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Association Of Long-Term Consumption Of Repeatedly Heated Mix Vegetable Oils In Different Doses And Hepatic Toxicity Through Fat Accumulation, Gul Ambreen, Afshan Siddiq, Kashif Hussain 2020 Aga Khan University

Association Of Long-Term Consumption Of Repeatedly Heated Mix Vegetable Oils In Different Doses And Hepatic Toxicity Through Fat Accumulation, Gul Ambreen, Afshan Siddiq, Kashif Hussain

Department of Biological & Biomedical Sciences

Background: Hepatic diseases are one of the chief reasons for worldwide morbidity and mortality. The increased incidence in Asian countries is driving researchers to explore preventive ways from nature. It is more practical to go with healthy routine edibles like vegetable oils to avoid environmental and chemical hepatic injuries. With the use of thermally oxidized oils overproduction of reactive oxygen species (ROS) with overwhelmed cellular antioxidants defense system results in oxidative stress, the known cause of cardiovascular diseases (CVDs), cancers and neurodegenerative disorders. Little is investigated about the effect of daily used oxidized cooking oils on hepatic function changes with ...


An Evaluation Of The Susceptibility Of Goats To Larkspur Toxicosis, Kevin D. Welch, Clint A. Stonecipher, Dale R. Gardner, Benidict T. Green, Daniel Cook 2020 USDA-ARS

An Evaluation Of The Susceptibility Of Goats To Larkspur Toxicosis, Kevin D. Welch, Clint A. Stonecipher, Dale R. Gardner, Benidict T. Green, Daniel Cook

Poisonous Plant Research (PPR)

Larkspurs (Delphinium spp.) are a major cause of cattle losses in western North America, whereas sheep have been shown to be resistant to larkspur toxicosis. Goats are often used as a small ruminant model to study poisonous plants, even though they can be more resistant to some poisonous plants. It is not known how susceptible goats are to the adverse effects of larkspurs. In this study, we evaluated the susceptibility of goats to larkspur toxicosis by performing a dose-response study. We dosed goats with D. barbeyi collected near Cedar City, Utah at 3.3, 4.4, 6.6, 8.8 ...


Tip60 Regulation Of Δnp63Α Is Associated With Cisplatin Resistance, Akshay Hira, Andrew Stacy, Jin Zhang, Michael P. Craig, Madhavi Kadakia 2020 Wright State University - Main Campus

Tip60 Regulation Of Δnp63Α Is Associated With Cisplatin Resistance, Akshay Hira, Andrew Stacy, Jin Zhang, Michael P. Craig, Madhavi Kadakia

Symposium of Student Research, Scholarship, and Creative Activities Materials

About 5.4 million basal and squamous cell skin cancers are diagnosed every year in the US. ΔNp63a, a member of the p53 transcription factor family, is overexpressed in non-melanoma skin cancer and regulates cell survival, migration and invasion. TIP60 is histone acetyltransferase (HAT) which mediates cellular processes such as transcription and the DNA damage response (DDR). Previous studies in our lab have shown that overexpression of TIP60 induces ΔNp63a protein stabilization in a catalytic-dependent manner. Since ΔNp63a is known to transcriptionally regulate several DDR genes and promote cisplatin resistance, its stabilization by TIP60 may contribute to the failure of ...


Assessing Microplastic Pollution In Four Mile Run, An Urban Stream In Northern Virginia, Kurt Moser, Tessa Naughton-Rockwell, Louisa Wang, Ethan Litmans, Amanda Manoogian 2020 Four Mile Run Conservatory Foundation

Assessing Microplastic Pollution In Four Mile Run, An Urban Stream In Northern Virginia, Kurt Moser, Tessa Naughton-Rockwell, Louisa Wang, Ethan Litmans, Amanda Manoogian

Virginia Journal of Science

Microplastics are pollutants of concern in waterways and oceans for their persistence and impact on aquatic life and food webs. This study demonstrates a low-cost land-based sampling method to assess the extent of microplastic pollution found in Four Mile Run, an urban stream in Northern Virginia. Microplastic particle counts in environmental and treated wastewater ranged from 0.01-0.24 particles L-1 (mean 0.08 particles L-1) and from 2 to 446 µg L-1 (mean 70 µg L-1), with fibers found to be the most common microplastic category. Treated wastewater effluent was found to be a significant ...


