Biomedical Engineering and Bioengineering Commons^™

Three-Dimensional Printing Of The Epineurium For Peripheral Nerve Repair: A Comprehensive Review Of Novel Scaffolds For Nerve Conduits, Alynah J. Adams, Iulianna C. Taritsa, Kaavian Shariati, Aaron Dadzie, Jose A. Foppiani, Maria Jose Escobar-Domingo, Daniela Lee, Angelica Hernandez-Alvarez, Kirsten Schuster, Helen Xun

School of Medicine Publications

Background: Nerve conduits are used to bridge peripheral nerve defects caused by trauma, iatrogenic injury, or oncologic disruption. Three-dimensional (3D) biomimetic scaffolds for peripheral nerve regeneration have advanced significantly in recent years, driven by improvements in printing technology and neuronal seeding techniques. We report on published designer conduits that can recreate the epineurium, a critical yet challenging-to-manufacture feature of nerve tissue.

Methods: A medical librarian conducted a literature search for our systematic review on EMBASE, Web of Science, and PUBMED, following PRISMA guidelines, for articles from January 2010 to January 2026 for the systematic review. Descriptive statistical analysis was performed …

Fiber Optic Polarimetric Stress Sensor Improvements, Maxwell R. Richter, Max Randall, Mark C. Harrison

Engineering Faculty Articles and Research

The progression of diseases such as cancer has been correlated with tissue stiffness. For example, breast cancer tissue has been found to be stiffer than healthy mammary tissue. At present, stiffness measurement devices are not suitable for nondestructive, high-resolution measurements on small, delicate samples. We report a compact, portable, and sensitive fiber optic stress sensor that overcomes many of these limitations and is suitable for soft materials such as tissue. We demonstrate several improvements to a previous fiber stress sensor in physical hardware, software, and data analysis. We have designed and fabricated a custom enclosure to shield the sensitive setup …

Advancing Computational Analysis Of Fluorescence Imaging For Head And Neck Cancer Surgical Guidance, Yao Chen

Dartmouth College Ph.D Dissertations

The main goal of surgery for head and neck squamous cell carcinoma (HNSCC) is to remove the tumor completely while preserving as much healthy tissue as possible to enhance patient survival and reduce complications. However, achieving clear surgical margins is difficult due to the complex anatomy of the head and neck and the reliance on a surgeon’s visual and tactile assessments. Recently, near-infrared (NIR) fluorescence molecular imaging has shown potential for better tumor visualization during surgery, using targeted imaging agents like epidermal growth factor receptor (EGFR) probes. This has led to the development of fluorescence-guided surgery (FGS), which helps surgeons …

Sensing Negative-Cone Rotational Diffusion Of Dipole-Like Emitters, Yuanxin Qiu, Kaizhi A. Nie, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Fluorescence anisotropy and single-molecule orientation-localization microscopy (SMOLM) are powerful techniques that quantify the rotational diffusion of dipole-like emitters, which is important for sensing molecular interactions and chemical environments at the nanoscale. Numerous theoretical and experimental studies have thoroughly characterized single-molecule rotations even when those rotations are much faster than the detector integration time. Here, we extend the theory of measuring rotational diffusion to situations where a single dipole rotates uniformly everywhere outside of an isotropic cone of a certain size, termed a negative cone. This scenario corresponds to negative fluorescence anisotropy 𝑟 and has been observed in emitters exhibiting strong …

Pid Control For Lower Limb Exoskeletons: A Framework Evaluation, Javlonbek Rakhmatillaev, Vytautas Bučinskas

Chemical Technology, Control and Management

This research provides a detailed guideline for implementing and evaluating Proportional Integral Derivative (PID) control frameworks in lower limb rehabilitation exoskeleton robotics. It examines the role of control systems within rehabilitation robotics, outlines the principles of PID control, describes exoskeleton architecture, explores applications of PID control, reviews optimization strategies, presents experimental validations, and considers future developments in the field. The proposed control framework incorporates aspects of mechanical design, actuator and sensor selection, and PID-based control algorithms, thereby promoting safe, accurate, and individualized rehabilitation support. Recommendations and effective guidance for future work are also presented.

