Chemical Engineering Commons^™

Low-Dose Chemotherapy Of Hepatocellular Carcinoma Through Triggered-Release From Bilayer-Decorated Magnetoliposomes, Yanjing Chen, Yuan Chen, Da Xiao, Arijit Bose, Ruitang Deng, Geoffrey D. Bothun

Chemical, Biomolecular, and Materials Engineering Faculty Publications

Low-dose (LD) chemotherapy is a promising treatment strategy that may be improved by controlled delivery. Polyethylene glycol-stabilized bilayer-decorated magnetoliposomes (dMLs) have been designed as a stimuli-responsive LD chemotherapy drug delivery system and tested in vitro using Huh-7 hepatocellular carcinoma cell line. The dMLs contained hydrophobic superparamagnetic iron oxide nanoparticles within the lipid bilayer and doxorubicin hydrochloride (DOX, 2 μM) within the aqueous core. Structural analysis by cryogenic transmission electron microscopy and dynamic light scattering showed that the assemblies were approximately 120 nm in diameter. Furthermore, the samples consisted of a mixture of dMLs and bare liposomes (no nanoparticles), which provided …

Optical Properties Of Carbon Microcoils, Muneaki Hikita, Li Cao, Khalid Lafdi

Chemical and Materials Engineering Faculty Publications

Carbon microcoils (CMCs) have emerged as versatile material artifacts for a variety of applications due to their helical and spiral structures. Embedded in matrix, CMCs have already been demonstrated for their potential tactile/proximity sensor application. In this study, CMCs were prepared using a conventional chemical vapor deposition method, and then were functionalized with octadecylamine.

Upon photoexcitation, the functionalized CMCs exhibited photoluminescence in the visible region, which has never been found before. Similar to carbon based nanoparticles, the photoluminescence of CMCs was attributed to electron-hole radiative recombination after surface passivation. The results suggested that this kind of fluorescent functionalized CMCs might …

Design Of Functional Dendrimer Nanocarriers And Their Formulations In Propellant-Based Inhalers For Pulmonary Drug Delivery, Lin Yang

Wayne State University Dissertations

This Dissertation focuses on addressing two of the major challenges in developing pressurized metered dose inhalers for pulmonary drug / gene delivery to and through the lungs. First challenge is to design biocompatible moieties for the steric stabilization of suspension formulations in HFO-based propellants. Using a combination of tools including ab initio calculation, molecular dynamics simulation and high pressure tensiometry, potential fluorocarbon-philic moieties were systematically screened. Surfactants with those chemistries as tail fragments were studied at the HFO|H2O interface for their ability to lower the interfacial tension at HFO|H2O interface. Selected surfactants were further optimized for surfactant balance by altering …

Lab-Scale Fast-Hydropyrolysis And Vapor-Phase Catalytic Hydrodeoxygenation For Producing Liquid Fuel Range Hydrocarbons From Intact Biomass, Vinod Kumar Venkatakrishnan

Open Access Dissertations

Liquid transportation fuels are primarily produced from petroleum-based non-renewable carbon sources. Sustainably available lignocellulosic biomass, as a renewable form of atmospheric carbon, could be utilized to produce hydrocarbon-based fuels with high energy density. One of the process options for this conversion is the H2Bioil process, where biomass is rapidly heated in a hydrogen environment to produce fast-hydropyrolysis vapors that are catalytically upgraded in downstream hydrodeoxygenation (HDO) to produce hydrocarbons. This process has been modeled to have high carbon and energy efficiencies of ~70% and ~75%, respectively.

This dissertation presents the results of a lab-scale experimental proof-of-concept for the H2Bioil process …

Synthesis Of Nano-Sized Materials Using Atomic Layer Deposition, Sara Grace Simpson

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Biofuels Production Via Catalytic Hydrocracking Of Ddgs Corn Oil And Hydrothermal Decarboxylation Of Oleic Acid Over Transition Metal Carbides Supported On Al-Sba-15, Basem A. Al Alwan

Wayne State University Dissertations

The purpose of this research is to minimize the gap between the production of biofuels and the production of petroleum-based fuels by developing catalysts that can utilize renewable non-food based feedstocks (waste vegetable oils, algal oil, brown grease, etc.) and have great performance under low operation conditions. In particular, green diesel has become an attractive biofuel due to its superior properties that are quite similar to petroleum diesel. Therefore, no modifications are required to existing infrastructures. Three distinct experimental phases have been identified in order to achieve the objective of this work as follow:

First, the hydrocracking of distillers dried …

Characterization Of Macromolecular Structure Elements From A Green River Oil Shale, I. Extracts, Mark S. Solum, Charles L. Mayne, Anita M. Orendt, Ronald J. Pugmire, Jacob Adams, Thomas H. Fletcher

Faculty Publications

This paper is the first of two associated papers describing the structural details of three sections of an oil shale core taken at the Skyline 16 mine in the Utah Uinta Basin. Bitumen was extracted from the shale using methanol/dichloromethane. Kerogen was isolated from the shale, using a nine-step extraction procedure using HCl and HF. Bitumen samples from the three cores were analyzed using high-resolution ¹³C NMR liquid-state spectroscopy, showing carbon aromaticities of 7%−11%. Aliphatic carbons were dominated by methylene structures, with average aliphatic chain lengths of 24 carbons. The three parent shales and the demineralized kerogens were each …

