Assessment Of A Marine Polysaccharide For Use As Excipient In Pharmaceutical Hot-Melt Extrusion,
2014
New Jersey Institute of Technology
Assessment Of A Marine Polysaccharide For Use As Excipient In Pharmaceutical Hot-Melt Extrusion, Qing Ye
Theses
Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although HME is traditionally utilizing synthetic polymers to produce such dosages, biopolymers constantly gain ground by virtue of renewability, biocompatibility and in some cases biodegradability. In this work, the possibility of using Keltone, a marine polysaccharide derived from brown seaweed, as a polymeric excipient for pharmaceutical HME is explored. Keltone is insoluble in acidic pH and soluble in basic pH, therefore making …
Dispersion And Dissolution Kinetics Of Api Particles In Pharmaceutical Hot Melt Extrusion,
2014
New Jersey Institute of Technology
Dispersion And Dissolution Kinetics Of Api Particles In Pharmaceutical Hot Melt Extrusion, Wang Zhan
Theses
Pharmaceutical Hot Melt Extrusion (HME) is essentially a special case of polymer compounding. The elementary steps involved in traditional plastics melt processing are handling of particulates, melting, dispersive and distributive mixing, devolatilization and stripping, and finally pressurization and pumping. However, for pharmaceutical HME, the dissolution of the API (Active Pharmaceutical Ingredient) is an additional and very important elementary step, along with the melting of the polymeric excipient that precedes it, and mixing which accelerates the dissolution process. A major concern in pharmaceutical HME is the thermal degradation of the API. To avoid overexposure of API to heat while ensuring complete …
Experimental Determination Of The Mixing Requirements For Solid Suspension In Pharmaceutical Stirred Tank Reactors,
2014
New Jersey Institute of Technology
Experimental Determination Of The Mixing Requirements For Solid Suspension In Pharmaceutical Stirred Tank Reactors, Anqi Zhou
Theses
Glass and glass-lined, stirred-tank reactors are of significant importance in the pharmaceutical and related industries. Because of fabrication issues, a retreat blade impeller (RBI) with a low impeller clearance off the tank bottom is commonly used in glass-lined reactors, typically combined with a single baffle (providing only partial baffling conditions) mounted from the top of the reactor. In addition, these reactors are often provided with a torispherical bottom. Other configurations are also used, including full baffling or no baffles at all, hemispherical bottoms, and different impeller types. Despite their common use, some of the most important mixing characteristics of this …
Graphene-Supported Metal Nanoparticles And Its Potential Civilian And Military Applications,
2014
The British University in Egypt
Graphene-Supported Metal Nanoparticles And Its Potential Civilian And Military Applications, Hany A. Elazab Dr
Chemical Engineering
It is now well established that nanoparticles (1-100 nm) exhibit unique chemical and physical properties that differ from those of the corresponding bulk materials. The dependence of the properties of nanoscale materials on the size, shape and composition of the nanocrystal is a phenomenon of both fundamental scientific interest and many practical and technological applications. These properties are often different, and sometimes superior, to those of the corresponding bulk materials. Due to its unique properties and high surface area, Graphene has become a good candidate as an effective solid support for metal catalysts. The Nobel Prize in Physics for 2010 …
The Odijk Regime In Slits,
2014
Brigham Young University - Provo
The Odijk Regime In Slits, Douglas R. Tree, Wesley F. Reinhart, Kevin D. Dorfman
Faculty Publications
De Gennes’ blob theory has been remarkably successful at describing weakly confined polymers in both slits and channels, and comparable results surround Odijk’s theory of deflection segments for strongly confined wormlike polymers in nanochannels. However, given the success of Odijk’s theory in channels, it is remarkable that there is no comprehensive theory for the simple case of a wormlike polymer strongly confined between two parallel plates. We propose such a theory by drawing inspiration from the existing literature on ideal wormlike chains in slits and Daoud and de Gennes’ idea of mapping a slit-confined chain to a two-dimensional chain. We …
