Singh Center for Nanotechnology
California Polytechnic State University, San Luis Obispo
University of Tennessee, Knoxville
University of Arkansas, Fayetteville
Iowa State University
The University of Western Ontario
University of Massachusetts Amherst
Washington University in St. Louis
Development Of An Equation To Correlate Brite Tank Temperature And Pressure To Beverage Carbonation Concentration,
2022
University of Arkansas, Fayetteville
Development Of An Equation To Correlate Brite Tank Temperature And Pressure To Beverage Carbonation Concentration, Devyn Meyer
Biological and Agricultural Engineering Undergraduate Honors Theses
The Carbo Rock-It™ is an invention created to carbonate beverages at craft breweries. One of the Carbo Rock-It’s main features is that it does not add a significant volume of undissolved gas bubbles to the brite tank in which the beverage is carbonated. This may allow temperature and pressure readings from the brite tank to be used to determine the concentration of dissolved carbon dioxide in the beverage continuously in real time. This eliminates the need for manual samplings, which could save breweries time and allow for more controlled, accurate carbonation. The goal of this project was to develop ...
Insole Fall Prevention Device,
2022
California Polytechnic State University, San Luis Obispo
Insole Fall Prevention Device, Nick M. Hughes, Andrew M. Slaboda
Biomedical Engineering
Falls among the aging population occur every single day, with 1 in every 5 resulting in some injury and 300,000 hospitalized every year with a hip fracture [1]. The most popular and effective way to mitigate these falls is through physical therapist intervention. However, with the increased popularity in telerehab, many patients at risk for falls cannot accurately convey their gait tendencies to their physical therapists from the comfort of their home or while not in direct contact with the PT. A device like an insole, implanted with force sensors, which measures different parts of a patient’s foot ...
3d Bioprinting And Implantation Of Mouse Mammary Epithelial Structures Using A Custom Accessible 3d Bioprinting Platform,
2022
Old Dominion University
3d Bioprinting And Implantation Of Mouse Mammary Epithelial Structures Using A Custom Accessible 3d Bioprinting Platform, Xavier-Lewis Palmer, Saad Jafri, Patrick C. Sachs, Robert D. Bruno
College of Engineering & Technology (Batten) Posters
Prior work has shown that our bioprinting system can reliably produce human mammary organoids and tumoroids with high precision. However, this was not previously applied to mouse models, which are also important with respect to translational research in cancer drug development. To address this, we have produced protocols for the development of in vitro structures from murine mammary epithelial and tumor cells. Additionally, we assessed the translatability of both human and murine bioprinted organoids into mouse mammary fat pads over a period of 6 weeks. Our lab found that our produced organoids are reliable, they can survive in vivo, and ...
3d Bioprinted Structures From Cells Of Non-Epithelial Mesodermal And Endodermal Lineage Using A Custom Accessible 3d Bioprinting Platform,
2022
Old Dominion University
3d Bioprinted Structures From Cells Of Non-Epithelial Mesodermal And Endodermal Lineage Using A Custom Accessible 3d Bioprinting Platform, Xavier-Lewis Palmer, Annette Berkin, Patrick C. Sachs, Robert D. Bruno
College of Engineering & Technology (Batten) Posters
Prior work within our lab has demonstrated the ability to print both murine and human mammary organoids and tumoroids in vitro that can also be reliably transplanted into a murine host for translational studies. Peripherally, this bioprinting system has also been used for 3D printing neurons, stem cells, cancer cells, and a primary cell line rich with fibroblasts, but each of these efforts were with cells of ectodermal lineage. Thus, the system's capacity for use on cells of other origins had been untested. To address this, we have now developed protocols for cells of endodermal and non-epithelial mesodermal/mesenchymal ...
