Tolerance Threshold And Phyto-Assessment Of Cadmium And Lead In Vetiver Grass, Vetiveria Zizanioides (Linn.) Nash, Chuck Chuan Ng Mr
Chuck Chuan NG
Intergenerational Effects Of Nicotine In An Animal Model Of Paternal Nicotine Exposure, 2017 University of Massachusetts Medical School
Intergenerational Effects Of Nicotine In An Animal Model Of Paternal Nicotine Exposure, Markus Parzival Vallaster
GSBS Dissertations and Theses
Environmental conditions imposed onto organisms during certain phases of their life cycles such as embryogenesis or puberty can not only impact the organisms’ own health, but also affect subsequent generations. The underlying mechanisms causing intergenerational phenotypes are not encoded in the genome, but the result of reversible epigenetic modifications. This work investigates in a mouse model the impact of paternal nicotine exposure on the next generation regarding addictive behavior modulation, metabolic changes, and molecular mechanisms. It provides evidence that male offspring from nicotine-exposed fathers (NIC offspring) is more resistant to lethal doses of nicotine. This phenotype is gender-specific and depends ...
Mobility Characteristics Of Azithromycin In Soil, 2017 Purdue University
Mobility Characteristics Of Azithromycin In Soil, Ryan Minter, Jihyun Kim, Linda Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
The presence of pharmaceutical and personal care products (PPCPs) in the environment has become a widespread problem in recent decades. Azithromycin, a macrolide antibiotic commonly prescribed for infections in humans, has been detected in waste treatment plant discharge and surface waters across the world. Data on the mobility characteristics of azithromycin in soil is scarce, and further studies must be performed to explore the potential for azithromycin leaching to groundwater or becoming available for plant uptake. In this study, azithromycin sorption isotherms were measured on eight soils varying in pH, organic carbon content, and clay content. Soil was equilibrated with ...
Bioaccumulative And Toxic Effects Of Ingested Clean And Pbt-Saturated Microplastics On Oryzias Latipes (Japanese Medaka Fish): Method Development Towards Physiological And Chemical Analysis, 2017 University of Puget Sound
Bioaccumulative And Toxic Effects Of Ingested Clean And Pbt-Saturated Microplastics On Oryzias Latipes (Japanese Medaka Fish): Method Development Towards Physiological And Chemical Analysis, Kieran O'Neil
Honors Program Theses
Microplastics are major and often overlooked components of this global accumulation of plastic debris. Recent marine surveys in Puget Sound have found microplastic contamination in benthic communities such as forage fish and mussel populations, indicating the prevalence of microplastics throughout the water column and marine environment. In light of rapid and increasing accumulation of plastic debris and chemical pollutants in marine environments, the transfer of toxic chemicals to biota via microplastic ingestion is of significant concern. Preliminary research on the toxic effects of pollutants on biotic systems has identified microplastics as a transport mechanism for persistent bioaccumulative toxins (such as ...
Investigation De Regeneración Natural De Plantas Vasculares En La Reserva Madrigal Del Podocarpus / Investigation Of Natural Regeneration Of Vascular Plants In The Madrigal Reserve Of The Podocarpus, 2017 SIT Study Abroad
Investigation De Regeneración Natural De Plantas Vasculares En La Reserva Madrigal Del Podocarpus / Investigation Of Natural Regeneration Of Vascular Plants In The Madrigal Reserve Of The Podocarpus, Sy Baker
Independent Study Project (ISP) Collection
En el Sur de Ecuador, hay una historia larga de incendio que está asociada con la historia de la agricultura y ganadería a causa de las técnicas de tala y quema para despejar áreas para campos y también quemaduras intencionales para fertilizar los suelos y mejorar productividad agrícola (Fernandez et al 2015). En los últimos días de Noviembre de 2016, un incendio quemó campos, la Reserva Madrigal de Podocarpus, y parte del Parque Nacional Podocarpus en Loja, Ecuador—el enfoque de este estudio. En este estudio: (1) se registraron las especies y distribución de plantas pioneras y sobrevivientes, (2) la ...
The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, 2017 Georgia State University
The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, Tosin O. Ajala
DISCOVERY: Georgia State Honors College Undergraduate Research Journal
Stress is a state of disharmony or threatened homeostasis. The maintenance of homeostasis in stages of internal or external challenges, called stressors, requires constant adjustments of hormonal, behavioral, and autonomic functions. The nuances of life may bring about unwanted stress to the human body. Some of the top causes of stress in America include work, finances, relationships, and health. There are numerous physical and psychological symptoms associated with long-term “chronic” stress, which include chronic fatigue, frustration, irritability, insomnia, frequent headaches, chest and back pain, weakness, and weight gain or weight loss. These symptoms of chronic stress are associated with depression ...
