Pyronaridine Exerts Potent Cytotoxicity On Human Breast And Hematological Cancer Cells Through Induction Of Apoptosis, 2018 NYC College of Technology
Pyronaridine Exerts Potent Cytotoxicity On Human Breast And Hematological Cancer Cells Through Induction Of Apoptosis, Alberto Martinez, Paulina J. Villanueva, Sarah T. Baca, Rebecca E. Dejesus, Manuel Larragoity, Lisett Contreras, Denisse A. Gutierrez, Armando Varela-Ramirez, Renato J. Aguilera
Publications and Research
The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and non-cancerous (2) cells to PND for 72 hr, PND was found to exhibit consistent and potent cytotoxic activity at low micromolar (μM) concentrations that ranged from 1.6 μM to 9.4 μM. Moreover, PND exerted a significant selective cytotoxicity index (SCI) on five out of seven breast cancer cell lines tested, with favorable values of 2.5 to 4.4, as compared with the non-cancerous breast MCF-10A cell line. By using the same comparison, PND exhibited a significant SCI ...
Macrophytes And Atrazine In Ponds Of Southwest Missouri, 2018 Missouri State University
Macrophytes And Atrazine In Ponds Of Southwest Missouri, Christine Michelle Cornish
MSU Graduate Theses
Wetlands are often the ultimate destination of agrochemicals. The increased use of these pollutants has resulted in their increased transport, via runoff and spray drift, into wetlands. Atrazine, a commonly used herbicide, has been detected in surface water, groundwater, soil, and sediment, and has shown to have adverse impacts on aquatic biota, such as fish and amphibians. Few studies have reported on the relationships between atrazine and macrophytes. I measured atrazine concentrations in surface sediments in agricultural, conservation, and golf course ponds of southwest Missouri, and investigated how those concentrations might be related to macrophyte communities, and pond environmental characteristics ...
Defining The Radioresponse Of Mossy Cells, 2018 California State University, San Bernardino
Defining The Radioresponse Of Mossy Cells, Devon Ivy
Electronic Theses, Projects, and Dissertations
Clinical radiotherapy is used to treat a variety of brain tumors within the central nervous system. While effective, it can result in progressive and debilitating cognitive impairment that can diminish quality of life. These impairments have been linked to hippocampal dysfunction and corresponding deficits in spatial learning and memory. Mossy cells are a major population of excitatory neurons located within the dentate hilus and highly involved in hippocampal circuitry. They play critical roles in spatial navigation, neurogenesis, memory, and are particularly vulnerable to a variety of neurotoxic insults. However, their sensitivity to ionizing radiation has yet to be investigated in ...
Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender
Student Theses 2015-Present
This paper aims to shed light on the dissonance caused by the superimposition of Dominant Human Systems on Natural Systems. I highlight the synthetic nature of Dominant Human Systems as egoic and linguistic phenomenon manufactured by a mere portion of the human population, which renders them inherently oppressive unto peoples and landscapes whose wisdom were barred from the design process. In pursuing a radical pragmatic approach to mending the simultaneous oppression and destruction of the human being and the earth, I highlight the necessity of minimizing entropic chaos caused by excess energy expenditure, an essential feature of systems that aim ...
Water Capacity Of Paramo Soils, 2018 SIT Study Abroad
Water Capacity Of Paramo Soils, Rafael Robert
Independent Study Project (ISP) Collection
The pȧramo ecosystems in the high Ecuadorian Andes are grasslands characterized by challenging abiotic factors such as low temperatures and high solar radiation. Another key feature of pȧramos is the humidity and water availability in the ecosystem. Pȧramos are very important to the hydrology of the inter-Andean valley because they are water reserves that distribute fresh water to lower elevations. These hydrologic properties are made possible by the porous volcanic ash soils formed by the volcanic arc along the mountain range. This study is focused in the region of Chimborazo approximately 20 km from Riobamba the capitol ...
