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Design And Control Of A Peristaltic Pump To Simulate Left Atrial Pressure In A Conductive Silicone Model, Jeremy Collins 2021 University of Arkansas, Fayetteville

Design And Control Of A Peristaltic Pump To Simulate Left Atrial Pressure In A Conductive Silicone Model, Jeremy Collins

Mechanical Engineering Undergraduate Honors Theses

According to the CDC, atrial fibrillation is responsible for more than 454,000 hospitalizations and approximately 158,000 deaths per year. A common treatment for atrial fibrillation is catheter ablation, a process in which a long flexible tube is guided through the femoral artery and to the source of arrhythmia in the heart, where it measures the electrical potential at various locations and converts problematic heart tissue to scar tissue via ablation. This paper details the design and control of a low-cost ($400) peristaltic pump system using repetitive control to replicate blood pressure in the left atrium in a conductive ...


Immunomodulatory Biomaterials For Cancer Immunotherapy, Larry Donnell Stokes Jr 2021 University of Mississippi

Immunomodulatory Biomaterials For Cancer Immunotherapy, Larry Donnell Stokes Jr

Honors Theses

Cancer immunotherapy has become an effective treatment in the toolbox of oncologists. Immunotherapy offers a less toxic alternative to standard cancer treatments such as chemotherapy and can have prolonged curative effects to decrease cancer recurrence. Today, many drugs and biological agents have been developed that target the immune system and elicit an antitumor/cancer response. These agents are known collectively as cancer immunotherapies. While immunotherapies have radically improved treatment outcomes for many cancer patients, there are drawbacks to using these treatments. Immunotherapy treatments have poor clinical responses in patients with tumors that lack immunogenicity. Some of the treatments also pose ...


Catechol-Containing Copolymers As An Active Ingredient For Denture Adhesives, Vincent Ying Wun Kong 2021 The University of Western Ontario

Catechol-Containing Copolymers As An Active Ingredient For Denture Adhesives, Vincent Ying Wun Kong

Electronic Thesis and Dissertation Repository

Moisture inside the mouth adds challenge to making denture adhesives formulations. Some formulations have zinc to enhance adhesion on wet skin despite knowing the health hazards. Inspired by mussel foot proteins’ catechol unit’s strong underwater adhesion, nine catechol-containing copolymers (P1A-P3C) were synthesized by free radical polymerization of 3,4-dimethoxystyrene (3,4- DMS) with different styrene derivatives followed by deprotection. P1A-P3C were used to make Fn(P)-C-PBS denture adhesive formulations which had suitable shear stresses around ≥ 5 kPa satisfying ISO 10873. In-situ NMR studies of free radical polymerization of 3,4 - DMS and styrene derivatives allowed computation of their ...


Surface-Eroding Drug Delivery Films For Sequential And/Or Intermittent Release Of Psychoactive Drugs, Jason Price 2021 University of Mississippi

Surface-Eroding Drug Delivery Films For Sequential And/Or Intermittent Release Of Psychoactive Drugs, Jason Price

Honors Theses

ABSTRACT JASON BLAKE PRICE: Surface-Eroding Drug Delivery Films for Sequential and/or

Intermittent Release of Psychoactive Drugs For patients with psychiatric diseases, adherence to medication schedules, medication

errors, and abuse are common issues. Promising new forms of therapy for these patients, such as micro-dosed lysergic acid diethylamide (LSD), where patients receive 10-20% of a full dose every third day, present further drug delivery challenges. Sequential or intermittent release of drugs from an implanted device could ensure long-term drug compliance, automate drug dosing during the life of the implant, and eliminate potential for abuse and medication errors. To this end, we ...


Protein-Assisted Scalable Mechanochemical Exfoliation Of Few-Layer Biocompatible Graphene Nanosheets, Deepak-George Thomas, Steven De-Alwis, Shalabh Gupta, Vitalij K. Pecharsky, Deyny Mendivelso-Perez, Reza Montazami, Emily A. Smith, Nicole N. Hashemi 2021 Iowa State University

Protein-Assisted Scalable Mechanochemical Exfoliation Of Few-Layer Biocompatible Graphene Nanosheets, Deepak-George Thomas, Steven De-Alwis, Shalabh Gupta, Vitalij K. Pecharsky, Deyny Mendivelso-Perez, Reza Montazami, Emily A. Smith, Nicole N. Hashemi

Mechanical Engineering Publications

A facile method to produce few-layer graphene (FLG) nanosheets is developed using protein-assisted mechanical exfoliation. The predominant shear forces that are generated in a planetary ball mill facilitate the exfoliation of graphene layers from graphite flakes. The process employs a commonly known protein, bovine serum albumin (BSA), which not only acts as an effective exfoliation agent but also provides stability by preventing restacking of the graphene layers. The latter is demonstrated by the excellent long-term dispersibility of exfoliated graphene in an aqueous BSA solution, which exemplifies a common biological medium. The development of such potentially scalable and toxin-free methods is ...


