Biomedical Engineering and Bioengineering Commons^™

The Designing Of Contemporary Teaching- Learning Spaces According To Interactive Flow Action Local School Spaces-A Case Study, Aseel Jasem Al-Ataby, Anwar Subhi Ramadan Al-Qaraghuli

Al-Esraa University College Journal for Engineering Sciences

The world today faces many challenges related to environmental issues, as well as other social and economic challenges, and in light of intellectual, cognitive, and technical transformations, which led to the emergence of many new phenomena and concepts that correspond to them, including the concept of flow. This concept has been associated with many aspects of life, including architecture, whose importance has emerged recently in light of the challenge of the spread of the Corona virus and its effects on architecture with its residential, educational, and other spaces. This research focuses on the flow in the architectural space in general, …

A New Compact Triple-Band Micro-Strip Monopole Antenna Based On Minkowski Fractal Geometry, Hayder S. Ahmed, Zahra' Salah Ahmed, Sarah A. Hamood, Mohammed Sellab Hamza, Taha A. Elwi

Al-Esraa University College Journal for Engineering Sciences

Wireless communication systems have made significant advancements in size reduction, with antenna terminals remaining a primary challenge for system compatibility. As a result, much of industrial research is focused on antenna miniaturization in wireless systems. In this work, a novel compact Triple-Band Fractal (TBF) antenna is proposed, utilizing three coupling fractal patches with varying iteration levels of Minkowski geometry to provide three resonant bands. The antenna design is implemented using an antenna substrate with a dielectric constant of 10.8 and a thickness of 1.27 mm within the CST Microwave Studio environment. The zero iteration patch resonator is responsible for the …

The Role Of Community Participation In The Architectural Production, Allaa Ahmed Rasheed, Ibrahim Jawad Kadhim

Al-Esraa University College Journal for Engineering Sciences

The role of community participation as a power in building architectural output at the level of the act of thinking in architecture and the design process in non-existence is related to power and presence with act. The research is concerned with expanding knowledge in the direction of the holistic language and searching for the role that builds the privacy of the architectural product versus the community's societal identity. It studies the concept of act within the limits of existence at the level of community participation since the act of architecture is the act of man to meet certain needs and …

The Communicative Deviation In Contemporary Architectural Production, Haneen Hosham Abd-Alrahman, Panrizat Q. Hussein Fehmi

Al-Esraa University College Journal for Engineering Sciences

Deviation is one of the most important concepts discussed in various architectural and non-architectural theses when addressing the topic of creative production. It involves breaking away from the familiar and surpassing established architectural rules to create unique and excellent products that are characterized by their creativity and aesthetic appeal. Recognizing the significance of this concept in shaping contemporary architectural production, the research endeavors to explore the concept of connective displacement in architecture and delve into its essential aspects. The research identifies the research problem as the "cognitive deficiency surrounding connective displacement in the semantic structures embedded in architecture." The objective …

Developed Rc4 Algorithm With Double Reverse For Better Data Protect, Fouad Sahib Muhamed Alkhazraji

Al-Esraa University College Journal for Engineering Sciences

Computer security plays a crucial role in protecting users' data, and cryptographic techniques are commonly used for this purpose. Encryption is a method employed to ensure data confidentiality, whether it is stored on hard drives or transferred through various media. RC4 (Rivest Cipher 4) is a cryptographic algorithm that utilizes the same key for both encryption and decryption processes. It falls under the category of stream ciphers, which are widely utilized in numerous protocols due to their flexibility and speed. RC4 employs XOR (exclusive OR) function to implement its encryption and decryption steps. In this paper, a technique known as …

Morton-Ordered Gpu Lattice Boltzmann Cfd Simulations With Application To Blood Flow, Gerald Gallagher, Fergal J. Boyle

Conference Papers

Computational fluid dynamics (CFD) is routinely used for numerically predicting cardiovascular-system medical device fluid flows. Most CFD simulations ignore the suspended cellular phases of blood due to computational constraints, which negatively affects simulation accuracy. A graphics processing unit (GPU) lattice Boltzmann-immersed boundary (LB-IB) CFD software package capable of accurately modelling blood flow is in development by the authors, focusing on the behaviour of plasma and stomatocyte, discocyte and echinocyte red blood cells during flow. Optimised memory ordering and layout schemes yield significant efficiency improvements for LB GPU simulations. In this work, comparisons of row-major-ordered Structure of Arrays (SoA) and Collected …

