Capture And Release Gels For Optimized Storage (Cargos),
2019
University of Louisville
Capture And Release Gels For Optimized Storage (Cargos), Theodore S. Kalbfleisch Ii
Electronic Theses and Dissertations
Unassisted, the lifetime of many proteins outside their natural environment is very short. Scientists generally need to extract the sample, often in remote locations, and then transport, isolate, and store such biospecimens relatively far from the point of origin in order to study them. Currently, the most commonly used methods for storage of biospecimens are cryopreservation or refrigeration which, though effective, have their fair share of flaws. Cryopreservation and refrigeration-based storage of biospecimens requires a great deal of space and other resources to be effective. Furthermore, the hardware required for cold storage does not transport well. These factors make such …
Self-Assembled Nanoantenna Enhance Optical Activity And Transport In Scalable Thin Films And Interfaces,
2019
University of Arkansas, Fayetteville
Self-Assembled Nanoantenna Enhance Optical Activity And Transport In Scalable Thin Films And Interfaces, Keith Richard Berry Jr.
Graduate Theses and Dissertations
Continued population growth and the decrease of existing energy platforms demands long-term solutions for development and implementation of scalable plasmonic metamaterials for energy and agricultural applications. Self-assembled nanoantenna into random and ordered arrangements are advanced herein for optical and thermal enhancements in scalable thin film. An analytical approach to estimating the thermal dynamics of random arrangements of nanoantenna resulted in estimates within 30% across a range of geometric parameters, nanoantenna-containing media, and thermal parameters. Multimodal thermal dynamics of polymer thin films containing gold nanoparticles (AuNPs) were observed through the natural log of the dimensionless temperature driving force plotted versus time …
Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis,
2019
University of New Mexico - Main Campus
Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis, Leisha M. A. Martin
Nanoscience and Microsystems ETDs
Cystic fibrosis (CF) is the most common genetic disease resulting in the morbidity and mortality of Caucasian children and adults worldwide. Due to a genetic mutation resulting in malfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, CF patients produce highly viscous mucus in their respiratory tract. This leads to impairment of the mucociliary clearance of inhaled microbes. In addition to reduced microbial clearance, anoxic environmental conditions in the lungs promote biofilm-mode growth of the pathogenic bacterial species Pseudomonas aeruginosa. Chronic infections of P. aeruginosa begin in early childhood and typically persist until respiratory failure and death result. The …
Design Of A Portable Biogas Purification And Storage System,
2019
Western Michigan University
Design Of A Portable Biogas Purification And Storage System, Anikumar Kosna, Bade Shrestha
Faculty Research and Creative Activities Award (FRACAA)
The objective of this study is to propose and design a commercial portable purification and storage system to commercialize biogas (which mainly consists of 45 - 75 % of methane and 15 - 16% of carbon dioxide), produced from household/non-commercial biogas plants. The selection of purification process is based on the portability of the purification system.
Characterization And Quantification Of Highly Sulfated Glycosaminoglycan Isomers By Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation Ms/Ms,
2019
Missorui University of Science and Technology
Characterization And Quantification Of Highly Sulfated Glycosaminoglycan Isomers By Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation Ms/Ms, Juan Wei, Jiandong Wu, Yang Tang, Mark E. Ridgeway, Melvin A. Park, Catherine E. Costello, Joseph Zaia, Cheng Lin
Chemical and Biochemical Engineering Faculty Research & Creative Works
Glycosaminoglycans (GAGs) Play Vital Roles in Many Biological Processes and Are Naturally Present as Complex Mixtures of Polysaccharides with Tremendous Structural Heterogeneity, Including Many Structural Isomers. Mass Spectrometric Analysis of GAG Isomers, in Particular Highly Sulfated Heparin (Hep) and Heparan Sulfate (HS), is Challenging Because of their Structural Similarity and Facile Sulfo Losses during Analysis. Herein, We Show that Highly Sulfated Hep/HS Isomers May Be Resolved by Gated-Trapped Ion Mobility Spectrometry (Gated-TIMS) with Negligible Sulfo Losses. Subsequent Negative Electron Transfer Dissociation (NETD) Tandem Mass Spectrometry (MS/MS) Analysis of TIMS-Separated Hep/HS Isomers Generated Extensive Glycosidic and Cross-Ring Fragments for Confident Isomer …
The Effect Of Calcination Rate On The Structure Of Mesoporous Bioactive Glasses,
2019
Missouri University of Science and Technology
