Biomedical Engineering and Bioengineering Commons^™

Comparative Performance Of Physiological Vital-Sign Forecasting Under Random And Patient-Wise Splitting Using Deep Learning, Lavanya Vasavi Chittem Reddy

Theses and Dissertations

Physiological vital-sign forecasting estimates future measurements based on recent temporal patterns and can support analysis of continuously recorded monitoring data. This study comparatively evaluated deep feedforward, recurrent, bidirectional recurrent, long short-term memory, and bidirectional long short-term memory architectures for one-step-ahead forecasting of peripheral oxygen saturation, heart rate, and pulse rate. Each model received consecutive observations of peripheral oxygen saturation, heart rate, pulse rate, respiratory rate, and age, while separate single-output models predicted the next value of the selected target.

Random and patient-wise data splitting were compared using identical input definitions, preprocessing procedures, model architectures, and training hyperparameters. The strongest architecture …

Estimation Of Unmeasurable External Disturbances Of A Dynamic Object Based On A Robust Adaptive Kalman Filter, Bunyod Mamurjon Ugli Buronov

Technical science and innovation

This article considers the problem of directly estimating unmeasurable external disturbances acting on a dynamic object under the condition that the state vector of the object is available for measurement. In the considered case, the problem is reduced to the estimation of an unknown input of a dynamic system. It is shown that when the system state is measurable, both a direct inversion scheme based on the object’s dynamic equation and filtering methods that eliminate the need for coarse numerical differentiation can be applied. For slowly varying disturbances, a random walk model with a small process noise covariance is proposed, …

Where Do We Go Now: An Examination Of The Role Of 3d Modeling In Cancer Research, Ella Claire Gregory, Hannah Noelle Cochran

ABE 4523/6523 Biomedical Materials

The development of three-dimensional tumor models has become an important area of cancer research. By incorporating biomaterials that can mimic the physical, chemical, and biological characteristics of the tumor environment. 3D models can provide a more physiologically relevant environment for studying tumor growth, cell interaction, metastasis, and drug response.

Evaluation Of The Metrological Characteristics Of An Ultrasonic Flowmeter For Water Resources, Makhsud Idrisovich Makhmudov, Uktam Farkhodovich Mamirov, Siroj Sobirovich Nurov

Technical science and innovation

This paper presents the results of evaluating the metrological characteristics of a developed ultrasonic flowmeter intended for measuring water flow in open channels. The study analyzes the main sources of measurement errors and classifies them into methodological, instrumental, additional, systematic, and random components. Experimental investigations were carried out to estimate the random and systematic errors under steady-state flow conditions. Using the least-squares method, the systematic error was separated into additive and multiplicative components, providing a basis for calibration and correction of the measurement results. The reliability of the developed measuring instrument was evaluated using the failure rate method based on …

Evaluation Of Level Measurement Uncertainty For Three Types Of Laser Level Meters Using The Gum Methodology: Calculated Uncertainty Budgets, Uncertainty Profile, And Hardware Component Requirements, Lazizbek Furkatjanovich Saidoripov, Barat Makhmudovich Akhmedov

Technical science and innovation

A methodology is presented for evaluating the uncertainty of liquid petroleum product level measurements using laser level meters based on different measurands’ informative parameters: propagation time, phase difference, and image coordinates. Based on analytical expressions for error components and a traceability chain to the national length standard, calculated uncertainty budgets are developed in accordance with JCGM 100 for time-of-flight, phase-based, and laser–television level meters. Under the assumed input conditions, the expanded uncertainties (k = 2) are 1.66, 0.73, and 1.02 mm, respectively. For the laser–television level meter budget, the Gaussian approximation is verified using the Monte Carlo method (JCGM 101): …

Analysis And Study Of The Content Of Chloride Salts In Oil, Natalia Evgenievna Sheina, Muborak Akramovna Mirshomilova

