Biomedical Engineering and Bioengineering Commons^™

Improving Cellular Retention And Distribution To Promote Arteriogenesis In A Mouse Model Of Chronic Arterial Occlusion, Nancy Huang

Biomedical Engineering

Peripheral Arterial Occlusive Disease (PAOD) affects millions of people in the United States, creating pain, discomfort, and limited mobility due to restricted blood flow from obstructed arteries. While current treatments include lifestyle changes and revascularization procedures, these options are often insufficient or inaccessible because of procedural pain and socioeconomic barriers. In some cases, this can lead to critical limb ischemia and amputation as a last resort. Increasing blood flow to the extremities by enhancing collateral vessel growth, a biological process called arteriogenesis, with cell-based therapies can redirect blood flow around obstructions and has potential to mitigate and treat the effects …

Iud Insertion Pain Management, Sandhya Sridhar, Olivia Armas, Lucy Campochiaro

Biomedical Engineering

This project focuses on developing an atraumatic cervical stabilization device that serves as a modern alternative to the traditional tenaculum used during IUD insertion procedures. Current devices rely on sharp metal prongs that pierce the cervix and often cause significant pain and bleeding. The goal of this project is to design a device that provides the same stability and control for clinicians while eliminating the need to puncture cervical tissue. The device is intended to be used by gynecologists, nurse practitioners, physician assistants, primary care physicians, or any medical professional performing an IUD insertion. The device is intended to be …

Cpap Belly Prevent, Alek Corpuz, Emma Hoffman, Danielle Tran

Biomedical Engineering

Neonates with low gestation periods often face complications such as respiratory distress syndrome, or RDS, which increases risk for complications such as necrotizing enterocolitis. Use of bCPAP helps facilitate regular breathing, but can also force air into the stomach and consequently cause abdominal distention. Clinicians currently use an already inserted feeding tube to vent the accumulated air, however this interrupts the feeding process.

The PreVent device was developed to allow for simultaneous feeding and venting. The dual function minimizes interruptions to NICU nurse workflow and improves capability to relieve abdominal distention before the onset of adverse complications.

Newborn Spinal Needle, Allison Inouye, Kyle Morton, Evan Russell

Biomedical Engineering

Spinal punctures, or lumbar punctures, are important diagnostic procedures used to collect cerebrospinal fluid (CSF) to diagnose issues in the central nervous system (CNS) such as meningitis. While these procedures are routinely performed on adult and neonatal patients, the current tools are not optimized for use on newborns. Existing spinal needles are often modified versions of adult devices, leading to challenges in fluid collection efficiency, user ergonomics, and patient safety when used in neonatal care.

The Newborn Spinal Needle Project aims to design and develop a spinal needle specifically optimized for neonatal anatomy and clinical workflow. The goal is to …

Orthopedic Bone Drill, Logan G. Schmid, Matthew T. Wold, May Geng

Biomedical Engineering

This project aims to design a bone drill for orthopedic procedures which alleviates the heat generated in the bone during drilling.

Ƒ(Cell): Software For Reproducible Analysis Of Optoretinograms, Robert F. Cooper, Mina Gaffney, Brea D. Brennan, Niko Rios

Biomedical Engineering Faculty Research and Publications

Purpose: There has been a marked increase in use of a noninvasive functional imaging technique called optoretinography (ORG). As more groups use ORGs, it is crucial to have a consistent methodology, and understand what analysis parameters influence repeatability. In this work, we present an open-source software library called ƒ(Cell) designed to facilitate reproducible and repeatable analyses of ORG data.