The Impact Of Nicotine Accumulation Exposure On Lithobates Catebeianus Larvae Mortality, Luke Micek 2020 University of Nebraska - Lincoln

The Impact Of Nicotine Accumulation Exposure On Lithobates Catebeianus Larvae Mortality, Luke Micek

UCARE Research Products

Cigarette butts are the most littered item in the world and contain over 4,000 chemicals, including the organic compound nicotine (Slaughter et al. 2011). Billions of cigarette butts are littered each year which may wash into bodies of water, impacting the local wildlife. To determine how introduced chemicals impact the environment, it is important to study its effects on indicator species. Amphibians, such as Lithobates catebeianus, act as indicator species due to their extreme sensitivity to chemical changes in its environment. The purpose of this research project was to obtain data to help determine the impact nicotine accumulation has ...


Multi-Label Model For Toxicity Prediction, Xiu Huan Yap, Michael L. Raymer 2020 Wright State University - Main Campus

Multi-Label Model For Toxicity Prediction, Xiu Huan Yap, Michael L. Raymer

Symposium of Student Research, Scholarship, and Creative Activities Materials

Most computational predictive models are specifically trained for a single toxicity endpoint. Since more than 1300 toxicity assays have been reported in the TOXCAST dashboard, achieving high coverage over this growing number of toxicity endpoints remains challenging. Furthermore, single-endpoint models lack the ability to learn dependencies between endpoints, such as those targeting similar biological pathways, which may be used to boost model performance. In this study, we characterize the performance of 3 multi-label classification (MLC) models, namely Classifier Chains (CC), Label Powersets (LP) and Stacking (SBR), on Tox21 challenge data. These MLC models employ the Problem Transformation approach, which is ...


Development, Validation, And Application Of A Novel Method To Separate And Quantify Silver Intracellular Uptake In Pseudomonas Aeruginosa, Mohammed A. Othman 2020 University of South Carolina

Development, Validation, And Application Of A Novel Method To Separate And Quantify Silver Intracellular Uptake In Pseudomonas Aeruginosa, Mohammed A. Othman

Theses and Dissertations

Silver nanoparticles (AgNPs) have attracted tremendous attention as a potential broadspectrum antimicrobial agent to overcome multidrug resistant (MDR) infections. However, a comprehensive understanding to AgNPs bactericidal mechanism of action and the relative role of particulate versus ionic Ag in AgNPs antibacterial activity is lacking but essential for their optimization for potential medical applications. Therefore, a novel method to separate and quantify Ag internalization in P. aeruginosa was developed and validated through multimethod approach. The methods used were optical density at 600 nm (OD600), LIVE/DEAD staining, transmission electron microscopy (TEM), and sorbed Ag liberation assays. After optimizing the method, it ...


Comparing Statistical Analyses To Estimate Thresholds In Ecotoxicology, Marcos Krull 2020 Virginia Institute of Marine Science

Comparing Statistical Analyses To Estimate Thresholds In Ecotoxicology, Marcos Krull

VIMS Articles

Different methods are used in ecotoxicology to estimate thresholds in survival data. This paper uses Monte Carlo simulations to evaluate the accuracy of three methods (maximum likelihood (MLE) and Markov Chain Monte Carlo estimates (Bayesian) of the no-effect concentration (NEC) model and Piecewise regression) in estimating true and apparent thresholds in survival experiments with datasets having different slopes, background mortalities, and experimental designs. Datasets were generated with models that include a threshold parameter (NEC) or not (log-logistic). Accuracy was estimated using root-mean square errors (RMSEs), and RMSE ratios were used to estimate the relative improvement in accuracy by each design ...


It’S Not Cuul To Juul: Nicotine Addiction, The Rise Of E-Cigarette Usage, And How Zebrafish Can Help, Anna Pearson 2020 DePauw University

It’S Not Cuul To Juul: Nicotine Addiction, The Rise Of E-Cigarette Usage, And How Zebrafish Can Help, Anna Pearson

Honor Scholar Theses

No abstract provided.


The Use Of Polymer-Coated Magnetic Nanoparticles For Amelioration Oil Toxicity And Enhancement Microbial Remediation, Amjed Alabresm 2020 University of South Carolina

The Use Of Polymer-Coated Magnetic Nanoparticles For Amelioration Oil Toxicity And Enhancement Microbial Remediation, Amjed Alabresm

Theses and Dissertations

Oil spills from different sources such as natural seeps, waste waters, runoffs and accidental oil spills can have serious effects on the environment while also resulting in potentially major economic damage. Due to the harmful effects of crude oil components on ecosystems, a rapid response to sequestrate oil is required to minimize any resulting environmental impact. Currently used oil removal methods, in addition to their advantages, also have severe limitations. New techniques have been developed including nanotechnology to address these limitations. A new type of nanoparticle (NP), composed of polyvinylpyrrolidone (PVP) coated iron oxide (magnetite), has been successfully used to ...


