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45 - The Sublethal Effects And Bioaccumulation Of 17a-Ethinyl Estradiol In Lumbriculus Variegatus, Kikelomo Ogunsemore 2018 Augusta University

45 - The Sublethal Effects And Bioaccumulation Of 17a-Ethinyl Estradiol In Lumbriculus Variegatus, Kikelomo Ogunsemore

Georgia Undergraduate Research Conference (GURC)

The threat of freshwater scarcity is a global concern. With less than 1% of Earth’s total water available for human consumption, there has been concern about toxic contaminants affecting available freshwater sources.

Freshwater sources are subject to contamination from toxic compounds and other harmful materials through improper sewage cleanup and pollution. Ethinyl estradiol, a synthetic, steroidal estrogen used in contraception, is present in varying concentrations across freshwater sources worldwide. Ethinyl estradiol (EE) is also classified as an endocrine disruptor that is known to interfere with the endocrine system. Endocrine disruptors can create adverse effects on bodily systems and have ...


Optimization Of Time-Weighted Average Air Sampling By Solid-Phase Microextraction Fibers Using Finite Element Analysis Software, Bulat Kenessov, Jacek A. Koziel, Nassiba Baimatova, Olga P. Demyanenko, Miras Derbissalin 2018 Al-Farabi Kazakh National University

Optimization Of Time-Weighted Average Air Sampling By Solid-Phase Microextraction Fibers Using Finite Element Analysis Software, Bulat Kenessov, Jacek A. Koziel, Nassiba Baimatova, Olga P. Demyanenko, Miras Derbissalin

Agricultural and Biosystems Engineering Publications

Determination of time-weighted average (TWA) concentrations of volatile organic compounds (VOCs) in air using solid-phase microextraction (SPME) is advantageous over other sampling techniques, but is often characterized by insufficient accuracies, particularly at longer sampling times. Experimental investigation of this issue and disclosing the origin of the problem is problematic and often not practically feasible due to high uncertainties. This research is aimed at developing the model of the TWA extraction process and optimization of TWA air sampling by SPME using finite element analysis software (COMSOL Multiphysics, Burlington, MA, USA). It was established that sampling by porous SPME coatings with high ...


Neurobehavioral Evaluation Of Mice Dosed With Water Hemlock Green Seeds And Tubers, Camila F. P. Orlando-Goulart, Kevin D. Welch, James A. Pfister, Daniel S. Goulart, Adilson D. Damasceno, Stephen T. Lee 2018 Federal University of Goiás

Neurobehavioral Evaluation Of Mice Dosed With Water Hemlock Green Seeds And Tubers, Camila F. P. Orlando-Goulart, Kevin D. Welch, James A. Pfister, Daniel S. Goulart, Adilson D. Damasceno, Stephen T. Lee

Poisonous Plant Research (PPR)

Water hemlock are plants of the genus Cicuta and are toxic to animals and humans. The primary toxin is cicutoxin, which is abundant in the tubers, but less abundant in other parts of the plant. Other cicutoxin-like compounds, such as cicutols, which may also contribute to the toxicity of water hemlock, are more abundant in non-tuber plant parts. The objective of this study was to determine the toxicity of different parts of water hemlock and characterize their effects on motor function/coordination in mice. An aqueous extract of green seeds, dry seeds, tubers, flowers and stems of water hemlock was ...


Effect Of Arsenic Exposure On Early Eye Development In Zebrafish (Danio Rerio), Remy S. Babich 2018 University of Maine

Effect Of Arsenic Exposure On Early Eye Development In Zebrafish (Danio Rerio), Remy S. Babich

Electronic Theses and Dissertations

Arsenic is a metalloid that contaminates drinking water supplies worldwide. Due to concerns for human health, the World Health Organization (WHO) and the U.S. Environmental Protection Agency (EPA) have established a safe level in drinking water of ≤ 10 ppb. Arsenic has been shown to have carcinogenic effects in humans at high and low doses. Chronic exposure may result in dermal conditions such as hyperkeratosis and hyperpigmentation. Recently, arsenic exposure has also been linked to lower IQ values in children. The effect of arsenic on neurogenesis, specifically eye development, has not been widely explored. This study aimed to examine the ...


