Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management,
2022
Purdue University
Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole
Purdue Journal of Service-Learning and International Engagement
EPICS (Engineering Projects in Community Service) is a service-learning design program run through Purdue University. It strives to teach students design skills through providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Bio-medical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. Members of a health care team often spend valuable time organizing cables associated with machines used to take patients’ vital signs. Due to time constraints and the fast-paced work environment, these cables may be mismanaged and damaged. The BME team is working on a …
Hypoxic Incubation Chamber,
2022
California Polytechnic State University, San Luis Obispo
Hypoxic Incubation Chamber, Simone Lisette Helfrich, Makenzie Nicole Jones
Biomedical Engineering: Graduate Reports and Projects
This paper describes the design, manufacturing, and testing of a novel controllable hypoxic incubator with fully functional oxygen gas control and temperature control in a humid environment. On the current market, a majority of the few hypoxic incubators use pre-mixed gas that does not offer precise control over gas concentration. The objective for this project was to create a chamber that allows the user to set the O2 concentration to varying set points of % O2 while maintaining the chamber at a constant body temperature, CO2 level, humidity, and sterility. To start the project, multiple concepts were developed for the …
Hypoxic Incubation Chamber,
2022
California Polytechnic State University, San Luis Obispo
Hypoxic Incubation Chamber, Simone Lisette Helfrich, Makenzie Nicole Jones
Master's Theses
This paper describes the design, manufacturing, and testing of a novel controllable hypoxic incubator with fully functional oxygen gas control and temperature control in a humid environment. On the current market, a majority of the few hypoxic incubators use pre-mixed gas that does not offer precise control over gas concentration. The objective for this project was to create a chamber that allows the user to set the O2 concentration to varying set points of % O2 while maintaining the chamber at a constant body temperature, CO2 level, humidity, and sterility. To start the project, multiple concepts were developed for the …
Low Intensity Vibration Protects The Weight Bearing Skeleton And Suppresses Fracture Incidence In Boys With Duchenne Muscular Dystrophy,
2022
Istituto Auxologico Italiano
Low Intensity Vibration Protects The Weight Bearing Skeleton And Suppresses Fracture Incidence In Boys With Duchenne Muscular Dystrophy, Maria Luisa Bianchi, Silvia Vai, Giovanni Baranello, Francesca Broggi, Stefan Judex, Thomas N. Hangartner, Clinton Rubin
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The ability of low intensity vibration (LIV) to combat skeletal decline in Duchenne Muscular Dystrophy (DMD) was evaluated in a randomized controlled trial. Twenty DMD boys were enrolled, all ambulant and treated with glucocorticoids (mean age 7.6, height adjusted Z scores [HAZ] of hip bone mineral density [BMD] −2.3). Ten DMD boys were assigned to stand for 10 min/d on an active LIV platform (0.4 g at 30 Hz), while 10 stood on a placebo device. Baseline and 14 month bone mineral content (BMC) and BMD of spine, hip, and total body were measured with DXA, and trabecular bone density …
Musculoskeletal Adaptation Of Young And Older Adults In Response To Challenging Surface Conditions,
2022
Boise State University
Musculoskeletal Adaptation Of Young And Older Adults In Response To Challenging Surface Conditions, Amy E. Holcomb, Nicholas L. Hunt, Amanda K. Ivy, Aidan G. Cormier, Tyler N. Brown, Clare K. Fitzpatrick
Mechanical and Biomedical Engineering Faculty Publications and Presentations
Over 36 million adults over 65 years of age experience accidental falls each year. The underlying neuromechanics (whole-body function) and driving forces behind accidental falls, as well as the effects of aging on the ability of the musculoskeletal system to adapt, are poorly understood. We evaluated differences in kinematics (lower extremity joint angles and range of motion), kinetics (ground reaction force), and electromyography (muscle co-contraction), due to changes in surface conditions during gait in 14 older adults with a history of falling and 14 young adults. We investigated the impact of challenging surfaces on musculoskeletal adaptation and compared the mechanisms …
Modification Of The Tumor Microenvironment Enhances Anti-Pd-1 Immunotherapy In Metastatic Melanoma,
2022
University of South Florida