Microbiome Targeted Therapies In Gulf War Illness, Diana Agnes Kimono 2020 University of South Carolina

Microbiome Targeted Therapies In Gulf War Illness, Diana Agnes Kimono

Theses and Dissertations

Gulf war illness (GWI) is a chronic multisymptomatic disorder affecting about 30% of veterans of the 1990-1991 Persian Gulf war. Affected veterans complain of chronic symptoms which begun during or shortly after the war and persist 30 years later. This dissertation is a report of three studies which use a murine model to investigate the microbiome as a therapeutic target in GWI. Mice were exposed to pesticides and the prophylactic drug pyridostigmine bromide (PB) and studied these chemical’s impact on the microbiome in both an acute and persistence model of GWI.

The first study looks at the effect of ...


Computational Tools For Analyzing Correlations Between Microbial Biological Diversity And Ecosystems, Behzad Torkian 2020 University of South Carolina

Computational Tools For Analyzing Correlations Between Microbial Biological Diversity And Ecosystems, Behzad Torkian

Theses and Dissertations

Metagenomics has developed into a reliable mechanism to analyze microbial diversity of microbial communities in the recent years. Through the use of next-generation sequencing, metagenomic studies can generate billions of short sequencing reads that are processed by computational tools. However, with the rapid adoption of metagenomics, a large amount of data has been produced. This high level of data production requires the development of computational tools and pipelines to manage data scalability and performance. In this thesis, we developed several tools that will aid in the exploration of the large amount of DNA sequence data, and we further developed a ...


Bacterial Water Quality Monitoring As Citizen Science In Congaree National Park, South Carolina, Shea McCarthy 2020 University of South Carolina

Bacterial Water Quality Monitoring As Citizen Science In Congaree National Park, South Carolina, Shea Mccarthy

Theses and Dissertations

Congaree National Park aims to preserve its natural and cultural resources while protecting these benefits for current and future enjoyment. Hydrologic features make up a large portion of the park and attract visitor recreation. There are several known sources of pollution that enter these waterways, mainly from upstream sources of waste discharge. The national park and its surrounding areas hold great ecological significance, however, there are many threats to the surface water quality in this area. Water quality degradation can impact the ecosystem, wildlife, and visitor experience. This project specifically considers exposure to fecal contamination in surface waters from upstream ...


Avoiding Drug Resistance By Substrate Envelope-Guided Design: Toward Potent And Robust Hcv Ns3/4a Protease Inhibitors, Ashley N. Matthew, Jacqueto Zephyr, Nageswara Rao Desaboini, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer 2020 University of Massachusetts Medical School

Avoiding Drug Resistance By Substrate Envelope-Guided Design: Toward Potent And Robust Hcv Ns3/4a Protease Inhibitors, Ashley N. Matthew, Jacqueto Zephyr, Nageswara Rao Desaboini, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

University of Massachusetts Medical School Faculty Publications

Hepatitis C virus (HCV) infects millions of people worldwide, causing chronic liver disease that can lead to cirrhosis, hepatocellular carcinoma, and liver transplant. In the last several years, the advent of direct-acting antivirals, including NS3/4A protease inhibitors (PIs), has remarkably improved treatment outcomes of HCV-infected patients. However, selection of resistance-associated substitutions and polymorphisms among genotypes can lead to drug resistance and in some cases treatment failure. A proactive strategy to combat resistance is to constrain PIs within evolutionarily conserved regions in the protease active site. Designing PIs using the substrate envelope is a rational strategy to decrease the susceptibility ...


The Role Of Insulin-Like Growth Factor 1 In Specific Brain Cells Following Ischemia, Cellas Hayes 2020 University of Mississippi

The Role Of Insulin-Like Growth Factor 1 In Specific Brain Cells Following Ischemia, Cellas Hayes

Graduate Student Council Research Grants

Overview: My name is Cellas Ari’ka Hayes, and I am a first-year graduate student in the School of Pharmacy Department of BioMolecular Sciences. I am pursuing a Ph.D. in Pharmaceutical Sciences with an emphasis in Pharmacology. My project will assess the effects of insulin-like growth factor-1(IGF-1), an anabolic polypeptide on the damage caused by ischemic stroke including glial cell death, neuronal tress, infarct size, neurological deficits, and behavioral changes.

Intellectual Merit: Ischemia is one of the largest causes of neurological deficits that in elderly individuals in the United States [1]. Since our life expectancy has increased concurrently ...


Development Of Itraconazole Topical Formulation In Skin Cancer Treatment, Praveen Kolimi 2020 University of Mississippi

Development Of Itraconazole Topical Formulation In Skin Cancer Treatment, Praveen Kolimi

Graduate Student Council Research Grants

Overview: I, Praveen Kolimi, pursuing a first-year graduate program at the department of pharmaceutics and drug delivery. This Graduate Student Council (GSC) grant proposal focus on topical application of Itraconazole (ICZ) in skin cancer treatment.