Using Mouse Models To Define How The P53 R72p Polymorphism Impacts The Adverse Effects Of Doxorubicin And Ionizing Radiation, 2016 The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
Using Mouse Models To Define How The P53 R72p Polymorphism Impacts The Adverse Effects Of Doxorubicin And Ionizing Radiation, Emily Dominguez
UT GSBS Dissertations and Theses (Open Access)
The single nucleotide polymorphism (SNP) at codon 72 of the tumor suppressor gene p53 codes for either an arginine (R) or proline (P) (p53 R72P). This SNP may impact how cells respond to genotoxic insult. Studies in cell culture and in tissues from mouse models of the SNP indicate that, in response to gentoxic treatment, the two variants may differentially induce apoptosis and expression of p53 target genes. In epidemiological studies, the P variant is associated with decreased cancer survival and increased risk of side-effects from genotoxic cancer treatment. Genotoxic therapy is still the mainstay of cancer treatment, and doxorubicin ...
An Analysis Of The Use Of Animal Models In Predicting Human Toxicology And Drug Safety, 2016 British Union for the Abolition of Vivisection
An Analysis Of The Use Of Animal Models In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls
Jarrod Bailey, Ph.D.
Animal use continues to be central to preclinical drug development, in spite of a lack of its demonstrable validity. The current nadir of new drug approvals and the drying-up of pipelines may be a direct consequence of this. To estimate the evidential weight given by animal data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive data set of 2,366 drugs, for which both animal and human data are available, including tissue-level effects and MedDRA Level 1–4 biomedical observations. This was done for three preclinical species ...
Are Electronic Cigarettes The Solution To Smoking Cessation?, 2016 James Madison University
Are Electronic Cigarettes The Solution To Smoking Cessation?, Heather L. Walsh, Audrey L. Mcmurray
Physician Assistant Capstones
Objectives: Little is known regarding the effectiveness of electronic cigarettes (e-cigarettes) as therapy to aid in smoking cessation. Many hypothesize that e-cigarettes are equally as effective or more effective than alternate smoking cessation therapies. The purpose of this review was to examine the evidence on effectiveness of e-cigarettes on smoking cessation and quitting behavior as compared to other smoking cessation therapies, or no therapy at all.
Methods: Searches were done in PubMed utilizing the terms “electronic cigarettes” and “smoking cessation” [MeSH terms]. In PubMed, the following filters limits were used: published in the last 5 years, human species, English language ...
In Vitro Monitoring Of Time And Dose Dependent Cytotoxicity Of Aminated Nanoparticles Using Raman Spectroscopy, 2016 Dublin Institute of Technology
In Vitro Monitoring Of Time And Dose Dependent Cytotoxicity Of Aminated Nanoparticles Using Raman Spectroscopy, Esen Efeoglu, Alan Casey, Hugh Byrne
No abstract provided.
Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, 2016 Université Reims Champagne-Ardenne, UMR-I 02 SEBIO
Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim Samai
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
Flow Cytometric Analysis For Cyanobacteria In 36 New Jersey Freshwater Bodies, 2016 Seton Hall University
Flow Cytometric Analysis For Cyanobacteria In 36 New Jersey Freshwater Bodies, Ruchit Patel
Seton Hall University Dissertations and Theses (ETDs)
Eutrophication, a process that occurs due to excessive accumulation of nutrients such as nitrogen and phosphorous is primarily from anthropogenic nitrogen and natural occurrences. This phenomenon causes cyanobacterial overgrowth which can potentially lead to toxic algal blooms that affect public drinking water sources and recreational usage. An immediate need to detect bloom forming cyanobacteria in freshwater bodies early hand is critical to implement prevention strategies. These microorganisms contain phycobiliproteins such as phycoerytrhin, and allophycocyanin as part of the phycobillisome that allow autofluorescence. In this study, 36 freshwater bodies from 14 New Jersey counties were collected and processed for flow cytometric ...
Evaluating The Cytotoxic Effects Of Cellulose Nanocrystals (Cncs) Using Autobioluminescent Yeast And Human Cells, 2016 University of Tennessee, Knoxville
Evaluating The Cytotoxic Effects Of Cellulose Nanocrystals (Cncs) Using Autobioluminescent Yeast And Human Cells, Julianna Hughes Burchett
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Cellulose nanocrystals (CNCs) are widely used in different industries including pharmaceutical and cosmetic production due to their adept physical and biological properties. Because CNCs are becoming a more prevalent material and have a high potential of being redistributed in the environment, it is important to understand their toxic potentials in biological systems, including organisms of various trophic levels. This study evaluated the cytotoxic effects of CNCs in the lower eukaryotic organism Saccharomyces cerevisiae and human embryonic kidney (HEK293) cells using autobioluminescent yeast and human cell reporters, respectively. The S. cerevisiae and HEK293 reporter cells were engineered to express a synthetic ...
The Influence Of Abiotic Factors On The Uptake And Elimination Of 3-Trifluoromethyl-4-Nitrophenol By Larval Sea Lamprey (Petromyzon Marinus), Benjamin Livingston Hlina
Theses and Dissertations (Comprehensive)
The backbone of sea lamprey (Petromyzon marinus) control in the Great Lakes is the use of the piscicide, 3-trifluoromethyl-4-nitrophenol (TFM), which is applied to streams containing larval sea lampreys. However, TFM effectiveness can be influenced by abiotic factors such as pH and temperature, which fluctuate daily and seasonally. The objectives of this thesis were to evaluate the influence of pH, temperature, and season on the toxicity, uptake, and elimination of TFM by larval sea lamprey. Radio-labeled TFM (14C-TFM) was used to determine how TFM uptake rates varied at different water pHs or temperatures during exposure to TFM at the ...