Modification Of The Tumor Microenvironment Enhances Anti-Pd-1 Immunotherapy In Metastatic Melanoma, Guilan Shi, Megan Scott, Cathryn G. Mangiamele, Richard Heller
Bioelectrics Publications
Resistance to checkpoint-blockade treatments is a challenge in the clinic. Both primary and acquired resistance have become major obstacles, greatly limiting the long-lasting effects and wide application of blockade therapy. Many patients with metastatic melanoma eventually require further therapy. The absence of T-cell infiltration to the tumor site is a well-accepted contributor limiting immune checkpoint inhibitor efficacy. In this study, we combined intratumoral injection of plasmid IL-12 with electrotransfer and anti-PD-1 in metastatic B16F10 melanoma tumor model to increase tumor-infiltrating lymphocytes and improve therapeutic efficacy. We showed that effective anti-tumor responses required a subset of tumor-infiltrating CD8+ and CD4 …
Correlating The Macrostructural Variations Of An Ion Gel With
Its Carbon Dioxide Sorption Capacity,
2022
University of Nebraska-Lincoln
Correlating The Macrostructural Variations Of An Ion Gel With Its Carbon Dioxide Sorption Capacity, Tung Nguyen,, Mona Bavarian, Siamak Nejati
Department of Chemical and Biomolecular Engineering: Faculty Publications
We report on a direct correlation between the macroscale structural variations and the gas sorption capacities of an ion gel. Here, we chose 1-ethyl-3-methylimidazolium bis(trifluoromethyl sulfonyl)imide ([Emim][TF2N]) and poly(vinylidene fluoride)-co-hexafluoropropylene (PVDF-HFP) as the ionic liquid and host polymer, respectively. The CO2 sorption in the thin films of the IL-polymer was measured using the gravimetric method. The results of our experiment showed that the trend in CO2 uptake of these mixtures was nonlinearly correlated with the content of IL. Here, we highlight that the variations in the molecular structure of the polymers were the main reason behind …
Advances In 3d Culture Systems For Therapeutic Discovery And Development In Brain Cancer,
2022
Technological University Dublin
Advances In 3d Culture Systems For Therapeutic Discovery And Development In Brain Cancer, Janith Wanigasekara, Patrick J. Cullen, Paula Bourke, Brijesh Tiwari, James F. Curtin
Articles
This review focuses on recent advances in 3D culture systems that promise more accurate therapeutic models of the glioblastoma multiforme (GBM) tumor microenvironment (TME), such as the unique anatomical, cellular, and molecular features evident in human GBM. The key components of a GBM TME are outlined, including microbiomes, vasculature, extracellular matrix (ECM), infiltrating parenchymal and peripheral immune cells and molecules, and chemical gradients. 3D culture systems are evaluated against 2D culture systems and in vivo animal models. The main 3D culture techniques available are compared, with an emphasis on identifying key gaps in knowledge for the development of suitable platforms …
Non-Antibiotic Antimicrobial Polydopamine Surface Coating To Prevent Stable Biofilm Formation On Satellite Telemetry Tags Used In Cetacean Conservation Applications,
2022
Michigan Technological University
Non-Antibiotic Antimicrobial Polydopamine Surface Coating To Prevent Stable Biofilm Formation On Satellite Telemetry Tags Used In Cetacean Conservation Applications, Ariana Smies, Jeremy Wales, Maureen Hennenfent, Laura Lyons, Caleigh R. Dunn, Jooke Robbins, Bruce Lee, Alexandre Zerbini, Rupak Rajachar
Michigan Tech Publications, Part 1
Satellite telemetry tags, used to monitor the migratory behavior of cetaceans, have the potential to be a vehicle for infection due to their invasive nature. Antibiotic coatings have been previously employed to reduce the chances of infection via the formation of a stable biofilm on the surface of the tags. However, increased use of antibiotics has the potential to lead to the development of antibiotic-resistant pathogens. To prevent the formation of antibiotic-resistant pathogens, a polydopamine surface coating that, when exposed to oxygen, releases low doses ( ~ 40-100 µ M ) of hydrogen peroxide over a prolonged period ( > 24 …
Extraction, Analysis, And Occurrence Of Per- And Polyfluoroalkyl Substances (Pfas) In Wastewater And After Municipal Biosolids Land Application To Determine Agricultural Loading,
2022
University of Nebraska-Lincoln
Extraction, Analysis, And Occurrence Of Per- And Polyfluoroalkyl Substances (Pfas) In Wastewater And After Municipal Biosolids Land Application To Determine Agricultural Loading, Justin Caniglia, Daniel D. Snow, Tiffany L. Messer, Shannon Bartelt-Hunt
Biomedical Engineering Faculty Publications