Technical science and innovation

The article addresses the critical issue of crude oil quality control, specifically focusing on the determination of chloride salts (sodium, calcium, and magnesium), which exert a destructive impact on processing equipment. The paper provides a detailed analysis of the adverse effects of salts, which lead to severe equipment corrosion, scaling, and a reduced yield of valuable oil fractions. The chemical principles and specific applications of two standardized methods for analyzing aqueous extracts according to GOST 21534-2021 and ASTM D3230 are described: indicator (argentometric and mercurimetric) and potentiometric titration. The experimental section presents the results of a comparative analysis of crude …

Analysis And Optimization Of Intelligent Control Of The Drying Process Under Uncertainty, Azizbek Nodirbekovich Yusupbekov, Marufjon Kobuljonovich Shodiev, Khusniddin Mamarasul Ugli Esonov

Technical science and innovation

This section proposes a multi-criteria Pareto-optimization algorithm, integrated with Herbert Simon's four-stage decision-making scheme (Intelligence–Design–Choice–Implementation) and an ANFIS-based adaptive controller, for simultaneously optimizing the mutually conflicting quality, energy, and time criteria of the wheat-drying process. The algorithm for constructing the set of Pareto-optimal solutions and selecting the compromise solution closest to the ideal point is presented step by step. The implementation of the ANFIS controller in the MATLAB/Simulink environment is comprehensively verified through a simulation block diagram, the Rule Viewer, the Surface Viewer, the training error-function graph, the RMSE convergence graph, and a learning-curve analysis. Training was carried out on …

Mathematical Modelling Of Nitrification And Denitrification Processes Based On Neuro-Fuzzy Bioreactor Models, Mirkhalil Agzamovich Ismailov, Boburbek Zokirjon Ugli Mannobjonov

Technical science and innovation

This paper presents the development and investigation of hybrid neural network and fuzzy models for the mathematical modelling of nitrification and denitrification processes in a biological wastewater treatment bioreactor. A comprehensive approach is proposed, integrating a mechanistic model of the ASM1/ASM2d type with neural networks (LSTM and Gaussian Process Regression), as well as a fuzzy control system based on an extended set of expert rules. A digital twin of the bioreactor was developed to allow for the prediction of the dynamic behavior of key parameters such as NH₄⁺, NO₃⁻, dissolved oxygen, etc. within a prediction range of 1 to 12 …

Development Of An Experimental Stand For The Study Of The Directions Of Movement And Velocity Of Air Flows In The Pneumatic Channel Of The Final Aspiration Of The Muz-16 Air Sieve Separator, Hanna Borisovna Torgan, Zulfiya Kakhramonovna Ergasheva

Technical science and innovation

The article presents the results of experimental studies on the rheological properties of pasta dough obtained from various types of wheat flour (bakery highest grade, as well as durum varieties of Belarusian selection). The regularities of changes in the yield shear stress, plastic viscosity, and shear rate of the semi-finished product were studied depending on the key technological factors of extrusion: moisture content (0.28–0.335 kg/kg), temperature (25–55 °C), and discharge pressure (up to 88 · 10^-5 Pa). The operating principle and design features of the modernized pressing unit and die using special converging-diverging (confuser-diffuser) inserts (according to the patents …

Research On The Effectiveness Of Various Methods For Primary Processing Of Silkworm Cocoons, Doston Ishmukhammat Ugli Samandarov

Technical science and innovation

This article presents the results of experimental studies of the primary processing (killing) of silkworm pupae using existing technological methods, as well as three different combinations of infrared (IR) and ultrasound (US). A series of pilot studies was conducted in the laboratory of the Department of Service Technology at Tashkent State Technical University on nine cocoon samples using existing technological equipment and an experimental setup developed under project AL-8724053050 and based on the combined effects of infrared radiation and ultrasound. A comparative evaluation of the studied processing methods was conducted based on the degree of pupal killing, moth hatching, process …

An Eco-Inspired Emulsion Membrane Harnessed With Waste Vegetable Oil For Effective Separation Of Ibuprofen: Insights Into Stability, Performance, And Kinetics, Huma Warsi Khan, A. Vijaya Bhaskar Reddy, Parvez Alam Khan, Samsur Akm Rahman, Muhammad Moniruzzaman

