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Pharmacology, Toxicology and Environmental Health Commons

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Extreme Fire As A Management Tool To Combat Regime Shifts In The Range Of The Endangered American Burying Beetle, Alison K. Ludwig, Daniel R. Uden, Dirac Twidwell 2020 University of Nebraska - Lincoln

Extreme Fire As A Management Tool To Combat Regime Shifts In The Range Of The Endangered American Burying Beetle, Alison K. Ludwig, Daniel R. Uden, Dirac Twidwell

Theses, Dissertations, and Student Research in Agronomy and Horticulture

This study is focused on the population of federally-endangered American burying beetles in south-central Nebraska. It is focused on changes in land cover over time and at several levels of spatial scale, and how management efforts are impacting both the beetle and a changing landscape. Our findings are applicable to a large portion of the Great Plains, which is undergoing the same shift from grassland to woodland, and to areas where the beetle is still found.


Tip60 Regulation Of Δnp63Α Is Associated With Cisplatin Resistance, Akshay Hira, Andrew Stacy, Jin Zhang, Michael P. Craig, Madhavi Kadakia 2020 Wright State University - Main Campus

Tip60 Regulation Of Δnp63Α Is Associated With Cisplatin Resistance, Akshay Hira, Andrew Stacy, Jin Zhang, Michael P. Craig, Madhavi Kadakia

Symposium of Student Research, Scholarship, and Creative Activities Materials

About 5.4 million basal and squamous cell skin cancers are diagnosed every year in the US. ΔNp63a, a member of the p53 transcription factor family, is overexpressed in non-melanoma skin cancer and regulates cell survival, migration and invasion. TIP60 is histone acetyltransferase (HAT) which mediates cellular processes such as transcription and the DNA damage response (DDR). Previous studies in our lab have shown that overexpression of TIP60 induces ΔNp63a protein stabilization in a catalytic-dependent manner. Since ΔNp63a is known to transcriptionally regulate several DDR genes and promote cisplatin resistance, its stabilization by TIP60 may contribute to the failure of ...


Multi-Label Model For Toxicity Prediction, Xiu Huan Yap, Michael L. Raymer 2020 Wright State University - Main Campus

Multi-Label Model For Toxicity Prediction, Xiu Huan Yap, Michael L. Raymer

Symposium of Student Research, Scholarship, and Creative Activities Materials

Most computational predictive models are specifically trained for a single toxicity endpoint. Since more than 1300 toxicity assays have been reported in the TOXCAST dashboard, achieving high coverage over this growing number of toxicity endpoints remains challenging. Furthermore, single-endpoint models lack the ability to learn dependencies between endpoints, such as those targeting similar biological pathways, which may be used to boost model performance. In this study, we characterize the performance of 3 multi-label classification (MLC) models, namely Classifier Chains (CC), Label Powersets (LP) and Stacking (SBR), on Tox21 challenge data. These MLC models employ the Problem Transformation approach, which is ...


The Impact Of Nicotine Accumulation Exposure On Lithobates Catebeianus Larvae Mortality, Luke Micek 2020 University of Nebraska - Lincoln

The Impact Of Nicotine Accumulation Exposure On Lithobates Catebeianus Larvae Mortality, Luke Micek

UCARE Research Products

Cigarette butts are the most littered item in the world and contain over 4,000 chemicals, including the organic compound nicotine (Slaughter et al. 2011). Billions of cigarette butts are littered each year which may wash into bodies of water, impacting the local wildlife. To determine how introduced chemicals impact the environment, it is important to study its effects on indicator species. Amphibians, such as Lithobates catebeianus, act as indicator species due to their extreme sensitivity to chemical changes in its environment. The purpose of this research project was to obtain data to help determine the impact nicotine accumulation has ...


Avoiding Drug Resistance By Substrate Envelope-Guided Design: Toward Potent And Robust Hcv Ns3/4a Protease Inhibitors, Ashley N. Matthew, Jacqueto Zephyr, Nageswara Rao Desaboini, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer 2020 University of Massachusetts Medical School

Avoiding Drug Resistance By Substrate Envelope-Guided Design: Toward Potent And Robust Hcv Ns3/4a Protease Inhibitors, Ashley N. Matthew, Jacqueto Zephyr, Nageswara Rao Desaboini, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

University of Massachusetts Medical School Faculty Publications

Hepatitis C virus (HCV) infects millions of people worldwide, causing chronic liver disease that can lead to cirrhosis, hepatocellular carcinoma, and liver transplant. In the last several years, the advent of direct-acting antivirals, including NS3/4A protease inhibitors (PIs), has remarkably improved treatment outcomes of HCV-infected patients. However, selection of resistance-associated substitutions and polymorphisms among genotypes can lead to drug resistance and in some cases treatment failure. A proactive strategy to combat resistance is to constrain PIs within evolutionarily conserved regions in the protease active site. Designing PIs using the substrate envelope is a rational strategy to decrease the susceptibility ...