Regulation Of Radioactive Fracking Waste, 2018 CUNY School of Public Health
Regulation Of Radioactive Fracking Waste, Elizabeth Ann Glass Geltman, Nichole Leclair
Publications and Research
Natural gas extracted form shale reached record production totals in 2015 in the United States and the US Energy Information Administration (EIA) forecasts natural gas production will continue to increase. Wastes from shale gas extraction can contain the radioactive isotopes radium-226 (Ra-226) and radium-228 (Ra-228), which decay further into radon (Rn). Exposure to radon, a form of naturally occurring radioactive materials (NORM), is the leading cause of lung cancer in the United States, after smoking. This article explores how states handle the disposal of technologically enhanced naturally occurring radioactive materials (TENORM) and/or NORM waste from oil and gas operations ...
The Combined Effects Of Atrazine And Tetracycline On Primary Producers And Zooplankton In Freshwater Microcosms, 2018 Georgia Southern University
The Combined Effects Of Atrazine And Tetracycline On Primary Producers And Zooplankton In Freshwater Microcosms, Madison R. Kelly
University Honors Program Theses
Widespread use of agrochemicals such as herbicides and antibiotics increases their likelihood of entering aquatic systems in mixture. Despite different modes of action, atrazine (herbicide) and tetracycline (antibiotic) adversely affect non-target photosynthetic organisms, such algae and macrophytes, with the potential to reduce food availability to higher trophic levels. However, the effects of simultaneous exposure to both contaminants have yet to be determined. I hypothesized that a mixture of atrazine and tetracycline affects freshwater communities differently than each compound alone. A microcosm experiment was conducted to test effects of environmentally relevant concentrations of atrazine (1 μg L-1) and tetracycline (1 ...
Exploring Science Identity: The Lived Experiences Of Underserved Students In A University Supplemental Science Program, 2017 University of New Orleans
Exploring Science Identity: The Lived Experiences Of Underserved Students In A University Supplemental Science Program, Lynette D. Perrault
University of New Orleans Theses and Dissertations
Underserved students attending under-resourced schools experience limited opportunities to engage in advanced science. An exploration into the influence a supplemental science program has on underserved students’ acquisition of science knowledge and skills to increase their pursuit of science was conducted to help explain science identity formation in students. The proliferation of supplemental science programs have emerged as a result of limited exposure and resources in science for underserved students, thus prompting further investigation into the influence supplemental science programs have on underserved students interest and motivation in science, attainment of science knowledge and skills, and confidence in science to promote ...
Organizational Effects Of Defeminizing Toxicants: Lessons Learned From An Environmental Sentinel Organism, The Fathead Minnow., 2017 University of Nebraska Medical Center
Organizational Effects Of Defeminizing Toxicants: Lessons Learned From An Environmental Sentinel Organism, The Fathead Minnow., Jonathan Ali
Theses & Dissertations
Endocrine disrupting compounds (EDCs) are chemicals that interfere with hormone function and are increasingly detected in aquatic environments, where they elicit adverse effects from exposed organisms. The toxicological effects of EDCs can be described as either activational (reversible) or organizational (irreversible), where the latter are associated with adverse outcomes in reproductive performance of adult fish. However, few studies have investigated the organizational impacts of anti-estrogenic or “defeminizing” EDCs, e.g. agrichemicals or pharmacological agents, in an environmentally-relevant or “sentinel” species. The objective of this study was to investigate the impacts of early-life EDC-initiated changes in estrogenic gene expression on organizational ...
Omega-3 Polyunsaturated Fatty Acids: Impact On Oxidative Stress, Antioxidant Responses And Vascular Function, 2017 University of New Mexico
Omega-3 Polyunsaturated Fatty Acids: Impact On Oxidative Stress, Antioxidant Responses And Vascular Function, Kayla R. Zehr
Biomedical Sciences ETDs
Cardiovascular disease (CVD) is the leading global cause of death, and cigarette smoking (CS) is a major risk factor for CVD. Although there are smoking cessation programs that include a combination of pharmacological and behavior treatments, failure to curb behavioral habits and pharmacological addiction leads to low cessation success rates. Thus, developing a treatment to decrease CVD risk is critical. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) decrease oxidative stress and have been shown to restore endothelial function, an indicator of CV health, in cigarette smokers. Metabolites of n-3 PUFAs have been shown to have CV-protective effects, but the mechanism by ...