Mechanism Of Insulin Aggregation: Applied To Alzheimer's Disease,
2014
University of Connecticut
Mechanism Of Insulin Aggregation: Applied To Alzheimer's Disease, Milos Atz
Honors Scholar Theses
Alzheimer’s disease, a debilitating neurodegenerative illness, is caused by the irreversible aggregation of beta-amyloid proteins in the brain. In Alzheimer’s brains, the protein can become disfigured, causing it to aggregate into long, insoluble fibers that deposit on brain tissue. Studying the aggregation mechanisms of amyloid proteins can lead to a deeper understanding of the progression of Alzheimer’s disease and possibly point towards a potential cure or treatment for the disease. Heat induced aggregation of insulin provides a model system to study the aggregation of amyloidogenic proteins. This study investigates the early stages of heat induced insulin aggregation using dynamic light …
Preparation And Characterization Of Pc And San Composites And Pc/San Blends With Graphene Nanofiller,
2014
University of South Carolina - Columbia
Preparation And Characterization Of Pc And San Composites And Pc/San Blends With Graphene Nanofiller, Marc Olivier-Blais
Senior Theses
For my thesis defense I plan to focus on both the scientific merit of my research and a reflection of what I personally gained from my experience in Germany. The central goal of this scientific study was to prepare a polymer blend with fine co-continuous blend morphology which contains well dispersed graphene nanofiller. Graphene is currently of great interest as a filler within the polymer nanocomposite community due to its excellent electrical conductivity, favorable mechanical properties, and high surface area. The polycarbonate (PC)/ Poly (styrene acrylonitrile) (SAN) blend system is of interest due to their ubiquitous use in both industrial …
Greenscreen: Software To Improve Campus Water And Energy Use,
2014
University of Connecticut - Storrs
Greenscreen: Software To Improve Campus Water And Energy Use, Andrew T. Silva
University Scholar Projects
Water and energy are intrinsically linked together. Energy is required to produce clean water and water is used heavily to generate energy. These two resources are constantly held in check, as they are vital to the sustained operation of towns, cities, and campuses. At the University of Connecticut (UConn), the consumption of water and energy is reduced by an efficient power plant and a brand new water reclamation facility. To reach beyond these accolades, it is essential that a deeper understanding of campus water usage is developed. Linking this knowledge with information about the energy consumption of UConn facilities will …
Enhancement Of Anaerobic Digestion Of Actual Industrial Wastewaters : Reactor Stability And Kinetic Modeling.,
2014
University of Louisville
Enhancement Of Anaerobic Digestion Of Actual Industrial Wastewaters : Reactor Stability And Kinetic Modeling., Mahyar Ghorbanian
Electronic Theses and Dissertations
Industrial plants pay disposal costs for discharging their wastewater that can contain pollutants, toxic organics and inorganics, to the sewer based on the Biological Oxygen Demand (BOD) or Chemical Oxygen Demand (COD) of the streams. It has become increasingly expensive for industry to meet stringent regulatory standards. One solution to reduce this cost is to anaerobically degrade the COD content, which in turn generates useful methane gas that can be used to generate useful energy or heat. Anaerobic Digestion (AD) is one of the most suitable renewable resources of conversion of industrial wastewaters to bioenergy, but it is not widely …
Classification And Quantification Of Phenotypic Characteristics Of Normal And Dysplastic Oral Cells,
2014
University of Arkansas, Fayetteville
Classification And Quantification Of Phenotypic Characteristics Of Normal And Dysplastic Oral Cells, Jackson W. Boice
Biomedical Engineering Undergraduate Honors Theses
Introduction Oral cancer accounts for 2.5% of all cancer cases in the United States. The 5 year survival rate or stage 1 or localized oral cancer is 82%, and the survival rate of unstaged oral cancer is only 50%; therefore, early diagnosis is key. Current clinical practices for determining malignancy of tissue include physical examination and surgical biopsy, which can be plagued by high variability between observers and are invasive for the patient. Proflavine intercalates between base pairs of nucleic acids and has excitation and emission peaks at 455 (+/- 20) nm and 515 nm respectively; therefore, it can be …
