Chemical Engineering Commons^™

A Peptoid-Based Targeted Drug Delivery System For The Treatment Of Metastatic Cancer, Hugh M. Purdy

Chemical Engineering Undergraduate Honors Theses

Development of a targeted drug delivery system is a critical step in the effort to improve cancer treatments. Such a system would greatly reduce the harmful side effects of chemotherapy by delivering toxic drugs directly to cancerous cells. Peptoids—synthetic compounds that can be easily produced from readily available amine monomers—have great potential for use in targeted drug delivery. This project aimed to develop peptoids that would bind to specific proteins expressed on the surface of cancer cells. These peptoids could be combined into a complex that would bind to the proteins with an even greater affinity than the individual compounds. …

Coal Fires: An Environmental Disaster, Lidsay Hoggatt

Chemical Engineering Undergraduate Honors Theses

The mission of the Coal Fire Gang (CFG) is to spread awareness about the global issue of uncontrolled coal fires, and to highlight them as a low-hanging fruit of immediate emissions reduction. This report summarizes CFG’s research for the WERC competition, for which this topic was chosen as an open task. Beyond raising awareness, CFG modeled, developed and built an experimentation apparatus meant to prove the validity of a relatively cheap extinguishing method which was also novel to the regions in which it could be employed. The apparatus, which simulated an underground coal fire, was used to test a sand …

Fabrication Of Nanoscale Features On Surfaces, James C. Proctor

Chemical Engineering Undergraduate Honors Theses

A method to form nanofeatures on the surface of a material by utilizing a prefabricated polymer nanostructures is proposed. A means by which the polymer structures can be produced is discussed. The advantages and disadvantages of this process and other nanolithography processes are evaluated.

Coal Fires: An Environmental Disaster, Daniel Robert Miskin

Chemical Engineering Undergraduate Honors Theses

The mission of the Coal Fire Gang (CFG) is to spread awareness about the global issue of uncontrolled coal fires, and to highlight them as a low-hanging fruit of immediate emissions reduction. This report summarizes CFG’s research for the WERC competition, for which this topic was chosen as an open task. Beyond raising awareness, CFG modeled, developed and built an experimentation apparatus meant to prove the validity of a relatively cheap extinguishing method which was also novel to the regions in which it could be employed. The apparatus, which simulated an underground coal fire, was used to test a sand …

Water System For Developing Countries/Disaster Relief Made With Local Materials, Cayla Tichy

Chemical Engineering Undergraduate Honors Theses

The United Nations estimates that water-borne illness accounts for 80% of deaths in developing nations and that nearly 1 in 6 do not have access to clean water (1). However, despite the ability to produce water in the developed world from complex streams such as wastewater or seawater, challenges remain in providing this basic resource in the developing world. Too often the approach has been to apply a high-tech solution, which requires significant technical expertise to run and significant financial resources to repair. Furthermore, as every developing nation faces different challenges, a new solution must be provided for each situation. …

Coal Fires - An Environmental Disaster, Nicholas Kordsmeier

Chemical Engineering Undergraduate Honors Theses

The mission of the Coal Fire Gang (CFG) is to spread awareness about the global issue of uncontrolled coal fires, and to highlight them as a low-hanging fruit of immediate emissions reduction. This report summarizes CFG’s research for the WERC competition, for which this topic was chosen as an open task. Beyond raising awareness, CFG modeled, developed and built an experimentation apparatus meant to prove the validity of a relatively cheap extinguishing method which was also novel to the regions in which it could be employed. The apparatus, which simulated an underground coal fire, was used to test a sand …

Water System For Developing Countries / Disaster Relief Made With Local Materials, Dong Joon Lee

Chemical Engineering Undergraduate Honors Theses

As the equipment builder of the team, I was responsible for building the treadle pump, the sand filter tank, the hand pump, and generating the instructions for each equipment. Each team member was responsible for certain parts of the water purification system, but everyone worked cohesively on all parts of the design when assistance was necessary. The original design for the treadle pump was a two-man powered pump which discharged water at 15 gallons per minute. Since our system only required less than half of the flow rate, and required another person to operate the bicycle, the pump was redesigned …

Coal Fires: An Environmental Disaster, Turner Tomlinson

Chemical Engineering Undergraduate Honors Theses

The mission of the Coal Fire Gang (CFG) is to spread awareness about the global issue of uncontrolled coal fires, and to highlight them as a low-hanging fruit of immediate emissions reduction. This report summarizes CFG’s research for the WERC competition, for which this topic was chosen as an open task. Beyond raising awareness, CFG modeled, developed and built an experimentation apparatus meant to prove the validity of a relatively cheap extinguishing method which was also novel to the regions in which it could be employed. The apparatus, which simulated an underground coal fire, was used to test a sand …