Fibrin-Based Engineered Vascular Tissues As Platforms For Cellular Studies And Disease Modeling, Khalil Dayekh 2021 The University of Western Ontario

Fibrin-Based Engineered Vascular Tissues As Platforms For Cellular Studies And Disease Modeling, Khalil Dayekh

Electronic Thesis and Dissertation Repository

Vascular tissue engineering (VTE) is an emerging alternative therapeutic intervention strategy to treat diseases such as atherosclerosis. While the ultimate goal of VTE is designing tissues to serve as graft substitutes, they can also serve as powerful tools to study tissue and disease development and drug discovery.

In this work, engineered vascular tissues from fibrin gel, mouse embryonic multipotent progenitor cell line (10T1/2 cells), and rat embryonic thoracic artery smooth muscle cells (A-10 cells) were used as models to study the Notch signaling pathway and vascular calcification. The 10T1/2 cells were successfully differentiated into vascular smooth muscle cells ...


Optimization Of Bilayer Lift-Off Process To Enable The Gap Size Of 1Μm Using Lor 3a And S1813, Yeonjoon Suh, George Patrick Watson 2021 Singh Center for Nanotechnology

Optimization Of Bilayer Lift-Off Process To Enable The Gap Size Of 1Μm Using Lor 3a And S1813, Yeonjoon Suh, George Patrick Watson

Protocols and Reports

Bilayer lift-off process for 1μm feature size is demonstrated using LOR 3A and S1813 photoresist. The thickness of photoresists was fixed, whereas development time is varied. The process was further investigated by measuring the undercut depth and undercut rate by scanning electron microscopy. An optimized and reproducible recipe is provided.


Trabecular Bone Organoid Model For Studying The Regulation Of Localized Bone Remodeling, Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, Jungwoo Lee 2021 University of Massachusetts Amherst

Trabecular Bone Organoid Model For Studying The Regulation Of Localized Bone Remodeling, Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, Jungwoo Lee

Open Access Publications by UMMS Authors

Trabecular bone maintains physiological homeostasis and consistent structure and mass through repeated cycles of bone remodeling by means of tightly localized regulation. The molecular and cellular processes that regulate localized bone remodeling are poorly understood because of a lack of relevant experimental models. A tissue-engineered model is described here that reproduces bone tissue complexity and bone remodeling processes with high fidelity and control. An osteoid-inspired biomaterial-demineralized bone paper-directs osteoblasts to deposit structural mineralized bone tissue and subsequently acquire the resting-state bone lining cell phenotype. These cells activate and shift their secretory profile to induce osteoclastogenesis in response to chemical stimulation ...


Pandemic Healthcare: Face Shield Modification, Nathan Giunto, Sefra Manos, Brandon Ross, Catherine Seno, Catherine Howell 2021 The University of Akron

Pandemic Healthcare: Face Shield Modification, Nathan Giunto, Sefra Manos, Brandon Ross, Catherine Seno, Catherine Howell

Williams Honors College, Honors Research Projects

Current face shields used in home and institutional healthcare settings create hardships for their wearers, which makes normal work routines more difficult. Recent mandates require healthcare workers to wear both surgical masks as well as plastic face shields when tending to patients. Unfortunately, the majority of face shields have been designed for hospital settings, which does not address the specific requirements for in-home therapist use. Some of the issues include their restrictive size, tendency to fog, susceptibility to glare, and sterilization and re-use issues. Our team proposes to design a face shield for homecare occupational therapists that addresses their unique ...


Controlled Membrane Remodeling By Nanospheres And Nanorods: Experiments Targeting The Design Principles For Membrane-Based Materials, Sarah Zuraw-Weston 2020 University of Massachusetts Amherst

Controlled Membrane Remodeling By Nanospheres And Nanorods: Experiments Targeting The Design Principles For Membrane-Based Materials, Sarah Zuraw-Weston

Doctoral Dissertations

In this thesis we explore two experimental systems probing the interactions of nanoparticles with lipid bilayer membranes. Inspired by the ability of cell membranes to alter their shape in response to bound particles, we report two experimental studies: one of nanospheres the other of long, slender nano-rods binding to lipid bilayer vesicles and altering the membrane shape. Our work illuminates the role of particle geometry, particle concentration, adhesion strength and membrane tension in how membrane morphology is determined. We combine giant unilamellar vesicles with oppositely charged nanoparticles, carefully tuning adhesion strength, membrane tension and particle concentration.