A Review Of Inhalation Exposure To Mold And Adverse Health Outcomes, Amanda S. Persad, Todd Stedeford, Marek Banasik, Tomasz T. Suchecki, Carlos A. Muro-Cacho 2018 Florida State University College of Law

A Review Of Inhalation Exposure To Mold And Adverse Health Outcomes, Amanda S. Persad, Todd Stedeford, Marek Banasik, Tomasz T. Suchecki, Carlos A. Muro-Cacho

Florida State University Journal of Land Use and Environmental Law

No abstract provided.


Mycotoxins: Mechanisms For Toxicity And Methods For Identifying Exposed Individuals, Carlos A. Muro-Cach, Todd Stedeford, Marek Banasik, Tomasz T. Suchecki, Amanda S. Persad 2018 Florida State University College of Law

Mycotoxins: Mechanisms For Toxicity And Methods For Identifying Exposed Individuals, Carlos A. Muro-Cach, Todd Stedeford, Marek Banasik, Tomasz T. Suchecki, Amanda S. Persad

Florida State University Journal of Land Use and Environmental Law

No abstract provided.


Toxicology And Risk Assessment Of Mycotoxins, Raymond D. Harbison, Todd Stedeford, Marek Banasik, Carlos A. Muro-Cacho 2018 Florida State University College of Law

Toxicology And Risk Assessment Of Mycotoxins, Raymond D. Harbison, Todd Stedeford, Marek Banasik, Carlos A. Muro-Cacho

Florida State University Journal of Land Use and Environmental Law

No abstract provided.


Evaluation Of Drug-Loaded Gold Nanoparticle Cytotoxicity As A Function Of Tumor Tissue Heterogeneity., Hunter Allan Miller 2018 University of Louisville

Evaluation Of Drug-Loaded Gold Nanoparticle Cytotoxicity As A Function Of Tumor Tissue Heterogeneity., Hunter Allan Miller

Electronic Theses and Dissertations

The inherent heterogeneity of tumor tissue presents a major challenge to nanoparticle-medicated drug delivery. This heterogeneity spans from the molecular to the cellular (cell types) and to the tissue (vasculature, extra-cellular matrix) scales. Here we employ computational modeling to evaluate therapeutic response as a function of vascular-induced tumor tissue heterogeneity. Using data with three-layered gold nanoparticles loaded with cisplatin, nanotherapy is simulated with different levels of tissue heterogeneity, and the treatment response is measured in terms of tumor regression. The results show that tumor vascular density non-trivially influences the nanoparticle uptake and washout, and the associated tissue response. The drug ...


Manganese Toxicity In The Dopamine Synthesis Pathway In Drosophila Melanogaster, Brandon Adair, Tamra E. Jones, Stefanie Otto-Hitt 2018 Carroll College

Manganese Toxicity In The Dopamine Synthesis Pathway In Drosophila Melanogaster, Brandon Adair, Tamra E. Jones, Stefanie Otto-Hitt

Life and Environmental Sciences Course-based Research Projects

Manganese is prevalent in Montana, and Manganese toxicity symptomatically resembles Parkinsons disease. The goal of this project was to determine whether exposure to high levels of Manganese affects the Dopamine synthesis pathway. For our experiment, we chose to measure the expression of the ple gene in Drosophila melanogaster that were exposed to Manganese during development. The ple gene codes for Tyrosine Hydroxylase, an enzyme that functions in the first rate-limiting step of Dopamine synthesis. We hypothesized that an abundance of Manganese would result in decreased expression of ple in larvae and observable motor function deficits among adult flies. To carry ...


Effects Of Sulfur Dioxide On Abda Gene Expression And Larval Development In Drosophila Melanogaster, Emma Esposito, Keenan McNally, Stefanie Otto-Hitt 2018 Carroll College

Effects Of Sulfur Dioxide On Abda Gene Expression And Larval Development In Drosophila Melanogaster, Emma Esposito, Keenan Mcnally, Stefanie Otto-Hitt

Life and Environmental Sciences Course-based Research Projects

In this experiment, we tested the effects sulfur dioxide exposure had on abd-A gene expression and larval development in Drosophila melanogaster. Previous studies showed that sulfur dioxide exposure inhibits development of gonads in adult flies and increases development time. We hypothesized that expression of abd-A would decrease in developing Drosophila exposed to sulfur dioxide. The abd-A gene is in the Hox gene family, which functions in the development of body segmentation. The abd-A gene is specific to the abdominal region of the fly, and is also important to the development of gonads and fat bodies. To test our hypothesis, we ...