Methods: We designed ƒ(Cell) as a Python software library that can co-register and analyze ORG datasets, while also enabling process auditing. To validate the software, we used our previously obtained normative optoretinography datasets as well as datasets from six …

Fixel-Based Analysis Of Pretreatment Mri Identifies White Matter Abnormalities In Pediatric Anti-Nmdar Encephalitis, Daniel Ackom, Janine Taitt-Tap, Scott A. Beardsley, Ricardo Vega, Alyssa Jobe, Andrew J. D. Crow, Brian Schmit, Lileth Mondok, Pradeep Javarayee

Biomedical Engineering Faculty Research and Publications

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune disorder in which conventional MRI often appears normal, leading to clinical–radiologic dissociation and hindering early diagnosis and monitoring. We retrospectively studied five pediatric patients with anti-NMDAR encephalitis and compared their pretreatment diffusion MRI to age- and sex-matched controls. Using fixel-based analysis (FBA), we quantified tract-specific white matter abnormalities at the individual level. All patients showed significantly reduced fiber density and cross-section, with patterns ranging from focal to widespread involvement. In two patients, FBA abnormalities corresponded to seizure lateralization on EEG despite normal MRI, emphasizing FBA's added value in detecting seizure-concordant injury. One patient, …

Improving Interlimb Coordination And Paretic Limb Use After Stroke Using A Novel Robotic Split-Crank Pedaling Device: A Cross-Sectional Study, Tom S. Ruopp, Brian Schmit, Sheila Schindler-Ivens

Biomedical Engineering Faculty Research and Publications

Background. Many stroke survivors cannot walk effectively, even after rehabilitation. Causes include impaired muscle activation, poor interlimb coordination, and limited restorative interventions. To address this, we developed CUped (pronounced “cupid”), a motorized split-crank pedaling device designed to compel use of the paretic limb and retrain interlimb coordination. We examined its within-session effects, comparing three proportional control schemes—assist (A), resist (R), and assist plus resist (A + R)—to identify which best promotes recovery-related movement.

Methods. Nineteen individuals with stroke and eleven controls pedaled in 5-min bouts, one per control scheme. Each bout included pre-test, exposure, and post-test periods. Participants were instructed …

Balancing Carbon Emissions In Façade Of Residential Buildings Through Bim-Lca: A Comparative Analysis Of Insulation Materials, Mehran Alipour

Journal of Sustainable Construction Materials and Technologies

Thermal insulation materials play a significant role in balancing buildings' total carbon emissions. Balancing involves applying the optimized amount of insulation materials to avoid excessive emissions in either the operational or embodied phases. Due to the wide range of insulation materials and variations of their specifications, it is vital to analyse them individually. The focus of this study is to optimize the amount of insulation materials in the facades of Residential Buildings (RB) to balance the amount of Operational Carbon Emissions (OCE) and Embodied Carbon Emissions (ECE) by applying the Building Information Modelling-Life Cycle Assessment (BIM-LCA) integration method. The Life …

Nanoscale Opportunities In Extracellular Matrix Mimicry, L. Andrew Lyon, Abbygail Caine, Elif Narbay, E. Daniel Cárdenas-Vásquez

Engineering Faculty Articles and Research

We present an overview of the composition, function, energetics, and dynamics of extracellular matrix and its relation to nanoscale structures and phenomena. These concepts are then related to the development of synthetic and biosynthetic materials that aim to mimic the extracellular matrix for regenerative medicine and tissue engineering technologies. Notable successes and advancements towards the goal of biomimicry are outlined, while remaining challenges and knowledge gaps towards that goal are highlighted. Finally, we frame the remaining challenges in the field in terms of nanoscience-related research opportunities that if solved, might prove to be transformative steps forward in the discipline.

Integrating Sustainable Material Procurement In Construction Waste Management: A Systematic Review With Narrative Synthesis For The Libyan Construction Sector, Ramzi Fouzi Hamad Abdullah, Safaa N Saud Al-Humairi, Zunirah Binti Mohd Talib

Journal of Sustainable Construction Materials and Technologies

Integrating sustainable material procurement with construction waste management is essential to reduce construction and demolition waste in Libya, where current practices remain largely reactive and disposal-oriented. This narrative review aims to develop a conceptual framework linking procurement decisions to waste-generation pathways in Libyan construction projects, clarifying how proactive, sustainability-driven purchasing can serve as a primary driver of waste prevention. Using a PRISMA-guided systematic search of Web of Science, Scopus, and IEEE Xplore for 2001–2026, and a bibliometric analysis via VOSviewer, 956 high-quality studies were synthesized to map global knowledge and to expose the paucity of integrated SMP–CWM studies in developing …