In the case of ...


Micro-Physiological Models To Mimic Mucosal Barrier Complexity Of The Human Intestine In Vitro, Abhinav Sharma 2020 University of Massachusetts Amherst

Micro-Physiological Models To Mimic Mucosal Barrier Complexity Of The Human Intestine In Vitro, Abhinav Sharma

Doctoral Dissertations

The mucosal barrier in the intestine is vital to maintain selective absorption of nutrients while protecting internal tissues and maintaining symbiotic relationship with luminal microbiota. This bio-barrier consists of a cellular epithelial barrier and an acellular mucus barrier. Secreted mucus regulates barrier function via in situ biochemical and biophysical interaction with luminal content that continually evolves during digestion and absorption. Increasing evidence suggests that a mucus barrier is indispensable to maintain homeostasis in the gastrointestinal tract. However, the importance of mucus barrier is largely underrated for in vitro mucosal tissue modeling. The major gap is the lack of experimental material ...


The Effects Of Solution Condition On Virus Filtration Performance, Fnu Namila 2020 University of Arkansas, Fayetteville

The Effects Of Solution Condition On Virus Filtration Performance, Fnu Namila

Theses and Dissertations

Virus filtration is an integral part of the downstream purification of mammalian cell culture-derived biotherapeutics to assure the viral safety of the products. Virus filtration membranes remove viruses based on a size-exclusion mechanism. Commercial parvovirus filers possess unique membrane structure and are designed to remove smaller non-enveloped parvoviruses with size 18-26 nm. However, some filters face issues, such as pre-mature fouling, the decline of filtrate flux, and reduction in virus retention. This doctoral dissertation focused on identifying the factors that influence the filtrate flux and the virus retention capability of commercial virus filters. The effects of solution pH and ionic ...


A Note From The Editor, Daphne Fauber 2020 Purdue University

A Note From The Editor, Daphne Fauber

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

This piece is a letter from Daphne Fauber, the editor of this issue of Ideas. In the letter, the editor introduces the work of Dr. Paschalis Gkoupidenis as well as the moment in time in which his Visiting Scholars talk occurs.


Mineralization Of Biomaterials For Bone Tissue Engineering, Xinchen Wu, Kierra Walsh, Brianna L. Hoff, Gulden Camci-Unal 2020 University of Massachusetts Lowell

Mineralization Of Biomaterials For Bone Tissue Engineering, Xinchen Wu, Kierra Walsh, Brianna L. Hoff, Gulden Camci-Unal

Open Access Publications by UMMS Authors

Mineralized biomaterials have been demonstrated to enhance bone regeneration compared to their non-mineralized analogs. As non-mineralized scaffolds do not perform as well as mineralized scaffolds in terms of their mechanical and surface properties, osteoconductivity and osteoinductivity, mineralization strategies are promising methods in the development of functional biomimetic bone scaffolds. In particular, the mineralization of three-dimensional (3D) scaffolds has become a promising approach for guided bone regeneration. In this paper, we review the major approaches used for mineralizing tissue engineering constructs. The resulting scaffolds provide minerals chemically similar to the inorganic component of natural bone, carbonated apatite, Ca5(PO4,CO3)3 ...


Evaluation Of Hyaluronic Acid To Modulate Oral Squamous Cell Carcinoma Growth In Vitro, Jordan Ringer, Bryan Morrison, Karl Kingsley 2020 University of Nevada, Las Vegas

Evaluation Of Hyaluronic Acid To Modulate Oral Squamous Cell Carcinoma Growth In Vitro, Jordan Ringer, Bryan Morrison, Karl Kingsley

Dental Medicine Faculty Publications

© 2020 MDPI AG. All rights reserved. Introduction: Previous studies have demonstrated that glycosaminoglycan hyaluronic acid (HA) is capable of mediating oral tumor growth. Some clinical evidence has suggested reduced HA expression predicts poor cancer prognosis and that HA-chemotherapy conjugates may function synergistically to inhibit oral tumor growth. Other studies have found conflicting results that suggest enhanced CD44-HA-mediated growth and proliferation. Due to the lack of clarity regarding HA function, the primary goal of this study was to investigate the effects of HA using well-characterized oral cancer cell lines. Methods: Using several commercially available oral squamous cell carcinoma lines (and a ...


