Biomaterials Commons^™

Biomimetic Cellulose-Based Biocomposites, Zion Michael

2022 MME Undergraduate Research Symposium

Biological structures such as termite nests, silk worm cocoons and honey bee combs integrate material, structure and form to produce biodegradable polymers and composites. Synthetic production of biomaterials through additive or woven processes has failed to achieve comparable material properties to their natural counterparts. For example, cellulose-based biocomposites have markedly less strength and toughness than cellulose micro and nanofibers found in nature. Termites produce a cellulose-based composite called “Carton” which serves as construction material for their nests. The process by which termites produce Carton is similar to the manufacturing process for electrospun cellulose fibers. Studying how termites produce Carton, a ...

Synthesis Of Alginate/Hydroxyapatite Beads For Acetaminophen Delivery, Anesylvia Angan, Nonni Soraya Sambudi

Makara Journal of Science

Conventional drug delivery systems usually involve the intake of multiple drugs, which could amplify the risk of overdosing. Acetaminophen is a widely used pain relief substance that is prone to accidental overdosing. Hence, a controlled drug delivery system is needed to ensure its efficacy. A nanocomposite hydroxyapatite/alginate system that was used as a drug carrier for acetaminophen was synthesized through the sol-gel method, and the mechanism underlying its controlled drug delivery was investigated. Spherical nanocomposite bead samples were synthesized by incorporating 5 wt%, 10 wt%, and 15 wt% hydroxyapatite into mixtures containing alginate. The mixtures were then dropped into ...

The Influence Of Processing And Additives On Cellulose Nanofiber Properties For Orthopedic Application, Mitchell P. Chesley

Electronic Theses and Dissertations

Current orthopedics are separated into three different classes of materials, metals, polymers, and ceramics. While these devices have had success throughout the years they are not without their faults. Metallic devices for example are usually extraordinarily stiff when compared with the surrounding bone. This difference in stiffness induces localized stress-shielding promoting cortical atrophy, which can lead to osteoporosis. Polymers while having the capacity of being biodegradable and bioabsorbable also have the potential to incite localized demineralization and weakness in surrounding bone. A result of breakdown byproducts not efficiently being evacuated from the area, which additionally acts as catalysts expediating the ...

Developing And Characterizing A Novel Tempo Cnf Hydrogel Adjuvant And Delivery System For Aquatic Vaccines, Kora Kukk

Electronic Theses and Dissertations

Aquaculture is a large part of the food production sector which is greatly expanding. One of the largest losses in aquaculture is due to pathogens. Current solutions for protecting farmed finfish from pathogens can be very expensive with variable efficiency. Current disease prevention strategies include vaccination. Types of vaccines include immersion vaccines, feed vaccines, and injectable vaccines. The most popular solution is oil-based injectable vaccines due to its protection. However, the oil-based adjuvant used in most of these formulations causes adverse reactions in the fish including reduced growth. These vaccines require multiple administrations throughout the fish’s lifetime causing unwanted ...

Continuous, Non-Destructive Detection Of Surface Bacterial Growth With Bioinspired Vascularized Polymers, Brandon Dixon

Electronic Theses and Dissertations

Reducing or eliminating bacteria on surfaces is vital for medical devices, drinking water quality, and industrial processes. Evaluating surface bacterial growth at buried interfaces can be problematic due to the time-consuming disassembly process required for obtaining standard surface samples. In this work, a continuous, non-destructive, and reusable method was developed to detect surface bacterial growth at buried interfaces. Inspired by vascular systems in nature that permit chemical communication between the surface and underlying tissues of an organism, bacterial-specific signals diffusing from cells on the surface were detected in channels filled with an inert carrier fluid embedded in a polymer matrix ...

Tissue-Engineered Living Pulmonary Valve For Young Adult Patients, Erica Hoskins

All Theses

Cardiovascular disease (CVD) is a non-communicable disease responsible for 659,000 deaths annually in the United States. While CVD can affect all components of the cardiovascular system, heart valve disease is responsible for 25,000 deaths yearly. Of specific interest is the pulmonary valve since there is limited research on resolving pathologies that affect it. Like the aortic and mitral valves, common pathologies include stenosis, regurgitation, and atresia. Notably, the pulmonary valve requires repair and replacement in pediatric patients and young adults due to congenital disabilities. Even with technological advances in valve replacements, limitations still present themselves for use with ...

Fabrication And Non-Covalent Functionalization And Characterization Of Graphene-Based Devices On Novel Substrate Cadmium Trithiophosphate (Iv) — Cdps, Abayomi Omotola Omolewu

Graduate Theses and Dissertations

With graphene at the center of several application areas such as sensing, circuits, high-frequency devices for communication systems, etc., it is crucial to understand how the intrinsic properties of devices made from graphene and other materials like platinum and palladium nanoparticles affect the performance of such devices for the specific application area. Many graphene-based devices for different application areas have focused mainly on the material composition of the graphene-based devices and how it affects performance parameters for the specific application. However, it would be insightful to understand how the intrinsic electrical properties of the graphene devices for different applications affect ...