Abbott Cardiac Electrophysiology Wet Lab Project, Melissa Kurani, Fiona Lynn

Biomedical Engineering: Graduate Reports and Projects

Cardiac mapping systems provide electrophysiologists with pertinent information about ablation treatment plans for patients who suffer from cardiac arrhythmias. This thesis describes the process of designing a functional wet lab that integrates with Abbott’s EnSite Precision 3D Mapping System, with the purpose of providing Cal Poly students and faculty with an opportunity to have a hands-on learning experience with cardiac mapping. This project encompassed a thorough literature review of cardiology, electrophysiology, and in vitro lab systems, followed by the design, manufacturing, and evaluation of a functional and anatomically representative wet lab. This is a continuation of previous master’s projects that …

Potassium And Sodium Sensing Isfet Device And Array, Liam Stephen Hayes

Electrical Engineering

The use of Ion-Sensitive Field Effect Transistors (ISFETs) as a means of testing a person’s potassium concentration in real-time has broad applications in the consumer space. An avid runner could use such a device to keep track of their hydration and salt levels. A hospital could use it for patients who require around-the-clock remote monitoring, and a variation of ISFETs are currently being used as continuous glucose monitors for diabetes patients. While ISFETs are not a new development in the field of microelectronics, their use as wearable devices has recently become relevant. The goal of this project is primarily to …

Sensorimotor Content Of Multi-Unit Activity In The Paramedian Lobule Of The Cerebellum, Esma Cetinkaya

Dissertations

Based on Center for Disease Control and Prevention report 2016, around 39.5 million people in the United States suffer from motor disabilities. These disabilities are due to traumatic conditions like traumatic brain injury (TBI), neurological diseases such as amyotrophic lateral sclerosis (ALS), or congenital conditions. One of the approaches for restoring the lost motor function is to extract the volitional information from the central nervous system (CNS) and control a mechanical device that can replace the function of a paralyzed limb through systems called Brain-Computer Interfaces (BCI).

One of the major challenges being faced in BCIs and also in general …

Development And Evaluation Of A Hand Exoskeleton For Neurorehabilitation Post Stroke, Ashley Joyce Mont

Dissertations

Stroke affects approximately 800,000 people in the United States each year, and due to its chronic effects, it is one of the leading causes of disability. Many individuals with stroke suffer the loss of motor function in their paretic upper extremity, and longitudinal studies show that 30 — 66% of individuals with hemiplegia fail to regain arm function six months post stroke. After a stroke, the brain undergoes neuroplasticity which will promote recovery of function. Investigators and clinicians are trying to develop rehabilitation interventions that can be designed to promote neuroplasticity, enhancing the recovery outcomes of therapy.

For individuals with …

Decoding Human Movement Through Experiments And Simulation, Vishnu Deep Chandran

Dissertations

The ability to walk or move independently plays a decisive role in one's quality of life. This human ability requires complex coordination with several systems, such as the nervous, muscular, skeletal, and sensory organs, to execute movement tasks. Hence, any disorder of these systems from injury, disease, or aging severely affects the ability to walk or move independently. Disabilities that impair movement severely affect the quality of life. Therefore, studying the changes affecting human movement is necessary to improve the lives of individuals with impaired movement. Since human movement is complex and many systems interact in non-intuitive ways, the overarching …

Interactive Software-Based Modeling For Gait Analysis Of Musculoskeletal Structures, Nada Masood Mirza, Adnan Ali, Mohamad Khairi Ishak

Makara Journal of Technology

Software for interactive musculoskeletal modeling applies diverse scientific and technological concepts to stimulate the movement of musculoskeletal figures. Several tools are available for biomechanical analysis in studying motion and capturing the musculoskeletal representation data to facilitate further evaluation for muscle activation. Musculoskeletal software, such as the OpenSim model, animates, and measures in 3D the structural movement of bones, muscles, joints, ligaments, and such structures in the human body. Users apply graphical interfaces to manipulate the movement science for fast and accurate analysis. OpenSim simulation software features a user-friendly interface to allow the proper clinical application in biomechanics and rehabilitation research. …

Bag3 Mutation Interferes Myofibril Integrity Of Hipsc-Derived Cardiomyocytes On A Dynamic Substrate, Xiangjun Wu

Theses - ALL

No abstract provided.

