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Pharmacology, Toxicology and Environmental Health Commons

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Cinderella And The Missing Slipper: Gender Dynamics In Water Management In The Coastal Region Of Bangladesh, Khalid Md. Bahauddin, Hamidul Huq 2019 Institute of Development Studies and Sustainability (IDSS), United International University (UIU), Bangladesh

Cinderella And The Missing Slipper: Gender Dynamics In Water Management In The Coastal Region Of Bangladesh, Khalid Md. Bahauddin, Hamidul Huq

wH2O: The Journal of Gender and Water

The water world is socially constructed, reflecting continuous gender inequalities and discrimination by those who hold dominant perspectives on water. This qualitative study was conducted in coastal areas of Bangladesh i.e. Bajua and Laodob union of Dacope upazilla of Khulna district. This study explored the gendered roles, responsibilities, and inequalities of access to and control over water management in the household, irrigation and agriculture. Results of this study lightened the importance of taking into account the complexity of power and negotiation in local water structures within women’s social realities. This study observed that there are considerable gender imbalance ...


Effects Of Chronic Ethanol Exposure On Stress Coping Style And Genetic States Of Zebrafish (Danio Rerio), Alexander Goodman 2019 University of Nebraska at Omaha

Effects Of Chronic Ethanol Exposure On Stress Coping Style And Genetic States Of Zebrafish (Danio Rerio), Alexander Goodman

Student Research and Creative Activity Fair

Neurotransmitter systems are important in regulating the stress response. If a behavioral response is disproportional to a stressor it is characterized as anxiety-like behavior. Many anxiolytic compounds, such as ethanol, increase stressor engagement, but how these compounds interact with an organism on a neurogenetic level is less understood. In this study, I assessed the impact of chronic ethanol treatment on behavior and gene expression of GABAAreceptors subunits on two strains of zebrafish. Each strain was selectively bred to display the proactive or reactive stress coping style where proactive individuals will actively engage a stressor more than reactive individuals ...


Saturated Fatty Acid Activates T Cell Inflammation Through A Nicotinamide Nucleotide Transhydrogenase (Nnt)-Dependent Mechanism, Grace McCambridge, Madhur Agrawal, Alanna Keady, Philip A. Kern, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath 2019 Merrimack College

Saturated Fatty Acid Activates T Cell Inflammation Through A Nicotinamide Nucleotide Transhydrogenase (Nnt)-Dependent Mechanism, Grace Mccambridge, Madhur Agrawal, Alanna Keady, Philip A. Kern, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath

Pharmacology and Nutritional Sciences Faculty Publications

Circulating fatty acids (FAs) increase with obesity and can drive mitochondrial damage and inflammation. Nicotinamide nucleotide transhydrogenase (NNT) is a mitochondrial protein that positively regulates nicotinamide adenine dinucleotide phosphate (NADPH), a key mediator of energy transduction and redox homeostasis. The role that NNT-regulated bioenergetics play in the inflammatory response of immune cells in obesity is untested. Our objective was to determine how free fatty acids (FFAs) regulate inflammation through impacts on mitochondria and redox homeostasis of peripheral blood mononuclear cells (PBMCs). PBMCs from lean subjects were activated with a T cell-specific stimulus in the presence or absence of generally pro-inflammatory ...


Thioredoxin Modulates Protein Arginine Deiminase 4 (Pad4)-Catalyzed Citrullination, Mitesh Nagar, Ronak Tilvawala, Paul R. Thompson 2019 University of Massachusetts Medical School

Thioredoxin Modulates Protein Arginine Deiminase 4 (Pad4)-Catalyzed Citrullination, Mitesh Nagar, Ronak Tilvawala, Paul R. Thompson

Open Access Articles

Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA. Recently, there has been a growing interest in investigating physiological regulators of PAD activity to understand the primary cause of the associated disorders. Apart from calcium, it is well-documented that a reducing environment activates the PADs. Although the concentration of thioredoxin (hTRX), an oxidoreductase that maintains the cellular reducing environment, is elevated in RA patients, its contribution toward RA progression or PAD activity has not been explored. Herein, we demonstrate that hTRX ...