Water System For Developing Countries / Disaster Relief Made With Local Materials, Lauren E. Cole

Chemical Engineering Undergraduate Honors Theses

At the beginning of this project, I elected to focus mainly on the electrolysis portion. I completed a lot of research on electrolysis in general, and then specifically on brine electrolysis, which is transforming a salt water solution into a sodium hypochlorite solution, or bleach. I researched all of the different types of electrode materials and purchased several electrodes in order to perform experiments. I researched several methods of electrolysis in use today. I performed several calculations about the electrolysis reaction, including the electric potential required to drive the reaction (approximately 1.0 volt), as well as what concentration of salt …

Comparing Virus Ultrafiltration Of Bacteriophages With Filtration Of Minute Virus Of Mice, Kent Smith

Graduate Theses and Dissertations

Industrial production of protein therapeutics demand rigorous testing and clearance of viruses. The U.S. Food and Drug Administration dictate the purity of pharmaceuticals with regards to viral contamination. As this testing is time consuming and expensive using mammalian cells and viruses, bacteriophages may provide a faster and cheaper alternative for membrane filtration processes. We used ultrafiltration membranes to filter protein solutions with viruses. Two bacteriophages were tested against membranes with two different pore sizes. These membranes were then tested by inverting the membrane's orientation. Flux measurements and log virus removal data were taken. Flux and log virus removal were seen …

Homochiral Metal-Organic Materials: Design, Synthetic And Enantioseletive Separation, Shi-Yuan Zhang

USF Tampa Graduate Theses and Dissertations

Owing to the growing demand for enantiopurity in biological and chemical processes, tremendous efforts have been devoted to the synthesis of homochiral metal-organic materials (MOMs) because of their potential applications in chiral separation and asymmetric catalysis. In this dissertation, the synthetic strategies for homochiral MOMs are discussed keeping the focus on their applications. Two distinct approaches have been taken to synthesize chiral structures with different topologies and accessible cavities. The chiral MOMs have been utilized in enantioselective separation of racemates.

Chiral variants of the prototypal metal-organic framework MOF-5, δ-CMOF-5 and [lambda]-CMOF-5, have been synthesized by preparing MOF-5 in the presence …

Electro-Catalytic Oxidation Of Hydrogen Peroxide On Au/ L-Methionine /Gc Electrode, Jian-Feng Fan, Xue-Mei Luo, Jing Li, Lou-Zhen Fan

Journal of Electrochemistry

The modified electrodes have been fabricated by generation of Au nanoparticle chains, which was produced by reaction between HAuCl4 and sodium citrate without any additional capping agents or surfactants. The self-assembled Au nanoparticles were attached to the surface of glassy carbon electrode (GCE) layer by layer, using L-methionine (L-Met), thiourea (TU), allyl thiourea (ATU) and polyvinylpyrrolidone (PVP) as a crosslinking agent, respectively. The experimental results showed that the electrochemical performance of the different modified electrodes varied in [Fe(CN)₆]^3-/4- solution. The Au/L-Met/GCE exhibited an excellent electrochemical property, which is superior to other modified electrodes. In addition, the catalysis …

Synthesis Of Platinum Nanocrystallites And Possible Electrocatalytic Properties For Methanol, Lei-Lei Lu, Bao-Zhong Du, Sha Sun, Jin-Fen Niu, Jie Zhao

Journal of Electrochemistry

Platinum nanocrystallites were synthesized by the colloidal method using oxamide as the stabilizer. The morphologies and electrocatalytic performances for methanol of platinum nanocrystallites prepared at different pH values and with different reactant ratios of precursor and stabilizer were investigated. It was found that the platinum nanocrystallites synthesized at pH=5 and with the reactant ratio of 1:20 showed the best electrocatalytic activity for methanol. The peak current density reached up to 1709 μA·cm^-2. Furthermore, the electrocatalytic activity of platinum nanocrystallites for methanol reduced significantly although the cyclic voltammograms in the blank solution were not obviously changed after exposing in …

Preparation Of Pt/H-Tio2 Catalyst With Improved Catalytic Performance For Methanol Electrooxidation, Jin Han, Zhi-You Zhou, Qiang Wang, Miao-Qiang Lv, Chi Chen, Shi-Gang Sun