Evaluating W.A.S.H. (Water, Sanitation And Hygiene) Interventions In Rural Schools Of West Bengal, India, Akudo Ejelonu, Huiran Feng, Thomas McKeon 2020 University of Pennsylvania

Evaluating W.A.S.H. (Water, Sanitation And Hygiene) Interventions In Rural Schools Of West Bengal, India, Akudo Ejelonu, Huiran Feng, Thomas Mckeon

wH2O: The Journal of Gender and Water

Poor sanitation exacerbates adverse health outcomes such as infectious disease, diarrhea and childhood stunting. People of India suffer from disproportionately high rates of poor sanitation. Diarrheal diseases are preventable and better sanitation can reduce disease transmission through improved access to latrines, hygiene education and clean water. A significant concentration of behaviors related to poor sanitation occurring in India requires sustainability and an assessment of programs working towards improving water access, sanitation and hygiene (WASH). We assessed the health and environmental impact of Non-Governmental Organizations (NGOs) such as Sarboday Sangha and Water for People which implemented WASH projects in about 141 ...


Future Leader In Sustainable Enterprise — Prescilla Awino, Akudo Ejelonu 2020 University of Pennsylvania

Future Leader In Sustainable Enterprise — Prescilla Awino, Akudo Ejelonu

wH2O: The Journal of Gender and Water

Prescilla is a trainer and a mentor of teenagers and young adolescent women. She successfully managed the Girls Leadership and Advocacy Series (GALS Kenya), a Program of Women Campaign International (WCI). WCI is a Philadelphia based non-profit organization that empowers women globally to actively participate in civil society, political leadership, economic development and peace building.


Barriers And Bias: Women In Water Utilities Are Breaking Them All, Swati Hegde 2020 University of Pennsylvania

Barriers And Bias: Women In Water Utilities Are Breaking Them All, Swati Hegde

wH2O: The Journal of Gender and Water

Around the world, women are the mainstays of society, from raising children to supporting families to caring for the needy. In developing countries, they are also usually responsible for collecting and providing water for the family. In doing so, their time, health, safety, education and income are compromised. Outdated and undisputed social norms create the biases that force women to bear the responsibility to secure and distribute water, thereby creating barriers to women’s advancement in educational opportunities and significantly reducing income-earning potential. Similarly, in the developed world, outdated social norms create biases and barriers in the water industry that ...


Good Mums: A Gender Equality Perspective On The Constructions Of The Mother In Handwashing Campaigns, Sue Cavill, Chelsea Huggett 2020 Freelance

Good Mums: A Gender Equality Perspective On The Constructions Of The Mother In Handwashing Campaigns, Sue Cavill, Chelsea Huggett

wH2O: The Journal of Gender and Water

The first part of this paper provides a brief overview of the framing of women in hygiene interventions. The following section provides a review of the literature on best practices for handwashing and hygiene, as framed by discourses on the good mother. The goal of this paper is to illustrate how promotional approaches are targeting mothers to change handwashing and hygiene behavior, and to contrast such interventions with the possibility of more gender transformative approaches. We argue that women don’t always implement the handwashing practices they would prefer. This is clearly not due to laziness and thoughtlessness, and it ...


Gender Contribution In Household Management Of Water And Its Impact On Residents Of Dholak Basti (Slum) In Haldwani City Of India, Yashi Gupta, Riyan Habeeb, Manya Singh, Anvita Pandey, Vishal Singh, Elizabeth Barker 2020 Center for Ecology Development and Research

Gender Contribution In Household Management Of Water And Its Impact On Residents Of Dholak Basti (Slum) In Haldwani City Of India, Yashi Gupta, Riyan Habeeb, Manya Singh, Anvita Pandey, Vishal Singh, Elizabeth Barker

wH2O: The Journal of Gender and Water

The paper explores water and gender sensitivity in one of the slum areas of Haldwani City, one of the fastest growing and least studied cities of Uttarakhand. The study is intended to contextualise the analysis of household water management and role of gender with respect to water management in the city. First, a city-wide ward wise analysis was conducted to identify wards with low socio-economic profile and high illiteracy based on Census of India, 2011 data and analysed spatially in Geographical Information System (GIS). The spatial analysis was followed by primary surveys in one of the identified wards and statistical ...