Given the ubiquitous detection of per- and polyfluoroalkyl substances (PFAS) within numerous soil and water environmental compartments, there is a need for global understanding of current methodologies for extracting water, solids, polar organic chemical integrative samplers (POCIS), and plant tissue for these substances. This study provides details of several current extraction methods, demonstrates the use of POCIS in monitoring these compounds in a wastewater environment, and provides evidence of detectable levels of certain PFAS compounds within Midwestern municipalities and agroecosystems. Validated extraction procedures help characterize occurrence and release of 18 PFAS in a midwestern wastewater treatment plant (WWTP), surface water, …
Traumatic Brain Injury Biomarkers, Simulations And Kinetics,
2022
Wright State University - Main Campus
Traumatic Brain Injury Biomarkers, Simulations And Kinetics, Celeste Hicks, Akshima Dhiman, Chauntel Barrymore, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
This paper reviews the predictive capabilities of blood-based biomarkers to quantify traumatic brain injury (TBI). Biomarkers for concussive conditions also known as mild, to moderate and severe TBI identified along with post-traumatic stress disorder (PTSD) and chronic traumatic encephalopathy (CTE) that occur due to repeated blows to the head during one’s lifetime. Since the pathways of these biomarkers into the blood are not fully understood whether there is disruption in the blood–brain barrier (BBB) and the time it takes after injury for the expression of the biomarkers to be able to predict the injury effectively, there is a need to …
Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated
Signaling And Mitochondrial Dysfunction,
2022
Louisiana State University Health Sciences Center
Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated Signaling And Mitochondrial Dysfunction, Sudha Sharma, Papori Sharma, Tara Bailey, Susmita Bhattarai, Utsab Subedi, Chloe Miller, Hosne Ara, Srivatsan Kidambi, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Department of Chemical and Biomolecular Engineering: Faculty Publications
Reactive oxygen species (ROS), a by-product of aerobic life, are highly reactive molecules with unpaired electrons. The excess of ROS leads to oxidative stress, instigating the peroxidation of polyunsaturated fatty acids (PUFA) in the lipid membrane through a free radical chain reaction and the formation of the most bioactive aldehyde, known as 4-hydroxynonenal (4-HNE). 4-HNE functions as a signaling molecule and toxic product and acts mainly by forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and lipids. The mitochondria have been implicated as a site for 4-HNE generation and adduction. Several studies clarified how 4-HNE affects the …
Fabricating 3-Dimensional Human Brown Adipose Microtissues For
Transplantation Studies,
2022
University of Nebraska-Lincoln
Fabricating 3-Dimensional Human Brown Adipose Microtissues For Transplantation Studies, Ou Wang, Li Han, Haishuang Lin, Mingmei Tian, Shuyang Zhang, Bin Duan, Soonkyu Chung, Chi Zhang, Xiaojun Lian, Yong Wang, Yuguo Lei
Department of Chemical and Biomolecular Engineering: Faculty Publications
Transplanting cell cultured brown adipocytes (BAs) represents a promising approach to prevent and treat obesity (OB) and its associated metabolic disorders, including type 2 diabetes mellitus (T2DM). However, transplanted BAs have a very low survival rate in vivo. The enzymatic dissociation during the harvest of fully differentiated BAs also loses significant cells. There is a critical need for novel methods that can avoid cell death during cell preparation, transplantation, and in vivo. Here, we reported that preparing BAs as injectable microtissues could overcome the problem. We found that 3D culture promoted BA differentiation and UCP-1 expression, and the optimal initial …
Computational Simulations Of The Effects Of Gravity On Lymphatic Transport,
2022
Massachusetts General Hospital
Computational Simulations Of The Effects Of Gravity On Lymphatic Transport, Huabing Li, Huajian Wei, Timothy P. Padera, James W. Baish, Lance L. Munn
Faculty Journal Articles
Physical forces, including mechanical stretch, fluid pressure, and shear forces alter lymphatic vessel contractions and lymph flow. Gravitational forces can affect these forces, resulting in altered lymphatic transport, but the mechanisms involved have not been studied in detail. Here, we combine a lattice Boltzmann-based fluid dynamics computational model with known lymphatic mechanobiological mechanisms to investigate the movement of fluid through a lymphatic vessel under the effects of gravity that may either oppose or assist flow. Regularly spaced, mechanical bi-leaflet valves in the vessel enforce net positive flow as the vessel walls contract autonomously in response to calcium and nitric oxide …
