Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression,
2024
University of Arkansas, Fayetteville
Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt
Chemical Engineering Undergraduate Honors Theses
Cardiac fibrosis, a large contributor to heart failure, is the excessive accumulation of extracellular matrix in response to stress or injury. There are no approved treatments for cardiac fibrosis, and targeting specific species involved creates complex problems for drug development, so a computational model of the cardiac fibroblast signaling network can be used to observe the interactions involved in the progression of cardiac fibrosis. In this paper, a new protein called galectin-3 is integrated into this existing model, and connections are established to expand the coverage of the network. The additions are described, simulated using Netflux biological system simulation software, …
Cooperative And Bifunctional Adsorbent-Catalyst Materials For In-Situ Vocs Capture-Conversion,
2024
Missouri University of Science and Technology
Cooperative And Bifunctional Adsorbent-Catalyst Materials For In-Situ Vocs Capture-Conversion, Sukanta K. Mondal, Peter Aina, Ali A. Rownaghi, Fateme Rezaei
Chemical and Biochemical Engineering Faculty Research & Creative Works
Volatile Organic Compounds (VOCs) Are Gases that Are Emitted into the Air from Products or Processes and Are Major Components of Air Pollution that Significantly Deteriorate Air Quality and Seriously Affect Human Health. Different Types of Metals, Metal Oxides, Mixed-Metal Oxides, Polymers, Activated Carbons, Zeolites, Metal-Organic Frameworks (MOFs) and Mixed-Matrixed Materials Have Been Developed and Used as Adsorbent or Catalyst for Diversified VOCs Detection, Removal, and Destruction. in This Comprehensive Review, We First Discuss the General Classification of VOCs Removal Materials and Processes and Outline the Historical Development of Bifunctional and Cooperative Adsorbent-Catalyst Materials for the Removal of VOCs from …
Future Of Process Safety: Insights, Approaches, And Potential Developments,
2024
Missouri University of Science and Technology
Future Of Process Safety: Insights, Approaches, And Potential Developments, Hossein Abedsoltan, Amirhesam Abedsoltan, Zeinab Zoghi
Chemical and Biochemical Engineering Faculty Research & Creative Works
This review explores the evolving landscape of process safety, emphasizing the integration of digitalization and advanced technologies. It assesses the role of the industrial Internet of Things, artificial intelligence, and machine learning (ML) in enhancing safety protocols. The paper examines predictive analytics, sensor technology advancements, and digital twins' contributions to safety optimization. It also discusses the future perspectives of risk management approaches, including proactive safety management systems, quantitative risk assessment techniques, and human reliability analysis. This comprehensive analysis provides insights into future developments and challenges in process safety.
Yeast Surface Display Of Multiple Heterologous Proteins Via Molecular And Biochemical Processing Techniques,
2024
University of Arkansas, Fayetteville
Yeast Surface Display Of Multiple Heterologous Proteins Via Molecular And Biochemical Processing Techniques, Shadrach Ibinola
Graduate Theses and Dissertations
The arming of yeast cell wall, also known as yeast surface display, is an effective technology for expressing target proteins extracellularly. It has been shown to provide bioengineered yeast with qualities that are not known to native yeast such as the ability to survive harsh conditions including high pH and temperature, for example. Furthermore, this technique has been implemented for various applications which include, protein engineering, bioethanol production, bioremediation, vaccine construction, and antibody development. The major mechanisms of yeast surface display exploit agglutination, flocculation, or proteins with internal repeats as the means by which a target (protein) is covalently attached …
Developing Anisotropic Soft Matter As Functional Materials To Interface With Biological Systems,
2024
University of Arkansas, Fayetteville
Developing Anisotropic Soft Matter As Functional Materials To Interface With Biological Systems, Homa Ghaiedi
Graduate Theses and Dissertations
Liquid crystals (LCs) constitute a subset of soft matter possessing hybrid characteristics from both liquid and crystalline phases. In this state, the center of masses remains uncorrelated similar to an isotropic phase, while the long axis of molecules aligns in parallel, resulting in molecules exhibiting orientational and positional order, either individually or concurrently. The directional alignment inherent in LCs arises from the asymmetrical shape and structure of the constituent molecules, causing a spontaneous self-assembly into ordered phases. This cooperative molecular behavior manifests distinctive optical features when subjected to cross polarizers. The remarkable sensitivity of LCs to external stimuli, including temperature, …
Thermogravimetric Analysis And Chemical Kinetics Of Waste Tires,
2024
University of Dar es Salaam
Thermogravimetric Analysis And Chemical Kinetics Of Waste Tires, Mahir Mohammed Said
Tanzania Journal of Engineering and Technology (TJET)
The focus of this paper is to analyse the pyrolysis reaction of waste tires. The pyrolysis was studied experimentally using thermal and chemical kinetics. The tires were pyrolyzed using thermogravimetry at a temperature range of 200 to 600°C, with heating rates of 10, 20, and 50°C/min. The activating energy was observed to increase with increased temperature. The highest activating energy was 101.02 kJ/mol at a heating rate of 50°C/min.
