Identification And Quantitation Of 3,4-Methylenedioxy-N-Methylamphetamine (Mdma, Ecstasy) In Human Urine By 1h Nmr Spectroscopy. Application To Five Cases Of Intoxication, Jonathan Liu, John Decatur, Gloria Proni, Elise Champeil
Publications and Research
Identification of 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) in five cases of intoxication using nuclear magnetic resonance (NMR) spectroscopy of human urine is reported. A new water suppression technique PURGE (Presaturation Utilizing Relaxation Gradients and Echoes) was used. A calibration curve was obtained using spiked samples. The method gave a linear response (correlation coefficient of 0.992) over the range 0.01–1 mg/mL. Subsequently, quantitation of the amount of MDMA present in the samples was performed. The benefit and reliability of NMR investigations of human urine for cases of intoxication with MDMA are discussed.
The Synthesis Of Azaperylene-9,10-Dicarboximides, 2010 Massachusetts Institute of Technology
The Synthesis Of Azaperylene-9,10-Dicarboximides, Brett Vanveller, Kojl Miki, Timorthy M. Swager
The efficient synthesis of a hydrophilic monomer bearing a three-dimensional noncompliant array of hydroxyl groups is described that prevents water-driven excimer features of hydrophobic poly(p-phenylene ethynylene) backbones. Sensitivity of the polymer to 3-nitrotyrosine is also discussesd.
Conformations Of A Model Protein Revealed By An Aggregating Cuᴵᴵ Porphyrin: Sensing The Difference, 2010 Swarthmore College
Conformations Of A Model Protein Revealed By An Aggregating Cuᴵᴵ Porphyrin: Sensing The Difference, G. De Luca, A. Romeo, L. M. Scolaro, Robert F. Pasternack
Chemistry & Biochemistry Faculty Works
Aggregated t-CuP binds to poly-L-glutamate through supramolecular interactions, revealing itself to be an extremely sensitive probe for the major conformations of the polymeric scaffold.
A Dielectric Affinity Microbiosensor, 2010 University of South Carolina - Columbia
A Dielectric Affinity Microbiosensor, Xian Huang, Siqi Li, Jerome S. Schultz, Qian Wang, Qiao Lin
We present an affinity biosensing approach that exploits changes in dielectric properties of a polymer due to its specific, reversible binding with an analyte. The approach is demonstrated using a microsensor comprising a pair of thin-film capacitive electrodes sandwiching a solution of poly(acrylamide-ran-3-acrylamidophenylboronic acid), a synthetic polymer with specific affinity to glucose. Binding with glucose induces changes in the permittivity of the polymer, which can be measured capacitively for specific glucose detection, as confirmed by experimental results at physiologically relevant concentrations. The dielectric affinity biosensing approach holds the potential for practical applications such as long-term continuous glucose ...
Analysis Of Non-Covalent Interactions Between The Nanoparticulate Fillers Andthe Matrix Polymer As Applied To Shape Memory Performance, 2010 Bowling Green State University
Analysis Of Non-Covalent Interactions Between The Nanoparticulate Fillers Andthe Matrix Polymer As Applied To Shape Memory Performance, I. Sedat Gunes, Cesar Perez-Bolivar, Feina Cao, Guillermo A. Jimenez, Pavel Anzenbacher, Sadhan C. Jana
Non-covalent interactions between filler particles and polyurethanes were investigated using fluorescence emission spectroscopy. The results were used in the analysis of shape memory (SM) performance of polyurethanes. Composites of shape memory polyurethane (SMPU) and carbon nanofiber (CNF), oxidized carbon nanofiber (ox-CNF), organoclay, silicon carbide, and carbon black were prepared from diphenylmethane diisocyanate, 1,4-butanediol, and poly(caprolactone) diol. It was revealed by fluorescence emission spectroscopy that primarily the urethane groups located in the hard segments of SMPU interacted with the polar functional groups on filler particles. A close correlation between the extent of non-covalent filler-matrix interactions, soft segment crystallinity, and ...
Homocystamides Promote Free-Radical And Oxidative Damage To Proteins, 2010 Portland State University
Homocystamides Promote Free-Radical And Oxidative Damage To Proteins, Martha Sibrian-Vazquez, Jorge O. Escobedo, Soojin Lim, George K. Samoei, Robert M. Strongin
Chemistry Faculty Publications and Presentations
Elevated levels of homocysteine are associated with several major diseases. However, it is not clear whether homocysteine is a marker or a causative agent. The majority (ca. 80%) of the homocysteine present in humans is protein bound. The study of the posttranslational modification of proteins by homocysteine and its cyclic congener, homocysteine thiolactone, is emerging as an area of great current interest for unraveling the ongoing “mediator/marker controversy” [Jacobsen DW (2009) Clin Chem 55:1–2]. Interestingly, many of the pathologies associated with homocysteine are also linked to oxidative stress. In the current study, chemical evidence for a causal ...
