Biomedical Devices and Instrumentation Commons^™

Non-Invasive Diagnostic Measures Of Sensorineural Hearing Loss In Chinchillas, Hannah M. Ginsberg, Satyabrata Parida, Michael G. Heinz

The Summer Undergraduate Research Fellowship (SURF) Symposium

According to the World Health Organization, disabling hearing loss affects nearly 466 million people worldwide. Sensorineural hearing loss (SNHL), which is characterized as damage to the inner ear (e.g., cochlear hair cells) and/or to the neural pathways connecting the inner ear and brain, accounts for 90% of all disabling hearing loss. More concerning is that significant perceptual and physiological aspects of SNHL remain “hidden” from standard clinical diagnostics. Hidden hearing loss (HHL) manifests as the inability to understand speech in loud, noisy environments (e.g., listening in a noisy restaurant) despite a normal audiogram (i.e., normal detection of soft sounds). Recently, …

Antimicrobial Efficacy And Safety Of A Novel Gas Plasma-Activated Catheter Lock Solution, Sudhir Bhatt, Poonam Mehta, Chen Chen, Dayle A. Daines, Leonard A. Mermel, Hai-Lan Chen, Michael G. Kong

Bioelectrics Publications

Antimicrobial lock solutions are important for prevention of microbial colonization and infection of long-term central venous catheters. We investigated the efficacy and safety of a novel antibiotic-free lock solution formed from gas plasma-activated disinfectant (PAD). Using a luminal biofilm model, viable cells of methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Candida albicans in mature biofilms were reduced by 6 to 8 orders of magnitude with a PAD lock for 60 min. Subsequent 24-h incubation of PAD-treated samples resulted in no detectable regrowth of viable bacteria or fungi. As a comparison, the use of a minocycline-EDTA-ethanol lock solution for 60 …

Determining The Effect Of Locally Delivered Bioactive Modulators On Macrophage Activation At The Implantation Site Of Different Biomaterials In Rats, Kamel Alkhatib

Graduate Theses and Dissertations

Altering the foreign body reaction by targeting macrophages has been of interest in the biomaterials field to improve the integration of longevity of implanted biomedical devices. The objective of this dissertation was to study the effect of locally delivered bioactive modulators on macrophage activation at the implantation site of different biomaterials in rats. Iloprost, a prostacyclin analog, was tested for its ability to direct macrophages to their pro-wound healing phenotype after the implantation of microdialysis probe in the subcutaneous space of male Sprague Dawley rats. This study showed that iloprost can shift macrophage activation states in vivo to the pro-wound …

Rotary Pump Speed Modulation To Produce Pulsatile Flow And Ventricular Volume Unloading., Connor Joseph Smith

Electronic Theses and Dissertations

Background: Continuous-flow (CF) left ventricular assist devices (LVADs) have gained widespread clinical acceptance as a treatment option for advanced heart failure (HF); however, they have also been associated with an increased risk of adverse events, including gastrointestinal bleeding, aortic insufficiency, and hemorrhagic stroke. It has been hypothesized that the increase in adverse event incidence may be due in part to diminished vascular pulsatility and high shear stress when CF-LVADs are operated at fixed speeds. Previous studies have shown that pump speed modulation generates greater levels of pulsatility in rotary pumps than when operated at fixed speeds. The objective of this …

Incorporating Germanium Oxide Into The Glass Phase Of Novel Zinc/Magnesium-Based Gpcs Designed For Bone Void Filling: Evaluating Their Physical And Mechanical Properties, Basel A. Khader, Omar Rodriguez, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

The structural role of Germanium (Ge), when substituting for Zinc (Zn) up to 8 mol % in the 0.48SiO₂-0.12CaO-0.36ZnO-0.04MgO glass series, was investigated with respect to both the glass chemistry and also the properties of glass polyalkenoate cements (GPCs) manufactured from them. The Network connectivity (NC) of the glass was calculated to increase from 1.83 to 2.42 with the addition of GeO₂ (0-8 mol %). Differential thermal analysis (DTA) results confirmed an increase in the glass transition temperature (T_g) of the glass series with GeO₂ content. X-ray photoelectron spectroscopy (XPS) showed an increase in …