Characterization Of Macromolecular Structure Elements From A Green River Oil Shale, Ii. Characterization Of Pyrolysis Products By 13c Nmr, Gc/Ms, And Ftir, Thomas H. Fletcher, Ryan Gillis, Jacob Adams, Trent Hall

Faculty Publications

This paper is Part II of a study of the chemical structural components of the organic matter of oil shale in the Green River formation. Three sections of a well-characterized oil shale core from the Utah Green River formation were demineralized, and the resulting kerogen was pyrolyzed at 10 °C/min in nitrogen at atmospheric pressure at temperatures up to 525 °C. The pyrolysis products (light gas, tar, and char) were analyzed using ¹³C NMR, GC/MS, and (FTIR). Pyrolysis yields of 80% (daf basis) were achieved at these conditions, with 60% daf tar yield at the highest temperature. The solid-state …

A Post-Installed Subsea Monitoring System For Structural And Flow Assurance Evaluation, David Brower, Alexis Brower, John Hedengren, Reza Asgharzadeh Shishavan

Faculty Publications

This paper describes major advancements for deploying sensing systems on existing subsea structures as part of the Clear Gulf study. In the past, a major shortcoming of post-installed monitoring systems has been poor coupling between the sensor and structure; this study provided methods to overcome this problem. Both subsea field testing and laboratory testing were performed to verify these advancements. The Clear Gulf study is a collaboration between the offshore energy industry and NASA with the goals of risk mitigation, safety, efficiency and environmental concerns in the offshore energy industry. The study is ongoing and has investigated new methods to …

Co2 Char Gasification Rates Of Sawdust, Switchgrass, And Corn Stover In A Pressurized Entrained-Flow Reactor, Thomas H. Fletcher, Aaron D. Lewis, Emmett G. Fletcher

Faculty Publications

An entrained-flow flat-flame burner reactor was used to measure apparent CO2 gasification rates of near-spherical biomass chars of poplar sawdust, switchgrass, and corn stover using particle residence times1258−1891 K and 6.1− 13.5 atm, respectively. A new method was developed to produce near-spherical particles from nonspherical biomass chars. The apparent CO2 gasification rates for the three biomass chars with mean diameters near 100 μm were fit to a global first-order model, and the optimal kinetic parameters are reported. The measured gasification rate of poplar sawdust was about 3.9 times faster than that of switchgrass char, but only about 20% faster than …

Co2 Gasification Rates Of Petroleum Coke In A Pressurized Flat-Flame Burner Entrained-Flow Reactor, Aaron D. Lewis, Emmett G. Fletcher, Thomas H. Fletcher

Faculty Publications

Two petcoke samples were gasified by CO2 at total pressures of 10 and 15 atm in a high-pressure flat-flame burner reactor at conditions where the bulk phase consisted of either 40 or 90 mol % CO2 with gas temperatures up to 1909 K. Particle diameters of 45−75 μm were used in the experiments. The morphology of the two petroleum coke chars was drastically different and evaluated using scanning electron microscopy images of the chars. The mass release data caused by CO2 gasification of the petcoke chars were fit to a global first-order model, and the optimal kinetic parameters are reported. …

Application Of L-Systems To Geometrical Construction Of Chamise And Juniper Shrubs, Dallan R. Prince, Marianne E. Fletcher, Chen Shen, Thomas H. Fletcher

Faculty Publications

Improved models of fire spread and fire characteristics are desired for live shrub fuels, since the majority of existing research efforts focus on either dead fuel beds or crown fires in trees. Efforts have been made to improve live fuel modeling, including detailed studies of individual leaf combustion, with results incorporated into a shrub combustion model for broadleaf species. However, this approach was not well-suited to non-broadleaf shrubs since their fuel consists of long needle-covered branches rather than easily discretized leaves. Methods were therefore developed to simulate the branching structure of chamise (Adenostoma fasciculatum) and Utah juniper (Juniperus osteosperma). The …

Simulation Of The Evolution Of Pressure In A Lignite Particle During Pyrolysis, He Yang, Sufen Li, Thomas H. Fletcher, Ming Dong, Weishi Zhou

Faculty Publications

The evolution of pressure in a lignite particle during pyrolysis was simulated on the basis of the gas motion equation in porous media and considering the Klinkenberg effect. The chemical percolation devolatilization (CPD) model was used to describe pyrolysis. The pore diameter in the particle is close to the average free path of volatile gas molecules; therefore, the solid phase restrains the movement of gas. Because flow out of the particle is restricted, the internal pressure rises. The internal pressure first increases and then decreases during pyrolysis, and the evolution is influenced by heating conditions. The pressure rise is larger …

Pretreatment Of Cellulosic Biomass By Iron-Containing Magnetic Ionic Liquid Dissolution, Christopher Roth Riley

