Biomedical Engineering and Bioengineering Commons^™

Biomaterials With Diverse Physical & Chemical Signals For Tissue Engineering Applications, Mohammed Mehdi Benmassaoud

Theses and Dissertations

Cells within natural tissues are exposed to a myriad of biochemical and biophysical cues, and it is challenging to recapitulate these signals in vitro. The goal of this dissertation is to create materials with distinct biophysical and biochemical signals as platforms that induce controllable yet diverse cellular responses. To evaluate the effects of heterogeneous biophysical cues on cell behavior, cells were encapsulated in porous scaffold-hydrogel composites, and it was found that cellular metrics (morphology, matrix mechanosensing) varied within soft (hydrogel) and rigid (scaffold) composite regions. To create soft materials with spatially defined biochemical signals, hydrogels that can be subsequently photopatterned …

A Protocol For Coupling Volumetrically Dynamic In Vitro Experiments To Numerical Physiology Simulation For A Hybrid Cardiovascular Model, Abraham Umo, Ethan Kung

Publications

Objective: The Physiology Simulation Coupled Experiment (PSCOPE) is a hybrid modeling framework that enables a physical fluid experiment to operate in the context of a closed-loop computational simulation of cardiovascular physiology. Previous PSCOPE methods coupled rigid experiments to a lumped parameter network (LPN) of physiology but are incompatible with volumetrically dynamic experiments where fluid volume varies periodically. We address this limitation by introducing a method capable of coupling rigid, multi-branch, and volumetrically dynamic in-vitro experiments to an LPN. Methods: Our proposed method utilizes an iterative weighted-averaging algorithm to identify the unique solution waveforms for a given PSCOPE model. We confirm …

Impulse, Fall 2022, University Marketing And Communications, Jerome J. Lohr College Of Engineering

Impulse (Jerome J. Lohr College of Engineering Publication)

2 | Sanjeev Kumar Takes Helm as College’s 12th Dean
5 | College Develops Partnerships in India, Turkey
6 | Faculty News
8 | Aerofly — Profs, Alum Partner To Build Unique Drone
10 | Researchers Find Way to Extend Produce Shelf Life
12 | SDSU Claims National Title in Quarter-Scale Tractors
14 | Nation’s Top ASCE Chapter Housed at SDSU
16 | National Geo-Video Title Won By State Students
18 | Summer Brings Engineering Camps to Campus
20 | Haleigh Timmer — Money on the Court, In Classroom
22 | Daniel Burkhalter — Day in the Life of Student-Athlete …

Investigating The Impact Of Endothelial Dysfunction And Aging On Vascular Remodeling Using Mouse Models, Liya Du

Theses and Dissertations

Endothelial dysfunction, characterized by a reduction in the bioavailability of nitric oxide (NO), is a major factor in the initiation and progression of atherosclerosis, an age-related chronic inflammatory process in the arterial wall and the leading cause of mortality and morbidity globally. A better understanding of alterations in vascular structure and function associated with endothelial dysfunction can facilitate the early detection of atherosclerosis and the development of potential pharmaceutical interventions. This study aims to clarify the impact of endothelial dysfunction in conjunction with aging on the microstructure of aortic extracellular matrix (ECM) and to elucidate the relationship between microstructural adaptation …

Histomechanical Compatibility Of Coronary Artery Bypass Grafts, Colton J. Kostelnik

Theses and Dissertations

Coronary artery disease is a localized form of atherosclerosis that can severely restrict blood flow to the heart often requiring a surgical intervention known as coronary artery bypass grafting (CABG) to reestablish perfusion to this essential circulation. To some extent, the selection of the autograft tissue is at the surgeon’s discretion with factors such as stenosis location and the existing tissue’s pathological state contributing to a choice that could be deterministic in surgical outcomes. Many post-operative complications and premature graft failures originate from graft-target tissue incompatibilities and altered blood flow patterns. We hypothesize that mechanical mismatching between the graft material …

Functionality Of The Gracilis Collateral Is Impaired Following Arteriogenesis And Cell Transplantation, Ada A. Tadeo

Biomedical Engineering

Peripheral Arterial Disease involves narrowed arteries, reducing blood flow to limbs. Increasing blood flow to those extremities is possible by redirecting the blood to flow through natural bypasses (i.e. collateral arteries), which can enlarge via arteriogenesis to maintain blood supply once the prominent arteries have become occluded. This study aims to investigate how arteriogenesis affects collateral function, if myoblast transplantation can stimulate collateral growth, and how that in turn may affect collateral function. Femoral artery ligation was performed to mimic the blockage that occurs in patients with ischemic diseases on lean mice and mice with diet induced obesity (DIO). A …

Percutaneous-Reinforced Osteoplasty: A Review Of Emerging Treatment Strategies For Bone Interventions, Nischal Koirala, Jyotsna Joshi, Stephen F. Duffy, Gordon Mclennan