Developing Droplet Based 3d Cell Culture Methods To Enable Investigations Of The Chemical Tumor Microenvironment, Jacqueline Alexandria De Lora

Biomedical Sciences ETDs

Adaptation of cancer cells to changes in the biochemical microenvironment in an expanding tumor mass is a crucial aspect of malignant progression, tumor metabolism, and drug efficacy. In vitro, it is challenging to mimic the evolution of biochemical gradients and the cellular heterogeneity that characterizes cancer tissues found in vivo. It is well accepted that more realistic and controllable in vitro 3D model systems are required to improve the overall cancer research paradigm and thus improve on the translation of results, but multidisciplinary approaches are needed for these advances. This work develops such approaches and demonstrates that new droplet-based cell-encapsulation …

Control Design And Implementation Of An Active Transtibial Prosthesis, Joseph Klein

Master's Theses (2009 -)

Prior work at Marquette University developed the Marquette Prosthesis, an active transtibial prosthesis that utilized a torsional spring and a four-bar mechanism. The controls for the Marquette Prosthesis implemented a finite state control algorithm to determine the state of gait of the amputee along with two lower level controllers, a PI moment controller to control the moment during stance and a PID position controller to control the position during stance. The Marquette Prosthesis was successful in mimicking the gait profile presented by Winter. However, after completing human subject testing, the Marquette Prosthesis was insufficient in trying to match the gait …

Wearable Assistive Technologies For Autism: Opportunities And Challenges, Emma Mansouri Benssassi, Juan-Carlos Gomez, Louanne E. Boyd, Gillian R. Hayes, Juan Ye

Engineering Faculty Articles and Research

Autism is a lifelong developmental condition that affects how people perceive the world and interact with others. Challenges with typical social engagement, common in the autism experience, can have a significant negative impact on the quality of life of individuals and families living with autism. Recent advances in sensing, intelligent, and interactive technologies can enable new forms of assistive and augmentative technologies to support social interactions. However, researchers have not yet demonstrated effectiveness of these technologies in long-term real-world use. This article presents an overview of the social and sensory challenges of autism, which offer great opportunities and challenges for …

Fixing Vertebral Compression Fractures With Medtronic, Kelly Fitzgerald, Trevor Bingham, Alex Denbaugh, Jordan Tang, Jon Stearns

Industrial and Manufacturing Engineering

No abstract provided.

Annuloplasty Mti: Improved Tooling For Annuloplasty Ring Manufacturing, Justin David Smith, Spencer Lee Combs, Luke Edward Maly

Mechanical Engineering

The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.

Identification System For Heart Valve Manufacturing, Nicholas Robert Jensen, Edgar Davis Nix, Judith Evelyn Gonzalez, Albert Austin Liddicoat

Mechanical Engineering

Abstract withheld due to NDA constraints

Transcatheter Heart Valve Leaflet Assembly Tooling Improvement Final Design Report, James Craig Sherman, Zachary Robert Dicks, Luke Edward Williams

Mechanical Engineering

Statement of Confidentiality: The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.

Dynamic Model For Simulating Motion Of The Right Ventricle, Brian Michael Larsen, Sam Koopman Porter, John Francis D'Ambrosio

Mechanical Engineering

This report documents all the research, ideation, and mockups used to determine right ventricle motion and develop a system capable of reproducing that motion on a tissue sample. The model is intended for evaluating anchoring systems being developed by Edwards Lifesciences for use with tricuspid valve therapies. Several design solutions were considered for the primary functions of recreating motion of the right ventricle and attaching tissue to the device. From these ideas a primary means of producing motion and attaching tissue was selected. These ideas were then developed over the course of a school year to become the final system …

Extended-Use Ecg Monitor, Daniel Aaron Soski

Master's Theses

In this thesis, a prototype ECG monitor was developed that is integrated into an elastic shirt and takes a 3-lead ECG for over 5 days. The high-quality measurements can be used to identify markers indicative of various detrimental heart conditions. Measurements recorded by the device are encrypted and stored onto a micro-SD card. Current Holter monitors are expensive and have functional lives less than 48 hours; however, extended duration monitoring has been proven more useful in diagnosis. The device designed demonstrates that ECG measurements can be taken over longer durations without sacrificing quality, comfort, or device cost.