Design Of Novel Metalloenzymes And Investigation Of Protein-Metal Interactions, Alona Kulesha

Dissertations - ALL

Metalloproteins are the proteins that utilize metals or metal complexes as cofactors and exhibit a wide range of functions from oxygen transport and regulation of transcription to hydroxylation of alkanes and water splitting, even though they employ a limited set of metals and metal-binding ligands. The investigation of metalloprotein amino acid sequence, structure and function relationships can uncover the principles behind natural metalloprotein design and opens the possibility of their implication as scaffolds for the design of novel catalysts and biomaterials. Protein engineering is a set of techniques that allows to install new functionalities into existing proteins or to design …

Leveraging Isocyanate Chemistry For Low Cost And Highly Functional Hydrogels, Henry Beaman

Dissertations - ALL

The development of novel biomaterials is an important step in providing higher quality products for wound healing, drug delivery, and tissue engineering. Progress is consistently being made in the development of new polymers, yet new polymer systems are often expensive and/or involve complex multistep synthesis methods. These limitations could hinder the translation and scalability of functionalized materials. To address the issues of complex synthesis and high cost, we have devised strategies for polymeric modification using isocyanate chemistry. Isocyanates are used in the manufacturing of polyurethanes. Isocyanates are highly reactive with common functional groups, such as amines, hydroxyls, and carboxylic acids. …

Targeted Mesenchymal Stem Cell Differentiation From Induced Pluripotent Stem Cells For Therapeutic Application, Tackla Winston

Dissertations - ALL

Over the past decade, mesenchymal stem cells have increasingly gained interest as a cell source for the treatment of a variety of diseases. This is because they play several roles in tissue homeostasis and regeneration, such as altering the immune response to limit inflammation, aiding tissue repair through the release of various proteins, cytokines and growth factors, or differentiating into functional cells in specific tissues. The interest in MSCs for biomanufacturing applications has resulted in the development of various protocols to differentiate them from pluripotent sources. These protocols, however, fail to account for the differences that exist between MSCs from …

Analysis And Visualization Of Molecular Docking 2hi4 Protein, Innas Widiasti

Indonesian Journal of Medical Chemistry and Bioinformatics

The crystal structure of the human microsomal complex P450 1A2 with alpha-naphthoflavone, a cytochrome P450 (CYP) enzyme is particularly important, as it is abundant in the human liver and alters a more diverse xenobiotic array than any other group of metabolic enzymes. CYP1A2 is abundantly found in the liver and involved in the metabolism of about 10% of clinically used drugs metabolized by CYP enzymes. The current drug discovery and development mostly uses high-throughput screening (HTS). However, this regular method is time-consuming and costly. To address the issue, an advanced drug discovery and development method namely chemical compound database screening …

Engineering Temporal And Spatial Complexity In Biomaterial Scaffolds For Cardiac Disease Modeling And Mechanobiology, Chenyan Wang

Dissertations - ALL

Temporal and spatial mechanical cues play an important role in heart development, function, and disease manifestation. A deeper understanding of cardiac mechanobiology is especially important for fundamental biology and clinical diagnosis or heart disease treatment. Currently, human induced pluripotent stem cells (hiPSCs) are widely used to build human cell or tissue models, but culturing them in a petri dish fail to recapitulate the mechanical complexity in the native heart. To create a mechanical environment with better pathophysiological relevance, biomaterial scaffolds are usually employed to mimic the mechanical cues originated from extracellular matrix (ECM) remodeling. The goal of this dissertation is …

Cellular Bioenergetics: Experimental Evidence For Alcohol-Induced Adaptations, Liz Simon, Patricia E. Molina

School of Medicine Faculty Publications

At-risk alcohol use is associated with multisystemic effects and end-organ injury, and significantly contributes to global health burden. Several alcohol-mediated mechanisms have been identified, with bioenergetic maladaptation gaining credence as an underlying pathophysiological mechanism contributing to cellular injury. This evidence-based review focuses on the current knowledge of alcohol-induced bioenergetic adaptations in metabolically active tissues: liver, cardiac and skeletal muscle, pancreas, and brain. Alcohol metabolism itself significantly interferes with bioenergetic pathways in tissues, particularly the liver. Alcohol decreases states of respiration in the electron transport chain, and activity and expression of respiratory complexes, with a net effect to decrease ATP content. …

The Role Of Small Gtpases In Regulating Blood-Brain Barrier Mechanotransduction, Brandon Jude Deore

Theses and Dissertations

Fluid shear stress is an important mediator of vascular permeability, yet the molecular mechanisms underlying the effect of shear on the blood-brain barrier (BBB) have yet to be clarified in cerebral vasculature despite its importance for brain homeostasis.. Neurological symptoms including the formation of microclots, stroke, and other neurological pathologies associated with changes in cerebral blood flow are hallmarks of BBB dysfunction. The in vitro model used in this dissertation is compatible with real-time measurement of barrier function using a transendothelial electrical resistance as well as immunocytochemistry and dextran permeability assays. These experiments reveal that there is a threshold level …