Functional Classification Of Skeletal Muscle Networks. Ii. Applications To Pathophysiology,
2012
University of California - San Diego
Functional Classification Of Skeletal Muscle Networks. Ii. Applications To Pathophysiology, Yu Wang, Jack Winters, Shankar Subramaniam
Biomedical Engineering Faculty Research and Publications
In our preceding companion paper (Wang Y, Winters J, Subramaniam S. J Appl Physiol. doi: 10.1152/japplphysiol.01514.2011), we used extensive expression profile data on normal human subjects, in combination with legacy knowledge to classify skeletal muscle function into four models, namely excitation-activation, mechanical, metabolic, and signaling-production model families. In this paper, we demonstrate how this classification can be applied to study two well-characterized myopathies: amyotrophic lateral sclerosis (ALS) and Duchenne muscular dystrophy (DMD). Using skeletal muscle profile data from ALS and DMD patients compared with that from normal subjects, normal young in the case of DMD, we delineate molecular mechanisms …
Easily Implantable And Stable Nail-Fastener For Skeletal Fixation And Method,
2012
Kettering University
Easily Implantable And Stable Nail-Fastener For Skeletal Fixation And Method, Patrick Atkinson, David Lecronier
Mechanical Engineering Patents
An intramedullary nail (20) for insertion into the medullary canal (26) in a bone (24) surrounded by the cortex (28) and defines a bore (34) extending transverse to the intramedullary nail (20). A threaded fastener (22) extends along a fastener axis (A) and has a compression portion (48) having a compression portion diameter (DCP), and a threaded portion (50) having a threaded portion diameter (DTP) extending through a near cortex hole (40) and a far cortex hole (42), both holes (40, 42) radially overlapping the bore (34) and the threaded portion diameter (DTP) threadedly engaging the bore (34). A compression …
Impairments In Sensorimotor Control During Pursuit And Compensatory Tracking In Individuals With Multiple Sclerosis,
2012
Marquette University
Impairments In Sensorimotor Control During Pursuit And Compensatory Tracking In Individuals With Multiple Sclerosis, Scott A. Beardsley, Heenan M., Robert A. Scheidt, D. Woo, J. Bobholz
Biomedical Engineering Faculty Research and Publications
No abstract provided.
Differential Mitochondrial Toxicity Screening And Multi- Parametric Data Analysis,
2012
Purdue University
Differential Mitochondrial Toxicity Screening And Multi- Parametric Data Analysis, Maria V. Tsiper, Jennifer Sturgis, Larisa V. Avramova, Shilpa Parakh, Raymond Fatig, Ana Juan-García, Nianyu Li, Bartek Rajwa, Padma Narayanan, C. W. Wualls Jr., Joseph P. Robinson, Vincent J. Davisson
Weldon School of Biomedical Engineering Faculty Publications
Early evaluation of new drug entities for their potential to cause mitochondrial dysfunction is becoming an important task for drug development. Multi-parametric high-content screening (mp-HCS) of mitochondrial toxicity holds promise as a lead in-vitro strategy for drug testing and safety evaluations. In this study, we have developed a mp-HCS and multi-parametric data analysis scheme for assessing cell responses to induced mitochondrial perturbation. The mp-HCS measurements are shown to be robust enough to allow for quantitative comparison of biological systems with different metabolic pathways simulated by alteration of growth media. Substitution of medium glucose for galactose sensitized cells to drug action …
Monosynaptic Functional Connectivity In Cerebral Cortex During Wakefulness And Under Graded Levels Of Anesthesia,
2012
Marquette University
Monosynaptic Functional Connectivity In Cerebral Cortex During Wakefulness And Under Graded Levels Of Anesthesia, Jeannette A. Vizuete, Siveshigan Pillay, Kamran Diba, Kristina M. Ropella, Anthony G. Hudetz
Biomedical Engineering Faculty Research and Publications
The balance between excitation and inhibition is considered to be of significant importance for neural computation and cognitive function. Excitatory and inhibitory functional connectivity in intact cortical neuronal networks in wakefulness and graded levels of anesthesia has not been systematically investigated. We compared monosynaptic excitatory and inhibitory spike transmission probabilities using pairwise cross-correlogram (CCG) analysis. Spikes were measured at 64 sites in the visual cortex of rats with chronically implanted microelectrode arrays during wakefulness and three levels of anesthesia produced by desflurane. Anesthesia decreased the number of active units, the number of functional connections, and the strength of excitatory connections. …
Computational Model Of Neuron-Astrocyte Interputational Model Of Neuron-Astrocyte Interactions During Focal Seizure Generationactions During Focal Seizure Generation,
2012
CUNY City College
Computational Model Of Neuron-Astrocyte Interputational Model Of Neuron-Astrocyte Interactions During Focal Seizure Generationactions During Focal Seizure Generation, Davide Reato, Mario Cammarota, Lucas C. Parra, Giorgio Carmignoto
Publications and Research
Empirical research in the last decade revealed that astrocytes can respond to neurotransmitters with Ca2+ elevations and generate feedback signals to neurons which modulate synaptic transmission and neuronal excitability. This discovery changed our basic understanding of brain function and provided new perspectives for how astrocytes can participate not only to information processing, but also to the genesis of brain disorders, such as epilepsy. Epilepsy is a neurological disorder characterized by recurrent seizures that can arise focally at restricted areas and propagate throughout the brain. Studies in brain slice models suggest that astrocytes contribute to epileptiform activity by increasing neuronal excitability …
An Indigoidine Biosynthetic Gene Cluster From Streptomyces Chromofuscus Atcc 49982 Contains An Unusual Indb Homologue,
2012
Utah State University
An Indigoidine Biosynthetic Gene Cluster From Streptomyces Chromofuscus Atcc 49982 Contains An Unusual Indb Homologue, Dayu Yu, Fuchao Xu, Jonathan Valiente, Siyuan Wang, Jixun Zhan
Biological Engineering Faculty Publications
A putative indigoidine biosynthetic gene cluster was located in the genome of Streptomyces chromofuscus ATCC 49982. The silent 9.4-kb gene cluster consists of five open reading frames, named orf1, Sc-indC, Sc-indA, Sc-indB, and orf2, respectively. Sc-IndC was functionally characterized as an indigoidine synthase through heterologous expression of the enzyme in both Streptomyces coelicolor CH999 and Escherichia coli BAP1. The yield of indigoidine in E. coli BAP1 reached 2.78 g/l under the optimized conditions. The predicted protein product of Sc-indB is unusual and much larger than any other reported IndB-like protein. The N-terminal portion of this enzyme resembles IdgB and the …
Toe Brace Designs,
2012
Wright State University - Main Campus
Toe Brace Designs, Tarun Goswami, Allison L. Van Horn, Alexander O. Sheets
Biomedical, Industrial & Human Factors Engineering Faculty Publications
In various embodiments, provided are braces for use in supporting the metatarophalangeal joint, reducing or maintaining the intermetatarsal angle, enhancing or maintaining alignment of the hallux, or combinations thereof in a subject having hallux valgus.
