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The Wet Bridge Transfer System: An Novel In Vitro Tool For Assessing Exogenous Surfactant As A Pulmonary Drug Delivery Vehicle, Brandon J. Baer 2019 University of Western Ontario

The Wet Bridge Transfer System: An Novel In Vitro Tool For Assessing Exogenous Surfactant As A Pulmonary Drug Delivery Vehicle, Brandon J. Baer

Western Research Forum

Background:

Due to its complex branching structure, direct drug delivery to the remote areas of the lung is a major challenge. Consequently, most therapies, such as those treating pulmonary infection and inflammation, must utilize large systemic dosing, with the potential for adverse side effects. A novel alternative strategy is to use exogenous surfactant, a material capable of distributing throughout the lung, as a pulmonary drug delivery vehicle.

Objective:

Utilize an in vitro transferring system to assess exogenous surfactant (BLES) as a pulmonary delivery vehicle for different therapeutics.

Methods:

An in vitro technique was developed to simultaneously study surfactant delivery and ...


Arts Of Living On A Damaged Planet: Ghosts And Monsters Of The Anthropocene By Anna Lowenhaupt Tsing, Heather Anne Swanson, Elaine Gan, And Nils Bubandt, Randy Lee Cutler 2019 Emily Carr Institute of Art & Design

Arts Of Living On A Damaged Planet: Ghosts And Monsters Of The Anthropocene By Anna Lowenhaupt Tsing, Heather Anne Swanson, Elaine Gan, And Nils Bubandt, Randy Lee Cutler

The Goose

Review of Anna Lowenhaupt Tsing, Heather Anne Swanson, Elaine Gan, and Nils Bubandt's Arts of Living on a Damaged Planet: Ghosts and Monsters of the Anthropocene.


Development And Validation Of A Lc-Ms/Ms Method For Detection And Quantification Of 18 Antidepressants In Whole Blood, Linda Kim 2019 CUNY John Jay College

Development And Validation Of A Lc-Ms/Ms Method For Detection And Quantification Of 18 Antidepressants In Whole Blood, Linda Kim

Student Theses

Antidepressants are one of the most commonly prescribed drugs in America, with researchers reporting one in six Americans take some form of psychiatric drugs-mostly antidepressants (NBC News, 2016). Antidepressants are often present in combination with other drugs in suicides and drug-related deaths, so a sensitive and specific method to detect and quantify antidepressants is necessary. We developed a method for the detection and quantification of 18 different antidepressants in whole blood, with a range of 2.5-900 ng/mL and LOQ of 2.5 ng/mL. Three hundred uL of blood was used and the analytes were extracted using solid-phase ...


Health Disparities Among South Asians: Is Food Insecurity The Missing Link?, Valentina Chawdhury 2019 California State University, San Bernardino

Health Disparities Among South Asians: Is Food Insecurity The Missing Link?, Valentina Chawdhury

Electronic Theses, Projects, and Dissertations

Objective: Food insecurity among South Asians in the US is a public health issue. Food insecure adults face a plethora of adverse outcomes and research shows that individuals with ancestral origins from South Asia have a higher susceptibility rate for cardiovascular disease after migrating to urban environments. As such, the goal of this study was to research possible barriers South Asians face when creating cultural dishes in the US.

Methods: This was a convergent parallel mixed-methods analysis to understand how South Asians feel about food insecurity. Pricing and availability of cultural food items were obtained from South Asian and Western ...


Fouling And Aging In Membrane Filtration : Hybrid Afm-Based Characterization, Modelling And Reactive Membrane Design, Wanyi Fu 2019 New Jersey Institute of Technology

Fouling And Aging In Membrane Filtration : Hybrid Afm-Based Characterization, Modelling And Reactive Membrane Design, Wanyi Fu

Dissertations

Membrane filtration has been extensively used in water and wastewater treatment, desalination, dairy making, and biomass/water separation. However, membrane fouling, aging and insufficient removal efficiency for dissolved organic matters remain major challenges for wider industrial applications. In order to tackle these challenges, this doctoral dissertation investigates mechanisms of membrane fouling and development of antifouling membrane filtration technologies. Specifically, four major research areas are explored: (i) nanoscale physicochemical characterization of the chemically modified polymeric membranes; (ii) quantitative modelling between membrane properties and membrane fouling and defouling kinetics; (iii) development of quantitative structure-activity relationships for membranes that undergo thermal and chemical ...


