Nanocarbon Modification Of Membranes For Enhanced Water Desalination And Water Treatment, 2020 New Jersey Institute of Technology
Nanocarbon Modification Of Membranes For Enhanced Water Desalination And Water Treatment, Worawit Intrchom
Water scarcity is foreseen to be one of the great global issues in the coming decades. The challenges are not only in providing water supply to cope with the growing public demand, but recovering clean water to natural resources. Clean water supply, from brackish and seawater is attractive. Membrane distillation (MD) is an emerging thermal membrane-based process that has been used for desalination and other pollutant separations from water. MD can be operated at low temperature, so low-grade energy sources are a good alternative heat source for MD. High salt rejection and low membrane fouling also make MD interesting for ...
Houston, We Have A Problem: Humanity & Home In 2001: A Space Odyssey, 2020 Johns Hopkins University
Houston, We Have A Problem: Humanity & Home In 2001: A Space Odyssey, Charlotte Grace Mcgill Wood
2020 JHU Richard Macksey National Undergraduate Humanities Research Symposium
Stanley Kubrick's watershed film 2001: A Space Odyssey (1968) is epic in its undertaking. In just under three hours, Kubrick attempts to capture the totality of human history, beginning before the evolution of humankind as we know it and ending in a kind of post-physical dream space. The question of the environment's role weighs heavily throughout, as humankind becomes increasingly divorced from the Earth and begins a love affair with the wider universe. This affair is, of course, mediated. It is possible only because of suits and ships, tools invented by and for humans that allow them to ...
Microplastic Monitoring In Richardsonius Balteatus From Ross Lake, Wa, 2020 Western Washinton University
Microplastic Monitoring In Richardsonius Balteatus From Ross Lake, Wa, Sarah Vanlandingham, Anne Fuenzalida
Recent work has shown that microplastics are present in glaciers. This is a concern for water bodies such as Ross Lake (WA) where glacier runoff may transport the microplastics into the watershed and be available to aquatic organisms. Currently there is no evaluation of how organism storage methods may impact microplastic recovery. In this study microplastic type and color in whole body Richardsonius balteatus (redside shiners) from Ross Lake were counted. Fish were collected from Ross Lake on July 6th, 2019. Approximately half of the samples were stored in ethanol and the remainder on ice. Characteristics including color and type ...
Combinatorial Pharmacogenomic Algorithm Is Predictive Of Citalopram And Escitalopram Metabolism In Patients With Major Depressive Disorder, 2020 University of Alabama, Birmingham
Combinatorial Pharmacogenomic Algorithm Is Predictive Of Citalopram And Escitalopram Metabolism In Patients With Major Depressive Disorder, Richard C. Shelton, Anthony J. Rothschild
Pharmacogenomic tests used to guide clinical treatment for major depressive disorder (MDD) must be thoroughly validated. One important assessment of validity is the ability to predict medication blood levels, which reflect altered metabolism. Historically, the metabolic impact of individual genes has been evaluated; however, we now know that multiple genes are often involved in medication metabolism. Here, we evaluated the ability of individual pharmacokinetic genes (CYP2C19, CYP2D6, CYP3A4) and a combinatorial pharmacogenomic test (GeneSight Psychotropic(R); weighted assessment of all three genes) to predict citalopram/escitalopram blood levels in patients with MDD. Patients from the Genomics Used to Improve DEpression ...
Indomethacin Exposure Is Associated With Birthweight In Extremely Preterm Infants: Non-Standard Exposure With Standard Weight-Based Dosing, Bradley C. Stockard
No abstract provided.
Hiv-1 Tat Interactions With Opioids Are Modulated By Progesterone And Estradiol, 2020 University of Mississippi
Hiv-1 Tat Interactions With Opioids Are Modulated By Progesterone And Estradiol, Dejun Jackson
HIV infection and combined substance abuse are comorbid epidemics. Previous studies show that concurrent opioid drug use may potentiate HIV-1-mediated neurotoxicity partly via interactions with opioids. Preclinical studies suggest that the HIV-1 trans-activator of transcription (Tat), an HIV regulatory protein, can synergize with opioids to exacerbate its already neurotoxic effects. However, its interactions with clinical opioids, such as oxycodone, have yet to be elucidated. Additionally, Tat disrupts a number of systems including the dopaminergic system, which contribute to its capacity to potentiate the rewarding effects of abused drugs. Although the neurotoxic effects of Tat may be inhibited by gonadal steroids ...
Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque
Exposure to cannabinoids during critical development periods has increased with epileptic children being commonly prescribed CBD for seizures and pregnant women taking it recreationally. Many studies have been done on the possible benefits and drawbacks of cannabinoid exposure on the human brain, but not much is known about how it can affect the developing brain long-term. To see the potential adverse effects of cannabinoid exposure during critical stages of development and discover potential developmental origins of disease in consuming cannabinoids during embryogenesis, zebrafish embryos (6-96 hours post fertilization) were exposed to varying concentrations of CBD (0.02, 0.1, 0 ...
Study Of Pharmaceutical Tablets Using Raman Mapping, 2020 University of Mississippi
Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly
Covalent bonds are the strongest type of bonds holding molecules together. Based on the pattern of bonding of the molecule, the atoms associated with the bond will vibrate at a specific frequency. Utilizing vibrational spectroscopy, such as Raman spectroscopy, these unique vibrational frequencies can be used to detect the presence of analytes over a selected area. Furthermore, the intensities of the vibrational modes can be tracked to comparatively quantify the concentration of analytes at various locations. This is a method of great importance due to its ability to compare pharmaceutical tablets synthesized with different techniques. Here, the presence and concentration ...
Long-Distance Phasing Of A Tentative "Enhancer" Single-Nucleotide Polymorphism With, 2020 Children's Mercy Hospital
Long-Distance Phasing Of A Tentative "Enhancer" Single-Nucleotide Polymorphism With, Erin C. Boone, Wendy Y. Wang, R Gaedigk, Mariana Cherner, Anick Bérard, J Steven Leeder, Neil A. Miller, Andrea Gaedigk
Manuscripts, Articles, Book Chapters and Other Papers
Background: The CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements. It was proposed that rs5758550, located 116 kb downstream of the CYP2D6 gene locus, increases gene expression and thus contributes to variability in CYP2D6 activity. This finding has, however, not been validated. The purpose of the study was to address a major technological barrier, i.e., experimentally linking rs5758550, also referred to as the "enhancer" single-nucleotide polymorphism (SNP), to CYP2D6 haplotypes >100 kb away. To ...
Formation Of Nanoparticles For The Oral Delivery Of Small Molecules By Flash Nanoprecipitation, 2020 University of Pennsylvania
Formation Of Nanoparticles For The Oral Delivery Of Small Molecules By Flash Nanoprecipitation, Jing Zhi Lo
Master of Chemical Sciences Capstone Projects
Nanoparticles have shown considerable potential in many biological applications including drug delivery, bio-imaging, and medical diagnostics. Specifically, the development of nanoparticle-based drug formulations holds opportunities to improve the dissolution rate and oral availability of poorly water-soluble drugs. The goal of this project is to improve oral bioavailability of a small molecule drug (“G-1”) through the formation of nanoparticles using the flash nanoprecipitation (FNP) process. Interestingly, “G-1” formed ~80 nm particles that are electrostatically stabilized without the use of stabilizing polymers and concentration as high as 160 mg/mL of “G-1” formed nanoparticles. Additionally, trehalose was found to be an effective ...
The Influence Of Climate Change On Disease And Public Health, 2020 St. John Fisher College
The Influence Of Climate Change On Disease And Public Health, Natalie Petruzelli
The Review: A Journal of Undergraduate Student Research
This paper attempts to analyze the growing influence of climate change on the spread and development of diseases, as well as how this continues to affect public health and medical administrations around the world. The prevalence of airborne, waterborne, and vector-borne diseases have been found to be exacerbated as a result of climate change. In addition to this, the paper addresses the reemergence of eliminated diseases and ancient pathogens due to changing temperatures and weather patterns. Finally, the effect of these different conditions on national and international public health organizations and policies is analyzed, including projections on what can be ...
