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State Estimation, Covariance Estimation, And Economic Optimization Of Semi-Batch Bioprocesses, Ronald Hunter Alexander 2023 West Virginia University

State Estimation, Covariance Estimation, And Economic Optimization Of Semi-Batch Bioprocesses, Ronald Hunter Alexander

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the most critical aspects of any chemical process engineer is the ability to gather, analyze, and trust incoming process data as it is often required in control and process monitoring applications. In real processes, online data can be unreliable due to factors such as poor tuning, calibration drift, or mechanical drift. Outside of these sources of noise, it may not be economically viable to directly measure all process states of interest (e.g., component concentrations). While process models can help validate incoming process data, models are often subject to plant-model mismatches, unmodeled disturbances, or lack enough detail to track …


Nonlinear Dynamic Analysis And Control Of Chemical Processes Using Dynamic Operability, San Quan Dinh 2023 West Virginia University

Nonlinear Dynamic Analysis And Control Of Chemical Processes Using Dynamic Operability, San Quan Dinh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nonlinear dynamic analysis serves an increasingly important role in process systems engineering research. Understanding the nonlinear dynamics from the mathematical model of a process helps to find the boundaries of all achievable process conditions and identify the system instabilities. The information on such boundaries is beneficial for optimizing the design and formulating a control structure. However, a systematic approach to analyzing nonlinear dynamics of chemical processes considering such boundaries in a quantifiable and adaptable way is yet to exist in the literature. The primary aim of this work is to formulate theoretical concepts for dynamic operability, as well as develop …


Techno-Economic Analysis And Optimization Of Hydrogen And Mechanical Energy Storage Systems, Pavitra Senthamilselvan Sengalani 2023 West Virginia University

Techno-Economic Analysis And Optimization Of Hydrogen And Mechanical Energy Storage Systems, Pavitra Senthamilselvan Sengalani

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increasing significance of renewable energy sources is thrusting the load cycling of fossil-fueled power plants (FFPP), designed to operate under nominal-load conditions. Integration of energy storage systems (ESS) with the FFPPs such as hydrogen energy storage (HES) and mechanical energy storage facility such as compressed air energy storage (CAES) shows the potential to minimize the levelized cost of electricity during high demand scenarios and also minimize the negative impacts of off-design FFPP operation. The deployment of energy storage facilities at the FFPP level have considerable potential advantages as they can be exploited within the existing equipment items and facilities …


Performance Evaluation Of Udsm Network To Deliver Multimedia Elearning Contents: Case Of Coict, Mercy Mbise 2022 Department of Computer Science and Engineering, University of Dar es Salaam, P. O. Box 33335, Dar es Salaam, TANZANIA

Performance Evaluation Of Udsm Network To Deliver Multimedia Elearning Contents: Case Of Coict, Mercy Mbise

Tanzania Journal of Engineering and Technology (TJET)

The use of technology in education in Sub-Saharan Africa has been reported to be hindered by many factors including inadequate Information and Communication Technology (ICT) infrastructure, low internet speed, and lack of skills to use educational technologies. This paper aim at evaluating how the available ICT infrastructure at the College of Information and Communication Technologies (CoICT) can support, with acceptable Quality of Service (QoS), the delivery of multimedia applications for eLearning services. The evaluation was performed over a network testbed implemented in a computer laboratory for wired and wireless connections. The testbed consisted of five personal computers (PCs) connected via …


Investigating The Support For Agility In Developing Government Software Systems: A Case Of Three East African Countries, Leonard Peter Binamungu 2022 University of Dar es salaam

Investigating The Support For Agility In Developing Government Software Systems: A Case Of Three East African Countries, Leonard Peter Binamungu

Tanzania Journal of Engineering and Technology (TJET)

Agile Software Development Methods support an iterative and incremental way of developing software systems while responding to change by prioritising various aspects at different times. This differs from traditional sequential methods like Waterfall, in which one software development stage has to be completed before starting the next stage. To produce software systems that meet the requirements of their institutions, several governments in Africa have issued standards and guidelines to be followed during the development of government software systems. Such standards and guidelines specify the specific activities and deliverables for each stage of software development. While well-intentioned, such guidelines and standards …


Development Of Directed Randomization For Discussing A Minimal Security Architecture, Henrique Oyama, Dominic Messina, Keshav Kasturi Rangan, Akkarakaran Francis Leonard, Kip Nieman, Helen Durand, Katie Tyrrell, Katrina Hinzman, Michael Williamson 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