Optimizing In Vitro Extracellular Matrix Production Using Polymer Scaffolds With Targeted Pore Size,
2014
University of Arkansas, Fayetteville
Optimizing In Vitro Extracellular Matrix Production Using Polymer Scaffolds With Targeted Pore Size, Addison M. Walker
Biomedical Engineering Undergraduate Honors Theses
Extracellular matrix (ECM) has been shown to provide the framework needed for healthy tissue to grow after experiencing an injury. The optimization of growing ECM is a pressing concern in the tissue regeneration field. From prior research, an in vitro approach for harvesting ECM has been created using polyurethane (PU) foams seeded with cells. Our approach aimed at discovering if the pore size of the foams increased the amount of recovered ECM. Scaffolds of targeted pore size were created by separating sugar granules using a sieve, packing the sugar into a cylindrical mold, then pouring PU over the sugar. Three …
How Imbalanced Excitation And Inhibition May Cause Low Entropy Brain Dynamics,
2014
University of Arkansas, Fayetteville
How Imbalanced Excitation And Inhibition May Cause Low Entropy Brain Dynamics, Qusay Redwan Alfaori
Biomedical Engineering Undergraduate Honors Theses
To study the effect of the imbalance of excitation and inhibition neurons on brain entropy using a computer model of a brain. The brain model will be composed of a neural network and entropy of the neural network will be measured quantitatively. Entropy in this context quantifies how many different patterns of activated neurons the brain can create. Imbalance between excitation and inhibition neurons causes the brain to malfunction, which can be an underlying cause of autism.
5ht And The 5ht Receptors- Relevance To Cardiac Valve Disease,
2014
University of Arkansas, Fayetteville
5ht And The 5ht Receptors- Relevance To Cardiac Valve Disease, Christopher Ryan Martindale
Biomedical Engineering Undergraduate Honors Theses
Recent studies have revealed that elevated levels of serotonin or 5HT lead to valve dysfunction. A mouse model was successfully established to investigate the effects on the aortic valve in subjects with elevated 5HT levels along with cardiovascular hypertension. For each two-week trial, eight C57BL/6J mice were divided into the following expermental groups: control, 5HT, angiotensin II, and 5HT+angiotensin II. The drug was delivered to the mice via osmotic pumps (Ang II: 0.4ng/g/min, 5HT:0.0025ng/g/min) or direct injections(Ang II: 0.1 mg, 5HT: 2.12 mg, every other day) and the blood pressure of the mice was continually monitored via the CODA tail …
Evaluation Of An Inclined Gravity Settler For Microalgae Harvesting,
2014
Cleveland State University / currently at Newland Biotech, Ltd
Evaluation Of An Inclined Gravity Settler For Microalgae Harvesting, Zhaowei Wang, Jing Hou, Dustin Bowden, Joanne M. Belovich
Chemical & Biomedical Engineering Faculty Publications
BACKGROUND Given the small size of microalgae, and the low biomass concentrations obtained in light-limited cultures, the cost of algae harvesting is a significant barrier to commercial-scale production of biofuel from algae. A downward- flow inclined gravity settler was evaluated for its effectiveness in dewatering the microalgae Scenedesmus dimorphus and Chlorella vulgaris. RESULTS Experimental results showed that S. dimorphus can be concentrated up to 8-fold using a single settler stage, with a biomass recovery of 80%. Separation efficiency was independent of biomass concentration between 1 and 5 gdw L-1, suggesting that a two-stage sequential system of settlers may maximize biomass …
Reduction Of Ketoximes To Amines By Catalytic Transfer Hydrogenation Using Raney Nickel And 2-Propanol As Hydrogen Donor,
2014
University of Tennessee at Chattanooga
Reduction Of Ketoximes To Amines By Catalytic Transfer Hydrogenation Using Raney Nickel And 2-Propanol As Hydrogen Donor, Katherynne E. Taylor
Honors Theses
Ketoximes successfully underwent hydrogenolysis and hydrogenation under catalytic transfer conditions with Raney Nickel and 2-propanol as a hydrogen donor. Ketoximes were reduced to primary amines when 2% KOH was included in the reaction. In the absence of KOH N-isopropyl-secondary-amines were obtained in good yields.