Design And Optimization Of An Azeotropic Distillation Pilot Plant For The Production Of Pure Ethanol,
2024
Department of Chemical and Process Engineering, College of Engineering and Technology, University of Dar es Salaam, P.O. Box 35131, Dar es Salaam, Tanzania
Design And Optimization Of An Azeotropic Distillation Pilot Plant For The Production Of Pure Ethanol, Samwel V. Manyele
Tanzania Journal of Engineering and Technology (TJET)
This study aimed to design an azeotropic distillation plant using Aspen Plus® V10 software and determine optimal process conditions for producing pure ethanol greater than 95% from pre-concentrated near-azeotropic ethanol-water solution. The non-random two-liquid Redlich-Kwong thermodynamic model was the base method for property analysis and performance prediction. Modelling and simulation of the converged process were conducted for fixed column variables (R = 5, N = 12 and p = 1 atm). Plant operating parameters were varied in the range of 0 to 1 for the pre-heater vapour fraction, 2 to 10 for the column feed plates (NFP), 2 to 6 …
Enhanced Post Deposition Annealing Conditions On The Fabrication Of High Quality Thermochromic Vanadium Dioxide Films,
2024
Department of Physics, University of Dar es Salaam, P.O. Box 35063, Dar es Salaam, Tanzania
Enhanced Post Deposition Annealing Conditions On The Fabrication Of High Quality Thermochromic Vanadium Dioxide Films, Nuru R. Mlyuka
Tanzania Journal of Engineering and Technology (TJET)
Sputter deposition of thermochromic VO2 thin films for smart window applications has been faced with several challenges including the need for high deposition temperature, extremely precise and narrow range of oxygen/argon flow ratio and target poisoning during sputtering. Deposition of VO2 at room temperature without oxygen followed by post-deposition annealing has been cited as one of the potential mitigations to the challenge. In this study, the effects of post-deposition annealing conditions on the structural, electrical and optical properties of VO2 thin films are reported. The films were prepared on soda lime glass substrates using DC magnetron sputtering of metallic vanadium …
Production Of Biofertilizer From Fruit And Garden Waste,
2024
Department of Chemical and Process Engineering, College of Engineering and Technology, University of Dar es Salaam, P.O. Box 351313, Dar es Salaam, Tanzania
Production Of Biofertilizer From Fruit And Garden Waste, Neema Msuya
Tanzania Journal of Engineering and Technology (TJET)
The project focused on the production of bio-fertilizer from fruit and garden waste, with a specific emphasis on utilizing pineapple tops in the composting process. The objective was to produce and assess the properties of the bio fertilizer obtained from this process and evaluate its potential application in agriculture. In this study, the composting process was done in a 0.7 m long, 0.85 wide and 1.1 m high vessel, and 0.238 m3 pineapple top wastes, resulting in 0.35 m3 of biofertilizer. The bio fertilizer produced exhibited favorable characteristics, including a moisture content of 36%, pH of 7.1, and a total …
Study Of The Effects Of Thermal Aging Coupled With Shot-Peening Treatment Of Carbonitrided Din 1.6587 Low Alloy Steel On Retained Austenite And Residual Stresses,
2024
Department of Mining and Mineral Processing Engineering, School of Mines and Geosciences, University of Dar es Salaam, P.O. Box 35052, Dar es Salaam, Tanzania
Study Of The Effects Of Thermal Aging Coupled With Shot-Peening Treatment Of Carbonitrided Din 1.6587 Low Alloy Steel On Retained Austenite And Residual Stresses, Richard J. Katemi
Tanzania Journal of Engineering and Technology (TJET)
This work investigated the effects of thermal aging and shot-peening of carbonitrided 1.6587 steel grade on retained austenite and residual stresses. After carbonitriding samples contained maximum of 0.87% carbon, 0.34% nitrogen and 50 mass. -% retained austenite. Thermal aging conditions investigated were -30°C, 90°C and 150°C while the aging period were 14, 96 and 720 hours. After thermal aging, some of the samples were subjected to shot-peening treatment using standard cut wire shots StD – G3 - 0.6 mm VDFI 8001 with intensity in the range of 0.25 to 0.30 mmA and coverage of 1.00 to 1.24 x 98%. It …
Assessing Hydrolysis Performance Of Ce(Oh)4@Pim-1 Composites Functionalized With Amidoxime, Aldoxime, And Carboxylate Groups Toward Dimethyl 4-Nitrophenylphosphonate, A Nerve Agent Simulant,
2024
Missouri University of Science and Technology
Assessing Hydrolysis Performance Of Ce(Oh)4@Pim-1 Composites Functionalized With Amidoxime, Aldoxime, And Carboxylate Groups Toward Dimethyl 4-Nitrophenylphosphonate, A Nerve Agent Simulant, Peter O. Aina, Sukanta K. Mondal, Ali A. Rownaghi, Fateme Rezaei
Chemical and Biochemical Engineering Faculty Research & Creative Works