Development Of Directed Randomization For Discussing A Minimal Security Architecture, Henrique Oyama, Dominic Messina, Keshav Kasturi Rangan, Akkarakaran Francis Leonard, Kip Nieman, Helen Durand, Katie Tyrrell, Katrina Hinzman, Michael Williamson

Chemical Engineering and Materials Science Faculty Research Publications

Strategies for mitigating the impacts of cyberattacks on control systems using a control-oriented perspective have become of greater interest in recent years. Our group has contributed to this trend by developing several methods for detecting cyberattacks on process sensors, actuators, or both sensors and actuators simultaneously using an advanced optimization-based control strategy known as Lyapunov-based economic model predictive control (LEMPC). However, each technique comes with benefits and limitations, both with respect to one another and with respect to traditional information technology and computer science-type approaches to cybersecurity. An important question to ask, therefore, is what the goal should be of …


Cybersecurity And Dynamic Operation In Practice: Equipment Impacts And Safety Guarantees, Kip Nieman, Dominic Messina, Matthew Wegener, Helen Durand 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

Cybersecurity And Dynamic Operation In Practice: Equipment Impacts And Safety Guarantees, Kip Nieman, Dominic Messina, Matthew Wegener, Helen Durand

Chemical Engineering and Materials Science Faculty Research Publications

Though dynamic operation of chemical processes has been extensively explored theoretically in contexts such as economic model predictive control or even considering the potential for cyberattacks on control systems creating non-standard operating policies, important practical questions remain regarding dynamic operation. In this work, we look at two of these with particular relevance to process safety: (1) evaluating dynamic operating policies with respect to process equipment fidelity and (2) evaluating procedures for determining the parameters of an advanced control law that can promote both dynamic operation as well as safety if appropriately designed. Regarding the first topic, we utilize computational fluid …


A Control Barrier Function Perspective On Lyapunov-Based Economic Model Predictive Control, Helen Durand, Aaron D. Ames 2022 Wayne State University

A Control Barrier Function Perspective On Lyapunov-Based Economic Model Predictive Control, Helen Durand, Aaron D. Ames

Chemical Engineering and Materials Science Faculty Research Publications

No abstract provided.


Control Implemented On Quantum Computers: Effects Of Noise, Nondeterminism, And Entanglement, Kip Nieman, Keshav Kasturi Rangan, Helen Durand 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

Control Implemented On Quantum Computers: Effects Of Noise, Nondeterminism, And Entanglement, Kip Nieman, Keshav Kasturi Rangan, Helen Durand

Chemical Engineering and Materials Science Faculty Research Publications

Quantum computing has advanced in recent years to the point that there are now some quantum computers and quantum simulators available to the public for use. In addition, quantum computing is beginning to receive attention within the process systems engineering community for directions such as machine learning and optimization. A logical next step for its evaluation within process systems engineering is for control, specifically for computing control actions to be applied to process systems. In this work, we provide some initial studies regarding the implementation of control on quantum computers, including the implementation of a single-input/single-output proportional control law on …


Actuator Cyberattack Handling Using Lyapunov-Based Economic Model Predictive Control, Keshav Kasturi Rangan, Henrique Oyama, Helen Durand 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

Actuator Cyberattack Handling Using Lyapunov-Based Economic Model Predictive Control, Keshav Kasturi Rangan, Henrique Oyama, Helen Durand

Chemical Engineering and Materials Science Faculty Research Publications

Cybersecurity has gained increasing interest as a consequence of the potential impacts of cyberattacks on profits and safety. While attacks can affect various components of a plant, prior work from our group has focused on the impact of cyberattacks on control components such as process sensors and actuators and the development of detection strategies for cybersecurity derived from control theory. In this work, we provide greater focus on actuator attacks; specifically, we extend a detection and control strategy previously applied for sensor attacks and based on an optimization-based control technique called Lyapunov-based economic model predictive control (LEMPC) to detect attacks …


Test Methods For Image-Based Information In Next-Generation Manufacturing, Henrique Oyama, Dominic Messina, Renee O'Neill, Samantha Cherney, Minhazur Rahman, Keshav Kasturi Rangan, Govanni Gjonaj, Helen Durand 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

Test Methods For Image-Based Information In Next-Generation Manufacturing, Henrique Oyama, Dominic Messina, Renee O'Neill, Samantha Cherney, Minhazur Rahman, Keshav Kasturi Rangan, Govanni Gjonaj, Helen Durand

Chemical Engineering and Materials Science Faculty Research Publications

Typical control designs in the process systems engineering literature have assumed that the primary sensing methodologies are traditional instruments such as thermocouples. Dig- italization is changing the landscape for manufacturing, and data-based sensing modalities (e.g., image-based sensing) are becoming of greater interest for plant control. These considerations require novel test/evaluation solutions. For example, process systems engineering researchers may wish to test image-based sensors in simulation. In this work, we provide preliminary thoughts on how image-based technologies might be evaluated via simulation for process systems.