Sound Insulation Performance Of Sustainable Lc3 Mortars With Barite And Waste Rubber Aggregates, Begüm Söyek Abay, Leyla Tanaçan

Journal of Sustainable Construction Materials and Technologies

This study investigates the potential of limestone calcined clay cement (LC3) as a sustainable binder for developing a single-layer composite material incorporating barite and rubber aggregates, hypothesized to achieve enhanced sound insulation performance compared to conventional multi-layered wall systems. Mortars were prepared using LC3 with 55% clinker, 30% metakaolin, 15% limestone, substituting 45% of cement clinker. Hybrid mixtures of barite and rubber aggregates (barite-to-rubber volume ratios of 2:1 and 1:2) were tested at aggregate-to-binder ratios of 2.0, 2.75, and 3.5 to evaluate their combined mass and damping effects on acoustic performance. Experiments were conducted to determine physical, mechanical, and acoustic …

From Lime To Geopolymers: Emerging Trends And Advances In Sustainable Soil Stabilization, Favour Chukwuebuka Egwu, Amin Eisazadeh

Journal of Sustainable Construction Materials and Technologies

Soil stabilization remains a critical challenge in geotechnical engineering, particularly for weak and expansive soils that compromise the safety and serviceability of infrastructure. Traditional stabilizers such as lime and cement have been widely applied; however, their limitations in terms of long-term durability, carbon footprint, and performance under aggressive environmental conditions necessitate alternative approaches. In recent years, geopolymer-based stabilizers derived from industrial by-products such as fly ash (FA), slag, and bottom ash (BA) have emerged as promising substitutes. This review critically examines the comparative performance of lime and geopolymer stabilization with respect to strength development, durability, compressibility, environmental impact, and economic …

Investigating The Behavior Of Self-Compacting Concrete Containing Scms And Recycled Fine Aggregates, Sachin Tiwari, Mahakavi P

Journal of Sustainable Construction Materials and Technologies

This study addresses the unresolved gap in quantifying how recycled fine aggregates (RFA) and metakaolin (MK) interact synergistically in self-compacting concrete (SCC), a relationship that previous works have studied only in isolation or without mechanistic justification. Twenty-five SCC mixtures containing MK (0–25%) and RFA (0–100%) were evaluated to generate a unified understanding of fresh behaviour, strength development, pore refinement, interfacial transition zone (ITZ) characteristics, and sustainability indicators. Results show that RFA alone increases water demand and reduces strength, while MK compensates for these losses by densifying the matrix and improving ITZ bonding, as confirmed through SEM analysis. An optimum synergy …

Nanoparticles May Improve How Antiviral Compounds Are Delivered For Herpes Virus 1, Emilia Huff

Research on Capitol Hill

HSV-1, a strain of herpes, infects the majority of adults in the US and has been linked to neurological damage.

Tetramethylbenzidine Loaded Pva Nanofibers Strip For Visual Detection Of Hydrogen Peroxide Via Cu2+ Catalysis And Its Applications, Samar A. Salim

Nanotechnology Research Centre

Background Advancements in sensor technology have facilitated the development of cost-effective and highly sensitive sensors which have significantly improved the detection of biological analytes in various fields. This study presents a novel approach for the detection of hydrogen peroxide (H₂O₂), a critical analyte in both biological and environmental systems. A simple and sensitive colorimetric sensing platform was developed based on polyvinyl alcohol (PVA) nanofibers loaded with tetramethylbenzidine (TMB). Results The nanofibers were characterized using scanning electron microscopy, confirming the formation of smooth, spindle-shaped fibers with diameters from 324 to 551 nm. The colorimetric detection method utilized TMB, which undergoes oxidation …