Publications and Research

Emulsion liquid membranes (ELMs) have emerged as excellent alternatives for the separation and recovery of biologically active drugs (BADs) from industrial waste at trace concentrations. Conventional ELMs generally utilize toxic petroleum-based solvents (PBS) that pose environmental and health risks. Although virgin vegetable oils have been appeared as sustainable alternatives to PBS, their widespread application is limited by economic constraints, resource sustainability, and competition with the food supply. In contrast, waste vegetable oil (WVO) represents an abundant, low-cost, and eco-friendly alternative, yet its potential as a green diluent for ELMs remains largely unexplored. To address this challenge, present study investigated the …

Experimental Study On The Behavior Of High-Strength Reinforced Concrete Beams With A Longitudinal Void, With And Without Micro Steel Fibers, At Different Shear Spans, Farah M. Hussein, Saif Altai, Shatha Alasadi, Ayoob A. Ibrahim, Arshad Nadhom Shubber

Journal of Sustainable Construction Materials and Technologies

This study examines the impact of creating a longitudinal void in high-strength reinforced concrete (RC) beams to decrease concrete volume. Testing involved three groups: solid beams (SB), beams with a 75 mm void (VB), and beams with a void incorporating 1.2% micro-steel fibers (VBSF), across various shear spans (a/d) of 1.8, 2.7, and 3.6. Results indicated that increased a/d led to a 54.2% reduction in peak loads and a 119.2% increase in deflection for solid beams. The void negatively affected load-bearing at a/d = 1.8 with a 25% peak load reduction and brittle failure. At a/d = 2.7, effects were …

Main Challenges To China’S Scientific Research Instrument Innovation From Perspective Of The United States Export Controls, Jing Li, Daixie Chen, Qinghua Lin, Guohua Xiao

Bulletin of Chinese Academy of Sciences (Chinese Version)

China has long been heavily dependent on imports of scientific research instruments, making this sector particularly vulnerable to intensified technological containment by the United States and other Western countries and their efforts to maintain technological dominance. Since the Donald Trump’s tenure as the 45th president of the United States began in 2017, the United States has frequently used export controls to suppress China’s scientific and technological progress, posing great security risks to China. Based on a review of the development of scientific research instrument innovation in China, this article analyzes the updates and trends of the United States export controls …

Use Of Generative Ai Tools In An Undergraduate Engineering Design Course, Wei Yin, Esther Ocharo, Lillian Best, Harrison Martin

International Journal of Transformative Teaching and Learning in Higher Education

Generative AI tools are widely used by college students. This study aimed to investigate the best ways to teach students the limits of AI, especially in hands-on engineering classes. A class project in a sophomore biomedical engineering class was used to test the effectiveness of generative AI tools in supporting engineering CAD design and 3D modeling. Students were tasked with designing a finger basketball toy, creating 2D engineering drawings, and creating a physical prototype using 3D modeling and printing. Students used ChatGPT, Copilot, and Gemini to support the completion of the design project. Students’ manual work demonstrated satisfactory skills in …

Parametric Study On The Plastic Hinge Length Of Precast Concrete Columns With Grouted Sleeve Connections, Rizky Tri Amalia, Harun Alrasyid

Journal of Sustainable Construction Materials and Technologies

The use of precast concrete structures with grouted sleeve (GS) connections has gained significant traction in the acceleration of bridge construction. The plastic hinge length (Lp) is a critical parameter for assessing the seismic performance and deformation capacity of such structural members. The previous study has proposed empirical equations for Lp in monolithic columns; however, a comprehensive understanding of the influential parameters on Lp in precast concrete columns with GS connections remains limited. This study presents a detailed parametric investigation to evaluate the effects of key design parameters on the plastic hinge length of a precast concrete columns with GS …

Comparative Analysis Of Takagi-Sugeno And Mamdani Fuzzy Inference Architectures With Anfis-Based Automated Rule Generation For Eeg-Based Cognitive State Monitoring, Amina Radončić, Mehrija Hasičić, Jasmin Kevrić