Civil and Environmental Engineering Faculty Publications

Percutaneous-reinforced osteoplasty is currently being investigated as a possible therapeutic procedure for fracture stabilization in high-risk patients, primarily in patients with bone metastases or osteoporosis. For these patients, a percutaneous approach, if structurally sound, can provide a viable method for treating bone fractures without the physiologic stress of anesthesia and open surgery. However, the low strength of fixation is a common limitation that requires further refinement in scaffold design and selection of materials, and may potentially benefit from tissue-engineering-based regenerative approaches. Scaffolds that have tissue regenerative properties and low inflammatory response promote rapid healing at the fracture site and are …

Synthesis Of Alginate/Hydroxyapatite Beads For Acetaminophen Delivery, Anesylvia Angan, Nonni Soraya Sambudi

Makara Journal of Science

Conventional drug delivery systems usually involve the intake of multiple drugs, which could amplify the risk of overdosing. Acetaminophen is a widely used pain relief substance that is prone to accidental overdosing. Hence, a controlled drug delivery system is needed to ensure its efficacy. A nanocomposite hydroxyapatite/alginate system that was used as a drug carrier for acetaminophen was synthesized through the sol-gel method, and the mechanism underlying its controlled drug delivery was investigated. Spherical nanocomposite bead samples were synthesized by incorporating 5 wt%, 10 wt%, and 15 wt% hydroxyapatite into mixtures containing alginate. The mixtures were then dropped into calcium …

An Introductory Module In Medical Image Segmentation For Bme Students, Christine Buffinton, Donna Ebenstein, James W. Baish

Faculty Journal Articles

To support recent trends toward the use of patient-specific anatomical models from medical imaging data, we present a learning module for use in the undergraduate BME curriculum that introduces image segmentation, the process of partitioning digital images to isolate specific anatomical features. Five commercially available software packages were evaluated based on their perceived learning curve, ease of use, tools for segmentation and rendering, special tools, and cost: ITK-SNAP, 3D Slicer, OsiriX, Mimics, and Amira. After selecting the package best suited for a stand-alone course module on medical image segmentation, instructional materials were developed that included a general introduction to imaging, …

Model-Based Determination Of The Synchronization Delay Between Mri And Trajectory Data., Paul Ioan Dubovan, Corey Allan Baron

Robarts Imaging Publications

PURPOSE: Real-time monitoring of dynamic magnetic fields has recently become a commercially available option for measuring MRI k-space trajectories and magnetic fields induced by eddy currents in real time. However, for accurate image reconstructions, sub-microsecond synchronization between the MRI data and field dynamics (ie, k-space trajectory plus other spatially varying fields) is required. In this work, we introduce a new model-based algorithm to automatically perform this synchronization using only the MRI data and field dynamics.

METHODS: The algorithm works by enforcing consistency among the MRI data, field dynamics, and receiver sensitivity profiles by iteratively alternating between convex optimizations for (a) …

Predicting Insulin Pump Therapy Settings, Riccardo L. Ferraro, David Grijalva, Alex Trahan

SMU Data Science Review

Millions of people live with diabetes worldwide [7]. To mitigate some of the many symptoms associated with diabetes, an estimated 350,000 people in the United States rely on insulin pumps [17]. For many of these people, how effectively their insulin pump performs is the difference between sleeping through the night and a life threatening emergency treatment at a hospital. Three programmed insulin pump therapy settings governing effective insulin pump function are: Basal Rate (BR), Insulin Sensitivity Factor (ISF), and Carbohydrate Ratio (ICR). For many people using insulin pumps, these therapy settings are often not correct, given their physiological needs. While …

Effects Of Cell-Cell Signaling On Mesenchymal Stem Cell Mechanosensing And Adaptation To Dynamic Material, Matthew E. Lowe

Theses and Dissertations

The goal of this research is to identify the role of engineered cell-cell signals on how cells sense material properties. Mesenchymal stem cells (MSCs) are adult cells whose behavior is regulated by matrix mechanosensing, which is characterized by stiffness-dependent changes in cell shape and the nuclear localization of mechano-transducer proteins including YAP (Yes-associated Protein). MSC area and nuclear YAP translocation increase with increasing stiffness, and although low levels of N-cadherin-based cell-cell signaling reduce this effect, two fundamental questions remain: (1) do engineered cell-cell signals at higher concentrations further reduce matrix mechanosensing, and (2) does N-cadherin signaling affect MSC adaptation to …

Effect Of Degradation Of Methylene Blue Dye (Mb) By Using Erbium Oxide (Er2o3) Nps, Hind Ahmed Jasim, Farah Farman Abbass, Sarah A. Hamood, Hind Mohammed Hassan, Mohammed Sellab Hamza

Al-Esraa University College Journal for Engineering Sciences

In an experiment investigating the photo catalytic degradation of methylene blue using varied concentrations of Er2O3 nanoparticles, different conditions were tested including with and without sunshine, as well as in the absence of a UV source. The presence of a UV source was also considered in the research. UV-Visible spectroscopy was utilized to characterize the catalysts. The degradation of methylene blue dye was monitored by spectrophotometry by tracking dye absorbance at regular time intervals and adjusting the dye concentration. The results indicated that the most effective degradation of methylene blue dye occurred during a 5-hour irradiation time and in the …