Strategic Research On Rebco High-Temperature Superconducting Tapes, Tianping Ying, Dongliang Wang, Pengtao Yang, Lin Zhao, Zhongtang Xu, Ziyi Liu, Chao Yao, Yanwei Ma, Xingjiang Zhou, Jinguang Cheng, Zhong Fang

Bulletin of Chinese Academy of Sciences (Chinese Version)

High-temperature superconducting materials, represented by REBCO (REBa2Cu3O7-δ, where RE denotes rare-earth elements), are of significant strategic importance in fields such as energy, healthcare, and large-scale scientific facilities due to their excellent performance in the liquid nitrogen temperature range. However, they still face severe challenges in long-tape uniformity, production cost, and engineering reliability. Future development must shift toward a “material-processing-application” collaborative innovation model, aiming at enhancing flux pinning, optimizing the interfaces and mechanical properties of the multilayer structure, and integrating scalable and intelligent fabrication technologies to promote the low-cost and stable production of high-performance tapes. This study analyzes the core application …

Neuproio: A Dual-Action Solid Drug Nanoparticle Topical Formulation For Simultaneous Intraocular Pressure Reduction And Neuroprotection For Glaucoma, Lei Xu, Mu Li, Lin Qi, Tzu Chen Wang, Dong Liu, Vimalin Jeyalatha Mani, Hsin Yin Chuang, Qingbo Yang, Ruipu Mu, Samira Mahdi, Da Huang, Honglan Shi, Yang Hu, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glaucoma is a leading cause of irreversible blindness, primarily due to elevated intraocular pressure (IOP) that damages the retina and optic nerve. Most topical glaucoma treatments focus solely on IOP-lowering without direct neuroprotection, as drug delivery to the posterior eye is challenging. Here, we developed NeuProIO, a dual-action solid drug nanoparticle (NP) eye drop for simultaneous IOP reduction and neuroprotection. Using flash nanoprecipitation in a multi-inlet vortex mixer, we fabricated the first NeuProIO solid drug NPs incorporating the repurposed neuroprotective agent maprotiline (MAP) and the IOP-lowering agent betaxolol (BX), forming MAP/BX NPs for synergistic glaucoma treatment. The NeuProIO improved stability …

Intravascular Ultrasound Is More Accurate Than Angiography In Arteriovenous Vascular Access Lesions, James W. Decker, Dima Banihani, Curtis Honshideler, Saran Lotfollahzadeh, David Jasen Wu Wong, Alik Farber, Jeffrey J. Siracuse, Najia Idrees, Laura Dember, Mohammad Bader, Suvranu Ganguli, Vijaya Kolachalama, Tarek Shazly

Faculty Publications

Background:

Conventional angiography remains the standard diagnostic modality for arteriovenous (AV) access dysfunction in hemodialysis patients, but its geometric accuracy is limited. Intravascular ultrasound (IVUS) offers superior lesion detection, yet its absolute measurement accuracy remains uncertain. Using three-dimensional (3D) printed vascular conduits as reference standards, we assessed the accuracy of IVUS versus angiography, hypothesizing that complex conduit geometry, quantified by Gaussian curvature, would exacerbate angiographic error.

Methods

Clinically relevant AV access geometries were modeled with computer-aided design (CAD) and fabricated using 3D printing. Lumen diameters were measured by contrast angiography and IVUS and compared with CAD dimensions. Conduit geometry was …

In Situ Detection Of Dead Cells From Live Cells Via A Dc Plus Low Frequency Ac Resistive Pulse Sensor, Jiang Zhe, Ge Zhang, Joseph Ketchum, Ashely Wong

University Research

Differentiation and detection of live and dead cells are critical for assessing cell viability in biomedical research, evaluating drug efficacy, and monitoring cytotoxicity in therapeutic applications. We present a microfluidic sensor that consists of two successive resistive pulse sensing channels. An excitation signal composed of a low-frequency AC (75 kHz) component and a DC bias was used to measure four key parameters. Through the AC measurement, differences in cell impedance causes variations in phase angle and voltage peak. From the DC measurement, cell size can be inferred from the resistive pulse magnitude, and the cell’s zeta potential is represented by …