Challenges Of Constructing Entrainment Map For Arbitrary Circadian Models,
2022
Colby College
Challenges Of Constructing Entrainment Map For Arbitrary Circadian Models, Yuxuan (Nelson) Wu
Honors Theses
The entrainment map, developed by Dr.Diekman and Dr.Bose, is claimed to be a 1-dimensional map that produces a better prediction for phase-locking than methods than the phase response curve for circadian models. In his paper, he constructs the entrainment map for the two-dimensional circadian model, the Novak-Tyson model, and the other two higher-dimensional circadian models. For this thesis, we concentrate on exploring if it is viable to construct the entrainment map for other circadian models that are not included in his paper: the Becker-Weimann model and the Relogio model. In addition, we discuss the challenges of constructing the ...
Quantifying And Reversing Compensatory Movements By Persons Post-Stroke In The Ambient Setting,
2021
University of Tennessee, Knoxville
Quantifying And Reversing Compensatory Movements By Persons Post-Stroke In The Ambient Setting, Aaron Miller
Doctoral Dissertations
Nearly 800,000 people in the United States suffer stroke annually. Following the onset of stroke, survivors will exhibit deficits, such as hemiplegia, which will limit their function and ability to perform activities of daily living (ADLs). In order to regain independence, many stroke survivors will employ maladaptive compensatory strategies to help with the completion of tasks. Compensation is generally defined as any performance of a task that is different than the way it may have been performed before the onset of a neurodegenerative disorder. While for some severely impaired individuals, compensation may be necessary, for most these maladaptive strategies ...
Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community,
2021
Purdue University
Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi
Purdue Journal of Service-Learning and International Engagement
Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are ...
Mixed-Reality Visualization Environments To Facilitate Ultrasound-Guided Vascular Access,
2021
The University of Western Ontario
Mixed-Reality Visualization Environments To Facilitate Ultrasound-Guided Vascular Access, Leah Groves
Electronic Thesis and Dissertation Repository
Ultrasound-guided needle insertions at the site of the internal jugular vein (IJV) are routinely performed to access the central venous system. Ultrasound-guided insertions maintain high rates of carotid artery puncture, as clinicians rely on 2D information to perform a 3D procedure. The limitations of 2D ultrasound-guidance motivated the research question: “Do 3D ultrasound-based environments improve IJV needle insertion accuracy”. We addressed this by developing advanced surgical navigation systems based on tracked surgical tools and ultrasound with various visualizations. The point-to-line ultrasound calibration enables the use of tracked ultrasound. We automated the fiducial localization required for this calibration method such that ...
Improving Healthspan Through Patient-Derived Artificial Organs From Induced Pluripotent Stem Cells And Two-Photon Polymerization,
2021
University of Pennsylvania
Improving Healthspan Through Patient-Derived Artificial Organs From Induced Pluripotent Stem Cells And Two-Photon Polymerization, Connor Espenshade
Protocols and Reports
Senescence, from the shortening of telomeres, accumulation of mutations, epigenetic hypomethylation, and other causes, begins an eventual cycle of decline in every patient. Stem cells disappear as a function of age, which in turn impairs cellular replication. Moreover, when fully differentiated cells are induced back into induced pluripotent stem cells (iPSCs), they not only revert to a state of pre-differentiation, but also to a younger cellular age. Their aging clocks turn back: their telomeres become longer and DNA methylation reverts back to an earlier age. It should therefore be possible to use iPSCs to replace the missing stem cells from ...
Dimensionality Reduction For Classification Of Object Weight From Electromyography,
2021
Chapman University
Dimensionality Reduction For Classification Of Object Weight From Electromyography, Elnaz Lashgari, Uri Maoz
Psychology Faculty Articles and Research
Electromyography (EMG) is a simple, non-invasive, and cost-effective technology for measuring muscle activity. However, multi-muscle EMG is also a noisy, complex, and high-dimensional signal. It has nevertheless been widely used in a host of human-machine-interface applications (electrical wheelchairs, virtual computer mice, prosthesis, robotic fingers, etc.) and, in particular, to measure the reach-and-grasp motions of the human hand. Here, we developed an automated pipeline to predict object weight in a reach-grasp-lift task from an open dataset, relying only on EMG data. In doing so, we shifted the focus from manual feature-engineering to automated feature-extraction by using pre-processed EMG signals and thus ...
