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Effects Of Uv-A Light Treatment On Ammonia, Hydrogen Sulfide, Greenhouse Gases, And Ozone In Simulated Poultry Barn Conditions, Myeongseong Lee, Jisoo Wi, Jacek A. Koziel, Heekwon Ahn, Peiyang Li, Baitong Chen, Zhanibek Meiirkhanuly, Chumki Banik, William S. Jenks 2020 Iowa State University and Chungnam National University

Effects Of Uv-A Light Treatment On Ammonia, Hydrogen Sulfide, Greenhouse Gases, And Ozone In Simulated Poultry Barn Conditions, Myeongseong Lee, Jisoo Wi, Jacek A. Koziel, Heekwon Ahn, Peiyang Li, Baitong Chen, Zhanibek Meiirkhanuly, Chumki Banik, William S. Jenks

Agricultural and Biosystems Engineering Publications

Gaseous emissions, a side effect of livestock and poultry production, need to be mitigated to improve sustainability. Emissions of ammonia (NH3), hydrogen sulfide (H2S), greenhouse gases (GHGs), and odorous volatile organic compounds (VOCs) have a detrimental effect on the environment, climate, and quality of life in rural communities. We are building on previous research to bring advanced oxidation technologies from the lab to the farm. To date, we have shown that ultraviolet A (UV-A) has the potential to mitigate selected odorous gases and GHGs in the context of swine production. Much less research on emissions mitigation has been conducted in ...


The Reliability Of Histamine Pharmacodynamic Response Phenotype Classification In Children With Allergic Disease., Shaun S Kumar, Xiaoxi Liu, Catherine M Sherwin, Bridgette Jones 2020 Children's Mercy Hospital

The Reliability Of Histamine Pharmacodynamic Response Phenotype Classification In Children With Allergic Disease., Shaun S Kumar, Xiaoxi Liu, Catherine M Sherwin, Bridgette Jones

Manuscripts, Articles, Book Chapters and Other Papers

We have identified distinct histamine pharmacodynamic response phenotypes in children with allergic disease utilizing histamine iontophoresis with laser Doppler (HILD). These response phenotypes may be relevant in guiding therapeutic decision making for agents targeting the allergic response pathways. However, the reliability of these response phenotypes has not been assessed. Therefore, we performed HILD in children with allergic rhinitis and/or asthma on two to three separate occasions. HILD response-time data were analyzed in NONMEM using a linked effect PKPD model. Examination of observed vs. classified response phenotypes predicted response plots and the sum of residuals. The intraclass correlation coefficient (ICC ...


Gender Contribution In Household Management Of Water And Its Impact On Residents Of Dholak Basti (Slum) In Haldwani City Of India, Yashi Gupta, Riyan Habeeb, Manya Singh, Anvita Pandey, Vishal Singh, Elizabeth Barker 2020 Center for Ecology Development and Research

Gender Contribution In Household Management Of Water And Its Impact On Residents Of Dholak Basti (Slum) In Haldwani City Of India, Yashi Gupta, Riyan Habeeb, Manya Singh, Anvita Pandey, Vishal Singh, Elizabeth Barker

wH2O: The Journal of Gender and Water

The paper explores water and gender sensitivity in one of the slum areas of Haldwani City, one of the fastest growing and least studied cities of Uttarakhand. The study is intended to contextualise the analysis of household water management and role of gender with respect to water management in the city. First, a city-wide ward wise analysis was conducted to identify wards with low socio-economic profile and high illiteracy based on Census of India, 2011 data and analysed spatially in Geographical Information System (GIS). The spatial analysis was followed by primary surveys in one of the identified wards and statistical ...


Barriers And Bias: Women In Water Utilities Are Breaking Them All, Swati Hegde 2020 University of Pennsylvania

Barriers And Bias: Women In Water Utilities Are Breaking Them All, Swati Hegde

wH2O: The Journal of Gender and Water

Around the world, women are the mainstays of society, from raising children to supporting families to caring for the needy. In developing countries, they are also usually responsible for collecting and providing water for the family. In doing so, their time, health, safety, education and income are compromised. Outdated and undisputed social norms create the biases that force women to bear the responsibility to secure and distribute water, thereby creating barriers to women’s advancement in educational opportunities and significantly reducing income-earning potential. Similarly, in the developed world, outdated social norms create biases and barriers in the water industry that ...