Development Of A Decellularized Hydrogel Composite And Its Application In A Novel Model Of Disc-Associated Low Back Pain In Female Sprague Dawley Rats, David Lillyman

Biological Systems Engineering--Dissertations, Theses, and Student Research

Chronic low back pain is a global socioeconomic crisis compounded by an absence of reliable, curative treatments. The predominant pathology associated with chronic low back pain is degeneration of intervertebral discs in the lumbar spine. During degeneration, nerves can sprout into the intervertebral disc tissue and be chronically subjected to inflammatory and mechanical stimuli, resulting in pain. Pain arising from the intervertebral disc, or disc-associated pain, is a complex, multi-faceted disorder which necessitates valid animal models to screen therapeutics and study pathomechanisms of pain.

While many research teams have created animal models of disc degeneration, the translation of these platforms ...

Motion And Crosslinked Polyethylene Wear In Reverse Total Shoulder Arthroplasty, Christopher Millward

Electronic Thesis and Dissertation Repository

The reverse total shoulder arthroplasty (RTSA) has quickly grown to become the most commonly used shoulder arthroplasty design; however, reports have shown evidence of RTSA failures related to polyethylene wear and damage. Therefore, the present work investigated the wear of crosslinked polyethylene (XLPE) in environments similar to that of an in vivo RTSA. Additionally, a computational model was developed based on a previous study of the shoulder motions obtained from a selection of typical patients with RTSA. This model quantified the amount of glenohumeral motion that an RTSA may be subjected to in vivo and provided an approximate value for ...

Tensile Testing Of 3d Printed Tpu Samples For Pediatric Biomaterial Applications, Sheridan C. Perry, Rodriguez M. Rafael, Victor Huayamave, Bryan M. Gonzalez, Kim Dae-Won, Zachary R. Nadeau

PanaSoMM

Additive Manufacturing (AM) has, in recent years, become one of the most widespread and preferred prototyping methods. The most popular additive manufacturing method is Fused Deposition Modeling. FDM’s popularity is primarily attributed to its 3 major strengths of rapid prototyping, variability in material choice, and subject specific nature. The medical industry is one of the larger industries that has benefited from 3D printing especially in the terms of medical trainers. Unfortunately, most medical trainers that are developed (either being 3d printed or through traditional manufacturing processes) are poor substitutes for the human body. This can be attributed to either ...

Eagle Medical Tray Denesting & Debris Removal Process, Nicholas Allen Ungefug, Noah Chavez, Susana Shu-Lin Okhuysen, Michael Augustine Pennington

Industrial and Manufacturing Engineering

Eagle Medical Incorporated is a contract medical device packaging and sterilization company. The company purchases thermoformed medical packaging trays, which maintain the sterility of medical devices, from various manufacturers. To ensure packaging quality and to prevent cleanroom contamination, Eagle Medical inspects and sterilizes each blister tray that they order. This process is an essential non-value-added activity that creates a bottleneck. Cleanroom employees must stop packaging medical devices and attend to the processing of blister trays and packaging solutions. The blister trays arrive at Eagle’s facility in nested stacks. Vibration and movement during shipping further compresses the stacks, which makes ...

Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner

Honors Theses

Crutches are a mobility assistive device that are often used in various situations, such as post- surgical rehabilitation and recovery after injury. The current crutch tip design that is used on today’s crutches are often unstable and do not provide quality movement on different terrains, such as snow, ice, mud, and wet surfaces. These problems would be solved with a new tip design that could be attached to existing crutches or manufactured with the crutch itself. The team’s solution to this problem is a crutch tip with modular parts. The tip would attach to the shaft of the ...

Rheological Behavior Of Dspc-, Dbpc-, And Dppc-Oxygen Microbubbles And Their Effectiveness In Improving Survival In A Rat Model Of Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome, Riaz Ur Rehman Mohammed

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Acute respiratory distress syndrome (ARDS) causes 75,000 deaths in the U.S., annually. It is characterized by hypoxemia and damage to the lung alveoli. ARDS Management strategies involve extracorporeal membrane oxygenation (ECMO) and mechanical ventilation, but none of these methods improve the mortality rates. Oxygen microbubbles (OMBs) consist of a lipid shell with an oxygen core and have potential to augment oxygenation to manage ARDS. Previous studies demonstrated significant improvements in systemic oxygenation and mortality upon administering OMBs.

We replicated an ARDS rat model by intratracheal administration of lipopolysaccharide at a 24 mg/kg dose. After inducing the disease ...