Development Of A Wireless Telemetry Load And Displacement Sensor For Orthopaedic Applications,
2021
The University of Western Ontario
Development Of A Wireless Telemetry Load And Displacement Sensor For Orthopaedic Applications, William Anderson
Electronic Thesis and Dissertation Repository
Due to sensor size and supporting circuitry, in vivo load and deformation measurements are currently restricted to applications within larger orthopaedic implants. The objective of this thesis is to repurpose a commercially available low-power, miniature, wireless, telemetric, tire-pressure sensor (FXTH87) to measure load and deformation for future use in biomechanical applications. The capacitive transducer membrane of the FXTH87 was modified, and a relationship was reported between applied compressive deformation and sensor signal value. The sensor package was embedded within a deformable enclosure to illustrate potential applications of the sensor for monitoring load. Finite element analysis was an effective tool to ...
Developing A Lab-Scale Fluidized Bed Dryer System To Enhance Rough Rice Drying Process,
2021
University of Arkansas, Fayetteville
Developing A Lab-Scale Fluidized Bed Dryer System To Enhance Rough Rice Drying Process, Kaushik Luthra
Graduate Theses and Dissertations
For more than half of the world's population, rice (Oryza sativa L.) is a staple meal. However, rice growers encounter difficulties supplying this demand, particularly in developing nations, where rice is susceptible to spoilage if the moisture content is not lowered to a safe level soon after harvest. As a result, traditional drying methods, such as sun drying and natural air drying, are commonly used by rice growers, particularly in underdeveloped nations. However, these procedures are time-consuming and can lead to rice spoilage. On the other hand, fluidized bed drying is a well-established technology that might give rice growers ...
Synthesis And Performance Testing Of Ecm Fiber Scaffolds,
2021
University of Arkansas, Fayetteville
Synthesis And Performance Testing Of Ecm Fiber Scaffolds, Cassandra Reed
Graduate Theses and Dissertations
The progression of regenerative medicine has advanced the treatment of multiple illnesses and injuries throughout the years. A good example of the benefits of this research is the work that has gone into volumetric muscle loss (VML), where more than 20% of the muscle is loss. Skeletal muscle makes up 40% of the human body so a loss of that size greatly diminishes the strength, the flexibility, physiology, and quality of life of the injured individual. For that reason, various techniques are used to counteract the loss of structure and innate cellular signaling in order to circumvent that from happening ...
Microfluidic Electrical Impedance Spectroscopy System Automation And Characterization,
2021
California Polytechnic State University, San Luis Obispo
Microfluidic Electrical Impedance Spectroscopy System Automation And Characterization, Keaton Frahmann
Master's Theses
In this work, a novel microfluidic cell culture platform capable of automated electrical impedance measurements and immunofluorescence and brightfield microscopy was developed for further in-vitro cellular research intended to optimize cell culture conditions. The microfluidic system design, fabrication, automation, and design verification testing are described. Electrical and optical measurements of the 16 parallel cell culture chambers were automated via a custom LabView interface. A proposed design change will enable gas diffusion, removing the need for an environmental enclosure and allow long-term cell culture experiments. This "lab on a chip" system miniaturizes and automates experiments improving testing throughput and accuracy while ...
Portable Ventilator,
2021
California Polytechnic State University, San Luis Obispo
Portable Ventilator, Bradley C. Weeks, Jack W. Brewer, Sanders Sanabria
Electrical Engineering
The current COVID-19 pandemic has heavily impacted the healthcare system in the United States and elsewhere. The need for patients to have access to a hospital with a ventilator along with a shortage of ventilators for recovery and at-home care as a result of minimal hospital vacancy for patients has been greatly stressed. The presented problem is both an unmet demand and supply of portable and effective ventilators. Existing ventilators have many shortcomings that should be addressed: size, weight, cost, and complexity of current ventilators confines users to stay in a medical facility whilst being monitored by professionals. This both ...