Hydrology And Macroinvertebrates As Biological Indicators- An Integrated Study Of The Río Zamora Watershed, Loja, Ecuador, Isabel Ryde
Independent Study Project (ISP) Collection
Water quality and access is under grave threat in Ecuador, yet remains poorly studied. Macroinvertebrates were used as biological indicators to study water quality around Reserva Natural Madrigal del Podocarpus, Loja Province, Ecuador. Data on macroinvertebrates was combined with hydrologic measurements of stream functions. Macroinvertebrate sampling was conducted from 6 sites within the Upper Río Zamora watershed. Geologic outcrops were observed along several roadcuts and stream banks. Hydrologic data was collected by measuring discharge, elevation change, and finding the highest permanent spring. The EPT index (number of EPT individuals and percentage of EPT individuals) and the BMWP/Colombia Index for ...
Epigenetic Instability Induced By Dna Base Lesion Via Dna Base Excision Repair, 2017 Florida International University
Epigenetic Instability Induced By Dna Base Lesion Via Dna Base Excision Repair, Zhongliang Jiang
FIU Electronic Theses and Dissertations
DNA damage can cause genome instability, which may lead to human cancer. The most common form of DNA damage is DNA base damage, which is efficiently repaired by DNA base excision repair (BER). Thus BER is the major DNA repair pathway that maintains the stability of the genome. On the other hand, BER mediates DNA demethylation that can occur on the promoter region of important tumor suppressor genes such as Breast Cancer 1 (BRCA1) gene that is also involved in prevention and development of cancer. In this study, employing cell-based and in vitro biochemical approaches along with bisulfite DNA sequencing ...
Intergenerational Effects Of Nicotine In An Animal Model Of Paternal Nicotine Exposure, 2017 University of Massachusetts Medical School
Intergenerational Effects Of Nicotine In An Animal Model Of Paternal Nicotine Exposure, Markus Parzival Vallaster
GSBS Dissertations and Theses
Environmental conditions imposed onto organisms during certain phases of their life cycles such as embryogenesis or puberty can not only impact the organisms’ own health, but also affect subsequent generations. The underlying mechanisms causing intergenerational phenotypes are not encoded in the genome, but the result of reversible epigenetic modifications. This work investigates in a mouse model the impact of paternal nicotine exposure on the next generation regarding addictive behavior modulation, metabolic changes, and molecular mechanisms. It provides evidence that male offspring from nicotine-exposed fathers (NIC offspring) is more resistant to lethal doses of nicotine. This phenotype is gender-specific and depends ...
Mobility Characteristics Of Azithromycin In Soil, 2017 Purdue University
Mobility Characteristics Of Azithromycin In Soil, Ryan Minter, Jihyun Kim, Linda Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
The presence of pharmaceutical and personal care products (PPCPs) in the environment has become a widespread problem in recent decades. Azithromycin, a macrolide antibiotic commonly prescribed for infections in humans, has been detected in waste treatment plant discharge and surface waters across the world. Data on the mobility characteristics of azithromycin in soil is scarce, and further studies must be performed to explore the potential for azithromycin leaching to groundwater or becoming available for plant uptake. In this study, azithromycin sorption isotherms were measured on eight soils varying in pH, organic carbon content, and clay content. Soil was equilibrated with ...
Bioaccumulative And Toxic Effects Of Ingested Clean And Pbt-Saturated Microplastics On Oryzias Latipes (Japanese Medaka Fish): Method Development Towards Physiological And Chemical Analysis, 2017 University of Puget Sound
Bioaccumulative And Toxic Effects Of Ingested Clean And Pbt-Saturated Microplastics On Oryzias Latipes (Japanese Medaka Fish): Method Development Towards Physiological And Chemical Analysis, Kieran O'Neil
Honors Program Theses
Microplastics are major and often overlooked components of this global accumulation of plastic debris. Recent marine surveys in Puget Sound have found microplastic contamination in benthic communities such as forage fish and mussel populations, indicating the prevalence of microplastics throughout the water column and marine environment. In light of rapid and increasing accumulation of plastic debris and chemical pollutants in marine environments, the transfer of toxic chemicals to biota via microplastic ingestion is of significant concern. Preliminary research on the toxic effects of pollutants on biotic systems has identified microplastics as a transport mechanism for persistent bioaccumulative toxins (such as ...