Synthesis Of Monodisperse Nanoscintillators At High Temperatures For Biomedical Relevant Applications, Eric Zhang

All Dissertations

Luminescent sub-100 nm particulates continuously generate immense research interest in the biomedical field for imaging, theranostics, and optogenetics. Conventionally, upconversion nanoparticles or UV activated semiconductors are studied, however these materials are limited by biological barriers such as the skin which reduces the penetration depth of these excitation sources, tissue's auto- fluorescence, and toxicity. One approach to overcome these challenges is to use nanoscintillators (sub-100 nm materials that can generate visible light using high energy excitation sources such as x-rays) which can generate light locally to the human body. Numerous scintillators have been reported since the discovery of x-rays from ...

Study Of Porosity Of Gelatin-Alginate Hydrogels To Model Brain Matter For Studying Traumatic Brain Injuries, Apolline Vincent

Honors Scholar Theses

Traumatic brain injuries (TBIs) affect brain tissue and neuronal signaling, leading to many side effects including death. Research on TBIs is limited by the lack of accurate brain matter models to study the physiological and cellular reaction. Alginate-gelatin hydrogels have been designed and modified to mimic the mechanical properties of the brain to act as an accurate in vitro model. This Honors thesis aims to verify the porous microstructure of gelatin-alginate hydrogels through Scanning Electron Microscopy (SEM) to understand how gelatin and alginate affect the microstructure. I measured the pore sizes of each hydrogel using ImageJ, compared the average pore ...

Exploring The Effects Of Varied Land Use On Elemental Concentrations Within Streams, Logan Jennings

Biological and Agricultural Engineering Undergraduate Honors Theses

It is well documented that human activity influences the chemistry of surrounding waters. As such, it is possible that there is a link between land use within a watershed and the chemical composition of the stream. The objectives of this study are to determine if varied land use does affect the concentrations of macronutrients and trace elements present in the streams of Northwest Arkansas, and if so, to determine what extent urban and agricultural development are responsible for these changes. Water samples were collected across 19 streams in the Northwest Arkansas region between January and March of 2022. Water samples ...

Drug-Facilitated Sexual Assault At The University Of Arkansas, Barrett Weidman

Chemical Engineering Undergraduate Honors Theses

This work was written to fulfill two main purposes. First, to help survivors of Drug-Facilitated Sexual Assault (DFSA) process their experience by compiling the toxicological, pharmacological, and distribution of the three most used date-rape drugs. Second, to gauge the knowledge and interest of University of Arkansas students regarding drug impairments, sexual assault education, and bystander intervention training. A survey was conducted for the latter and revealed that 91.6% of students believe the University’s existing sexual assault prevention education and bystander intervention training have room for improvement. Also, 37.1% of students who have received this education report that ...

Single Asperity Fretting Corrosion Of Traditional And Additively Manufactured Metallic Biomaterials: Quantitative Analysis From Acetabular Tapers To Micron And Nanometer Scale Tribocorrosion, Annsley Mace

All Dissertations

Mechanically assisted crevice corrosion (MACC) of metallic biomaterials continues to be a significant degradation mode. This is, in part, due to a lack of understanding of fundamental micron- and sub-micron scale mechanisms of metal degradation in biological environments. Metal-metal (or metal-hard) load bearing surfaces of hip arthroplasties are subjected to fretting crevice corrosion (FCC, one form of MACC). Current work in tribocorrosion involves large contact area tests with multiple asperities, with a distribution of load and wear that changes over time. A more systematic and controlled study of the FCC micro- and nanomechanics is needed.

Therefore, the goal of this ...

Insect Antennae As Bioinspirational Superstrong Fiber-Based Microfluidics, Griffin J. Donley

All Theses

Nature is frequently turned to for inspiration for the creation of new materials. Insect antennae are hollow, blood-filled fibers with complex shape, and are cantilevered at the head. The antenna is muscle-free, but the insect can controllably flex, twist, and maneuver it laterally. To explain this behavior, a comparative study of structural and tensile properties of the antennae of Periplaneta americana (American cockroach), Manduca sexta (Carolina hawkmoth), and Vanessa cardui (painted lady butterfly) was performed. These antennae demonstrate a range of distinguishable tensile properties, responding either as brittle fibers (Manduca sexta) or strain-adaptive fibers that stiffen when stretched (Vanessa cardui ...

Insole Fall Prevention Device, Nick M. Hughes, Andrew M. Slaboda

Biomedical Engineering

Falls among the aging population occur every single day, with 1 in every 5 resulting in some injury and 300,000 hospitalized every year with a hip fracture [1]. The most popular and effective way to mitigate these falls is through physical therapist intervention. However, with the increased popularity in telerehab, many patients at risk for falls cannot accurately convey their gait tendencies to their physical therapists from the comfort of their home or while not in direct contact with the PT. A device like an insole, implanted with force sensors, which measures different parts of a patient’s foot ...