Communications of the IIMA

Fuzzy inference systems have demonstrated considerable promise for EEG-based cognitive state monitoring in neurodegenerative conditions. However, two design decisions significantly influence system performance and clinical applicability: the choice of inference architecture (Takagi-Sugeno vs Mamdani) and the method of rule and membership function generation (manual expert-driven vs data-driven automated). This paper presents a comparative analysis of both dimensions in the context of an EEG-based Alzheimer’s disease monitoring system operating on the ds004504 OpenNeuro dataset (88 subjects: 36 AD, 23 FTD, 29 HC). A Takagi-Sugeno system, implemented as a hybrid FSM-Fuzzy architecture, is compared against a Mamdani equivalent across four axes: inference …

Hydration-Tunable Ionic Liquid-In-Oil Microemulsions For Increased Transdermal Delivery Of High-Molecular-Weight Proteins, Roy Jabidash, Kiyohiro Toyofuku, Rie Wakabayashi, Yoshirou Kawaguchi, Noriho Jeffrey Kamiya, Muhammad Moniruzzaman, Masahiro Goto

Publications and Research

Transdermal delivery of high-molecular-weight proteins is challenging because of their large molecular size and hydrophilicity, and the barrier properties of the stratum corneum. We report a hydrated ionic liquid-in-oil (HIL/O) microemulsion for transdermal delivery of high-molecular-weight proteins. A biocompatible ionic liquid (IL) composed of cholinium cation and propionate anion, optimized at 45 wt% hydration, was developed as a protein-compatible solubilization medium that dissolved ovalbumin (molecular mass ∼ 45 kDa) and bovine serum albumin (molecular mass ∼ 66 kDa), whereas lower hydration levels were insufficient for effective protein dissolution. Following solubilization, circular dichroism spectroscopy showed recovery of the native-like secondary structures …

Affordable Thermal Control For Cell Culture Chambers: An Open-Source, Pid-Based Heating Module, Majid Rostami, Sesha Sai Ramineni, Sangyoon J. Han

Michigan Tech Publications

Commercial environmental control systems for live cell imaging chambers frequently cost $10,000–20,000. This paper presents an open-source, PID-controlled heating module built entirely from off-the-shelf components for approximately $500. The system employs four adhesively mounted polyimide heater pads driven at 12 VDC through a closed-loop chain: a K-type thermocouple feeds a Delta DTB4848LV controller, whose analog output is converted to PWM and applied to the heaters via an opto-isolated MOSFET switch. The required heating power was determined through analytical thermal sizing and verified by finite-element simulation (ANSYS Mechanical), confirming that the cell culture region reaches 37°C at steady state. Bench testing …

Evolution Of Raman And Photoluminescence Response In Molybdenum Disulfide Thin Films Deposited Via Thermal Atomic Layer Deposition, Wesley Jen, John D. Hues, Icelene Leong, Nolan H. Olaso, Ravindra K. Kanjolia, Mansour Moinpour, Steven M. Hues, Elton Graugnard

Boise State University Publications and Presentations

In order to enable further advances in microelectronics, new processes capable of precisely depositing films are required. This is especially true of processes meant for depositing two-dimensional (2D) transition metal dichalcogenides, such as MoS2, a material of particular interest due to its high potential mobility even at a thickness of a few atoms. In this work, we report industry-compatible processes for depositing crystalline MoS2 with a high degree of precision. We demonstrate the successful conversion of both MoOx and MoSx films deposited via thermal atomic layer deposition using bis(tert-butylimido)bis(dimethylamino)Mo(VI) and H2O or H2S, respectively, into crystalline MoS2 films after an …

Isolating Human Monocytes And Characterizing Human Macrophage Polarization Through Flow Cytometry And Morphological Analysis, Arthur Peter Klujian