Investigating Confounding Factors In Shear Wave Speed Measurements Of Fibrotic Liver Tissues: A Computer Simulation Study, Emily J. Miller, Yongmei Jin, Jingfeng Jiang

Michigan Tech Publications

Screening patients with liver fibrosis and identifying those at risk of developing advanced liver fibrosis is of clinical interest. Shear wave elastography (SWE), a promising non-invasive screening tool used to distinguish healthy tissue from diseased tissue, measures tissue shear wave speed (SWS) to describe tissue stiffness and identify liver fibrosis. However, considerable variations in the reported results have been found. We propose that the heterogeneity of the liver tissue background, such as the presence of fatty liver tissue and the preferred local orientation of the scarred fibrotic liver tissues embedded into the liver parenchyma, may contribute to the uncertainty in …

The Impact Of Human Myoblasts On Macrophage Polarization In A Coculture Model, Elisabeth Ann Stodola

Biomedical Engineering

Peripheral Artery Disease (PAD) is characterized by the buildup of atherosclerotic plaque in the lower extremities that occludes blood flow, and affects over 200 million people worldwide. Without effective treatment, PAD can lead to claudication, ischemia, ulcers, and gangrene. PAD causes more amputations in the United States than any other condition, and for severe cases that require revascularization, procedures benefit fewer than 50% of patients. This demonstrates a clear need for alternative therapies. Potential therapies for PAD target expansion of collateral blood vessels around the area of occlusion – a process called arteriogenesis to compensate for loss of blood flow …

Design And Validation Of A Wearable Respiratory Protection System For Wildland Firefighters, Oliver Pilon

Master's Theses

Wildland and Wildland–Urban Interface firefighters are routinely exposed to hazardous smoke with fine particulate matter, carbon monoxide, volatile organic compounds, and other toxic combustion products. Existing protective gear has significant limitations and shortcomings for these conditions. Respirators with tight-fitting facepieces make it difficult to breathe and speak. On the other hand, self-contained breathing apparatuses are too heavy, have a limited duration of use, and do not work well with long wildland fire scenes, while smaller protective equipment like N-95’s and gaiters provide very little protection. These constraints contribute to low adoption rates and prolonged occupational exposure.

This thesis presents the …

Plm-Effector: Unleashing The Potential Of Protein Language Models For Bacterial Secreted Protein Prediction, Dandan Zheng, Lihong Chen, Guansong Pang, Jian Yang

Research Collection School Of Computing and Information Systems

Bacterial secreted proteins, particularly effectors delivered by specialized secretion systems, are key mediators of virulence and host-pathogen interactions. However, accurate computational identification remains challenging, as many existing methods rely heavily on sequence similarity or handcrafted features, and often focus on a single secretion system. Recent studies have reported that some bacterial effectors may be associated with more than one secretion system, highlighting the complexity of secretion system annotation and motivating the development of system-aware computational prediction approaches. Here, we present PLM-Effector, a hybrid deep learning framework that integrates modern protein language models (PLMs) with multiple neural architectures via a two-layer …

Fixel-Based Analysis Of Pretreatment Mri Identifies White Matter Abnormalities In Pediatric Anti-Nmdar Encephalitis, Daniel Ackom, Janine Taitt-Tap, Scott A. Beardsley, Ricardo Vega, Alyssa Jobe, Andrew J. D. Crow, Brian Schmit, Lileth Mondok, Pradeep Javarayee

Biomedical Engineering Faculty Research and Publications

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune disorder in which conventional MRI often appears normal, leading to clinical–radiologic dissociation and hindering early diagnosis and monitoring. We retrospectively studied five pediatric patients with anti-NMDAR encephalitis and compared their pretreatment diffusion MRI to age- and sex-matched controls. Using fixel-based analysis (FBA), we quantified tract-specific white matter abnormalities at the individual level. All patients showed significantly reduced fiber density and cross-section, with patterns ranging from focal to widespread involvement. In two patients, FBA abnormalities corresponded to seizure lateralization on EEG despite normal MRI, emphasizing FBA's added value in detecting seizure-concordant injury. One patient, …

Development Of An Automated Platform For Cell Biology Experiments, Dipendra Nepal

Shelby Hall Graduate Research Forum Posters

Cell biology experiments involve repetitive tasks such as pipetting, sample preparation, and imaging, which are typically performed manually. These manual processes can introduce variability, reduce efficiency, and increase the cost of biomedical research. To address these challenges, our lab is developing a modular robotic platform, iEye™, to automate key steps in cell biology workflows [1]. The system is designed as self-contained modules, allowing flexible development and integration of different functionalities. In this work, we focus on a sample preparation module that integrates a 6-degree-of-freedom robotic arm, a motorized stage, and a pneumatic pipetter. This module is being developed to automate …

Ai Driven Assessment For Clinical Scenarios, Sudhanshu Tarale, Bhushan Lohar, Ninad Pandit

Shelby Hall Graduate Research Forum Posters

Beta 1 captured granular data to validate the system’s ability to measure clinical thoroughness and deliver real-time feedback. Data collection formally approved by the USA IRB (Protocol 25 037; #22849172).

