. The particle size, polydispersity index and zeta potential of Ag-FSE CSNPs were determined using dynamic light scattering (DLS) technique. …

Implementation Of Magnesium Alloy Az91d On Wire And Arc Additive Manufacturing, David Adrian Martinez Holguin

Open Access Theses & Dissertations

As progress on Additive Manufacturing (AM) techniques focusing on ceramics and polymers evolve, metals continue to be a challenging material to manipulate when fabricating products. Current methods, such as Selective Laser Sintering (SLS) and Electron Beam Melting (EBM) face many intrinsic limitations due to the nature of their processes. Material selection, elevated cost and low deposition rates are some of the barriers to consider when one of these methods is to be used for the fabrication of engineering products. The research here presented demonstrates the use of a Wire and Arc Additive Manufacturing (WAAM) system for the creation of metallic …

Enhancements In Alginate Microencapsulation Technology & Impacts On Cell Therapy Development, Marwa Belhaj

Theses and Dissertations

Biodegradable alginate microcapsules (MC) are recently becoming widely used in the biomedical field, and have shown effectiveness as a drug delivery system. Alginate has been used in microencapsulation due to its simple gelling process, biodegradability, excellent biocompatibility, and its stability under in-vivo conditions. Alginate polymer is a natural polysaccharide derived from brown seaweed and has the ability to polymerize rapidly in the presence of cations to form a porous matrix. In order to advance the previous system for efficient protein and peptide delivery, we further lyophilized the peptide-filled microcapsules and we were able to rehydrate, and test them for sustained …

Synthesis And Characterization Of Thermoresponsive Hydrogels Based On N-Isopropylacrylamide Crosslinked With 4,4′-Dihydroxybiphenyl Diacrylate, Shuo Tang, Martha Floy, Rohit Bhandari, Manjula Sunkara, Andrew J. Morris, Thomas D. Dziubla, J. Zach Hilt

Chemical and Materials Engineering Faculty Publications

A novel crosslinker [4,4′-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures. These novel hydrogels also displayed resiliency through multiple swelling–deswelling cycles, and their temperature responsiveness was reversible. The successful synthesis of NIPAAm-based hydrogels crosslinked with 44BDA has led to a …

3d Printed Pcu/Uhmwpe Polymeric Blends For Artificial Knee Meniscus, Raissa Araujo Borges

Graduate Theses and Dissertations

3D printing was used to fabricate porous artificial knee meniscus material from biocompatible polymeric blends of polycarbonate-urethane (PCU) and ultra-high-molecular-weight polyethylene (UHMWPE) to enable “weep” lubrication that mimics the native meniscus. 3D printed and molded pure PCU, as well as molded PCU and UHMWPE, were used for comparison. Preliminary printing was done to evaluate the impact of process parameters on the results. The samples were subject to a variety of rotational oscillating friction and wear tests under simulated body fluid and loading conditions to replicate the natural motion of the knee. Results show that 3D printed PCU samples yielded a …

Portable 6 Lead 4 Electrode Ekg, Cody Magnuson, Wes Archbold

Electrical Engineering

This project focused on designing a small, portable, 6 lead 4 electrode electrocardiogram (EKG) machine with enough accuracy and resolution to successfully diagnose clinical issues. The electrical design used to measure signals originating from the heart can be broken up into three stages. The first stage is the human device interface. Next, is the analog block that filters out common mode noise and conditions the signal for digital encoding using instrumentation amplifiers, a right leg circuit, high pass, low pass, and an amplifier. This circuit filters all frequencies above and below the frequency band of meaningful data (1-160Hz), rejects signals …

Computer-Aided Diagnoses (Cad) System: An Artificial Neural Network Approach To Mri Analysis And Diagnosis Of Alzheimer's Disease (Ad), Berizohar Padilla Cerezo

Master's Theses

Alzheimer’s disease (AD) is a chronic and progressive, irreversible syndrome that deteriorates the cognitive functions. Official death certificates of 2013 reported 84,767 deaths from Alzheimer’s disease, making it the 6th leading cause of death in the United States. The rate of AD is estimated to double by 2050. The neurodegeneration of AD occurs decades before symptoms of dementia are evident. Therefore, having an efficient methodology for the early and proper diagnosis can lead to more effective treatments.

Neuroimaging techniques such as magnetic resonance imaging (MRI) can detect changes in the brain of living subjects. Moreover, medical imaging techniques are the …

Hierarchical Fusion Based Deep Learning Framework For Lung Nodule Classification, Kazim Sekeroglu

LSU Doctoral Dissertations

Lung cancer is the leading cancer type that causes the mortality in both men and women. Computer aided detection (CAD) and diagnosis systems can play a very important role for helping the physicians in cancer treatments. This dissertation proposes a CAD framework that utilizes a hierarchical fusion based deep learning model for detection of nodules from the stacks of 2D images. In the proposed hierarchical approach, a decision is made at each level individually employing the decisions from the previous level. Further, individual decisions are computed for several perspectives of a volume of interest (VOI). This study explores three different …

Activation Of The Phospholipid Scramblase Tmem16f By Nanosecond Pulsed Electric Field (Nspef) Facilitates Its Diverse Cytophysiological Effects, Claudia Muratori, Andrei G. Pakhomov, Elena Gianulis, Jade Meads, Maura Casciola, Peter A. Mollica, Olga N. Pakhomova