Amigos Por Agua, Pamela J. Lazos 2020 Environmental Attorney and Writer

Amigos Por Agua, Pamela J. Lazos

wH2O: The Journal of Gender and Water

The role of non-profit organizations in outfitting the developing world with clean water has become more extensive as the world’s population grows, especially in places such as Nicaragua, the second poorest country in the western hemisphere. Nicaraguans suffer high rates of kidney disease, respiratory illnesses and parasites as a result of water borne diseases. NGOs such as Amigos for Christ are stepping in to fill the void in Chinandega where the local government lacks the financial wherewithal to provide a basic WASH infrastructure to its inhabitants. It is the goal of Amigos for Christ to bring water to every ...


The Effects Of Trichloroethylene On The Germination And Early Development Of Radish, Butternut Squash, Corn, And Soybean, Sarah Jaksich 2020 University of Nebraska at Omaha

The Effects Of Trichloroethylene On The Germination And Early Development Of Radish, Butternut Squash, Corn, And Soybean, Sarah Jaksich

Student Research and Creative Activity Fair

Trichloroethylene (TCE) is a small molecule used as a metal degreaser and as an extraction solvent for lipids. Historically, TCE has been used to clean missiles and rockets after testing at military sites. However, TCE has decreased in use due to its potential health hazards. TCE is particularly dangerous because it is soluble in water and easily seeps into ground water. As a result, TCE has contaminated groundwater in Mead, Nebraska. The town is near the formal Nebraska Ordnance Plant, a military factory specializing in bomb assembly, ammonium nitrate production, and explosives burning. Soil sampling in Mead indicated TCE levels ...


The Connection Between Indoor Air Quality And Mental Health Outcomes, William L. Taylor 2020 Air Force Institute of Technology

The Connection Between Indoor Air Quality And Mental Health Outcomes, William L. Taylor

Theses and Dissertations

Mental health among United States citizens, military members, and veterans warrant research into factors not fully considered for their effects on mental health. The built environment is increasingly recognized as a potential influence on the mental health of occupants. Specifically, indoor air quality is theorized to contribute to mental illness. Through the development of a literature review, specific air pollutants common in the built environment were identified, and the mechanisms behind their effect on mental health were explored. A model framework is outlined, estimating the number of cases of major depressive disorder attributable to indoor exposure to particulate matter. The ...


Retrospective Cohort Study Of Pure Tone Audiometry Threshold Shifts From Ototoxic Substance, Continuous Noise, And Impulse Noise Exposures At Tinker Air Force Base From 2005 To 2019, Marc J. Blair 2020 Air Force Institute of Technology

Retrospective Cohort Study Of Pure Tone Audiometry Threshold Shifts From Ototoxic Substance, Continuous Noise, And Impulse Noise Exposures At Tinker Air Force Base From 2005 To 2019, Marc J. Blair

Theses and Dissertations

This retrospective cohort epidemiology study sought to establish the comparative risks and potential indicators of hearing loss associated with combinations of ototoxic substances, impulse noise, and continuous noise exposure. Currently, there is not an existing model or methodology in the Department of Defense (DoD) that joins occupational exposure data and pure tone audiometric data. After developing an integrated database model for Tinker Air Force Base, the largest of three depot installations within Air Force Material Command, 2,372 individuals were grouped into eight combinations of exposure groups with a minimum three years exposure duration to hazards. The incidence rates and ...


The Diffusion Of Artificial Intelligence/Machine Learning Methods And Data Analytics Into An Undergraduate Nursing Research Course, Mary Anne Schultz 2020 California State University, San Bernardino

The Diffusion Of Artificial Intelligence/Machine Learning Methods And Data Analytics Into An Undergraduate Nursing Research Course, Mary Anne Schultz

Q2S Enhancing Pedagogy

The project is the adoption of principles of Artificial Intelligence (AI)/Machine Learning and Data Analytics into a traditional nursing research (hypothesis testing) course. Necessitated by the recent entrance of “Big Data” use in health care, there is an urgent need to inject an understanding of the AI/ML techniques necessary to extract, organize and derive meaning from this huge amount of evidence in clinical decision-making. In fact, our department recently approved the adoption of Precision Health (PH) (the clinical use of the plethora of highly-individualized data in health & medical decisions) principles into six undergraduate courses, NURS 4222 (Nursing Research ...