Optimization Of Dna Extraction From Human Milk, 2020 Winthrop University
Optimization Of Dna Extraction From Human Milk, Cassandra Z. Rutherford
Background: Techniques are emerging for determining the best and most cost-effective way to test for human milk adulteration. Currently, the literature is focused on the use of qPCR testing, a technique used to isolate and amplify pieces of DNA for analysis. However, no recommendation currently exists on the best DNA extraction kit to use to achieve optimal DNA yield or purity from human milk samples for downstream qPCR use. Thus, the objective of this study is to assess and compare two DNA extraction kits for use with human milk samples for future DNA-based analysis in the testing for bovine milk ...
Baclofen-Induced Changes In The Resting Brain Modulate Smoking Cue Reactivity: A Double-Blind Placebo-Controlled Functional Magnetic Resonance Imaging Study In Cigarette Smokers, 2020 Old Dominion University
Baclofen-Induced Changes In The Resting Brain Modulate Smoking Cue Reactivity: A Double-Blind Placebo-Controlled Functional Magnetic Resonance Imaging Study In Cigarette Smokers, Ariel Ketcherside, Kanchana Jagannathan, Sudipto Dolui, Nathan Hager, Nathaniel Spilka, Chaela Nutor, Hengyi Rao, Teresa Franklin, Reagan Wetherill
Psychology Faculty Publications
Objective: Smoking cue-(SC) elicited craving can lead to relapse in SC-vulnerable individuals. Thus, identifying treatments that target SC-elicited craving is a top research priority. Reduced drug cue neural activity is associated with recovery and is marked by a profile of greater tonic (resting) activation in executive control regions, and increased connectivity between executive and salience regions. Evidence suggests the GABA-B agonist baclofen can reduce drug cue-elicited neural activity, potentially through its actions on the resting brain. Based on the literature, we hypothesize that baclofen’s effects in the resting brain can predict its effects during SC exposure.
Methods: In ...
Effects Of Nicotine On Attention: Role Of Orexin-1 Receptors, 2020 William & Mary
Effects Of Nicotine On Attention: Role Of Orexin-1 Receptors, Stacy Pitcairn
Undergraduate Honors Theses
The orexin (also called hypocretin) system projects to a wide array of brain regions and is activated by drugs of abuse. The orexin system is best known for its function in wakefulness and arousal, but recent research has suggested that orexins play a vital role in attentional processing. The orexin-1 receptor has been implicated in crucial mechanisms of attention, specifically the transmission of acetylcholine to the cortex. Nicotine is a commonly administered psychoactive drug that has been shown to have cognitive-enhancing effects. Nicotine appears to target the orexin system, suggesting a potential role of the orexin system in mediating the ...
Phospholipid Remodeling Via Exogenous Polyunsaturated Fatty Acid Uptake Modulates Stress Resistance In Vibrio Cholerae, 2020 University of Tennessee at Chattanooga
Phospholipid Remodeling Via Exogenous Polyunsaturated Fatty Acid Uptake Modulates Stress Resistance In Vibrio Cholerae, William Strike
Antibiotic-resistant pathogens represent an escalating threat to public health worldwide, substantially increasing the burden of healthcare and community-acquired infections. Several factors contribute to the emergence and spread of this threat, including but not limited to improper antibiotic use and prescriptions in health-care settings and the community, increasing global travel and migration from countries that have higher levels of antibiotic-resistant pathogens, and a lack of new antibiotics under development. According to the World Health Organization, rising rates of resistance among Gram-negative bacteria (such as Vibrio cholerae) are of particular concern. These bacteria have evolved a number of endogenous membrane remodeling strategies ...