Good Mums: A Gender Equality Perspective On The Constructions Of The Mother In Handwashing Campaigns, Sue Cavill, Chelsea Huggett 2020 Freelance

Good Mums: A Gender Equality Perspective On The Constructions Of The Mother In Handwashing Campaigns, Sue Cavill, Chelsea Huggett

wH2O: The Journal of Gender and Water

The first part of this paper provides a brief overview of the framing of women in hygiene interventions. The following section provides a review of the literature on best practices for handwashing and hygiene, as framed by discourses on the good mother. The goal of this paper is to illustrate how promotional approaches are targeting mothers to change handwashing and hygiene behavior, and to contrast such interventions with the possibility of more gender transformative approaches. We argue that women don’t always implement the handwashing practices they would prefer. This is clearly not due to laziness and thoughtlessness, and it ...


Amigos Por Agua, Pamela J. Lazos 2020 Environmental Attorney and Writer

Amigos Por Agua, Pamela J. Lazos

wH2O: The Journal of Gender and Water

The role of non-profit organizations in outfitting the developing world with clean water has become more extensive as the world’s population grows, especially in places such as Nicaragua, the second poorest country in the western hemisphere. Nicaraguans suffer high rates of kidney disease, respiratory illnesses and parasites as a result of water borne diseases. NGOs such as Amigos for Christ are stepping in to fill the void in Chinandega where the local government lacks the financial wherewithal to provide a basic WASH infrastructure to its inhabitants. It is the goal of Amigos for Christ to bring water to every ...


Future Leader In Sustainable Enterprise — Prescilla Awino, Akudo Ejelonu 2020 University of Pennsylvania

Future Leader In Sustainable Enterprise — Prescilla Awino, Akudo Ejelonu

wH2O: The Journal of Gender and Water

Prescilla is a trainer and a mentor of teenagers and young adolescent women. She successfully managed the Girls Leadership and Advocacy Series (GALS Kenya), a Program of Women Campaign International (WCI). WCI is a Philadelphia based non-profit organization that empowers women globally to actively participate in civil society, political leadership, economic development and peace building.


Evaluating W.A.S.H. (Water, Sanitation And Hygiene) Interventions In Rural Schools Of West Bengal, India, Akudo Ejelonu, Huiran Feng, Thomas McKeon 2020 University of Pennsylvania

Evaluating W.A.S.H. (Water, Sanitation And Hygiene) Interventions In Rural Schools Of West Bengal, India, Akudo Ejelonu, Huiran Feng, Thomas Mckeon

wH2O: The Journal of Gender and Water

Poor sanitation exacerbates adverse health outcomes such as infectious disease, diarrhea and childhood stunting. People of India suffer from disproportionately high rates of poor sanitation. Diarrheal diseases are preventable and better sanitation can reduce disease transmission through improved access to latrines, hygiene education and clean water. A significant concentration of behaviors related to poor sanitation occurring in India requires sustainability and an assessment of programs working towards improving water access, sanitation and hygiene (WASH). We assessed the health and environmental impact of Non-Governmental Organizations (NGOs) such as Sarboday Sangha and Water for People which implemented WASH projects in about 141 ...


The Effects Of Trichloroethylene On The Germination And Early Development Of Radish, Butternut Squash, Corn, And Soybean, Sarah Jaksich 2020 University of Nebraska at Omaha

The Effects Of Trichloroethylene On The Germination And Early Development Of Radish, Butternut Squash, Corn, And Soybean, Sarah Jaksich

Student Research and Creative Activity Fair

Trichloroethylene (TCE) is a small molecule used as a metal degreaser and as an extraction solvent for lipids. Historically, TCE has been used to clean missiles and rockets after testing at military sites. However, TCE has decreased in use due to its potential health hazards. TCE is particularly dangerous because it is soluble in water and easily seeps into ground water. As a result, TCE has contaminated groundwater in Mead, Nebraska. The town is near the formal Nebraska Ordnance Plant, a military factory specializing in bomb assembly, ammonium nitrate production, and explosives burning. Soil sampling in Mead indicated TCE levels ...


The Diffusion Of Artificial Intelligence/Machine Learning Methods And Data Analytics Into An Undergraduate Nursing Research Course, Mary Anne Schultz 2020 California State University, San Bernardino

The Diffusion Of Artificial Intelligence/Machine Learning Methods And Data Analytics Into An Undergraduate Nursing Research Course, Mary Anne Schultz

Q2S Enhancing Pedagogy

The project is the adoption of principles of Artificial Intelligence (AI)/Machine Learning and Data Analytics into a traditional nursing research (hypothesis testing) course. Necessitated by the recent entrance of “Big Data” use in health care, there is an urgent need to inject an understanding of the AI/ML techniques necessary to extract, organize and derive meaning from this huge amount of evidence in clinical decision-making. In fact, our department recently approved the adoption of Precision Health (PH) (the clinical use of the plethora of highly-individualized data in health & medical decisions) principles into six undergraduate courses, NURS 4222 (Nursing Research ...