Journal of Electrochemistry

White TiO₂ nanorods were synthesized by hydrothermal method with TiCl₄ as a precursor. As-synthesized TiO₂ nanorods were further subjected to high-temperature (550 ^oC) heat treatment for 2 h under H₂ atmosphere to prepare gray black hydrogen-treated TiO₂ (H-TiO₂) nanorods with oxygen vacancies and Ti³⁺ interstitial atoms. The Pt nanoparticles of 1.9 nm were supported on these two types of TiO₂ nanorods to form Pt/TiO₂ and Pt/H-TiO₂ catalysts. XRD data indicates that the crystal structure of TiO₂ was still reserved as rutile after hydrogen treatment, but the surface …

Electrocatalytic Oxidation Of Glycerol At The Platinum Electrode Modified With An Nd-Fe-Moo42- Cyano-Bridged Mixed Coordination Polymer, Yong-Jun Ma, Yu-Xiu Tian, Jing Liu, Min Zhou, Jing Ding, Zhi-Mei Jin, Xiang-Mei Wang

Journal of Electrochemistry

A platinum electrode decorated with the ordered Nd-Fe-MoO₄^2- cyano-bridged mixed coordination polymer was successfully prepared by electrodeposition in virtue of the lyotropic liquid crystal soft template methods, and electrocatalytic oxidation behavior of glycerol was investigated on the chemically modified electrode by cyclic voltammetry. The influences of experimental factors such as the concentrations of H⁺ and SO₄^2- in electrolytes, glycerol concentration and scan rate on the electrocatalytic activity of glycerol at the modified electrode were also studied. It indicated that the proper amount of SO₄^2- in weakly acidic electrolyte could help to improve the …

Effect Of Temperature On The Self-Humidifying Open-Cathode Proton Exchange Membrane Fuel Cell, Si-Chen Zhao, Ben Wang, Qiu-Hong Jia, Ming Han, Yu-Hong Xie

Journal of Electrochemistry

Based on the experiments about the output characteristics of a home-made temperature-controlled PEMFC system with atmospheric pressure and no external humidifying condition in different loading voltages and operating temperatures, the optimum operating temperature at different loading voltages can be obtained by tracking the output characteristics of PEMFC operating over a range of temperatures. By analyzing the fitted data the kinetic parameters are evaluated and the effect of different operating temperatures on the PEMFC performance is discussed from a view of electrode kinetics.

Enhancement Of Mass Transfer And Electron Usage For Syngas Fermentation, James J. Orgill

Theses and Dissertations

Biofuel production via fermentation is produced primarily by fermentation of simple sugars. Besides the sugar fermentation route, there exists a promising alternative process that uses syngas (CO, H2, CO2) produced from biomass as building blocks for biofuels. Although syngas fermentation has many benefits, there are several challenges that still need to be addressed in order for syngas fermentation to become a viable process for producing biofuels on a large scale. One challenge is mass transfer limitations due to low solubilities of syngas species. The hollow fiber reactor (HFR) is one type of reactor that has the potential for achieving high …

A Sequential Grid, Relaxation Method For Use In Oil Reservoir Simulation, Brian Stimpson, Dr. Hugh Hales

Journal of Undergraduate Research

The demand for petroleum products has never been higher, despite the opposition and environmental skepticism that has been present against the petroleum industry in recent years. This requires the production of petroleum products to increase. However, as politics and nature will have it, the waning supply of petroleum is becoming ever more difficult to access and tap into. To make sure we are using our reserves in the best possible ways, this industry must adapt, create better technology, and have careful planning and predictions.

Advanced Measuring Techniques Of Ionic And Electronic Conductivities In Battery Electrodes, Joshua Flygare, Dr. Dean Wheeler

Journal of Undergraduate Research

Introduction: There are many significant barriers still to be overcome before chemical storage becomes satisfactory. One of the most significant issues is how much the electrodes vary in their electronic and ionic conductivities. Both of these issues are highly complex. My funding was used to help me learn the basic mathematics and physics that occur inside of batteries. I used this understanding to make two models, one using COMSOL multiphysics, and another cruder model using Excel. The most significant change made in my execution from my original proposal was I used all of my time in understanding and making models, …

Spin Cycle: Hand Powered Washing For Peru, Jared Bruton, Dr. Randy Lewis

Journal of Undergraduate Research

Washing clothes is time consuming and physically difficult for women on the islands of Lake Titicaca. Women fill buckets with water and soap, allow the clothes to soak, rub them together to get the dirt out, and then wring them out. Doing this is physically demanding, especially during the harsh cold of winter. This project develops a human-powered, affordable, and easy to build clothes-washing device that allows women to save time and energy washing clothes. It builds on a similar washing machine project from one year ago, but seeks to reduce the cost of the hand-powered machine from 300 Peruvian …