The Effect Of Calcination Rate On The Structure Of Mesoporous Bioactive Glasses, Saidur Rahman, Andrew Mendonca, Adel Alhalawani, Deanna Polintan, Owen M. Clarkin, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Mesoporous bioactive glasses (MBGs) are designed to have high specific surface area. They are formulated by a sol–gel process to formulate the glass followed by calcination. This study evaluates how calcination heating rate influences the porous architecture, and thereby the specific surface area, of MBGs. MBGs of molar ratio 80:15:5 for SiO2 :CaO:P2 O 5 were calcined using both low (1 °C/min) and high (20 °C/min) heating rates, termed as L-MBG and H-MBG, respectively. The results obtained from small-angle X-ray diffraction (SAXRD) confirm that the MBGs possess 2D hexagonal (P6mm) spacing groups and wide-angle XRD confirms the amorphicity …
Raman Spectroscopy As A Predictive Tool For Monitoring Osteoporosis Therapy In A Rat Model Of Postmenopausal Osteoporosis,
2019
Missouri University of Science and Technology
Raman Spectroscopy As A Predictive Tool For Monitoring Osteoporosis Therapy In A Rat Model Of Postmenopausal Osteoporosis, J. Renwick Beattie, Antonia Sophocleous, M. Clare Caraher, Olive O'Driscoll, Niamh M. Cummins, Steven E.J. Bell, Mark R. Towler, Alireza Rahimnejad Yazdi, Stuart H. Ralston, Aymen I. Idris
Chemical and Biochemical Engineering Faculty Research & Creative Works
Pharmacological therapy of osteoporosis reduces bone loss and risk of fracture in patients. Modulation of bone mineral density cannot explain all effects. Other aspects of bone quality affecting fragility and ways to monitor them need to be better understood. Keratinous tissue acts as surrogate marker for bone protein deterioration caused by oestrogen deficiency in rats. Ovariectomised rats were treated with alendronate (ALN), parathyroid hormone (PTH) or estrogen (E2). MicroCT assessed macro structural changes. Raman spectroscopy assessed biochemical changes. Micro CT confirmed that all treatments prevented ovariectomy-induced macro structural bone loss in rats. PTH induced macro structural changes unrelated to ovariectomy. …
The Endocytotic Fate Of A Mesoporous Silica Nanoparticle Supported Lipid Bylayer Crispr Delivery Vehicle,
2019
University of New Mexico - Main Campus
The Endocytotic Fate Of A Mesoporous Silica Nanoparticle Supported Lipid Bylayer Crispr Delivery Vehicle, Angelea Maestas-Olguin
2019 Award Winners
No abstract provided.
Well-Ordered Mesoporous Silica And Bioactive Glasses: Promise For Improved Hemostasis,
2019
Missouri University of Science and Technology
Well-Ordered Mesoporous Silica And Bioactive Glasses: Promise For Improved Hemostasis, Sara Pourshahrestani, Nahrizul Adib Kadri, Ehsan Zeimaran, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Immediate control of uncontrolled bleeding and infection are essential for saving lives in both combat and civilian arenas. Inorganic well-ordered mesoporous silica and bioactive glasses have recently shown great promise for accelerating hemostasis and infection control. However, to date, there has been no comprehensive report assessing their specific mechanism of action in accelerating the hemostasis process and exerting an antibacterial effect. After providing a brief overview of the hemostasis process, this review presents a critical overview of the recently developed inorganic mesoporous silica and bioactive glass-based materials proposed for hemostatic clinical applications and specifically investigates their unique characteristics that render …
Slightly Fluorination Of Al2o3 Ald Coating On Li1.2mn0.54co0.13ni0.13o2 Electrodes: Interface Reaction To Create Stable Solid Permeable Interphase Layer,
2019
Missouri University of Science and Technology
Slightly Fluorination Of Al2o3 Ald Coating On Li1.2mn0.54co0.13ni0.13o2 Electrodes: Interface Reaction To Create Stable Solid Permeable Interphase Layer, Han Yu, Yan Gao, Xinhua Liang
Chemical and Biochemical Engineering Faculty Research & Creative Works
Improving the performance of cathodes by using surface coatings has proven to be an effective method for improving the stability of Li-ion batteries (LIBs), while a high-quality film satisfying all requirements of electrochemical inertia, chemical stability, and lithium-ion conductivity has not been found. In this study, a composite film composed of Al2O3 and AlF3 layers was coated on the surface of Li1.2Mn0.54Co0.13Ni0.13O2 (Li-rich NMC) based electrodes by atomic layer deposition (ALD). By varying the ratio of Al2O3 and AlF3, an optimal coating …
Synthesis Of Zif-8 For The Oxidative Dehydrogenation Of Ethane To Produce Ethylene,
2019
University of Alabama in Huntsville
Synthesis Of Zif-8 For The Oxidative Dehydrogenation Of Ethane To Produce Ethylene, Fausat Isu
Summer Community of Scholars Posters (RCEU and HCR Combined Programs)
No abstract provided.
