Composition-Structure-Property Relationships In Multicomponent Bioactive Glasses,
2010
Medical Engineering Design and Innovation Centre, Department of Manufacturing, Biomedical and Facilities Engineering, Cork Institute of Technology, Cork, Ireland.
Composition-Structure-Property Relationships In Multicomponent Bioactive Glasses, Sharon Murphy
Theses
Silicate glasses function effectively as bone grafts by stimulating bone regeneration through gene activation. However these materials offer little therapeutic potential for the regeneration of healthy bone in those suffering from metabolic bone diseases such as osteoporosis. Examining the composition-structure-property relationships arising from the incorporation of therapeutic ions such as strontium (Sr) and zinc (Zn) into such glasses in order to allow for healthy bone regeneration and antibacterial efficacy, as well as sodium (Na) to allow for controlled ion release was the objective of this work. Eight calcium-strontium-sodium-zinc-silicate glass compositions were produced, based on incremental additions of Sr and Na. …
Theory Of ‘Selectivity’ Of Label-Free Nanobiosensors – A Geometro-Physical Perspective,
2010
Purdue University - Main Campus
Theory Of ‘Selectivity’ Of Label-Free Nanobiosensors – A Geometro-Physical Perspective, Pradeep R. Nair, Muhammad A. Alam
Birck and NCN Publications
Modern label-free biosensors are generally far more sensitive and require orders of magnitude less incubation time compared to their classical counterparts. However, a more important characteristic regarding the viability of this technology for applications in Genomics/Proteomics is defined by the ‘Selectivity’, i.e., the ability to concurrently and uniquely detect multiple target biomolecules in the presence of interfering species. Currently, there is no theory of Selectivity that allows optimization of competing factors and there are few experiments to probe this problem systematically. In this article, we use the elementary considerations of surface exclusion, diffusion limited transport, and void distribution function to …