Analyzing Drug Release Kinetics From Water-Soluble Polymers, Sean M. Kelly, Arun K. Upadhyay, Akash Mitra, Balaji Narasimhan 2019 Iowa State University

Analyzing Drug Release Kinetics From Water-Soluble Polymers, Sean M. Kelly, Arun K. Upadhyay, Akash Mitra, Balaji Narasimhan

Chemical and Biological Engineering Publications

The ability to develop predictive mathematical models of therapeutic release from pharmaceutical formulations has enormous potential to enhance our understanding of such systems and improve the controlled release of the payload. The current work describes the development and testing of a one-dimensional model of drug transport from amorphous, swelling/dissolving polymers. Model parameters such as the diffusivities of water and drug, the initial loading of the drug, the polymer dissolution rate, drug-polymer interactions, and the tablet thickness were varied, demonstrating the ability to tune the release to be controlled by either drug diffusion or polymer chain disentanglement. In addition, predictions ...


5-Ht2a Deletion Protects Against Clozapine-Induced Hyperglycemia, Radhika Sudhir Joshi, Shishu Pal Singh, Mitradas M. Panicker 2019 University of Massachusetts Medical School

5-Ht2a Deletion Protects Against Clozapine-Induced Hyperglycemia, Radhika Sudhir Joshi, Shishu Pal Singh, Mitradas M. Panicker

Open Access Articles

Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT2A (Serotonin receptor subtype-2A). In this pilot study, we report for the first time that the 5-HT2A 'global' knockout mice (Htr2a(-/-)) are resistant to the Clozapine-induced hyperglycemia. Importantly though, the Htr2a(-/-) mice exhibit near normal basal glucose metabolism in the glucose tolerance tests. Collectively, the Htr2a(-/-) mice provide an important tool to study the Clozapine-induced hyperglycemia.


Sharing The Gift Of Water: A Hoosier-Haitian Partnership, Lauren Ward 2019 Purdue University

Sharing The Gift Of Water: A Hoosier-Haitian Partnership, Lauren Ward

Purdue Journal of Service-Learning and International Engagement

Engagement Methods for International Food Security (YDAE 49100) provided an opportunity for enrolled students to travel abroad to Cap-Haitïen, Haiti. As both a course in agriculture and a service-learning study abroad, the overarching goal was to inspire, engage, and teach Purdue and Haitian students through service learning in agriculture. This was done by developing a project with teammates during the fall semester that was then presented to students in Haiti during the International Agri-Symposium at Université Antenor Firmin over winter break.


Air Quality And Health Burden Of 2017 Northern California Wildfires, Susan O’Neill, Minghui Diao 2019 USDA Forest Service

Air Quality And Health Burden Of 2017 Northern California Wildfires, Susan O’Neill, Minghui Diao

Faculty Publications

No abstract provided.


Air Quality And Health Burden Of 2017 Northern California Wildfires, Susan O’Neill, Minghui Diao 2019 USDA Forest Service

Air Quality And Health Burden Of 2017 Northern California Wildfires, Susan O’Neill, Minghui Diao

Minghui Diao

No abstract provided.


Environmental And Anthropogenic Factors Affecting Coral Health, Kristin Jones 2019 Eastern Washington University

Environmental And Anthropogenic Factors Affecting Coral Health, Kristin Jones

2019 Symposium

Plastic pollution is a large and growing problem in our ever producing world. Not only does it litter our cities, but it is cluttering up the natural world as well, the largest being our oceans. Plastic is dumped into the seas where it floats and slowly breaks down into microplastics that are then ingested by marine animals. I will conduct an experiment to test the effects of micro plastics on coral health by subjecting palythoa corals to different plastic levels in a controlled environment. I hypothesize that corals will ingest micro plastics and will suffer health consequences, leading to a ...