Biomedical Engineering

Peripheral Artery Occlusive Disease (PAOD) is a cardiovascular disease that affects more than 200 million people. It is characterized by atherosclerosis, a biologic process where peripheral arteries are restricted due to a buildup in cholesterol and fats. This eventually leads to ischemia, developing complications such as chronic inflammation and possible limb amputation. The current standard of care for patients includes surgical revascularization and exercise therapy. These treatment strategies have had limited success with alleviating symptoms and restoring perfusion, however, many patients still experience ischemia and do not fully restore blood flow. Further exploration in pursuit of treating these shortcomings led …

Motor Imagery Eeg Decoding For Brain-Computer Interfaces: Structured Representation, Transfer, And Drift, Yiming Shen

Graduate Doctoral Dissertations

Motor imagery EEG decoding is often summarized by the accuracy of a final classifier, but the classifier is only the last stage of the pipeline. Before classification, the signal has already been shaped by preprocessing, feature extraction, source-session organization, and adaptation. This dissertation studies how feature representation, source-session transfer, and drift shape reliable MI-EEG decoding for brain-computer interfaces.

It first studies within-session decoding on public MI-EEG datasets using nested validation that keeps preprocessing, feature fitting, and model selection inside the training folds. This analysis separates gains from feature representation from gains due to nonlinear classification, and relates both comparisons to …

Probe Cytotoxic And Oxidative Stress Effects Of Nanoplastics On Caco-2 Cells: Insights From Raman Spectroscopy And Machine Learning, Bryan Gustafson, Negar Kosari, Emily Brothersen, Morgan Mosher, Anhong Zhou

Biological Engineering Student Research

Nanoplastics and microplastics have become an increasing ecological and health concern due to their widespread presence in the environment and food chain. In this study, Caco-2 cells were used as an in vitro model of the human intestinal epithelium to investigate the cytotoxic effects of polystyrene nanoparticles and microparticles of varying sizes, concentrations, and surface modification. Oxidative stress and apoptosis were evaluated following particle exposure. Raman spectroscopy, combined with machine learning analysis, was employed to detect and characterize biochemical alterations in the cells. Several peak ratios were selected to cluster data depending on size. A correlation between apoptosis and both …

Compact 1 Ghz Electron Paramagnetic Resonance Spectrometers For Preclinical Imaging Studies, Tanden A. Hovey

Electronic Theses and Dissertations

Magnetic resonance is one of the most generally useful scientific techniques. New horizons of understanding are revealed as technological advances make possible explorations of nuclear spins and electron spins at higher and lower magnetic fields and electromagnetic frequencies. While the greatest current effort is on ever higher magnetic fields and microwave frequencies, both in nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), the Eaton lab focusses on developing high signal-to-noise performance EPR at low microwave frequencies. EPR provides information about O2, pH, viscosity, glutathione concentrations, and reactive oxygen species in living organisms that MRI cannot. To yield clinically or …

A Longitudinal Study Of Achilles Tendon Adaptation In Ncaa Division I Female Gymnasts: Associations With Menstrual Status, Birth Control Use, Pain, Limb Dominance, And Training Exposure, Mattie Jane Hyde

Electronic Theses and Dissertations

This longitudinal study evaluated Achilles tendon (AT) thickness in 22 NCAA Division I (DI) female gymnasts across three consecutive seasons in relation to menstruation, birth control use, pain, limb dominance, training week, and year of collegiate competition. Weekly ultrasound and athlete survey data were analyzed using mixed-effects models for absolute AT thickness and change in thickness from baseline measurements. Associations were primarily characterized by interactions rather than uniform effects of individual predictors. A Pain × Limb Dominance × Week × Year interaction was associated with both thickness outcomes across season-specific and combined analyses, with relationship directions varying by limb, season …

An Investigation Of Pelvic Kinematics And Implications For Total Hip Arthroplasty, Kathryn Holland Colone

Electronic Theses and Dissertations

Total hip arthroplasty (THA) is one of the most commonly performed orthopaedic procedures, with approximately 500,000 surgeries performed annually in the United States alone. Although THA is widely regarded as highly successful, postoperative complications persist, highlighting the multifactorial nature of THA outcomes. Previous studies have demonstrated the importance of implant positioning and soft tissue mechanics, yet challenges remain in optimizing surgical decisions on a patient-specific basis. Recent advances in surgical planning tools have shifted the focus of preoperative planning toward optimizing patient-specific outcomes, highlighting the need to better understand how patient anatomy, surgical technique, and joint mechanics interact to influence …