Chemotherapeutic Drug Cytotoxicity Measurement With A 3d Biomimetic Microfluidic Device And Computational Fluid Dynamics Model, Maryam Moarefian, Caroline Jones, Luke Achenie, Danesh Tafti

Biology and Medicine Through Mathematics Conference

No abstract provided.

Design Of A Distributed Real-Time E-Health Cyber Ecosystem With Collective Actions: Diagnosis, Dynamic Queueing, And Decision Making, Yanlin Zhou

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

In this thesis, we develop a framework for E-health Cyber Ecosystems, and look into different involved actors. The three interested parties in the ecosystem including patients, doctors, and healthcare providers are discussed in 3 different phases. In Phase 1, machine-learning based modeling and simulation analysis is performed to remotely predict a patient's risk level of having heart diseases in real time. In Phase 2, an online dynamic queueing model is devised to pair doctors with patients having high risk levels (diagnosed in Phase 1) to confirm the risk, and provide help. In Phase 3, a decision making paradigm is proposed …

Design & Delivery Of Automated Winston-Lutz Test For Isocentric & Off-Axis Delivery Stability Utilizing Truebeam Developer Mode & Electronic Portal Imaging Device, Mahmoud Mohammad Yaqoub

UNLV Theses, Dissertations, Professional Papers, and Capstones

The uncertainties in treatment delivery cannot be ignored in radiation therapy. Thus, the quality assurance QA tests are very important task of the medical physicist in clinical practice. Assuring the coincidence between the mechanical isocenter of the Linear Accelerator (LINAC) and its radiation beams isocenter is one of the most important qualities need to be tested, and the Winston Lust (WL) test is the

most popular technique to perform this task, especially for the treatment modalities which need high precision in beam delivery such as the stereotactic radiosurgery/stereotactic body radiotherapy (SRS/SBRT). The linear accelerator-based SRS/SBRT is a well-established method in …

Design Of A Homeopathic Solution For Chronic Cough, Jacob Ziemke

Senior Honors Projects, 2010-2019

Chronic cough is most commonly defined as a cough that persists for more than eight weeks and is estimated to affect more than 30 million people in the United States at any given time. Diseases contributing to the onset of chronic cough include asthma, pulmonary fibrosis, lung cancer, postnasal drip, gastroesophageal reflux disease (GERD), and bronchitis, and may include lifestyle choices such as smoking. For those who seek medical advice, pharmaceuticals and speech therapy are two common methods of combating chronic cough but serve to mask the symptoms rather than treat the problem; frequently, chronic cough is misdiagnosed or cannot …

Computational Fluid Dynamics Model For Air Velocity Through A Poultry Transport Trailer In A Holding Shed, Christian Heymsfield

Graduate Theses and Dissertations

Broiler production in Arkansas was valued at over $3.6 billion in 2013 (University of Arkansas Division of Agriculture Cooperative Extension Service). Consequently, improvement in any phase of the production process can have significant economic impact and animal welfare implications. One area of concern for the poultry industry is thermal stress experienced by the birds after arrival at the processing plant and before they are taken in to be processed, during which time they are left to wait in holding sheds. Various cooling strategies exist to mitigate heat stress in holding sheds, but in most cases it is unlikely that they …

Pressure Acquisition System For In Vitro Mitral Valve Analysis, Laura Peck

Biomedical Engineering Undergraduate Honors Theses

In vitro testing of the mitral valve chordae tendineae is utilized to aid in the understanding of the stresses that occur in vivo and improve upon surgical solutions that exist for mitral valve repair. This project aimed to design the water control system for a left heart simulation chamber, as well as the pressure acquisition inside the chamber. A solenoid valve was utilized to control the water supply to the tank and was powered utilizing National Instruments software. National Instruments hardware and software was also used with the pressure transducer in order to obtain pressure readings from the chamber. The …