Quantum Computing And Resilient Design Perspectives For Cybersecurity Of Feedback Systems, Keshav Kasturi Rangan, Jihan Abou Halloun, Henrique Oyama, Samantha Cherney, Ilham Azali Assoumani, Nazir Jairazbhoy, Helen Durand, Simon Ka Ng 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

Quantum Computing And Resilient Design Perspectives For Cybersecurity Of Feedback Systems, Keshav Kasturi Rangan, Jihan Abou Halloun, Henrique Oyama, Samantha Cherney, Ilham Azali Assoumani, Nazir Jairazbhoy, Helen Durand, Simon Ka Ng

Chemical Engineering and Materials Science Faculty Research Publications

Cybersecurity of control systems is an important issue in next-generation manufac- turing that can impact both operational objectives (safety and performance) as well as process designs (via hazard analysis). Cyberattacks differ from faults in that they can be coordinated efforts to exploit system vulnerabilities to create otherwise unlikely hazard scenarios. Because coordination and targeted process manipulation can be characteristics of attacks, some of the tactics previously analyzed in our group from a control system cybersecurity perspective have incorporated randomness to attempt to thwart attacks. The underlying assumption for the generation of this randomness has been that it can be achieved …


Challenges And Opportunities For Next-Generation Manufacturing In Space, Kip Nieman, A. F. Leonard, Katie Tyrell, Dominic Messina, Rebecca Lopez, Helen Durand 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

Challenges And Opportunities For Next-Generation Manufacturing In Space, Kip Nieman, A. F. Leonard, Katie Tyrell, Dominic Messina, Rebecca Lopez, Helen Durand

Chemical Engineering and Materials Science Faculty Research Publications

With commercial space travel now a reality, the idea that people might spend time on other planets in the future seems to have greater potential. To make this possible, however, there needs to be flexible means for manufacturing in space to enable tooling or resources to be created when needed to handle unexpected situations. Next-generation manufacturing paradigms offer significant potential for the kind of flexibility that might be needed; however, they can result in increases in computation time compared to traditional control methods that could make many of the computing resources already available on earth attractive for use. Furthermore, resilience …


On-Line Process Physics Tests Via Lyapunov-Based Economic Model Predictive Control And Simulation-Based Testing Of Image-Based Process Control, Henrique Oyama, A. F. Leonard, Minhazur Rahman, Govanni Gjonaj, Michael Williamson, Helen Durand 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

On-Line Process Physics Tests Via Lyapunov-Based Economic Model Predictive Control And Simulation-Based Testing Of Image-Based Process Control, Henrique Oyama, A. F. Leonard, Minhazur Rahman, Govanni Gjonaj, Michael Williamson, Helen Durand

Chemical Engineering and Materials Science Faculty Research Publications

Next-generation manufacturing involves increasing use of automation and data to enhance process efficiency. An important question for the chemical process industries, as new process systems (e.g., intensified processes) and new data modalities (e.g., images) are integrated with traditional plant automation concepts, will be how to best evaluate alternative strategies for data-driven modeling and synthesizing process data. Two methods which could be used to aid in this are those which aid in testing data-based techniques on-line, and those which enable various data-based techniques to be assessed in simulation. In this work, we discuss two techniques in this domain which can be …


On-Line Process Physics Tests Via Lyapunov-Based Economic Model Predictive Control And Simulation-Based Testing Of Image-Based Process Control, Henrique Oyama, Akkarakaran Francis Leonard, Minhazur Rahman, Govanni Gjonaj, Michael Williamson, Helen Durand 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

On-Line Process Physics Tests Via Lyapunov-Based Economic Model Predictive Control And Simulation-Based Testing Of Image-Based Process Control, Henrique Oyama, Akkarakaran Francis Leonard, Minhazur Rahman, Govanni Gjonaj, Michael Williamson, Helen Durand