Improved Oxidative Stability In Biodiesel Via Commercially-Viable Processing Strategies,
2014
Clemson University
Improved Oxidative Stability In Biodiesel Via Commercially-Viable Processing Strategies, Gregory Lepak
All Theses
Biodiesel made from waste cooking oil (WCO) frequently requires antioxidants to meet oxidation stability specifications set forth in ASTM D6751 or EN 14214. In contrast, unrefined cottonseed oil (CSO), containing tocopherols and high concentrations of gossypol, a toxic polyphenolic antioxidant, is unique for biodiesel processing because it produces biodiesel resulting in higher oxidation stability. During biodiesel production, however, only a portion of these endogenous natural antioxidants are suspected to be retained. Because the economics of biodiesel manufacturing rely upon inexpensive sources of triglycerides, emphasis was placed upon developing improved alternative commercially-viable processing strategies where WCO is the main source of …
Outlining The Biocidal Mechanisms Of Synthetic Antimicrobial Peptide Mimics,
2014
University of Southern Mississippi
Outlining The Biocidal Mechanisms Of Synthetic Antimicrobial Peptide Mimics, Tyler D. Brown
Honors Theses
Each day, antibiotic resistance affects the livelihood of individuals worldwide, especially in relation to hospital-acquired diseases. In an effort to combat this resistance, antimicrobial peptides, small biopolymers produced naturally by multicellular organisms, can be used to selectively eliminate bacteria and have demonstrated great potential as alternatives to conventional antibiotics. Many naturally-occurring antimicrobial peptides possess high concentrations of lysine and arginine amino acid residues, which are protonated and positively-charged at physiological pH. Herein, we describe the design and synthesis of antimicrobial peptide mimics, using amino acid mimics. N-3-aminopropyl methacrylamide (APMA) and 3-guanidinopropyl methacrylamide (GPMA) monomers mimic the amino acid residues lysine …
Study Of The Structure-Property Relationships That Determine The Effects Of Latexes And Starch Containing Latex Emulsions On The Performance Of The Barrier Coatings (Sub-Coat) For Paper,
2014
University of Southern Mississippi
Study Of The Structure-Property Relationships That Determine The Effects Of Latexes And Starch Containing Latex Emulsions On The Performance Of The Barrier Coatings (Sub-Coat) For Paper, Joanna Marie Monfils
Master's Theses
The history of carbonless paper dates back to the 1940s. Before this, a carbon copy sheet was needed between sheets of paper to be able to produce one or more copies simultaneously during writing. The pressure from a pen or typewriter would help deposit the ink of the carbon paper onto the blank sheet of paper under the original written sheet to create a “carbon copy.” This method did however, have its disadvantages. Not only did it produce a limited number of copies, but it was also a messy process. So came the creative process of using microencapsulated dyes to …
Identifying, Monitoring, Quantifying And Converting Algae To Bio-Fuels In Bio-Reactors,
2014
University of Arkansas, Fayetteville
Identifying, Monitoring, Quantifying And Converting Algae To Bio-Fuels In Bio-Reactors, Alice C. Jernigan
Graduate Theses and Dissertations
Growing algae as a source for bio-fuels has become an area of interest due to concerns about global warming and the reliability and ecology of the production of fossil fuels. Dried algae harvested from a pilot water quality improvement technology at the Rockaway Wastewater Treatment Facility in New York were examined as a source of carbohydrates and lipids for the production of bio-fuels in bio-reactors. The length of storage time, storage conditions, sugar and lipid extraction processes, and fuel production were studied. The results show that if the algae is stored dry (0.015 g/g algae even after a year in …
Membrane Compatibility With Switchable Polarity Draw Solutions For Use In Forward Osmosis Applications,
2014
University of Connecticut - Storrs
Membrane Compatibility With Switchable Polarity Draw Solutions For Use In Forward Osmosis Applications, Benjamin Joseph Coscia
Honors Scholar Theses
Water scarcity is problem being faced worldwide and present in every continent. Close to one-fifth of the world’s population has difficulty acquiring safe water, and the problem is worsening as populations continue to grow in poorer countries. As the availability of unimpaired freshwater sources dwindle, water sources, such as the oceans and saline ground waters, must be tapped. However, desalination technologies are very expensive due to a high energy requirement. Forward osmosis (FO) is a process which may be able to replace or become integrated with existing desalination technologies like reverse osmosis. FO relies on an osmotic agent, or draw …