In recent years, significant attention has been directed toward evaluating the reactivity of diverse polymers to gauge their catalytic activity against hazardous chemicals. Among these polymers, pim-1 has emerged as an exceptional candidate due to its noteworthy attributes including high surface area, excellent solubility, and the capability to fine-tune the nitrile functional groups along its polymeric backbone. In this study, we explored the impact of different functional groups, such as amidoxime (ax), aldoxime (ox), and carboxylate (cooh), on the degradation of dimethyl 4-nitrophenylphosphonate (dmnp) in comparison to pure pim-1 and their respective ce(oh)4-loaded polymer composites. Remarkably, the pim-1-ax analog exhibited …
Lung Cancer Drug Study Using Alc Nanoparticles,
2024
Missouri University of Science and Technology
Lung Cancer Drug Study Using Alc Nanoparticles, Noah Sparks
Undergraduate Research Conference at Missouri S&T
In a previous project it was determined ALC polarized lipid nanoparticles have a high transfection efficiency in some lung cancer cell lines. Building off this information, these ALC particles will now be tested with an actual lung cancer drug. This process will consist of searching articles for promising lung cancer drugs and selecting one for use. The ALC particles will then undergo a comprehensive drug study using multiple lung cancer cell lines with the selected drug. Aspects such as drug release rate, transfection rate, cytotoxicity, etc. will be determined. The goal is to determine whether ALC nanoparticles show real promise …
Biosensors For Antibacterial Medical Applications,
2024
Missouri University of Science and Technology
Biosensors For Antibacterial Medical Applications, Ryan Fagan, Shelby Wallen
Undergraduate Research Conference at Missouri S&T
Healthcare associated infections are significant concern in medicine and as antibiotics are becoming less effective, we need new alternative methods to treat them. We are testing various materials that can be used to prevent infections in healthcare settings and in wound treatments. These materials include bioactive glass and modified hydrogel materials. From these studies we've learned these are effective in killing bacteria and preventing infections. The goal of this project is to determine the mechanism at which these materials kill bacteria. Our approach is to construct biosensor strains that can indicate bacterial stress response to antimicrobial agents. We have used …
Ionizable Lipid Nanoparticles Fabrication For Gene Delivery,
2024
Missouri University of Science and Technology
Ionizable Lipid Nanoparticles Fabrication For Gene Delivery, Noah Sparks, Lei Xu, Hu Yang
Undergraduate Research Conference at Missouri S&T
In this project ionizable lipids were analyzed for their efficacy in delivery of mRNA in multiple metastatic lung cancer cells. Different ionizable lipids with their molar ratio in making the LNPs were analyzed in order to enhance the nucleic acid delivery to cytoplasm. Phospholipids also play a role in targeting efficacy of the LNPs to the lung cells. Different combination of ionizable lipids with multiple phospholipids were studied for physical characterization and in-vitro transcription efficiency. Transcription efficiency was then quantified using flow cytometry and optimal particles for transcription were noted.
Investigating The Role Of Fluid Shear Stress During Metastasis On Enhanced Breast Cancer Extravasation,
2024
Louisiana State University and Agricultural and Mechanical College
Investigating The Role Of Fluid Shear Stress During Metastasis On Enhanced Breast Cancer Extravasation, Alejandra M. Ham
LSU Master's Theses
In 2022, ~288,000 American women were diagnosed with metastatic breast cancer which was the leading cause of patient mortality with ~43,000 American women succumbing to the disease. Women can be diagnosed with four different molecular subtypes of breast cancer: luminal A, luminal B, human epithelial growth receptor type 2 enriched (HER2+), and triple-negative breast cancer (TNBC). TNBC accounts for ~12% of all breast cancers, yet it has the worst outcomes. TNBC is highly invasive, with ~46% of TNBC patients developing metastatic disease. A further understanding of metastatic TNBC is needed to provide a greater understanding of how to treat this …
Mitigation Of Potential Risks In Chemical Laboratories: A Focused Review,
2024
Missouri University of Science and Technology
Mitigation Of Potential Risks In Chemical Laboratories: A Focused Review, Hossein Abedsoltan, Mark B. Shiflett
Chemical and Biochemical Engineering Faculty Research & Creative Works
This review paper presents an analysis of safety practices in chemical laboratories. It encompasses a systematic exploration of various facets including risk assessment, hazard mitigation, and the implementation of safety protocols. Emphasis is placed on the critical role of continuous education and training, advocating a proactive safety culture, and adapting to technological advancements. Additionally, the paper underscores the importance of adhering to regulatory standards, promoting exceeding baseline compliance toward establishing best practices in laboratory safety. This comprehensive approach highlights the dynamic, multifaceted nature of laboratory safety, positioning it as a fundamental aspect of scientific research.