The Effect Of Metal Pollutants On Cell Growth And Ttherm0058490expressionint Etrahymenathermophila, Inderbir Bains, William French, Stefanie Otto-Hitt 2018 Carroll College

The Effect Of Metal Pollutants On Cell Growth And Ttherm0058490expressionint Etrahymenathermophila, Inderbir Bains, William French, Stefanie Otto-Hitt

Life and Environmental Sciences Course-based Research Projects

In this experiment, we sought to answer the following question: Do higher levels of metal exposure affect expression of the TTHERM 00584900 gene in Tetrahymena thermophila? The TTHERM 00584900 gene produces an ATP-binding cassette protein that is responsible for removing metals and metalloids from Tetrahymena thermophila. It is hypothesized that the expression of TTHERM 00584900 will increase with exposure to metals. In order to test this hypothesis, Tetrahymena thermophila were randomly assigned to either a control group, which was cultured in a normal growth medium, or a treatment group, whichin addition to the medium was exposed to water contaminated with ...


Effects Of The Everyday Toxin, Titanium Dioxide, On Drosophila Melanogaster Nervous System Development, Maria Carparelli, Kelsey Ripley, Stefanie Otto-Hitt 2018 Carroll College

Effects Of The Everyday Toxin, Titanium Dioxide, On Drosophila Melanogaster Nervous System Development, Maria Carparelli, Kelsey Ripley, Stefanie Otto-Hitt

Life and Environmental Sciences Course-based Research Projects

Titanium dioxide (TiO2) is a widely used compound found in everything from food packaging to sunscreens. When ingested, TiO2 is readily transported across membranes and efficiently stored within cells. Previous studies showed that exposure to TiO2 results in underdeveloped nervous systems. For our study, we attempted to answer the following question: Will exposing Drosophila melanogaster larvae to TiO2 affect expression of the Neur gene and development of the central nervous system? The Neur gene is crucial during the celldetermination stage of development as its encoded protein helps specify neuroblast development and aids in nervous system and sensory organ development. It ...


Effect Of Potassium Bromate On Oxr1 Gene Expression And Cell Growth In Tetrahymena Thermophila, Scott Khale, Brendan McMahon, Stefanie Otto-Hitt 2018 Carroll College

Effect Of Potassium Bromate On Oxr1 Gene Expression And Cell Growth In Tetrahymena Thermophila, Scott Khale, Brendan Mcmahon, Stefanie Otto-Hitt

Life and Environmental Sciences Course-based Research Projects

The purpose of our experiment was to answer the question: Does oxidative damage, induced by potassium bromate (KBrO3), affect growth rate and expression of the OXR1 gene in Tetrahymena thermophila? Potassium Bromate was chosen as the environmental stressor because it is a strong oxidizing agent that is used as a leavening agent in baked goods. It was hypothesized that expression of OXR1 would increase in Tetrahymena cells that were exposed to potassium bromate and that their growth rate would decrease. The exact mechanism and function of the OXR1 gene is still unknown; however, the literature suggests that it is required ...


Effect Of Nitrate Pollution On Tetrahymena Thermophila, Reegan DeBruycker, Hannah Sylvester, Stefanie Otto-Hitt 2018 Carroll College

Effect Of Nitrate Pollution On Tetrahymena Thermophila, Reegan Debruycker, Hannah Sylvester, Stefanie Otto-Hitt

Life and Environmental Sciences Course-based Research Projects

The question under investigation in this project was: Does an elevated concentration of nitrates have a negative eect on cell growth and expression of the CDC16 gene in the organism Tetrahymena thermophila? Exposure of Tetrahymena cultures to nitrates mimics the exposure of these organisms to nitrate pollution in the environment, which can occur due to septic tank leakage, nitrogen-rich fertilizer run o, and agricultural processes. The EPA standard for nitrate concentrations in drinking water is a maximum of 10ppm. In our experiment, Tetrahymena cultures were treated with media that contained 30ppm of nitrates for one week. The 30ppm nitrate concentration ...