Activation Of The Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia By Restoring Cholinergic Interneuron Function, Lauren Malave 2020 The Graduate Center, City University of New York

Activation Of The Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia By Restoring Cholinergic Interneuron Function, Lauren Malave

All Dissertations, Theses, and Capstone Projects

Many types of neurons act as multimodal signaling centers. Yet, we have only limited insight into the regulation and functional consequences of neuronal co-transmission. For example, dopamine (DA) neurons, whose degeneration causes motor deficits characteristic of Parkinson’s Diseases (PD), communicate with all their targets by DA but only a selective subset of their targets using GABA, Glutamate, and the secreted cell signaling protein Sonic Hedgehog (Shh). It is unknown whether Levo-dopamine (L-Dopa) induced dyskinesia (LIDs), a severely debilitating side effect of DA supplementation in PD, might appear because DA neuron targets are exposed to high DA- but low Shh- ...


Appalachian Environmental Health Literacy: Building Knowledge And Skills To Protect Health, Anna G. Hoover, Annie Koempel, W. Jay Christian, Kimberly I. Tumlin, Kelly G. Pennell, Steven Evans, Malissa McAlister, Lindell E. Ormsbee, Dawn Brewer 2020 University of Kentucky College of Public Health

Appalachian Environmental Health Literacy: Building Knowledge And Skills To Protect Health, Anna G. Hoover, Annie Koempel, W. Jay Christian, Kimberly I. Tumlin, Kelly G. Pennell, Steven Evans, Malissa Mcalister, Lindell E. Ormsbee, Dawn Brewer

Journal of Appalachian Health

Environmental health literacy (EHL) is an emerging, multidisciplinary field that promotes understanding of how environmental exposures can affect human health. After discussing the regional relevance of environmental health knowledge and skills, this article describes three ongoing Appalachian projects that are focused on measuring and building EHL.


In-Vitro Localisation And Degradation Of Few-Layer Mos2 Submicrometric Plates In Human Macrophage-Like Cells: A Label Free Raman Micro-Spectroscopic Study, Caroline Moore, Andrew Hrvey, Jonathan N. Coleman, Hugh J. Byrne, Jennifer McIntyre 2020 Technological University Dublin

In-Vitro Localisation And Degradation Of Few-Layer Mos2 Submicrometric Plates In Human Macrophage-Like Cells: A Label Free Raman Micro-Spectroscopic Study, Caroline Moore, Andrew Hrvey, Jonathan N. Coleman, Hugh J. Byrne, Jennifer Mcintyre

Articles

Monitoring the uptake, micro-environment and fate of micro or nano scaled particulate materials in cells is of paramount importance for the emerging fields of toxicology and medicine. Such particulate materials are known to interfere with colorimetric assays and many such assays record only a single end-point. Therefore, there is a need for a label-free, cost effective technique with little or no inference from the particulate materials. Raman micro-spectroscopy was used to simultaneously interrogate the integrity of few-layer MoS2 submicrometric plates in human macrophage-like cells, in-vitro, as well as the biochemical characteristics of the local micro-environment in which they are encompassed ...


Data Mining Raman Microspectroscopic Responses Of Cells To Drugs In Vitro Using Multivariate Curve Resolution-Alternating Least Squares, David Perezguaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh J. Byrne 2020 Technological University Dublin

Data Mining Raman Microspectroscopic Responses Of Cells To Drugs In Vitro Using Multivariate Curve Resolution-Alternating Least Squares, David Perezguaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh J. Byrne

Articles

Raman microspectroscopy is gaining popularity for the analysis of time-dependent biological processes such as drug uptake and cellular response. It is a label-free technique which acquires signals from a large variety of components, including cell biomolecules and exogenous compounds such as drugs and nanoparticles, and is commonly employed for in vitro analysis of cells and cell populations with no labelling or staining required. By monitoring the changes to the Raman spectra of the cell as a result of a perturbing agent (e.g. exposure to a drug or toxic agent), one can study the associated changes in cell biochemistry involved ...


Potential Of Raman Spectroscopy For The Analysis Of Plasma/Serum In The Liquid State: Recent Advances, Drishya Rajan Parachalil, Jennifer McIntyre, Hugh J. Byrne 2020 Technological University Dublin

Potential Of Raman Spectroscopy For The Analysis Of Plasma/Serum In The Liquid State: Recent Advances, Drishya Rajan Parachalil, Jennifer Mcintyre, Hugh J. Byrne

Articles

There is compelling evidence in the literature to support the application of Raman spectroscopy for analysis of bodily fluids in their native liquid state. Naturally, the strategies described in the literature for Raman spectroscopic analysis of liquid samples have advantages and disadvantages. Herein, recent advances in the analysis of plasma/serum in the liquid state are reviewed. The potential advantages of Raman analysis in the liquid form over the commonly employed infrared absorption analysis in the dried droplet form are initially highlighted. Improvements in measurement protocols based on inverted microscopic geometries, clinically adaptable substrates, data preprocessing and analysis, and applications ...


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