Intellectual Merit: 5.4 million skin cancer cases are reported each year in the United States. A study disclosed that one among five Americans are likely to develop skin cancer in their entire life. 9. Skin cancer can be distinguished into two types, malignant melanoma (MM) and non-melanoma skin cancer (NMSC) 1, 8. NMSC further classified into squamous cell carcinoma (SCC) and basal cell carcinoma ...


Α-Tocopherol Succinate Nanostructured Lipid Carriers For The Ocular Delivery Of The Anti-Neoplastic Agent, Sushrut Marathe 2020 University of Mississippi

Α-Tocopherol Succinate Nanostructured Lipid Carriers For The Ocular Delivery Of The Anti-Neoplastic Agent, Sushrut Marathe

Graduate Student Council Research Grants

Overview: Retinoblastoma (RB) is a rare form of cancer that rapidly develops from the immature cells of the retina, the light-detecting tissue of the eye. The treatment options of RB has been limited to enucleation, external beam radiotherapy, episcleral plaque radiotherapy and cryotherapy. α-Tocopherol succinate(αTS), has been proven to an effective apoptogenic agent. It can enhance the efficiency of the anticancer agent1. Paclitaxel (Ptx) is a potent chemo agent and is widely used in the treatment of various types of cancers. However, clinical use of Paclitaxelis limited by systemic toxicity, rapid clearance and resistance 2,3.The formulation of ...


Assessment Of Underlying Neurocircuitry In Dysregulation Of The Hypothalamic Pituitary Adrenal Stress Axis In Hiv-1 Tat Male Mice, Salahuddin Mohammed 2020 University of Mississippi

Assessment Of Underlying Neurocircuitry In Dysregulation Of The Hypothalamic Pituitary Adrenal Stress Axis In Hiv-1 Tat Male Mice, Salahuddin Mohammed

Graduate Student Council Research Grants

Overview: My name is Salahuddin Mohammed, a 2nd year PhD graduate student from Dr. Jason Paris’ Lab. My research dissertation focuses on investigating the neuroendocrine underpinnings of HIV-and opioid-mediated anxiety-/depression-like behavior and cognitive impairment via experiments utilizing humans and animal models. Through this work I strive to delineate the underlying mechanism for the neuroHIV symptomology and develop novel therapeutic agents which can ameliorate HIV-1 mediated Tat-neurotoxicity. Approximately 50% of the HIV infected patients suffer from HIV associated neurocognitive disorders (HAND) which can be exacerbated by drug use/abuse. Some neuroHIV symptoms include anxiety, major depressive disorder, neurocognitive impairment, and ...


Development Of Inhalable Nano-Lipid Carriers For The Treatment Of Pulmonary Aspergillosis Using Hot Melt Extrusion Technology, Gauri Shadambikar 2020 University of Mississippi

Development Of Inhalable Nano-Lipid Carriers For The Treatment Of Pulmonary Aspergillosis Using Hot Melt Extrusion Technology, Gauri Shadambikar

Graduate Student Council Research Grants

Overview: I am Gauri Shadambikar, second year PhD. student in department of Pharmaceutics and Drug Delivery. Pulmonary Aspergillosis is an infection caused by a type of mold and can have serious effects on patients with a weak immune system or with underlying lung disease1. Itraconazole, a triazole is a compound with a broad antifungal spectrum. 2. An inhalation-based drug delivery system has the advantage of rapid onset of action directly at the site of infection along with controlled and prolonged delivery. 3. Hence the aim of my project was to prepare inhalable nano-lipid carriers (NLC) which would be a viable ...


Synthesis Of Fluoroflavonoids As Potential Antioxidant Against Alzheimer’S Disease., Maali Alshammari 2020 University of Mississippi

Synthesis Of Fluoroflavonoids As Potential Antioxidant Against Alzheimer’S Disease., Maali Alshammari

Graduate Student Council Research Grants

Overview: Maali Alshammari joined the lab of Professor David A. Colby in spring of 2017; she's currently a third-year Ph.D. student in medicinal chemistry in the graduate program in the Department of BioMolecular Sciences at the University of Mississippi. Maali's project involves the syntheses of fluoroflavones to improve the potency of the antioxidant activity of the original non-fluorinated flavones. The fluoroflavones will potentially be used as neuroprotective agents to prevent the toxic effect of ROS and used to prevent neurogenerative diseases like Alzheimer's.

Intellectual Merit: We are in need of medications that prevent Alzheimer's disease ...


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