The Effect Of Imidacloprid On Honey Bee Queen Fecundity, Jamilyn Martin, Julia D. Fine, Amy Cash-Ahmed, Gene E. Robinson 2018 Kaskaskia College

The Effect Of Imidacloprid On Honey Bee Queen Fecundity, Jamilyn Martin, Julia D. Fine, Amy Cash-Ahmed, Gene E. Robinson

PRECS 2018

Imidacloprid is a neonicotinoid insecticide commonly used in agricultural settings to control insect pests by acting as an agonist of acetylcholine receptors and inducing paralysis and mortality. In small doses, imidacloprid can cause loss of memory and foraging ability along with impaired learning and a lowered immune response in western honey bees (Apis mellifera). Effects of neonicotinoid insecticides on colony reproduction have been documented including decreased colony expansion, queen failure and replacement, and decreased queen egg laying.

For this study, we examined the effects of imidacloprid on the fecundity of queen bees when their worker attendants were exposed to low ...


Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth 2018 CUNY John Jay College

Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth

Student Theses

A liquid chromatography tandem mass spectrometry (LC-MSMS) method was developed and validated to detect for the presence of zolpidem in human hair samples. Zolpidem is a sedative hypnotic whose adverse effects make it a common drug found in drug facilitated crimes (DFC). It is important to be able to detect and quantitate the drug after a long period of time due to the victim’s delayed reporting of the crime. Hair’s long window of detection makes it a useful matrix for DFC investigations. The linear range of the assay was targeted at 2 pg/mg to 1,000 pg ...


Δ-9-Thc Effect On The Dopamine Transporter, Brooke E. Nielsen 2018 CUNY John Jay College

Δ-9-Thc Effect On The Dopamine Transporter, Brooke E. Nielsen

Student Theses

Understanding the mechanism behind drugs of abuse is one of the key elements to understanding why addiction is so prevalent in society. The goal of this research was to determine the effect that a popular cannabinoid, Δ -9-tetrahydrocannabinol has on the regulation of dopamine neurotransmitter in the synapses. It was hypothesized that the addictive high users experience from using Δ-9-THC had a direct effect on lowering the dopamine transporter protein on cell surface causing a buildup of dopamine in the synapse. The results of the study show that the higher concentration of Δ-9-THC that the cells were exposed to caused ...


Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender 2018 Fordham University

Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender

Student Theses 2015-Present

This paper aims to shed light on the dissonance caused by the superimposition of Dominant Human Systems on Natural Systems. I highlight the synthetic nature of Dominant Human Systems as egoic and linguistic phenomenon manufactured by a mere portion of the human population, which renders them inherently oppressive unto peoples and landscapes whose wisdom were barred from the design process. In pursuing a radical pragmatic approach to mending the simultaneous oppression and destruction of the human being and the earth, I highlight the necessity of minimizing entropic chaos caused by excess energy expenditure, an essential feature of systems that aim ...


Examining The Roles Of Genetic And Environmental Factors In Drosophila Melanogaster Hematopoiesis And Innate Immune System, Minkyung Lee 2018 Baruch College

Examining The Roles Of Genetic And Environmental Factors In Drosophila Melanogaster Hematopoiesis And Innate Immune System, Minkyung Lee

Student Theses

Nearly 24 million people are affected by autoimmune diseases in the United States. Main causes of autoimmune diseases have been attributed to genetic predisposition and environmental exposure to chemicals such as hormones and pesticides. Due to the large population that are affected by autoimmune diseases, it is critical to understand the mechanisms behind them. In this study, we sought to explore both genetic and environmental factors that affect hematopoiesis, or the formation of specific blood cells, and immune system in Drosophila melanogaster. As Drosophila melanogaster have conserved pathways of hematopoiesis as humans, they were used as the model organism for ...


Developing A Risk Assessment Protocol To Quantify Distribution And Uptake Of Persistent Organic Pollutants In Glacial Outflows, Kimberley Rain Miner 2018 University of Maine

Developing A Risk Assessment Protocol To Quantify Distribution And Uptake Of Persistent Organic Pollutants In Glacial Outflows, Kimberley Rain Miner

Electronic Theses and Dissertations

Pollutants released by industrialized nations between 1960 and 2004 have been transported northward through atmospheric processes and deposited into glaciated alpine ecosystems. Many of these chemicals retain their original structure and are absorbed into the biota thousands of miles away from where they were originally utilized. With a warming climate increasing the melt of alpine glaciers, these glaciers may be introducing growing amounts of toxins into the watershed. While studies have demonstrated the existence of resident pollutants within glaciated ecosystems, no one has developed a risk assessment to identify sources and quantity of risk posed by these compounds when released ...


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