Full Issue: Volume 12, Number 2, 2019 Touro College and University System

Full Issue: Volume 12, Number 2

The Science Journal of the Lander College of Arts and Sciences

No abstract provided.


Capsacin And Analgesia, Mimi Kornwasser 2019 Touro College

Capsacin And Analgesia, Mimi Kornwasser

The Science Journal of the Lander College of Arts and Sciences

Capsaicin is the active compound responsible for the pungency of hot chilli. Research has discovered its ability to desensitize peripheral nociceptive fibers which is useful in treating chronic pain disorders, specifically neuropathic pain syndromes. Capsaicin treatment comes in a variety of mediums including patches and creams and has been clinically proven to bring relief to patients with disorders such as post herpetic neuralgia, chronic regional pain syndrome and HIV related neuralgia. Exciting new forms of treatment are also in development and promise breakthroughs in the near future in this relatively young field of capsaicin-based analgesia.


Does In-Vitro Fertilization Increase The Risk For Birth Defects?, Tehila Tropper 2019 Touro College

Does In-Vitro Fertilization Increase The Risk For Birth Defects?, Tehila Tropper

The Science Journal of the Lander College of Arts and Sciences

Since 1978 when the first “petri dish” baby was born, In-Vitro Fertilization (IVF) has been used as a tool to give couples struggling with infertility the opportunity to have children. Using this method of Assisted Reproductive Technology (ART), the woman is given medication to stimulate her ovaries for the maturation of multiple eggs, which are then retrieved via needle aspiration, fertilized in a petri dish, and inserted in the uterus with the hopes of achieving a successful pregnancy. Many times IVF is completed with another technique known as Intracytoplasmic Sperm Injection (ICSI), where the sperm is injected straight into the ...


Car T-Cell Therapy For Acute Lymphoblastic Leukemia, Esther Langner 2019 Touro College

Car T-Cell Therapy For Acute Lymphoblastic Leukemia, Esther Langner

The Science Journal of the Lander College of Arts and Sciences

Despite all the available therapies, Acute Lymphoblastic Leukemia (ALL) remains extremely difficult to eradicate. Current available therapies, which include chemotherapy, radiation, and stem cell transplants, tend to be more successful in treating children than adults. While adults are more likely than children to relapse after treatment, the most common cause of treatment failure in children is also relapse. Improved outcomes for all ALL patients may depend upon new immunotherapies, specifically CAR T-cell therapy. CAR T-cell therapy extracts a patient’s own T-cells and modifies them with a CD19 antigen. This modification allows the new T-cells to recognize and kill cancer ...


The Effects Of Rf-Emf On The Child Brain, Aaron Skaist 2019 Touro College

The Effects Of Rf-Emf On The Child Brain, Aaron Skaist

The Science Journal of the Lander College of Arts and Sciences

It has long been debated whether or not cell phones have a deleterious effect on the brain. Recent studies indicate that the electro-magnetic field emitted by cell phones called RF-EMF is linked to cancer. Guidelines created to limit the exposure have not been changed since 1981 and do not consider children. The mechanism thought to cause cancer is reactive oxygen species (ROS), which cause the creation of micronuclei. RF-EMF poses a greater threat to children than adults. This is due to the major anatomical differences between the head of a child and an adult. The skull of a child is ...


Triggers Of Spermatogenesis, Moses Bibi 2019 Touro College

Triggers Of Spermatogenesis, Moses Bibi

The Science Journal of the Lander College of Arts and Sciences

Of the 7% of men affected with infertility, about 54% suffer from pre-testicular and/or testicular factor induced azoospermia/ oligospermia. This agenesis of spermatozoa has been the subject of much andrology research over the past 50 years, with a particular focus in the triggers of spermatogenesis. While much of their work is limited to murine populations, researchers have put a lot of emphasis on the spermatogonial stem cell (SSC) niche as the source of the trigger(s). By following physiological patterns exhibited in the seminiferous epithelium, researchers have been able to detect distinct morphological stages that correlate with spermatogonial germ-line ...