Tourniquet Tester, Tyler Offerman, Thuy Nguyen, Ryan Ly, Cody Hoeptner

Biomedical Engineering

The Tourniquet Tester is a device intended to be used as a standardized testing device for tourniquets. Due to the lack of a standard testing device for testing tourniquets that can produce accurate and reproducible results, it is difficult to test the efficacy of tourniquets currently being sold on the market. A standard testing device that can produce consistent and reproducible results would allow tourniquet manufacturing companies to properly test the efficacy of their product and develop proper guidelines and directions for users of the product. Medical professionals and military personnel who may use tourniquets in their line of work …

Babycheck, Ayla V. Campbell, Eleanor M. Tweedy

Biomedical Engineering

The BabyCheck project was created to design and test a device that can collect a small blood sample from the fetal scalp during labor. The goal is to reduce uncertainty when fetal heart rate tracings are unclear, especially in Category II cases where it can be difficult for clinicians to decide the safest next step. Current monitoring methods either rely on interpreting heart rate patterns or use more invasive procedures to gather biochemical information. BabyCheck was designed to provide a simpler and more controlled way to collect a small blood sample that could help guide these decisions.

The final prototype …

Jaundease Phototherapy Vest Test Plan, Sujay Panthulu, Jasdev Banwait, Gwynn Moss, Solomon M. Fernandez

Biomedical Engineering

Neonatal hyperbilirubinemia is a common condition affecting more than 60% of newborns, caused by an excess buildup of bilirubin in the blood due to the liver’s limited ability to process it efficiently [1]. The standard treatment involves hospital-based phototherapy, where infants are placed in incubators under blue light to break down bilirubin in the skin. Although effective, this approach requires infants to remain under the lights for 12–18 hours per day, often with eye protection, and separated from their parents—disrupting early bonding and potentially contributing to toxic stress that can impact neurological and emotional development [2]. While at-home phototherapy solutions …

Improving Cellular Retention And Distribution To Promote Arteriogenesis In A Mouse Model Of Chronic Arterial Occlusion, Nancy Huang

Biomedical Engineering

Peripheral Arterial Occlusive Disease (PAOD) affects millions of people in the United States, creating pain, discomfort, and limited mobility due to restricted blood flow from obstructed arteries. While current treatments include lifestyle changes and revascularization procedures, these options are often insufficient or inaccessible because of procedural pain and socioeconomic barriers. In some cases, this can lead to critical limb ischemia and amputation as a last resort. Increasing blood flow to the extremities by enhancing collateral vessel growth, a biological process called arteriogenesis, with cell-based therapies can redirect blood flow around obstructions and has potential to mitigate and treat the effects …

Iud Insertion Pain Management, Sandhya Sridhar, Olivia Armas, Lucy Campochiaro

Biomedical Engineering

This project focuses on developing an atraumatic cervical stabilization device that serves as a modern alternative to the traditional tenaculum used during IUD insertion procedures. Current devices rely on sharp metal prongs that pierce the cervix and often cause significant pain and bleeding. The goal of this project is to design a device that provides the same stability and control for clinicians while eliminating the need to puncture cervical tissue. The device is intended to be used by gynecologists, nurse practitioners, physician assistants, primary care physicians, or any medical professional performing an IUD insertion. The device is intended to be …

Cpap Belly Prevent, Alek Corpuz, Emma Hoffman, Danielle Tran

Biomedical Engineering

Neonates with low gestation periods often face complications such as respiratory distress syndrome, or RDS, which increases risk for complications such as necrotizing enterocolitis. Use of bCPAP helps facilitate regular breathing, but can also force air into the stomach and consequently cause abdominal distention. Clinicians currently use an already inserted feeding tube to vent the accumulated air, however this interrupts the feeding process.

The PreVent device was developed to allow for simultaneous feeding and venting. The dual function minimizes interruptions to NICU nurse workflow and improves capability to relieve abdominal distention before the onset of adverse complications.

Newborn Spinal Needle, Allison Inouye, Kyle Morton, Evan Russell

Biomedical Engineering

Spinal punctures, or lumbar punctures, are important diagnostic procedures used to collect cerebrospinal fluid (CSF) to diagnose issues in the central nervous system (CNS) such as meningitis. While these procedures are routinely performed on adult and neonatal patients, the current tools are not optimized for use on newborns. Existing spinal needles are often modified versions of adult devices, leading to challenges in fluid collection efficiency, user ergonomics, and patient safety when used in neonatal care.

The Newborn Spinal Needle Project aims to design and develop a spinal needle specifically optimized for neonatal anatomy and clinical workflow. The goal is to …

Orthopedic Bone Drill, Logan G. Schmid, Matthew T. Wold, May Geng

Biomedical Engineering

This project aims to design a bone drill for orthopedic procedures which alleviates the heat generated in the bone during drilling.