Bioelectrics Publications

Nanosecond pulsed electric fields (nsPEF) are emerging as a novel modality for cell stimulation and tissue ablation. However, the downstream protein effectors responsible for nsPEF bioeffects remain to be established. Here we demonstrate that nsPEF activate TMEM16F (or Anoctamin 6), a protein functioning as a Ca²⁺-dependent phospholipid scramblase and Ca²⁺-activated chloride channel. Using confocal microscopy and patch clamp recordings, we investigated the relevance of TMEM16F activation for several bioeffects triggered by nsPEF, including phosphatidylserine (PS) externalization, nanopore-conducted currents, membrane blebbing, and cell death. In HEK 293 cells treated with a single 300-ns pulse of 25.5 kV/cm, …

Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are useful tools to analyze brain activities given active stimulation. However, the electromagnetic noise from the MRI distorts the brain signal recording and damages the subject with excessive heat generated on the electrodes attached to the skin. MRI-compatible recording and stimulation systems previously developed at LIBI lab were capable of removing the electromagnetic noise during the imaging process. Previously, the hardware systems had required the integrative software that could control both circuits simultaneously and enable users to easily change recording and stimulation parameters. Graphical user interface (GUI) programmed with computer language informed …

Optimization Of Prosthetic Hands: Utilizing Modularity To Improve Grip Force, Grasp, And Versatility, Jordan William Harris

UNLV Theses, Dissertations, Professional Papers, and Capstones

It has been demonstrated that although many varieties of upper limb prosthetics exist, commercially available prosthetics are outdated and unsatisfactory. Ineffectiveness and limitations have led to some prosthesis wearers having to own multiple devices, whereas others have given up on them entirely. Even though ample research has been conducted to design and test new hand designs, the industry appears to rest in an overall stagnated state.

It was proposed here, that one problem with prosthetic research is an excess of variables involved in testing, and therefore the improper application of the scientific method. It seems that each time a research …

Perspective: The Physics, Diagnostics, And Applications Of Atmospheric Pressure Low Temperature Plasma Sources Used In Plasma Medicine, M. Laroussi

Electrical & Computer Engineering Faculty Publications

Low temperature plasmas have been used in various plasma processing applications for several decades. But it is only in the last thirty years or so that sources generating such plasmas at atmospheric pressure in reliable and stable ways have become more prevalent. First, in the late 1980s, the dielectric barrier discharge was used to generate relatively large volume diffuse plasmas at atmospheric pressure. Then, in the early 2000s, plasma jets that can launch cold plasma plumes in ambient air were developed. Extensive experimental and modeling work was carried out on both methods and much of the physics governing such sources …

Skin Tone Tracking Device (Chromaband), Ziyang Bian

Computer Engineering

It’s long been said that your skin is a window into your health and with many illnesses the first signs of trouble actually show up in your skin. So if we have this natural warning system, then why isn’t anyone able to effectively use it to predict changes in our health? The problem is that currently there is no reliable way to accurately measure the change in skin tone and how these changes may or may not change with variations in health. This project’s aim is to design and develop a device that will record the changes in a user’s …

Poly Drop, Zachary T. Scott, Lilly J. Paul

Computer Engineering

Poly Drop is a software interface to control an Open Drop digital micro-fluidics system. We obtained a hardware system from Gaudi labs. Our task was to create a Graphical User Interface that made the control of the device easier and more automated for better testing. We created software that had 3 parts: a control GUI, arduino code to control the hardware, and Image Analysis that gives the user information such as location and color of liquid drops as they move across the electrode grid of the Open Drop system. The GUI was developed using Java Swing. The communication between the …

Hand (Motor) Movement Imagery Classification Of Eeg Using Takagi-Sugeno-Kang Fuzzy-Inference Neural Network, Rory Larson Donovan

Master's Theses

Approximately 20 million people in the United States suffer from irreversible nerve damage and would benefit from a neuroprosthetic device modulated by a Brain-Computer Interface (BCI). These devices restore independence by replacing peripheral nervous system functions such as peripheral control. Although there are currently devices under investigation, contemporary methods fail to offer adaptability and proper signal recognition for output devices. Human anatomical differences prevent the use of a fixed model system from providing consistent classification performance among various subjects. Furthermore, notoriously noisy signals such as Electroencephalography (EEG) require complex measures for signal detection. Therefore, there remains a tremendous need to …

Ecg Classification Using Adaptive Neuro-Fuzzy Inference System, Jason N. Rivera, Kelsey C. Rodriguez

Electrical Engineering

ECG classification using Adaptive Neuro-Fuzzy Inference System (ANFIS), sponsored by Professor Yu, involves the diagnosis of six cardiovascular conditions by analyzing one single neural network. Today’s ECG signal instrumentation does not have the ability to characterize cardiovascular diseases without a doctor’s complete evaluation and diagnosis. Our project gives a promising solution to the inability in the current market’s ECG signal instrumentation to correctly evaluate and diagnose cardiovascular diseases. ECG signal reportings is a non-invasive process that will lead to many more applications of advanced signal processing and data analysis/diagnosis of cardiovascular diseases. The inputs to the ANFIS are annotations of …