Should Subclinical Hypothyroidism Be Treated?, Rachel Kaufman 2019 Touro College

Should Subclinical Hypothyroidism Be Treated?, Rachel Kaufman

The Science Journal of the Lander College of Arts and Sciences

Subclinical Hypothyroidism, SCH, has been detected with increasing frequency in recent years and has brought about major controversies regarding management and treatment [Meier et al., 2001]. The condition is characterized as having a high concentration of thyroid stimulating hormone, yet normal thyroid hormone levels and is often asymptomatic. Scientific articles retrieved from various databases helped determine some of the long term risk factors associated with SCH, including progression to overt hypothyroidism, fatty liver disease, cardiovascular disease, neuropsychiatric complications and reproductive malfunctions. Studies determining the clinical and metabolic effects of L-thyroxine hormone replacement therapy on symptoms and potential risks of SCH ...


Adenosine A2a Receptor Subpopulation And Dopamine D4 Receptor Effects On Psychostimulant-Induced Behavior, Nicholas Haynes 2019 University of Colorado at Boulder

Adenosine A2a Receptor Subpopulation And Dopamine D4 Receptor Effects On Psychostimulant-Induced Behavior, Nicholas Haynes

Psychology and Neuroscience Graduate Theses & Dissertations

Drug addiction is a chronic relapsing disorder affecting millions of people. No effective treatment exists for psychostimulant use disorder, stressing the importance to investigate underlying mechanisms mediating this disorder. Psychostimulants like cocaine and methamphetamine (MA) impact behavior by modulating neurotransmitter signaling systems in the nucleus accumbens (NAc). In this region, converging dopamine and glutamate signals interact with receptors to influence cellular functioning. The neuromodulator, adenosine, has received attention regarding its ability to affect both dopamine and glutamate signaling through converging intracellular signaling associated with metabotropic receptor proteins. Adenosine A2A receptors (A2ARs) and dopamine D4 receptors (D4s ...


Hospital Experiences With Hurricane Harvey In Harris County, Texas, Emmanuelle Nicole Roberge Hines 2019 University of Colorado at Boulder

Hospital Experiences With Hurricane Harvey In Harris County, Texas, Emmanuelle Nicole Roberge Hines

Geography Graduate Theses & Dissertations

Hospitals should be capable of delivering both day-to-day and emergency services at surge capacity during extreme weather events, but flooding causes complications with power generation, provision of clean water, patient safety, communication, and hospital access. The sudden arrival of Hurricane Harvey on the Texas coast served as a reminder that no recent comprehensive study of Harris County’s healthcare system vulnerability to extreme flooding events had been conducted. This study first completed a geospatial analysis comparing which hospitals were at risk of flooding pre-Harvey with the actual flooding impacts post-Harvey. The mapping results revealed inconsistencies between the predicted and observed ...


A Mutation In Cav2.1 Linked To A Severe Neurodevelopmental Disorder Impairs Channel Gating, Sidharth Tyagi 2019 University of Colorado at Boulder

A Mutation In Cav2.1 Linked To A Severe Neurodevelopmental Disorder Impairs Channel Gating, Sidharth Tyagi

Integrative Physiology Graduate Theses & Dissertations

Ca2+ flux via voltage-gated Ca2+ channels is essential to the regulation of membrane excitability, neurotransmission, and a variety of intracellular signaling processes. CaV2.1 is the predominant Ca2+ channel present in the presynaptic terminals of both neuromuscular junctions and many central synapses. Point mutations in CaV2.1 can drastically alter channel gating and expression, and indeed have been linked to two paroxysmal disorders – Episodic Ataxia Type 2, and Familial Hemiplegic Migraine Type 1. With the novel whole-exome sequencing technique, mutations linked to a new class of more severe disorders have been found with phenotypes like Episodic Ataxia ...


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