Multi-Responsive Macromolecular Coacervate Complexes For Efficient Biomolecular Encapsulation And Controlled Release,
2019
Wayne State University
Multi-Responsive Macromolecular Coacervate Complexes For Efficient Biomolecular Encapsulation And Controlled Release, Adrian Lorenzana
Research Opportunities for Engineering Undergraduates (ROEU) Program 2018-19
The project investigates the mechanistic (entropic) formation of organic-inorganic coacervates with improved mechanical strength. We seek to control and modify material properties and stimuli-responsive characteristics of hybrid coacervates, and to explore new practical applications of organic-inorganic coacervate complexes, i.e. (bio)separation, wastewater treatment, drug delivery, battery electrolyte and electrodes.
Overview Of Homechem: House Observations Of Microbial And Environmental Chemistry,
2019
Colorado State University - Fort Collins
Overview Of Homechem: House Observations Of Microbial And Environmental Chemistry, Delphine K. Farmer, Marina E. Vance, Jon P. D. Abbatt, Andrew Abeleira, Michael R. Alves, Richard Corsi, Peter F. Decarlo, Allen H. Goldstein, Vicki H. Grassian, Lea Hildebrandt Ruiz, Jose L. Jimenez, Tara Kahan, Multiple Additional Authors
Mechanical and Materials Engineering Faculty Publications and Presentations
The House Observations of Microbial and Environmental Chemistry (HOMEChem) study is a collaborative field investigation designed to probe how everyday activities influence the emissions, chemical transformations and removal of trace gases and particles in indoor air. Sequential and layered experiments in a research house included cooking, cleaning, variable occupancy, and window-opening. This paper describes the overall design of HOMEChem and presents preliminary case studies investigating the concentrations of reactive trace gases, aerosol particles, and surface films. Cooking was a large source of VOCs, CO2, NOx, and particles. By number, cooking particles were predominantly in the ultrafine mode. Organic aerosol dominated …
Modification Of Lipid Microenvironments On Solid Support Structures For Use In Transmembrane Protein Assays,
2019
CUNY City College
Modification Of Lipid Microenvironments On Solid Support Structures For Use In Transmembrane Protein Assays, William J. Houlihan
Dissertations and Theses
Gamma-Secretase (γ-secretase) is a transmembrane protease of increasing interest, which has been shown to have significant connections to both cancer and Alzheimer’s disease. γ-secretase cleaves both Notch-1, a transmembrane signaling protein, and Amyloid precursor protein (APP), a transmembrane protein whose cleavage may result in the formation of β-amyloid plaques in the brain. Notch-1 and APP are widely studied proteins that have substantial impacts on the development and proliferation of cancer and Alzheimer’s disease, respectively. Notch-1 partakes in the signaling of apoptosis in damaged and mutated cells, thus its cleavage by γ-secretase within the plasma membrane has ramifications on cell growth …
Accumulation Of Di-2-Ethylhexyl Phthalate From Polyvinyl Chloride Flooring Into Settled House Dust And The Effect On The Bacterial Community,
2019
University of Oregon
Accumulation Of Di-2-Ethylhexyl Phthalate From Polyvinyl Chloride Flooring Into Settled House Dust And The Effect On The Bacterial Community, Samantha Velazquez, Chenyang Bi, Jeff Kline, Susie Nunez, Richard Corsi, Ying Xu, Suzanne L. Ishaque
Mechanical and Materials Engineering Faculty Publications and Presentations
Di-2-ethylhexyl phthalate (DEHP) is a plasticizer used in consumer products and building materials, including polyvinyl chloride flooring material. DEHP adsorbs from material and leaches into soil, water, or dust and presents an exposure risk to building occupants by inhalation, ingestion, or absorption. A number of bacterial isolates are demonstrated to degrade DEHP in culture, but bacteria may be susceptible to it as well, thus this study examined the relation of DEHP to bacterial communities in dust. Polyvinyl chloride flooring was seeded with homogenized house dust and incubated for up to 14 days, and bacterial communities in dust were identified at …
Effects Of Micro-Features On Cell Detachment From Poly(N-Isopropylacrylamide) Coated Polydimethylsiloxane Membranes,
2019
The University of Akron
Effects Of Micro-Features On Cell Detachment From Poly(N-Isopropylacrylamide) Coated Polydimethylsiloxane Membranes, Luke Webel
Williams Honors College, Honors Research Projects