Plasma-Generated Ozone For Odor Removal, Jordan Marot

Seton Hall University Dissertations and Theses (ETDs)

Ozone (O₃) is gaining popularity for its use in industrial and environmental applications, including water treatment, air purification, disinfection, and odor remediation. As a powerful oxidizing agent, ozone is highly effective in destroying harmful bacteria and degrading hazardous gas pollutants such as hydrogen sulfide (H₂S). Dielectric barrier discharge (DBD) reactors are widely used for commercial ozone production under atmospheric-pressure conditions. However, ozone yield and selectivity are strongly influenced by operating parameters, particularly gas flow rate, which affects residence time, energy transfer, and competing byproduct chemistry.

This study explores the influence of the air flow rate on …

Enhancing Algae Biofilm Quantity And Value Through Controlled Light Intensity For Treatment Of Municipal Anaerobic Digestor Effluent, Joshua D. Wintch, Ronald C. Sims

Biological Engineering Student Research

Rotating algae biofilm reactors (RABRs) have been shown to remove nutrients from wastewater and to cultivate algae for bioproducts. Another key variable in RABR technology for cultivating microalgae biomass is light intensity. The goal of this study was to address a gap in the design and operation of algae biofilm reactors by analyzing the effects of light intensity on biomass quality and quantity, chemical precipitation of phosphorus, and phosphorus uptake into biomass. This study utilized a triplicate laboratory-scale experiment with PAR intensities from 10 to 2000 µmol m⁻²·s⁻¹. Municipal wastewater anaerobic digester effluent (ADE) was utilized …

Deciphering The Rules Of Odor-Driven Learning In The Fruit Fly Olfactory System, Cole B. Hanan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Odorant identity is encoded by patterns of activity across olfactory receptor neurons (ORNs) and their corresponding glomeruli in the antennal lobe (AL). An odorant's valence can be modified by experience, allowing animals to associate previously neutral odors with appetitive or aversive outcomes. However, some odors appear resistant to such reassignment, and the factors determining whether an odor can acquire learned valence and whether that association generalizes to chemically related odors remain poorly understood. This thesis uses Drosophila melanogaster to address this question using a fully automated proboscis extension reflex (PER) conditioning assay. Odorants are presented via a computer-controlled olfactometer, reward …

A Functional Ultrasound Imaging (Fusi) Pipeline For Investigating Brain-Wide Hemodynamics During Torpor-Like Hypothermia, Owen J. Culver

McKelvey School of Engineering Graduate Student Theses & Dissertations

Torpor is a regulated state of reduced metabolic demand that enables animals to conserve energy under unfavorable environmental conditions. The controlled induction of a similar state, termed synthetic torpor, has potential applications in ischemic protection, organ preservation, cancer treatment, radiation protection, and long-term spaceflight. Although neuronal populations within the preoptic hypothalamus have been shown to initiate hypothermic and hypometabolic states, the distributed cerebral hemodynamic dynamics accompanying their induction and maintenance remain poorly understood. In this thesis, we developed an accessible functional ultrasound imaging (fUSI) acquisition and analysis pipeline and applied it to investigate cerebral hemodynamics during chemogenetic activation of the …

Designing And Evolving The Life Support System For Spacex Starship: Toward Closed-Loop Sustainability For Mars Missions, Frányerson R. López Ochoa

Discovery Day - Daytona Beach

The development of a robust Life Support System (LSS) is essential for enabling long-duration human spaceflight beyond Low Earth Orbit (LEO), particularly for missions to Mars. SpaceX Starship represents a next-generation spacecraft designed to support such missions; however, its Environmental Control and Life Support System (ECLSS) remains under active development. This work evaluates the current status of Starship’s LSS by analyzing publicly available data, NASA Human Landing System requirements, and heritage systems such as the International Space Station (ISS) ECLSS and Crew Dragon.