Integrating Online Instruction And Hands-On Laboratory Activities For Summer Learning For Students Of Color: A Design Case In Forensic Science, Douglas Elrick, Jiaqi Yu, Connie Hargrave 2019 Iowa State University

Integrating Online Instruction And Hands-On Laboratory Activities For Summer Learning For Students Of Color: A Design Case In Forensic Science, Douglas Elrick, Jiaqi Yu, Connie Hargrave

Constance P. Hargrave

The popularity of TV shows such as Crime Scene Investigation (CSI) has generated high school students’ interest in forensics. Yet, forensic science is not commonly accessible to students, and especially students of color who often attend under-resourced high schools. This article presents the design, development, and evaluation of an online forensics course created for high school students of color who were a part of an informal science, technology, engineering, and mathematics (STEM) educational development program. Two essential elements guided the course design: the target learners (high school students of color) and integrating online instruction and hands-on laboratory activities involving real-world ...


The Proof-Of-The-Concept Of Application Of Pelletization For Mitigation Of Volatile Organic Compounds Emissions From Carbonized Refuse-Derived Fuel, Andrzej Białowiec, Monika Micuda, Antoni Szumny, Jacek Łyczko, Jacek A. Koziel 2019 Iowa State University and Wrocław University of Environmental and Life Sciences

The Proof-Of-The-Concept Of Application Of Pelletization For Mitigation Of Volatile Organic Compounds Emissions From Carbonized Refuse-Derived Fuel, Andrzej Białowiec, Monika Micuda, Antoni Szumny, Jacek Łyczko, Jacek A. Koziel

Agricultural and Biosystems Engineering Publications

Waste can be effectively reused through the production of carbonized refuse-derived fuel (CRDF) that enables further energy recovery. Developing cleaner production of CRDF requires consideration of practical issues of storage and handling. Thus, it needs to be ensured that CRDF does not pose an excessive risk to humans and the ecosystem. Very few studies indicate a wide variety of volatile organic compounds (VOCs) are present in CRDF, some of which are toxic. During handling, storage, transportation, and use of VOC-rich CRDF, workers and end-users could be exposed to emissions that could pose a health and safety hazard. Our recent study ...


Extraction, Purification And Evaluation Of Prmt5-Inhibitory Phytochemical Compounds For The Treatment Of Prostate Adenocarcinoma, Oliver H. Richmond III 2019 Clark Atlanta University

Extraction, Purification And Evaluation Of Prmt5-Inhibitory Phytochemical Compounds For The Treatment Of Prostate Adenocarcinoma, Oliver H. Richmond Iii

Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University

The development and advancement of prostate cancer is supported by a plethora of genetic and proteomic abnormalities, including events of post-translational modifications. The protein arginine methyltransferase 5 (PRMT5) enzyme regulates epigenetic events of histone modifications and protein post-translational modifications within protein signaling pathways. PRMT5 functions by catalyzing the symmetric dimethylation of terminal arginine residues on target protein substrates. Under abnormal conditions of overexpression and upregulation, PRMT5 methyltransferase activity constitutively drives the growth and proliferation of dysregulated cells. Overexpression or upregulation of PRMT5 correlates with disease progression as observed among numerous cancer types, including breast, colorectal, leukemia, lung, melanoma and prostate ...


Reversal Of P-Glycoprotein And Breast Cancer Resistance Protein Mediated Multidrug Resistance In Vitro Using In Silico Identified Novel Compounds, Amila Nanayakkara 2019 Southern Methodist University

Reversal Of P-Glycoprotein And Breast Cancer Resistance Protein Mediated Multidrug Resistance In Vitro Using In Silico Identified Novel Compounds, Amila Nanayakkara

Biological Sciences Theses and Dissertations

Multidrug resistance (MDR) is a major cause of chemotherapy failure. Overexpression of ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two well-studied drug transporters which are associated with MDR. These two transporters also act as a major functional unit of the blood brain barrier to protect the brain from xenobiotics and toxins. Lack of clinically approved P-gp and BCRP inhibitors renders chemotherapy treatments of many MDR cancers ineffective and obstructs drug uptake into the brain.

Using computational methods, we have identified new compounds that inhibit P-gp (Brewer et al., Mol. Pharmacol. 2014). Several of these ...