Architecture Between Development And Ability Programs, Allaa Ahmed Rasheed, Ibrahim Jawad Kadhim

Al-Esraa University College Journal for Engineering Sciences

The development of architecture and its pursuit of perfection can only be achieved through society to reach a specific result when meeting new desires that arise as a result of human development, expanding individual and societal needs, and deepening their relationships in multifaceted ways. The research focuses on development as it requires a clear cumulative vision of the integrative relationship between practice and participation in interpreting the act (effect) from the force (influence). It emphasizes that the power of capabilities is understood through learning and education in describing the capabilities of architecture. This involves adopting new ideas and intellectual premises …

The Designing Of Contemporary Teaching- Learning Spaces According To Interactive Flow Action Local School Spaces-A Case Study, Aseel Jasem Al-Ataby, Anwar Subhi Ramadan Al-Qaraghuli

Al-Esraa University College Journal for Engineering Sciences

The world today faces many challenges related to environmental issues, as well as other social and economic challenges, and in light of intellectual, cognitive, and technical transformations, which led to the emergence of many new phenomena and concepts that correspond to them, including the concept of flow. This concept has been associated with many aspects of life, including architecture, whose importance has emerged recently in light of the challenge of the spread of the Corona virus and its effects on architecture with its residential, educational, and other spaces. This research focuses on the flow in the architectural space in general, …

A New Compact Triple-Band Micro-Strip Monopole Antenna Based On Minkowski Fractal Geometry, Hayder S. Ahmed, Zahra' Salah Ahmed, Sarah A. Hamood, Mohammed Sellab Hamza, Taha A. Elwi

Al-Esraa University College Journal for Engineering Sciences

Wireless communication systems have made significant advancements in size reduction, with antenna terminals remaining a primary challenge for system compatibility. As a result, much of industrial research is focused on antenna miniaturization in wireless systems. In this work, a novel compact Triple-Band Fractal (TBF) antenna is proposed, utilizing three coupling fractal patches with varying iteration levels of Minkowski geometry to provide three resonant bands. The antenna design is implemented using an antenna substrate with a dielectric constant of 10.8 and a thickness of 1.27 mm within the CST Microwave Studio environment. The zero iteration patch resonator is responsible for the …

The Role Of Community Participation In The Architectural Production, Allaa Ahmed Rasheed, Ibrahim Jawad Kadhim

Al-Esraa University College Journal for Engineering Sciences

The role of community participation as a power in building architectural output at the level of the act of thinking in architecture and the design process in non-existence is related to power and presence with act. The research is concerned with expanding knowledge in the direction of the holistic language and searching for the role that builds the privacy of the architectural product versus the community's societal identity. It studies the concept of act within the limits of existence at the level of community participation since the act of architecture is the act of man to meet certain needs and …

The Communicative Deviation In Contemporary Architectural Production, Haneen Hosham Abd-Alrahman, Panrizat Q. Hussein Fehmi

Al-Esraa University College Journal for Engineering Sciences

Deviation is one of the most important concepts discussed in various architectural and non-architectural theses when addressing the topic of creative production. It involves breaking away from the familiar and surpassing established architectural rules to create unique and excellent products that are characterized by their creativity and aesthetic appeal. Recognizing the significance of this concept in shaping contemporary architectural production, the research endeavors to explore the concept of connective displacement in architecture and delve into its essential aspects. The research identifies the research problem as the "cognitive deficiency surrounding connective displacement in the semantic structures embedded in architecture." The objective …

Developed Rc4 Algorithm With Double Reverse For Better Data Protect, Fouad Sahib Muhamed Alkhazraji

Al-Esraa University College Journal for Engineering Sciences

Computer security plays a crucial role in protecting users' data, and cryptographic techniques are commonly used for this purpose. Encryption is a method employed to ensure data confidentiality, whether it is stored on hard drives or transferred through various media. RC4 (Rivest Cipher 4) is a cryptographic algorithm that utilizes the same key for both encryption and decryption processes. It falls under the category of stream ciphers, which are widely utilized in numerous protocols due to their flexibility and speed. RC4 employs XOR (exclusive OR) function to implement its encryption and decryption steps. In this paper, a technique known as …

Morton-Ordered Gpu Lattice Boltzmann Cfd Simulations With Application To Blood Flow, Gerald Gallagher, Fergal J. Boyle

Conference Papers

Computational fluid dynamics (CFD) is routinely used for numerically predicting cardiovascular-system medical device fluid flows. Most CFD simulations ignore the suspended cellular phases of blood due to computational constraints, which negatively affects simulation accuracy. A graphics processing unit (GPU) lattice Boltzmann-immersed boundary (LB-IB) CFD software package capable of accurately modelling blood flow is in development by the authors, focusing on the behaviour of plasma and stomatocyte, discocyte and echinocyte red blood cells during flow. Optimised memory ordering and layout schemes yield significant efficiency improvements for LB GPU simulations. In this work, comparisons of row-major-ordered Structure of Arrays (SoA) and Collected …