The Connection Between Indoor Air Quality And Mental Health Outcomes, William L. Taylor 2020 Air Force Institute of Technology

The Connection Between Indoor Air Quality And Mental Health Outcomes, William L. Taylor

Theses and Dissertations

Mental health among United States citizens, military members, and veterans warrant research into factors not fully considered for their effects on mental health. The built environment is increasingly recognized as a potential influence on the mental health of occupants. Specifically, indoor air quality is theorized to contribute to mental illness. Through the development of a literature review, specific air pollutants common in the built environment were identified, and the mechanisms behind their effect on mental health were explored. A model framework is outlined, estimating the number of cases of major depressive disorder attributable to indoor exposure to particulate matter. The ...


Retrospective Cohort Study Of Pure Tone Audiometry Threshold Shifts From Ototoxic Substance, Continuous Noise, And Impulse Noise Exposures At Tinker Air Force Base From 2005 To 2019, Marc J. Blair 2020 Air Force Institute of Technology

Retrospective Cohort Study Of Pure Tone Audiometry Threshold Shifts From Ototoxic Substance, Continuous Noise, And Impulse Noise Exposures At Tinker Air Force Base From 2005 To 2019, Marc J. Blair

Theses and Dissertations

This retrospective cohort epidemiology study sought to establish the comparative risks and potential indicators of hearing loss associated with combinations of ototoxic substances, impulse noise, and continuous noise exposure. Currently, there is not an existing model or methodology in the Department of Defense (DoD) that joins occupational exposure data and pure tone audiometric data. After developing an integrated database model for Tinker Air Force Base, the largest of three depot installations within Air Force Material Command, 2,372 individuals were grouped into eight combinations of exposure groups with a minimum three years exposure duration to hazards. The incidence rates and ...


Amylin As A Potential Link Between Type 2 Diabetes And Alzheimer Disease, Florin Despa, Larry B. Goldstein, Geert Jan Biessels 2020 University of Kentucky

Amylin As A Potential Link Between Type 2 Diabetes And Alzheimer Disease, Florin Despa, Larry B. Goldstein, Geert Jan Biessels

Pharmacology and Nutritional Sciences Faculty Publications

No abstract provided.


Immunogenicity In Clinical Practice And Drug Development: When Is It Significant?, Valentina Shakhnovich, Bernd Meibohm, Amy Rosenberg, Andrzej M. Kierzek, Rachel Hasenkamp, Ryan S. Funk, Craig J. Thalhauser, Piet H. van der Graaf, Yow Ming C. Wang, Lora Hamuro 2020 Children's Mercy Hospital

Immunogenicity In Clinical Practice And Drug Development: When Is It Significant?, Valentina Shakhnovich, Bernd Meibohm, Amy Rosenberg, Andrzej M. Kierzek, Rachel Hasenkamp, Ryan S. Funk, Craig J. Thalhauser, Piet H. Van Der Graaf, Yow Ming C. Wang, Lora Hamuro

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.


Catalytic, Selective, And Stereocontrolled Construction Of C4 Quaternary And Homobenzylic Dihydroisoquinolones By Sp3 C–H Benzylation, Timothy K. Beng, Antonio Moreno 2020 Central Washington University

Catalytic, Selective, And Stereocontrolled Construction Of C4 Quaternary And Homobenzylic Dihydroisoquinolones By Sp3 C–H Benzylation, Timothy K. Beng, Antonio Moreno

All Faculty Scholarship for the College of the Sciences

C1 benzylated isoquinoline derivatives constitute the core of benzylisoquinoline alkaloids (BIAs). However, their C4 congeners remain elusive. Here, we describe a diastereoselective, catalytic, and modular C(sp3)–C(sp3) coupling protocol wherein β-amino sp3 C–H bonds of readily affordable vicinally functionalized dihydroisoquinolones are replaced by sp3 C–benzyl bonds. The method provides expedient access to C4 quaternary and homobenzylic dihydroisoquinolones, which are attractive fragments for potential drug discovery.