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs,
2022
Wright State University - Main Campus
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs,
2022
Wright State University - Main Campus
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …
Electrochemical Behaviour And Direct Cell Viability Analysis Of Hybrid Implants Made Of Ti-6al-4v Lattices Infiltrated With A Bioabsorbable Zn-Based Alloy,
2022
Ben-Gurion University of the Negev
Electrochemical Behaviour And Direct Cell Viability Analysis Of Hybrid Implants Made Of Ti-6al-4v Lattices Infiltrated With A Bioabsorbable Zn-Based Alloy, Noa Gabay Bass, Galit Katarivas Levy, Tomer Ron, Razi Vago, Jeremy Goldman, Amnon Shirizly, Eli Aghion
Michigan Tech Publications, Part 1
Biodegradable metals are being developed for biomedical implants or components of implants. Biodegradable zinc-based materials, in particular, have been shown to promote bone regeneration in orthopaedic applications. Here, we investigated the potential of a hybrid Ti-Zn system, comprising a Ti-6Al-4V biostable lattice produced by additive manufacturing (AM) infiltrated by a bioabsorbable Zn-2%Fe alloy, to serve as an osseointegrated implant for dental and orthopaedic applications. The osseointegration of implants can be enhanced by a porous implant structure that facilitates bone ingrowth to achieve superior bonding between the bone tissue and the implant. The hybrid material was evaluated in terms of microstructure …
Experimental Investigation Of Low Velocity And High Temperature Solid Particle Impact Erosion Wear,
2022
University of Tulsa
Experimental Investigation Of Low Velocity And High Temperature Solid Particle Impact Erosion Wear, Evan Gietzen, Soroor Karimi, Nipun Goel, Siamack A. Shirazi, Michael Keller, Todd Otanicar
Mechanical and Biomedical Engineering Faculty Publications and Presentations
Next generation Concentrating Solar Power (CSP) plants utilizing solid particles as the heat transfer medium (HTM) are expected to achieve greater operational efficiencies. However, the erosion from the solid particles can cause significant damage to component materials. Low particle speeds (1–2 m/s) are proposed as a means of preventing excessive damage to containment materials. Within the current investigation, solid particle erosion of three potential containment materials, stainless-steel grade 316L, a nickel alloy (Inconel 740H), and a refractory material (Tufcrete 60 M), are examined at a particle impact speed of 1.6 m/s. CarboBead-HSP 40/70 particles, a candidate HTM for CSP systems, …
Safe Zones In Hip-Implant Designs To Resist Dislocation,
2022
Wright State University - Main Campus
Safe Zones In Hip-Implant Designs To Resist Dislocation, Himanshu Bhatt, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Major contributing parameters to hip implant dislocation include preoperative, intra-operative and post-operative factors. Implant geometry are design as well as non-design related. Femoral and acetabular component design features causing dislocation and/or resisting it are elucidated. Twelve implants were designed during this investigation were analyzed for dislocation resistance. A safe zone, establishes combinations of implant dimensions, was analyzed for all the 12 implants where implants were dislocation resistant. Head diameters between 26 mm to 32 mm, neck diameters closer to 14 mm, and neck angle between 25 to 35º were examined to be the safest ranges for hip implant designs.
Direct Material Property Determination: One-Dimensional Formulation Utilising Full-Field Deformation Measurements,
2022
University of South Carolina
Direct Material Property Determination: One-Dimensional Formulation Utilising Full-Field Deformation Measurements, Sreehair Rajan-Kattil, Michael A. Sutton, Subramani Sockalingam, Frank Thomas, Tusit Weerasooriya, Stephen Alexander
Faculty Publications
A direct approach is described to determine the elastic modulus distribution in a nominally heterogeneous material subject to tensile/compression loading and primarily experiencing deformations in the axial direction. The formulation is developed for uniaxial applications using basic theoretical constructs, resulting in a computational framework that has a matrix form [A] {E} = {R}, where the [A] matrix components are known functions of measured axial strains and axial positions, {R} components are known functions of axial body forces, applied loads and reactions and {E} components are the unknown elastic moduli at discrete locations along the length of the specimen. For a …