Chemical Engineering and Materials Science Faculty Research Publications

Next-generation manufacturing involves increas- ing use of automation and data to enhance process efficiency. An important question for the chemical process industries, as new process systems (e.g., intensified processes) and new data modalities (e.g., images) are integrated with traditional plant automation concepts, will be how to best evaluate alternative strategies for data-driven modeling and synthesizing process data. Two methods which could be used to aid in this are those which aid in testing data-based techniques on-line, and those which enable various data-based techniques to be assessed in simulation. In this work, we discuss two techniques in this domain which can …


Quantum Computing And Resilient Design Perspectives For Cybersecurity Of Feedback Systems, Keshav Kasturi Rangan, Jihan Abou Halloun, Henrique Oyama, Samantha Cherney, Ilham Azali Assoumani, Nazir Jairazbhoy, Helen Durand, Simon Ka Ng 2022 Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI

Quantum Computing And Resilient Design Perspectives For Cybersecurity Of Feedback Systems, Keshav Kasturi Rangan, Jihan Abou Halloun, Henrique Oyama, Samantha Cherney, Ilham Azali Assoumani, Nazir Jairazbhoy, Helen Durand, Simon Ka Ng

Chemical Engineering and Materials Science Faculty Research Publications

Cybersecurity of control systems is an important issue in next-generation manufac- turing that can impact both operational objectives (safety and performance) as well as process designs (via hazard analysis). Cyberattacks differ from faults in that they can be coordinated efforts to exploit system vulnerabilities to create otherwise unlikely hazard scenarios. Because coordination and targeted process manipulation can be characteristics of attacks, some of the tactics previously analyzed in our group from a control system cybersecurity perspective have incorporated randomness to attempt to thwart attacks. The underlying assumption for the generation of this randomness has been that it can be achieved …


Optimization And Analysis Of A Styrene Production Process, Alexis Kimpel 2022 University of Mississippi

Optimization And Analysis Of A Styrene Production Process, Alexis Kimpel

Honors Theses

The production of styrene from ethylbenzene in Unit 500 is designed to start up in 2024 and operate for 12 years after startup. The engineering team was tasked with designing the process, creating an economic model, and optimizing the net present value (NPV). The process was simulated in AVEVA PRO/II Simulation for the design process and to estimate the size of equipment. Parametric and topological optimization was performed subsequently on the unit operations in the process. The NPV was improved by $423M from a base case of -$919M to an optimized case of -$496M. The project is recommended to continue …


Optimization Of Styrene From Ethylbenzene Case Study, Jabria Daria Thompson 2022 University of Mississippi

Optimization Of Styrene From Ethylbenzene Case Study, Jabria Daria Thompson

Honors Theses

The following pages detail the optimization process of styrene from ethylbenzene in the Styrene Production Plant, Unit 500. There were two parts of the assignment, each with slightly different end goals. The goal of the first part of the assignment, was to create a process that would effectively and efficiently increase the negative Net Present Value (NPV) of the production plant. Procedures taken in this process included developing a working kinetic process simulation model and optimizing this model through unit operations and heat integration, as well as developing an accurate economic model that will be used to evaluate the proposed …


A Data-Based Framework For Monitoring And Controlling Particulate Systems, Vidhyadhar Manee 2022 Louisiana State University and Agricultural and Mechanical College

A Data-Based Framework For Monitoring And Controlling Particulate Systems, Vidhyadhar Manee

LSU Doctoral Dissertations

One of the limitations of conventional monitoring tools in crystallization is the inability to deal with high solids concentration. Image-based monitoring, in which RGB images of the solution are captured and analyzed by an object detection software, has been a promising alternative. The software used in these tools primarily depends on hand-coded heuristics to distinguish between the signal and the noise. With the recent success of supervised deep learning, a newer paradigm has emerged in which the heuristics can be learnt from labeled images. This approach is founded on the idea that it is easier to develop labels for data …


Optimizing Virus Prefiltration For Biopharmaceutical Manufacturing, Solomon Isu 2022 University of Arkansas, Fayetteville

Optimizing Virus Prefiltration For Biopharmaceutical Manufacturing, Solomon Isu

Graduate Theses and Dissertations

Virus filters are single-use devices that use a size-based separation process. In virus filters, contaminating virus particles are retained while the therapeutic molecules pass through the membrane pores. Virus filters are an essential component of the overall virus clearance strategy. Sections 1 and 2 of this dissertation provide an introduction and extensive review of monoclonal antibody (mAb) process development, where virus filtration is pivotal. In section 3, prefiltration studies were performed with an industrially relevant IgG1 type mAb using adsorptive and size-exclusion-based prefilters with different mechanisms of action. This mAb has an isoelectric point range of 7.1 to 8.0 and …


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