Analysis Of Cannabinoids In Serum By Gc-Ms/Ms, 2020 CUNY John Jay College
Analysis Of Cannabinoids In Serum By Gc-Ms/Ms, Christie Cannarozzi
Due to recent changes in federal and state legislations, the availability and consumption of cannabis products have increased in the United States. The expanded use of recreational and medicinal cannabis products increases the importance of implementing sensitive and selective instrumental methods in toxicological laboratories, as legal implications may arise in forensic cases, such as driving under the influence of drugs (DUID). The purpose of this study was to perform a cross-validation for the quantitative analysis of cannabinoids (Δ9-tetrahydrocannabinol, cannabidiol, cannabinol, 11-hydroxy-Δ9-tetrahydrocannabinol, and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol) in serum by gas chromatography coupled to triple quadrupole tandem mass spectrometry (GCTQ). This method was fully ...
Impact Of Slco1b1 Genetic Variation On Rosuvastatin Systemic Exposure In Pediatric Hypercholesterolemia., 2020 Children's Mercy Hospital
Impact Of Slco1b1 Genetic Variation On Rosuvastatin Systemic Exposure In Pediatric Hypercholesterolemia., Jonathan B. Wagner, Susan M. Abdel-Rahman, Andrea Gaedigk, R Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Leon Van Haandel, J Steven Leeder
Manuscripts, Articles, Book Chapters and Other Papers
This study investigated the impact of SLCO1B1 genotype on rosuvastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8-21 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n = 13; 521CC, n = 2) and wild type controls (521TT, n = 13) completed a single oral dose pharmacokinetic study. The variability contributed by SLCO1B1 c.521 sequence variation to rosuvastatin (RVA) systemic exposure among our pediatric cohort was comparable to previous studies in adults. RVA concentration-time curve from 0-24 hours (AUC
Rna Therapeutics: Informational Drugs As A Pandemic Response Tool, 2020 University of Massachusetts Medical School
Rna Therapeutics: Informational Drugs As A Pandemic Response Tool, Anastasia Khvorova
UMass Center for Clinical and Translational Science Seminars
This presentation, hosted by the Community Engagement and Research Section, University of Massachusetts Medical School Center for Clinical and Translational Science, describes the development of siRNA-based approaches for modulation of COVID-19 in the lung in a three-month time frame.
This talk was the second in the COVID-19 Research Community Forum webinar series, a collaboration of the four federally-funded Clinical and Translational Science Awardees (CTSA) in Massachusetts, that provided an opportunity for community members, institutions and other organizations to be part of the discussions surrounding the COVID-19 pandemic. The MA CTSAs, consisting of the UMass Center for Clinical and Translational Science ...
Investigating The Effects Of Temperature On Lesser Celandine, 2020 Cleveland State University
Investigating The Effects Of Temperature On Lesser Celandine, Regina Bellian
The Downtown Review
This paper explores invasive species Ficaria verna (Lesser celandine) and the effects of temperature on its growth. Trials were completed with two treatments, 13OC cold temperature and 20OC ambient temperature. Germinated bulbils of Lesser celandine were planted on February 15, 2017 and placed in their respective growing chambers. The plants were watered weekly and monitored for growth until harvest on March 29, 2017. Upon harvest, the plants’ height, largest leaf diameter and biomass were measured after extraction from soil and the removal of the leftover soil debris. Average height was found to be 11.66cm for the cold treatment and ...
Understanding The Toxicity Of Single Hydrocarbons, Oil, And Dispersed Oil: A Species Sensitivity Assessment For Five Atlantic Coral Species, 2020 Nova Southeastern University
Understanding The Toxicity Of Single Hydrocarbons, Oil, And Dispersed Oil: A Species Sensitivity Assessment For Five Atlantic Coral Species, Nicholas R. Turner
HCNSO Student Theses and Dissertations
Coral reefs are keystone coastal ecosystems that are at risk of exposure to petroleum hydrocarbons from a range of sources, including oil spill incidents and chronic runoff, and are usually one of the highest valued natural resources for protection in Net Environmental Benefit Analysis (NEBA)/Spill Impact Mitigation Assessment (SIMA) of response methods and environmental damage. Previous research evaluating hydrocarbon impacts to corals has resulted in no clear characterization of sensitivity, as work has generally focused on higher-level effects, compounded by significant variability in experimental methodology. This represents an important knowledge gap in oil spill preparedness and response as it ...