Investigation De Regeneración Natural De Plantas Vasculares En La Reserva Madrigal Del Podocarpus / Investigation Of Natural Regeneration Of Vascular Plants In The Madrigal Reserve Of The Podocarpus, 2017 SIT Study Abroad
Investigation De Regeneración Natural De Plantas Vasculares En La Reserva Madrigal Del Podocarpus / Investigation Of Natural Regeneration Of Vascular Plants In The Madrigal Reserve Of The Podocarpus, Sy Baker
Independent Study Project (ISP) Collection
En el Sur de Ecuador, hay una historia larga de incendio que está asociada con la historia de la agricultura y ganadería a causa de las técnicas de tala y quema para despejar áreas para campos y también quemaduras intencionales para fertilizar los suelos y mejorar productividad agrícola (Fernandez et al 2015). En los últimos días de Noviembre de 2016, un incendio quemó campos, la Reserva Madrigal de Podocarpus, y parte del Parque Nacional Podocarpus en Loja, Ecuador—el enfoque de este estudio. En este estudio: (1) se registraron las especies y distribución de plantas pioneras y sobrevivientes, (2) la ...
Amitraz And Its Metabolite Modulate Honey Bee Cardiac Function And Tolerance To Viral Infection, Scott T. O'Neal, Carlyle C. Brewster, Jeffrey R. Bloomquist, Troy D. Anderson
Faculty Publications: Department of Entomology
The health and survival of managed honey bee (Apis mellifera) colonies are affected by multiple factors, one of the most important being the interaction between viral pathogens and infestations of the ectoparasitic mite Varroa destructor. Currently, the only effective strategy available for mitigating the impact of viral infections is the chemical control of mite populations. Unfortunately, the use of in-hive acaricides comes at a price, as they can produce sublethal effects that are difficult to quantify, but may ultimately be as damaging as the mites they are used to treat. The goal of this study was to investigate the physiological ...
Atp-Sensitive Inwardly Rectifying Potassium Channel Modulators Alter Cardiac Function In Honey Bees, Scott T. O'Neal, Daniel R. Swale, Jeffrey R. Bloomquist, Troy D. Anderson
Faculty Publications: Department of Entomology
ATP-sensitive inwardly rectifying potassium (KATP) channels couple cellular metabolism to the membrane potential of the cell and play an important role in a variety of tissue types, including the insect dorsal vessel, making them a subject of interest not only for understanding invertebrate physiology, but also as a potential target for novel insecticides. Most of what is known about these ion channels is the result of work performed in mammalian systems, with insect studies being limited to only a few species and physiological systems. The goal of this study was to investigate the role that KATP channels play in ...
The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, 2017 Georgia State University
The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, Tosin O. Ajala
DISCOVERY: Georgia State Honors College Undergraduate Research Journal
Stress is a state of disharmony or threatened homeostasis. The maintenance of homeostasis in stages of internal or external challenges, called stressors, requires constant adjustments of hormonal, behavioral, and autonomic functions. The nuances of life may bring about unwanted stress to the human body. Some of the top causes of stress in America include work, finances, relationships, and health. There are numerous physical and psychological symptoms associated with long-term “chronic” stress, which include chronic fatigue, frustration, irritability, insomnia, frequent headaches, chest and back pain, weakness, and weight gain or weight loss. These symptoms of chronic stress are associated with depression ...
Poison In Pink, 2017 University of Montana, Missoula
Poison In Pink, Sydney V. Cook
Graduate Student Theses, Dissertations, & Professional Papers
Humans slather, spray, mist, and cleanse their bodies with personal care products like lotion, hairspray, cologne, and shampoo every day. Our cupboards are stocked full of them, but few of us understand what is in those jars and bottles. We trust that if it’s on the shelf at the store, it’s safe. However, this is not always the case, and many personal care products contain chemicals that are harmful to human and environmental health.
My multi-disciplinary Environmental Studies thesis project combines evidenced-based research, interviews, nonfiction narrative, and science communication to create part of a book manuscript intended to ...