The tested hypothesis was that features on polydimethylsiloxane (PDMS) surfaces coated with a poly(N-isopropylacrylamide)/aminopropyltriethoxysilane or pNIPAAM/APTES thin film would accelerate cell detachment than the film coated on a unfeatured surface. This project tested samples with features generated by molds, wrinkling, and sandpaper roughened substrates. Surface feature generation methods were limited to mechanical means, and characterized by microscopy and strain rates. 50/50 mixtures of 1.5 wt.% pNIPAAM/ APTES were used to coat thin films (30-40 nm) on PDMS membranes by spin-coating, and the coated membranes were thermally annealed to chemically graft pNIPAAm/APTES on the membrane and their thermo-responsive property was assessed …
Fabrication And Characterization Of Nanofiber Nylon-6-Mwcnt As An Electrochemical Sensor For Sodium Ions Concentration Detection In Sweat,
2019
The University of Akron
Fabrication And Characterization Of Nanofiber Nylon-6-Mwcnt As An Electrochemical Sensor For Sodium Ions Concentration Detection In Sweat, Kelsey Mills
Williams Honors College, Honors Research Projects
Fabrication and characterization nylon-6-MWCNT nanofiber as an electrochemical sensor to detect sodium ion concentrations specifically in sweat. Using contact angle to determine surface morphology and chronoamperometry testing to identify ideal sensor conditions, tests optimized parameters like weight percent of nylon or other polymers, carbon nanotube (CNT) isomer, and solution concentration to determine reproducibility of functional sensors. Utilizing the electric qualities of carbon nanotubes partnered with the sodium ion selectivity of calixarene treatment and polymers unique properties like flexibility and scalability create open an arena for optimizing sodium ion sensors for further development for functional prototypes. Morphology tests showed that the …
Synthesis Of Drug Encapsulated Chitosan-Heparin Based Nanoparticles And Release Study,
2019
The University of Akron
Synthesis Of Drug Encapsulated Chitosan-Heparin Based Nanoparticles And Release Study, Trent Richwine
Williams Honors College, Honors Research Projects
The main objective of this honor’s project is to encapsulate drugs with different molecular weights inside of chitosan-heparin based nanoparticles (Cs-Hep NPs). Three different drugs with low (NNC), medium (IFN-γ), and large (BSA) molecular weights were chosen in order to compare all types of drugs and how they react with the nanoparticles. Analysis of particle size, zeta potential, and a release study was performed. The release took place over a 168-hour time period and liquid samples were taken throughout. The hypothesis was that the molecular weight of the drug will correlate to the physical properties of the nanoparticles. The results …
Chronoamperometry Analysis Of Sweat Sensor Technology,
2019
The University of Akron
Chronoamperometry Analysis Of Sweat Sensor Technology, Evan Fritz
Williams Honors College, Honors Research Projects
Due to the demand for in-situ electrolyte sodium sensors, prototype sensors have been produced to create a product for athletes and marathoners to monitor hydration levels. These senors address a desire in the marketplace for athletic monitoring for overall athlete wellness and performance. Sweat sensor samples were created using Multi-walled Carbon Nanotubes functionalized on a Nylon-6 fiber mat using cyclo-oligomeric Calixarene. This production process produces sensors capable of detecting sodium ion concentration present in human sweat in presence of an electric current. Chronoamperometry analysis is used in this manner to determine the functionality of the sensors. Much of the research …
Effects Of Hofmeister Ions On Transition Temperature Of Two Thermo-Responsive Polymers,
2019
The University of Akron
Effects Of Hofmeister Ions On Transition Temperature Of Two Thermo-Responsive Polymers, Joshua Moser
Williams Honors College, Honors Research Projects
It was hypothesized that through the use of Hofmeister Ions, the lower critical solution temperature (LCST) of poly(vinyl methyl ether) (PVME) and poly(ethylene glycol)- poly(N-isopropylacrylamide) (PEG-b-pNIPAAm) block-copolymer could be controlled. Through literature searches and small lab experiments, our team found that there may be a connection between Hofmeister effects and phase transition of a thermo-responsive polymer. To try and prove this, the lab team decided to take four cations (Mg2+,Na+, Cs+, K+) in solution with the thermo-responsive polymers and compared their LCST to solutions of the thermo-responsive polymer in de-ionized …