Aphid-Ant Relationships: The Role Of Cuticular Hydrocarbons
And Different Chemical Stimuli In Triggeringmutualistic Behavior,
2024
Humboldt-Universität zu Berlin, University of Agriculture and Life Sciences, Desert Research Center
Aphid-Ant Relationships: The Role Of Cuticular Hydrocarbons And Different Chemical Stimuli In Triggeringmutualistic Behavior, Amged El-Harairy, Ahmed El-Harairy, Alaa Mahfouz
Department of Chemical and Biomolecular Engineering: Faculty Publications
In ant-aphid interactions, various aphid species offer honeydew to the ant partner and increase their density by ant attendance, whilst others never attend ant species, in which case ants tend to treat them as prey. In this regard, ants should have the ability to distinguish myrmecophile aphid species from non-mutualistic species, so that mutualistic aphids will be accepted as partners rather than prey. Although ant-aphid interactions are now the focus of chemical ecology studies, the role of the different chemical stimuli in determining mutualistic interactions has not been completely clarified. Therefore, we have investigated the cuticular hydrocarbon profile of four …
Highly Efficient Dopamine Sensing With A Carbon Nanotube-Encapsulated Metal Chalcogenide Nanostructure,
2024
Missouri University of Science and Technology
Highly Efficient Dopamine Sensing With A Carbon Nanotube-Encapsulated Metal Chalcogenide Nanostructure, Harish Singh, Jiandong Wu, Kurt A.L. Lagemann, Manashi Nath
Chemical and Biochemical Engineering Faculty Research & Creative Works
Carbon nanotube-encapsulated nickel selenide composite nanostructures were used as nonenzymatic electrochemical sensors for dopamine detection. These composite nanostructures were synthesized through a simple, one-step, and environmentally friendly chemical vapor deposition method, wherein the CNTs were formed in situ from pyrolysis of a carbon-rich metallo-organic precursor. The composition and morphology of these hybrid NiSe2-filled carbon nanostructures were confirmed by powder X-ray diffraction, Raman, X-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy images. Electrochemical tests demonstrated that the as-synthesized hybrid nanostructures exhibited outstanding electrocatalytic performance toward dopamine oxidation, with a high sensitivity of 19.62 μA μM-1 cm-2, low detection limit, broad linear …
Challenges And Opportunities In Electrification Of Adsorptive Separation Processes,
2024
Missouri University of Science and Technology
Challenges And Opportunities In Electrification Of Adsorptive Separation Processes, Abdullah Al Moinee, Ali A. Rownaghi, Fateme Rezaei
Chemical and Biochemical Engineering Faculty Research & Creative Works
A global energy transition from fossil-based to renewable-based systems requires advancements in various energy sectors. Current chemical separation processes are quite energy-intensive and require significant advancement to make this transition happen. In the energy transition era, reducing the dependency of separation processes on fossil-based thermal energy seems inevitable for transitioning smoothly and meeting the stringent timelines. In particular, adsorption-based separation processes have the potential to be fully electrified through innovative strategies in developing stimuli-responsive adsorbents and swing processes. In this review, we discuss the recent efforts in electrification of adsorption processes and provide an overview of emerging materials and processes. …
Advancement In Heavy Oil Upgrading And Sustainable Exploration Emerging Technologies,
2024
Missouri University of Science and Technology
Advancement In Heavy Oil Upgrading And Sustainable Exploration Emerging Technologies, Youssef Yatimi, Jihane Mendil, Meena Marafi, Ahmed Alalou, Muthanna H. Al-Dahhan
Chemical and Biochemical Engineering Faculty Research & Creative Works
Upgrading heavy oil is a subject of high importance for fossil fuel industry due to the rapid depletion of light oil reservoirs and the consequent increased demand for upgrading heavy oil. In this review, the advancement made in heavy oil upgrading and the proposed sustainable emerging technologies dedicated to heavy oil processing have been discussed in a comprehensive and informative manner with consideration to the encountered associated with properties of heavy oil including its significant content of undesirable large molecular weight hydrocarbons, its high viscosity, and its elevated impurity level. The shortcomings of conventional crude oil upgrading technologies are outlined, …