Development Of An Integrated Salt Cartridge-Reverse Electrodialysis (Red) Device To Increase Electrolyte Concentrations Of Human Blood Flow To Power Biomedical Devices,
2021
University of Arkansas, Fayetteville
Development Of An Integrated Salt Cartridge-Reverse Electrodialysis (Red) Device To Increase Electrolyte Concentrations Of Human Blood Flow To Power Biomedical Devices, Caroline Campbell
Chemical Engineering Undergraduate Honors Theses
Emerging technologies in nanotechnology and biomedical sciences have led to an increase in biomedical implantable devices including cardiac pacemakers, artificial organs, drug pumps, and sensors. These devices require continuous stable and reliable power to operate, which creates the demand for the need to find a safe, reliable, and stable power source. A promising avenue for a power source for these devices is a miniaturized reverse electrodialysis (RED) biopower cell design that utilizes the salinity differences between bloodstreams that flow inside the human body. Initial results of the RED system demonstrate that higher gradient salinity differences between streams lead to a ...
Design Of Control Logic And The Human-Machine Interface For A Demonstration Plant Growth Chamber Implemented On A Programmable Logic Controller,
2021
University of Arkansas, Fayetteville
Design Of Control Logic And The Human-Machine Interface For A Demonstration Plant Growth Chamber Implemented On A Programmable Logic Controller, Rachael Koehler
Biological and Agricultural Engineering Undergraduate Honors Theses
This honors thesis covers the planning, development, and implementation of system controls and human-machine interface (HMI) for a demonstration plant growth chamber. The work is a continuation of an ongoing project to be used as an educational and recruiting tool manifesting the skills acquired from the Biological and Agricultural Engineering Department at the University of Arkansas’ College of Engineering. This work includes emergency controls, overall design interface, and controls for both the aeration and lighting subsystems of the growth chamber. Overall design interface controls established included development of two user modes, Administrator and Visitor. The Administrator user will have full ...
Development Of A Real-Time Single-Lead Single-Beat Frequency-Independent Myocardial Infarction Detector,
2021
Florida International University
Development Of A Real-Time Single-Lead Single-Beat Frequency-Independent Myocardial Infarction Detector, Harold Martin
FIU Electronic Theses and Dissertations
The central aim of this research is the development and deployment of a novel multilayer machine learning design with unique application for the diagnosis of myocardial infarctions (MIs) from individual heartbeats of single-lead electrocardiograms (EKGs) irrespective of their sampling frequencies over a given range. To the best of our knowledge, this design is the first to attempt inter-patient myocardial infarction detection from individual heartbeats of single-lead (lead II) electrocardiograms that achieves high accuracy and near real-time diagnosis. The processing time of 300 milliseconds to a diagnosis is just at the time range in between extremely fast heartbeats of around 300 ...
The Tierni Resistance Training System,
2021
California Polytechnic State University, San Luis Obispo
The Tierni Resistance Training System, Michael J. Hansen, Abigail M. Youngblood, Gabriel M. Johnson
Biomedical Engineering
The purpose of the Tierni Resistance Training System project was to design and construct functional workout apparel that has built-in resistance. For this product, the key customer requirements we set out to address were most importantly material comfort and functionality, followed by stylishness, lack of latex, safety for injured and uninjured users, and washer safety. To meet these customer requirements, we started by researching current resistance training technology, and used the findings as a springboard for our own design development. After initial brainstorming, engineering specifications were generated based on the customer requirements. These specifications revolved around the thermal insulation, pressure ...
How To Cleave Wafers: Latticegear Protocol,
2021
Singh Center for Nanotechnology
How To Cleave Wafers: Latticegear Protocol, Shenshen Wan, George Patrick Watson
Protocols and Reports
We report on the process protocol to cleave wafers using LatticeGear cleaving and scribing tools sets.