Reversal Of P-Glycoprotein And Breast Cancer Resistance Protein Mediated Multidrug Resistance In Vitro Using In Silico Identified Novel Compounds, Amila Nanayakkara 2019 Southern Methodist University

Reversal Of P-Glycoprotein And Breast Cancer Resistance Protein Mediated Multidrug Resistance In Vitro Using In Silico Identified Novel Compounds, Amila Nanayakkara

Biological Sciences Theses and Dissertations

Multidrug resistance (MDR) is a major cause of chemotherapy failure. Overexpression of ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two well-studied drug transporters which are associated with MDR. These two transporters also act as a major functional unit of the blood brain barrier to protect the brain from xenobiotics and toxins. Lack of clinically approved P-gp and BCRP inhibitors renders chemotherapy treatments of many MDR cancers ineffective and obstructs drug uptake into the brain.

Using computational methods, we have identified new compounds that inhibit P-gp (Brewer et al., Mol. Pharmacol. 2014). Several of these ...


Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel 2019 Iowa State University

Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel

Joe Smith

Purpose: To describe the pharmacokinetics (PK) of prednisone and prednisolone in tear fluid of dogs receiving oral prednisone at anti-inflammatory to immunosuppressive doses and to assess the impact of induced conjunctivitis on lacrimal drug levels.

Methods: Six healthy Beagle dogs were administered 4 courses of prednisone at 0.5, 1.0, 2.0, and 4.0 mg/kg given orally once a day for 5 days. At steady state, topical histamine was applied to induce mild (1 mg/mL) or severe (375 mg/mL) conjunctivitis in 1 eye of each dog and tear samples were collected from both eyes at ...


A Pharmacokinetic Model Of Lead Absorption And Calcium Competitive Dynamics, Anca R. Radulescu 2019 State University of New York at New Paltz

A Pharmacokinetic Model Of Lead Absorption And Calcium Competitive Dynamics, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.


Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel 2019 Iowa State University

Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With And Without Conjunctivitis, Lionel Sebbag, Yuqi Yan, Joe S. Smith, Rachel A. Allbaugh, Larry W. Wulf, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

Purpose: To describe the pharmacokinetics (PK) of prednisone and prednisolone in tear fluid of dogs receiving oral prednisone at anti-inflammatory to immunosuppressive doses and to assess the impact of induced conjunctivitis on lacrimal drug levels.

Methods: Six healthy Beagle dogs were administered 4 courses of prednisone at 0.5, 1.0, 2.0, and 4.0 mg/kg given orally once a day for 5 days. At steady state, topical histamine was applied to induce mild (1 mg/mL) or severe (375 mg/mL) conjunctivitis in 1 eye of each dog and tear samples were collected from both eyes at ...


Biotransformation Of Praziquantel By Cunninghamella Elegans, Umbelopsis Ramanniana, And Yarrowia Lipolytica Metabolism, Samuel Chivers 2019 University of the Incarnate Word

Biotransformation Of Praziquantel By Cunninghamella Elegans, Umbelopsis Ramanniana, And Yarrowia Lipolytica Metabolism, Samuel Chivers

Samuel Chivers

No abstract provided.


Design Of Cotton Fabric-Based Binary And Ternary Composite Materials Containing Nanostructured Zno, Tio2, And Plasmonic Nanoparticles: Photocatalytic Applications, Latanya Downer 2019 Kennesaw State University

Design Of Cotton Fabric-Based Binary And Ternary Composite Materials Containing Nanostructured Zno, Tio2, And Plasmonic Nanoparticles: Photocatalytic Applications, Latanya Downer

Master of Science in Chemical Sciences Theses

Nanostructure metals and metal oxides can be used for surface functionalization and combined with different materials to increase functionality. Recently, surface functionality has been of interest due to its multi-component and its ability to generate new material properties. One of its main application is the creation of nanomaterials because of its novel physical properties which contribute towards stabilization, strength, and catalytic properties. Nanomaterials makes it possible to fabricate objects in the nanoscale size range which offers beneficial physical properties. The nanomaterial distinctiveness allows for the creation of materials with unique characteristics for different applications such as photocatalytic coatings. Semiconductor and ...