An Information Architecture For Icme,
2012
Granta Design
An Information Architecture For Icme, William Marsden
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Multiscale Modeling For Material Design Of Solid Oxide Fuel Cell Electrode,
2012
The University of Tokyo
Multiscale Modeling For Material Design Of Solid Oxide Fuel Cell Electrode, Y. Umeno, S. Hara, T. Tada, N. Shikazono
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Some (Other) Uses Of Diffusion Couples In Metallurgy: Model Calibration And Mapping Transitions In Mechanisms,
2012
Department of Materials Engineering, Monash University
Some (Other) Uses Of Diffusion Couples In Metallurgy: Model Calibration And Mapping Transitions In Mechanisms, Christopher Hutchinson
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
From Genome To Flying Cyberalloys: The First Half Century,
2012
Northwestern University
From Genome To Flying Cyberalloys: The First Half Century, G. B. Olson
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
A Hybrid Computational-Experimental Approach For Automated Crystal Structure Solution,
2012
Northwestern University
A Hybrid Computational-Experimental Approach For Automated Crystal Structure Solution, Bryce Meredig, Scott Kirklin, Chris Wolverton
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Predicting Microstructure-Property Relationships In Structural Materials Via Multiscale Models Validated By In-Situ Synchrotron Observation,
2012
Manchester X-ray Imaging Facility
Predicting Microstructure-Property Relationships In Structural Materials Via Multiscale Models Validated By In-Situ Synchrotron Observation, Peter D. Lee, Lang Yuan, Chedtha Puncreobutr, S. Karagadde
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Nist Databases For Materials Research,
2012
National Institute of Standards & Technology
Nist Databases For Materials Research, T. Vanderah, Vicky Karen, Peter Linstrom, Donald Burgess
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
The Materials Project – A Public Materials Design Platform,
2012
Lawrence Berkeley National Laboratory
The Materials Project – A Public Materials Design Platform, Kristin Persson
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
New Stage Of Matnavi, Materials Database At Nims,
2012
National Institute for Materials Science
New Stage Of Matnavi, Materials Database At Nims, Toshio Ogata, Masayoshi Yamazaki
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Method And Apparatus For Utilizing Amplitude-Modulated Pulse-Width Modulation Signals For Neurostimulation And Treatment Of Neurological Disorders Using Electrical Stimulation,
2012
Kettering University
Method And Apparatus For Utilizing Amplitude-Modulated Pulse-Width Modulation Signals For Neurostimulation And Treatment Of Neurological Disorders Using Electrical Stimulation, Jeffrey Hargrove, Theodore Stokes, Mary L. Esty
Mechanical Engineering Patents
A computing device-controlled system is described for the generation of amplitude-modulated pulse-width modulation (AMPWM) signals for use in treating neurological dysfunction via cranial neurostimulation, where the AMPWM signal is specifically designed to minimize the electrical impedance of the tissues of the head. A low-frequency carrier signal is determined for the AMPWM signal by measuring EEG activity at a reference site or sites, generally corresponding with the location of suspected brain dysfunction. Carrier signal frequency is variably related to critical frequency components of the EEG power spectral density, determined from statistical analysis of amplitudes and variability, and dynamically changed as a …
Designing For Success: Developing Engineers Who Consider Universal Design Principles,
2012
University of Dayton
Designing For Success: Developing Engineers Who Consider Universal Design Principles, Kimberly Edginton Bigelow
Mechanical and Aerospace Engineering Faculty Publications
Engineers must design for a diverse group of potential users of their products; however, engineering curricula rarely include an emphasis on universal design principles. This research article details the effectiveness of a design project implemented in a first-year engineering course in an effort to raise awareness of the need for engineers to be more inclusive when designing. Students were asked to apply universal design principles to redesign an engineering laboratory to make it more usable to all, including individuals with disabilities who use the room. A representative from the university’s disability services staff, as well as individuals with first-hand experience …
Materials Design Based On Ab Initio Thermodynamics,
2012
Max Planck Institut
Materials Design Based On Ab Initio Thermodynamics, Jorg Neugebauer, Fritz Kormann, Blazej Grabowski, Tilmann Hickel, Dierk Raabe
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