Optimal Parameter Values For Accurate And Repeatable Nanoindentation Of Human Trabecular Bone, Stephen Matthew Kmak 2020 California Polytechnic State University, San Luis Obispo

Optimal Parameter Values For Accurate And Repeatable Nanoindentation Of Human Trabecular Bone, Stephen Matthew Kmak

Master's Theses

Nanoindentation techniques have not been standardized for use on bone tissues, making comparison of bone material properties obtained via nanoindentation across studies difficult and unreliable. This study determined a set of optimal parameter values for thermal drift correction time, dwell time, and loading rate that can be used to obtain accurate and repeatable material properties from human femoral trabecular bone through experimentation and statistical analysis. All testing was conducted using a single nanoindenter on a single trabeculae, with the assumption that material properties within the individual trabeculae were internally consistent. Parameters not of interest during this study, such as ambient ...


Designing Silk Protein-Based Composite Materials With Tunable Heat Transfer And Magnetic Properties, Ye Xue 2020 Rowan University

Designing Silk Protein-Based Composite Materials With Tunable Heat Transfer And Magnetic Properties, Ye Xue

Theses and Dissertations

Renewable and biocompatible silk protein materials with desired physical properties show promising applications in biomedical field. In this work, a set of protein-based composites with desired thermal and magnetic properties, enhanced by the appropriate distribution of nanofillers in the protein matrix in both 2D-film and 1D-fiber forms was investigated. Results indicate that secondary structures of silk protein materials regenerated by a formic acid-calcium chloride method are different from those of their respective natural silk fibers. Intramolecular beta-sheet structures were found to dominate these silk films, causing these regenerated samples to be water-insoluble but more flexible than traditional silk films with ...


3d Culture Strategies For The Dynamic Expansion And Preconditioning Of Adipose-Derived Stromal Cells On Decellularized Adipose Tissue Bioscaffolds, Tim Tian Han 2020 The University of Western Ontario

3d Culture Strategies For The Dynamic Expansion And Preconditioning Of Adipose-Derived Stromal Cells On Decellularized Adipose Tissue Bioscaffolds, Tim Tian Han

Electronic Thesis and Dissertation Repository

Adipose tissue engineering holds promise for the development of therapeutic strategies for subcutaneous adipose tissue regeneration to treat defects resulting from congenital birth defects, invasive surgical procedures and traumatic injuries. Decellularized adipose tissue (DAT) scaffolds represent a potential off-the-shelf tissue substitute for volume augmentation. Seeding the DAT with adipose-derived stromal cells (ASCs) has been shown to enhance adipose tissue regeneration in immunocompetent animals in vivo. Although promising, this strategy is limited by low cell attachment on the DAT. As such, this thesis focused on the development of bioreactor strategies to enhance the capacity of human ASCs to stimulate angiogenesis and ...


Effects Of Hard-To-Soft Segment Ratios On The Synthesis And Physico-Mechanical Properties Of Polyurethane Films, Aaron C. Wilson 2020 University of Texas at Tyler

Effects Of Hard-To-Soft Segment Ratios On The Synthesis And Physico-Mechanical Properties Of Polyurethane Films, Aaron C. Wilson

Mechanical Engineering Theses

Blood-contacting cardiovascular stents often induce a secondary clotting event due to unrestricted enzymatic activities. The use of hemocompatible polyurethane coatings on these implantable devices is one of the most promising methods to reduce device rejection. In this study, four commercial polyurethane films of various thicknesses and compositions were evaluated for their anticoagulation properties. Results suggested that these films exhibited excellent thermal and physico-mechanical properties while capable of increasing contact time with blood plasma by over a thousand-fold as compared to a control surface. Due to the unknown structure and composition of these commercial films, polyurethane samples were synthesized from toluene ...


Design Of A 3d Printed Bioreactor For Bone Cancer Research, Brooklyn K. VanDerWolde, Katelyn Hillson 2020 South Dakota State University

Design Of A 3d Printed Bioreactor For Bone Cancer Research, Brooklyn K. Vanderwolde, Katelyn Hillson

The Journal of Undergraduate Research

Bone cancer is an aggressive disease and has peak occurrence during physiological stimulation of growth and aging. Astronauts who undergo long-term space missions also acquire an increased risk of bone tissue degeneration and cancer. Few in-vitro models currently exist capable of reproducing the complex microenvironment of bone tissue to support multicellular activity in a three-dimensional structure. This limits the ability to understand disease progression and develop suitable treatment strategies. Therefore, developing a bone tissue model and an associated bioreactor is critical to understand the risks associated with cancer progression and improve treatment and preventions related to those risks. The goal ...


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