Phase Transition Enthalpy Measurements Of Organic And Organometallic Compounds. Sublimation, Vaporization And Fusion Enthalpies From 1880 To 2010, William E. Acree, James S. Chickos
No abstract provided.
Quantum Trajectory Dynamics In Imaginary Time With The Momentum-Dependent Quantum Potential, 2010 University of South Carolina--Columbia
Quantum Trajectory Dynamics In Imaginary Time With The Momentum-Dependent Quantum Potential, Sophya Garashchuk
The quantum trajectory dynamics is extended to the wave function evolution in imaginary time. For a nodeless wave function a simple exponential form leads to the classical-like equations of motion of trajectories, representing the wave function, in the presence of the momentum-dependent quantum potential in addition to the external potential. For a Gaussian wave function this quantum potential is a time-dependent constant, generating zero quantum force yet contributing to the total energy. For anharmonic potentials the momentum-dependent quantum potential is cheaply estimated from the global Least-squares Fit to the trajectory momenta in the Taylor basis. Wave functions with nodes are ...
Multiplexed Capillary Electrophoresis System, 2010 Iowa State University
Multiplexed Capillary Electrophoresis System, Edward S. Yeung, Huang-Tsung Chang, Eliza N. Fung, Qingbo Li, Xiandan Lu
Iowa State University Patents
The use of capillary electrophoresis (CE) has greatly improved DNA sequencing rates compared to conventional slab gel electrophoresis. Part of the improvement in speed, however, has been offset by the loss of the ability (inherent in slab gels) to accommodate multiple lanes in a single run. Highly multiplexed capillary electrophoresis, by making possible hundreds or even thousands of parallel sequencing runs, represents an attractive approach to overcoming the current throughput limitations of existing DNA sequencing instrumentation.
Homozygous Frameshift Mutation In Tmco1 Causes A Syndrome With Craniofacial Dysmorphism, Skeletal Anomalies, And Mental Retardation, 2010 DDC Clinic for Special Needs Children
Homozygous Frameshift Mutation In Tmco1 Causes A Syndrome With Craniofacial Dysmorphism, Skeletal Anomalies, And Mental Retardation, Baozhong Xin, Erik G. Puffenberger, Susan Turben, Haiyan Tan, Aimin Zhou, Heng Wang
Chemistry Faculty Publications
We identified an autosomal recessive condition in 11 individuals in the Old Order Amish of northeastern Ohio. The syndrome was characterized by distinctive craniofacial dysmorphism, skeletal anomalies, and mental retardation. The typical craniofacial dysmorphism included brachycephaly, highly arched bushy eyebrows, synophrys, long eyelashes, low-set ears, microdontism of primary teeth, and generalized gingival hyperplasia, whereas Sprengel deformity of scapula, fusion of spine, rib abnormities, pectus excavatum, and pes planus represented skeletal anomalies. The genome-wide homozygosity mapping using six affected individuals localized the disease gene to a 3.3-Mb region on chromosome 1q23.3-q24.1. Candidate gene sequencing identified a homozygous frameshift ...
A Bland–Altman Comparison Of The Lead Care® System And Inductively Coupled Plasma Mass Spectrometry For Detecting Low-Level Lead In Child Whole Blood Samples, Christina Sobin, Tanner Schaub, Natali Parisi, Eva De La Riva
Christina Sobin, Ph.D.
Chronic childhood lead exposure, yielding blood lead levels consistently below 10 μg/dL, remains a major public health concern. Low neurotoxic effect thresholds have not yet been established. Progress requires accurate, efficient, and cost-effective methods for testing large numbers of children. The LeadCare® System (LCS) may provide one ready option. The comparability of this system to the “gold standard” method of inductively coupled plasma mass spectrometry (ICP-MS) for the purpose of detecting blood lead levels below 10 μg/dL has not yet been examined. Paired blood samples from 177 children ages 5.2–12.8 years were tested with LCS ...
Analytical Chemistry 2.0, 2010 DePauw University
Analytical Chemistry 2.0, David Harvey
Chemistry & Biochemistry Faculty publications
No abstract provided.
Flavonoids And A Stilbene From Triadenum Fraseri (Spach) Gleason, 2010 Univeristy of Rhode Island
Flavonoids And A Stilbene From Triadenum Fraseri (Spach) Gleason, Liya Li, Daniel Woolridge, S. Ritchie Saing, John Jennings, Geneive E. Henry, Navindra P. Seeram
Chemistry Faculty Publications
No abstract provided.