The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, 2016 University of Kentucky
The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, Robert N. Helsley
Theses and Dissertations--Pharmacology and Nutritional Sciences
Cardiovascular disease (CVD) is the leading cause of death worldwide and is partially attributed to perturbations in lipid metabolism. Xenobiotics, such as pharmaceutical drugs and environmental chemicals, have been associated with increased risk of CVD in multiple large-scale human population studies, but the underlying mechanisms remain poorly defined. We and others have identified several xenobiotics as potent agonists for the pregnane X receptor (PXR), a nuclear receptor that can be activated by numerous drugs as well as environmental and dietary chemicals. However, the role of PXR in mediating the pathophysiological effects of xenobiotic exposure in humans and animals remains elusive ...
The Sublethal Physiological Effects Of Exposure To Copper And Silver Mixtures On Rainbow Trout (Oncorhynchus Mykiss), Wesley Truong
Theses and Dissertations (Comprehensive)
The mechanisms behind metal-metal interactions in freshwater environments are currently not well understood. Freshwater environments consist of many different types of metals, from those naturally present such as copper (Cu) and those that originate from anthropogenic sources like silver (Ag). Both Cu and Ag use apical sodium (Na+) channels for uptake into the gills of freshwater fish. In the gills, the mechanisms of Cu2+ and Ag+ toxicity appear to be similar to one another, which is by inhibiting Na+ /potassium (K+)- adenosine triphosphatase (NKA) and carbonic anhydrase (CA). Inhibition of NKA and CA results in ionoregulatory disturbances where branchial ...
Physical, Spectroscopic And Thermal Characterization Of Biofield Treated Fish Peptone, 2015 Trivedi Global Inc.
Physical, Spectroscopic And Thermal Characterization Of Biofield Treated Fish Peptone, Mahendra Trivedi
Mahendra Kumar Trivedi
Odorant Receptor-Based Discovery Of Natural Repellents Of Human Lice, 2015 University of California-Davis
Odorant Receptor-Based Discovery Of Natural Repellents Of Human Lice, Julien Pelletier, Pingxi Xu, Kyong-Sup Yoon, John M. Clark, Walter S. Leal
SIUE Faculty Research, Scholarship, and Creative Activity
The body louse, Pediculus humanus humanus, is an obligate blood-feeding ectoparasite and an important insect vector that mediates the transmission of diseases to humans. The analysis of the body louse genome revealed a drastic reduction of the chemosensory gene repertoires when compared to other insects, suggesting specific olfactory adaptations to host specialization and permanent parasitic lifestyle. Here, we present for the first time functional evidence for the role of odorant receptors (ORs) in this insect, with the objective to gain insight into the chemical ecology of this vector. We identified seven putative full-length ORs, in addition to the odorant receptor ...
Occupational Exposure To Isoflurane Anesthetic Gas In The Research Environment, 2015 University of Nebraska Medical Center
Occupational Exposure To Isoflurane Anesthetic Gas In The Research Environment, Andrea R. Mulvenon
Theses & Dissertations
This dissertation is a compilation of studies related to the halogenated anesthetic gas isoflurane. Historically, halogenated anesthetic gases have been used in the health care industry. In 1977 the National Institute for Occupational Safety and Health (NIOSH) issued a recommended exposure limit (REL) of two parts per million (ppm) averaged over one hour of exposure for halogenated anesthetic gases (NIOSH 1977). The purpose of the standard was to protect healthcare workers from exposure to halothane, methoxyflurane, and chloroform. However, isoflurane only became available after the NIOSH REL was adopted. Therefore, the NIOSH REL is not directly applicable to isoflurane. Moreover ...
Determination Of The Baseline Concentration Of Mercury And Percentage Of Organic Material In Sub-Alpine Forest Soil Before Clear Cutting Within The White Mountain National Forest, 2015 Trinity College
Determination Of The Baseline Concentration Of Mercury And Percentage Of Organic Material In Sub-Alpine Forest Soil Before Clear Cutting Within The White Mountain National Forest, Daniel Sunghoon Hong
Senior Theses and Projects
Clear-cutting has been practiced for centuries to provide timber for our societal needs. It is the most economically profitable method of timber harvesting but can create disturbances in the ecosystems when practiced irresponsibly. Clear-cutting vast parcels of land can have adverse effects on the quality of the soils, including erosion, loss of nutrients due to rapid runoff, and disruption of habitats and wildlife. Moreover, with large parcels of trees cut, soils are more exposed to direct airborne fallout and rapid runoff of trace metals such as mercury (Hg) into nearby fluvial systems. In the summer of 2013, soil samples were ...