Biotransformation Of Praziquantel By Cunninghamella Elegans, Umbelopsis Ramanniana, And Yarrowia Lipolytica Metabolism, Samuel Chivers 2019 University of the Incarnate Word

Biotransformation Of Praziquantel By Cunninghamella Elegans, Umbelopsis Ramanniana, And Yarrowia Lipolytica Metabolism, Samuel Chivers

Theses & Dissertations

Schistosomiasis is a neglected tropical disease rampant in developing countries. Widespread chemotherapy is reliant on a single drug, praziquantel, which increases the risk of resistance and creates an urgent need for the development of new alternatives for treatment. Fungal biotransformation is a well-documented tool in the pharmaceutical synthesis of new drugs. This study examined the efficacy of four fungal strains, Cunninghamella elegans (ATCC 9245 and ATCC 8688a), Umbelopsis ramanniana, (ATCC 9628) and Yarrowia lipolytica (ATCC 20225), in the biotransformation of praziquantel. Colonies were cultured, dosed with praziquantel, incubated for 5, 10 or 15 days to metabolize, after which the cultures ...


Paraoxonase 2 Is Critical For Non-Small Cell Lung Carcinoma Proliferation., Aaron Whitt 2019 University of Louisville

Paraoxonase 2 Is Critical For Non-Small Cell Lung Carcinoma Proliferation., Aaron Whitt

Electronic Theses and Dissertations

Non-small cell lung carcinoma (NSCLC) comprises 85% of lung cancer diagnoses and is plagued by drug resistance. Thus, elucidating the underlying mechanisms of NSCLC is paramount to expand future treatment options. Paraoxonase 2 (PON2), an intracellular enzyme with arylesterase and lactonase functions, has well-established anti-atherosclerotic activity. Recent studies show PON2 is overexpressed in a variety of tumors and confers drug resistance, although these interactions have not been thoroughly examined in NSCLC. Thus, we sought to investigate the role of PON2 in cellular proliferation using PON2-knockout mice, primary mouse cells, and NSCLC cell lines. Using these approaches, we demonstrate that PON2 ...


Development Of A Lectin-Fc Fusion Protein With Antiviral And Anti-Cancer Activity., Matthew William Dent 2019 University of Louisville

Development Of A Lectin-Fc Fusion Protein With Antiviral And Anti-Cancer Activity., Matthew William Dent

Electronic Theses and Dissertations

This thesis describes the development of a novel lectin-Fc fusion protein and its antiviral and anti-cancer activity. The molecule, Avaren-Fc (AvFc), is a fusion of a variant of the actinomycete lectin actinohivin (Avaren) and the Fc region of human IgG1, and is selective for the terminal α1,2-mannose residues found at the ends of high-mannose-type glycans that can be found on the surface of certain heavily glycosylated viruses and cancer cells. Here, AvFc was found to be able to neutralize simian immunodeficiency virus as well as Hepatitis C virus with nanomolar IC50 values. Furthermore, AvFc recognizes a number of ...


Internal Design Of A Hydroponics Greenhouse For Tri Cycle Farms, Sarah Gould 2019 University of Arkansas, Fayetteville

Internal Design Of A Hydroponics Greenhouse For Tri Cycle Farms, Sarah Gould

Biological and Agricultural Engineering Undergraduate Honors Theses

Hydroponics is the agricultural technique of growing plants without soil, using other growing media and added nutrients in a solvent. It is an attractive agricultural method over conventional agriculture because it is more water efficient, is less labor intensive, yields higher quality crops in less time, and is easier to control. According to the Digital Journal, “hydroponics crop value is anticipated to grow to USD 27.29 Billion by 2022 at an estimated CAGR of 6.39% from 2015 to 2020” (Sawant, 2016). Alongside this growing market acceptance for hydroponics, there is also a local demand that requires only a ...


Development Of Bar-Peptide Nanoparticles And Electrospun Fibers For The Prevention And Treatment Of Oral Biofilms., Mohamed Yehia Mahmoud 2019 University of Louisville

Development Of Bar-Peptide Nanoparticles And Electrospun Fibers For The Prevention And Treatment Of Oral Biofilms., Mohamed Yehia Mahmoud

Electronic Theses and Dissertations

Background: Periodontal diseases are globally prevalent inflammatory disorders that affect ~47% of U.S adults. Porphyromonas gingivalis (Pg) has been identified as a “keystone” pathogen that disrupts host-microbe homeostasis and contributes to the initiation and progression of periodontitis. Pg associates with oral streptococci in supragingival plaque and this interaction represents a potential target for therapeutic intervention. Previously our group developed a peptide (designated BAR), that potently inhibits Pg/Streptococcus gordonii (Sg) adherence in vitro and Pg virulence in a murine model of periodontitis. While efficacious, BAR (SspB Adherence Region) provided transient inhibition and required higher concentrations of BAR to disrupt ...


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