Electronic Theses and Dissertations

The focus of this project is to determine the effectiveness in the preprocessing of biomass when magnetic ionic liquids (MIL) (1-butyl-3-methylimidazolium tetrachloroferrate (Bmim[FeCl4]) and 1-ethyl-3-methylimidazolium tetrachloroferrate (Emim[FeCl4])) are used as a green solvent. Lignocellulose is a promising starting material for a plethora of products, ranging from biofuels to custom chemicals; however, lignocellulose is resistant to enzymatic degradation. Various biomass-preprocessing techniques such as microbial, mechanical, and chemical pretreatment are used for enhancing the digestibility of biomass to sugars for ethanol production. Varieties of ionic liquids have demonstrated the ability to fragment lignocellulose. However, after fragmentation, separation of biomass and ionic liquids …

Facile Fabrication Of Mesostructured Zn2sno4 Based Anode Materials For Reversible Lithium Ion Storage, Sai Karthik Karthik Addu

Wayne State University Theses

Increase in all electric and hybrid car sales from Electric drive transportation association show that Lithium-ion batteries stands as a promising option for these vehicles. Hence improving these batteries is the objective of this thesis. We try to improve the electrode material by using unique structures and coating carbon layers on the material.

We chose Zinc tin oxide (ZTO) as it has been shown in literature to be a good oxide for batteries. We tried improving it by making new Rubik-cube like microstructure of it and more interestingly coating a layer of carbon on it. We could show from our …

Domain Engineering Of Physical Vapor Deposited Two-Dimensional Materials, Tarek Alam, Baoming Wang, Raghu Pulavarthy, M. Amanul Haque, Christopher Muratore, Nicholas R. Glavin, Ajit K. Roy, Andrey A. Voevodin

Chemical and Materials Engineering Faculty Publications

Physical vapor deposited two-dimensional (2D) materials span larger areas compared to exfoliated flakes, but suffer from very small grain or domain sizes. In this letter, we fabricate freestanding molybdenum disulfide (MoS2) and amorphous boron nitride (BN) specimens to expose both surfaces. We performed in situ heating in a transmission electron microscope to observe the domain restructuring in real time. The freestanding MoS2 specimens showed up to 100× increase in domain size, while the amorphous BN transformed in to polycrystalline hexagonal BN (h-BN) at temperatures around 600 °C much lower than the 850–1000 °C range cited in the literature.

Evaluation Of Ceramic Coaxial Cable Sensors For Long-Term In-Situ Monitoring Of Geologic Co₂ Injection And Storage, Yurong Li

Masters Theses

"Monitoring is an essential component of CO₂ injection and storage projects in order to manage the injection process, identify leakage risks, provide early failure warnings, determine the movement of CO₂ plume and provide input into reservoir models. In-situ monitoring provides critical and direct data points that can be used to fulfill the above objectives. However, downhole sensors that can withstand the harsh conditions and run over decades of the project life cycle remain unavailable. A new idea of ceramic coaxial cable temperature, pressure and strain sensor has recently been put forward and the sensors are under development.

A high pressure …

Numerical Simulations For Wellbore Stability And Integrity For Drilling And Completions, Nevan Christopher Himmelberg

Masters Theses

"Conventional wellbore trajectory planning is commonly based on an Andersonian state of stress [SoS] and the optimum well azimuth and inclination for a specific depth can be determined using stereographic projections of the safe mud weight window. In this thesis a new methodology using the complete stress tensor is developed to determine optimal well trajectories for complex in-situ stress scenarios. This study uses a 3D finite element analysis to simulate the SoS based on an integrated 3D MEM. The model yields the complete stress tensor at every location for a planned future well path. Using standard equations to determine the …

An Analytical Pressure Model To Guide Downhole Sensor Placement For Carbon Dioxide Sequestration Monitoring, Yilin Mao

Masters Theses

"Injecting CO₂ into saline aquifers is currently the most viable approach to mitigate global greenhouse gas effect. Various monitoring techniques are required to achieve 99% accuracy in determining the location of the injected CO₂ plume. Sensor locations are critical to the monitoring quality necessary to meet this requirement but have scarcely been discussed. The pressure profile needs to be modeled accurately at the initial stage of CO₂ injection to guide sensor locations. The objective of this thesis was to develop an analytical solution for CO₂ sequestration based on time and distance. This will guide the locations of downhole pressure sensors …

Techno-Economic And Life-Cycle Modeling And Analysis Of Various Energy Storage Technologies Coupled With A Solar Photovoltaic Array, Brian Andrew Peterson

Masters Theses

"Renewable energies, such as wind and solar, are a growing piece of global energy consumption. The chief motivation to develop renewable energy is two-fold: reducing carbon dioxide emissions and reducing dependence on diminishing fossil fuel supplies. Energy storage is critical to the growth of renewable energy because it allows for renewably-generated electricity to be consumed at times when renewable sources are unavailable, and it also enhances power quality (maintaining voltage and frequency) on an electric grid which becomes increasingly unstable as more renewable energy is added. There are numerous means of storing energy with different advantages, but none has emerged …