Development Of A Hybrid Bayesian Network Model For Predicting Acute Fish Toxicity Using Multiple Lines Of Evidence, S. Jannicke Moe, Anders L. Madsen, Kristin A. Connors, Jane M. Rawlings, Scott E. Belanger, Wayne G. Landis, Raoul Wolf, Adam D. Lillicrap 2020 Norwegian Institute for Water Research (NIVA)

Development Of A Hybrid Bayesian Network Model For Predicting Acute Fish Toxicity Using Multiple Lines Of Evidence, S. Jannicke Moe, Anders L. Madsen, Kristin A. Connors, Jane M. Rawlings, Scott E. Belanger, Wayne G. Landis, Raoul Wolf, Adam D. Lillicrap

IETC Publications

A hybrid Bayesian network (BN) was developed for predicting the acute toxicity of chemicals to fish, using data from fish embryo toxicity (FET) testing in combination with other information. This model can support the use of FET data in a Weight-of-Evidence (WOE) approach for replacing the use of juvenile fish. The BN predicted correct toxicity intervals for 69%–80% of the tested substances. The model was most sensitive to components quantified by toxicity data, and least sensitive to components quantified by expert knowledge. The model is publicly available through a web interface. Further development of this model should include additional ...


Activation Of The Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia By Restoring Cholinergic Interneuron Function, Lauren Malave 2020 The Graduate Center, City University of New York

Activation Of The Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia By Restoring Cholinergic Interneuron Function, Lauren Malave

Dissertations, Theses, and Capstone Projects

Many types of neurons act as multimodal signaling centers. Yet, we have only limited insight into the regulation and functional consequences of neuronal co-transmission. For example, dopamine (DA) neurons, whose degeneration causes motor deficits characteristic of Parkinson’s Diseases (PD), communicate with all their targets by DA but only a selective subset of their targets using GABA, Glutamate, and the secreted cell signaling protein Sonic Hedgehog (Shh). It is unknown whether Levo-dopamine (L-Dopa) induced dyskinesia (LIDs), a severely debilitating side effect of DA supplementation in PD, might appear because DA neuron targets are exposed to high DA- but low Shh- ...


Appalachian Environmental Health Literacy: Building Knowledge And Skills To Protect Health, Anna G. Hoover, Annie Koempel, W. Jay Christian, Kimberly I. Tumlin, Kelly G. Pennell, Steven Evans, Malissa McAlister, Lindell E. Ormsbee, Dawn Brewer 2020 University of Kentucky College of Public Health

Appalachian Environmental Health Literacy: Building Knowledge And Skills To Protect Health, Anna G. Hoover, Annie Koempel, W. Jay Christian, Kimberly I. Tumlin, Kelly G. Pennell, Steven Evans, Malissa Mcalister, Lindell E. Ormsbee, Dawn Brewer

Journal of Appalachian Health

Environmental health literacy (EHL) is an emerging, multidisciplinary field that promotes understanding of how environmental exposures can affect human health. After discussing the regional relevance of environmental health knowledge and skills, this article describes three ongoing Appalachian projects that are focused on measuring and building EHL.


In-Vitro Localisation And Degradation Of Few-Layer Mos2 Submicrometric Plates In Human Macrophage-Like Cells: A Label Free Raman Micro-Spectroscopic Study, Caroline Moore, Andrew Hrvey, Jonathan N. Coleman, Hugh J. Byrne, Jennifer McIntyre 2020 Technological University Dublin

In-Vitro Localisation And Degradation Of Few-Layer Mos2 Submicrometric Plates In Human Macrophage-Like Cells: A Label Free Raman Micro-Spectroscopic Study, Caroline Moore, Andrew Hrvey, Jonathan N. Coleman, Hugh J. Byrne, Jennifer Mcintyre

Articles

Monitoring the uptake, micro-environment and fate of micro or nano scaled particulate materials in cells is of paramount importance for the emerging fields of toxicology and medicine. Such particulate materials are known to interfere with colorimetric assays and many such assays record only a single end-point. Therefore, there is a need for a label-free, cost effective technique with little or no inference from the particulate materials. Raman micro-spectroscopy was used to simultaneously interrogate the integrity of few-layer MoS2 submicrometric plates in human macrophage-like cells, in-vitro, as well as the biochemical characteristics of the local micro-environment in which they are encompassed ...


Data Mining Raman Microspectroscopic Responses Of Cells To Drugs In Vitro Using Multivariate Curve Resolution-Alternating Least Squares, David Perezguaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh J. Byrne 2020 Technological University Dublin

Data Mining Raman Microspectroscopic Responses Of Cells To Drugs In Vitro Using Multivariate Curve Resolution-Alternating Least Squares, David Perezguaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh J. Byrne

Articles

Raman microspectroscopy is gaining popularity for the analysis of time-dependent biological processes such as drug uptake and cellular response. It is a label-free technique which acquires signals from a large variety of components, including cell biomolecules and exogenous compounds such as drugs and nanoparticles, and is commonly employed for in vitro analysis of cells and cell populations with no labelling or staining required. By monitoring the changes to the Raman spectra of the cell as a result of a perturbing agent (e.g. exposure to a drug or toxic agent), one can study the associated changes in cell biochemistry involved ...


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