Laboratory Measurements Of Trace Gas Emissions From Biomass Burning Of Fuel Types From The Southeastern And Southwestern United States, 2010 University of Montana - Missoula
Laboratory Measurements Of Trace Gas Emissions From Biomass Burning Of Fuel Types From The Southeastern And Southwestern United States, I. R. Burling, Robert J. Yokelson, David W. T. Griffith, T. J. Johnson, P. Veres, J. M. Roberts, C. Warneke, S. P. Urbanski, J. Reardon, D. R. Weise, Wei Min Hao, J. De Gouw
Chemistry and Biochemistry Faculty Publications
Vegetation commonly managed by prescribed burning was collected from five southeastern and southwestern US military bases and burned under controlled conditions at the US Forest Service Fire Sciences Laboratory in Missoula, Montana. The smoke emissions were measured with a large suite of state-of-the-art instrumentation including an open-path Fourier transform infrared (OP-FTIR) spectrometer for measurement of gas-phase species. The OP-FTIR detected and quantified 19 gas-phase species in these fires: CO2, CO, CH4, C2H2, C2H4, C3H6, HCHO, HCOOH, CH3OH, CH3COOH, furan, H2O, NO, NO2, HONO, NH3, HCN, HCl, and SO2. Emission factors for these species are presented for each vegetation type burned ...
Charge Transfer And Nanostructure Formation During Electroless Etching Of Silicon, 2010 West Chester University
Charge Transfer And Nanostructure Formation During Electroless Etching Of Silicon, Kurt W. Kolasinski
No abstract provided.
Dynamics Of Porous Silicon Formation By Etching In Hf + V2o5 Solutions, 2010 West Chester University of Pennsylvania
Dynamics Of Porous Silicon Formation By Etching In Hf + V2o5 Solutions, Kurt W. Kolasinski, Justin B. Hartline, Bryan T. Kelly, Julia Yadlovskiy
No abstract provided.
Bismuth(Iii) Bromide In Organic Synthesis. A Catalytic Method For The Allylation Of Tetrahydrofuranyl And Tetrahydropyranyl Ethers, 2010 Illinois Wesleyan University
Bismuth(Iii) Bromide In Organic Synthesis. A Catalytic Method For The Allylation Of Tetrahydrofuranyl And Tetrahydropyranyl Ethers, Ram Mohan, Scott Krabbe, Veronica Angeles
A bismuth bromide-catalyzed (10.0 mol %) multicomponent reaction involving the allylation of THF- and THP-ethers, followed by in situ derivatization with acetic anhydride to generate highly functionalized esters has been developed under solvent-free conditions. To the best of our knowledge, this is the first report of a catalytic procedure for the allylation of THF- and THP-ethers to yield ring-opened products.
What Is Wrong With Water Barometers?, 2010 University of Nebraska at Omaha
What Is Wrong With Water Barometers?, Dan Sullivan, Robert W. Smith, E. J. Kemnitz, Kevin Barton, Robert M. Graham, Raymond A. Guenther, Larry Webber
Chemistry Faculty Publications
Every student who studies atmospheric pressure in physics or chemistry learns the principles behind the construction of barometers. Cistern barometers, such as those found in most laboratories, consist of a long glass tube containing an inverted column of liquid having an open end in a cistern of the liquid. Students learn that the column of liquid is supported by air pressure and is equal in weight to a column of air of the same diameter.
Sampling The Conformation Of Protein Surface Residues For Flexible Protein Docking, 2010 University of San Francisco
Sampling The Conformation Of Protein Surface Residues For Flexible Protein Docking, Patricia Francis-Lyon, S Gu, J Hass, N Amenta, P Koehl
Nursing and Health Professions Faculty Research and Publications
Background: The problem of determining the physical conformation of a protein dimer, given the structures of the two interacting proteins in their unbound state, is a difficult one. The location of the docking interface is determined largely by geometric complementarity, but finding complementary geometry is complicated by the flexibility of the backbone and side-chains of both proteins. We seek to generate candidates for docking that approximate the bound state well, even in cases where there is backbone and/or side-chain difference from unbound to bound states.
Results: We divide the surfaces of each protein into local patches and describe the ...
Transition-Metal Ion Exchange Using Poly(Ethylene Glycol) Oligomers As Solvents, 2010 University of South Carolina - Columbia
Transition-Metal Ion Exchange Using Poly(Ethylene Glycol) Oligomers As Solvents, Gina M. Canfield, Michael Bizimis, Susan E. Latturner
Poly(ethylene glycol) oligomers have been found to be effective as alternative solvents for the ion exchange of Mn2þ , Fe2 þ , and Co2þ into hydrated and dehydrated Zeolite X (Na80Al80Si112- O384 3 nH2O). When attempted in aqueous solutions, the exchange of these cations quickly leads to destruction of the zeolite structure within 1-2 exchange cycles. However, in PEG oligomer solvents, the structure can be maintained and exchanges of 48% (Co2þ ), 80% (Mn2þ ), and 91% (Fe2þ ) are observed after one cycle under hydrated conditions. When rigorous steps are taken to remove all water from the zeolite before exchange, absorption of the ...