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Impact Of Imidacloprid On Forebrain Mitochondrial Enzymatic Activities Ec50, Ic50 And Impacts Of Mellissa Extracts, Sarra Zouaoui, Rachid Rouabhi, Chahinez Taib, Zina Bouteraa, Salim Gasmi, Brahim Benaicha, Nadjiba Toualbia 2024 Laboratory of Toxicology and Ecosystem Pathologies, Echahid Cheikh Larbi Tebessi University, Tebessa, Algeria

Impact Of Imidacloprid On Forebrain Mitochondrial Enzymatic Activities Ec50, Ic50 And Impacts Of Mellissa Extracts, Sarra Zouaoui, Rachid Rouabhi, Chahinez Taib, Zina Bouteraa, Salim Gasmi, Brahim Benaicha, Nadjiba Toualbia

Journal of Bioresource Management

Neonicotinoids are new generation of neuroactive pesticides, used against a wide specter of insect species, and many non-target beings are affected with these pesticides’ impacts. Our work was focused on the impact of 5, 10, 15, 20, 25 and 30 mg/kg of Imidacloprid the nicotinergic neuronal pathway inhibitor (N-ACh receptors) on the activities of mitochondrial detoxification enzymes (Catalase, SOD, GST and GPx) and acetylcholine esterase (AchE) in forebrain region of Wistar rats. Direct impact on enzymes activities was measured and the IC50, EC50 with or without Mellissa extracts were investigated. Our results showed that the IC50 of imidacloprid on …


A Randomized Double Blind Placebo Controlled Trial To Assess The Safety And Efficacy Of A Patented Fenugreek (Trigonella Foenum-Graecum) Seed Extract In Type 2 Diabetics, Rajinder Singh Gupta, Amarjit Singh Grover, Pawan Kumar, Apurva Goel, Samudra P. Banik, Sanjoy Chakraborty, Mehul Rungta, Manashi Bagchi, Partha Pal, Debasis Bagchi 2024 Gian Sagar Medical College & Hospital

A Randomized Double Blind Placebo Controlled Trial To Assess The Safety And Efficacy Of A Patented Fenugreek (Trigonella Foenum-Graecum) Seed Extract In Type 2 Diabetics, Rajinder Singh Gupta, Amarjit Singh Grover, Pawan Kumar, Apurva Goel, Samudra P. Banik, Sanjoy Chakraborty, Mehul Rungta, Manashi Bagchi, Partha Pal, Debasis Bagchi

Publications and Research

Background: Fenugreek plant (Trigonella foenum-graecum) constitutes a traditionally acclaimed herbal remedy for many human ailments including diabetes, obesity, neurodegenerative diseases, and reproductive disorders. It is also used as an effective anti-oxidative, anti-inflammatory, antibacterial, and anti-fungal agent. The seed of the plant is especially enriched in several bioactive molecules including polyphenols, saponins, alkaloids, and flavonoids and has demonstrated potential to act as an antidiabetic phytotherapeutic. A novel patented formulation (Fenfuro®) was developed in our laboratory from the fenugreek seeds which contained >45% furostanolic saponins (HPLC).

Objective: A placebo-controlled clinical compliance study was designed to assess …


Molecular And Physicochemical Studies Of Mrsa Resistant To Antibiotics: A Known Beyond, Himanshu Bhogekar, Ritesh P. Bhole, Pramod B. Khedekar, Rupesh V. Chikhale 2024 Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440033, Maharashtra, India

Molecular And Physicochemical Studies Of Mrsa Resistant To Antibiotics: A Known Beyond, Himanshu Bhogekar, Ritesh P. Bhole, Pramod B. Khedekar, Rupesh V. Chikhale

Palestinian Medical and Pharmaceutical Journal

As we see in the community, environment, and daily life, bacterial, microbial, and viral infection creates the severe problem. The medical field is continuously worried about the treatment of infections caused by the microorganism. Day by day, the microorganism in nature becomes stronger and gains more susceptibility to major infections. The researcher continuously works on the development of new antibiotic to break infectivity of the microorganism. But bacteria have the characteristic to adapt in a new environment by generating resistance. Many antibiotics since the discovery of penicillin work on the effects of bacteria for a short duration of time, and …


Validation Of A Triple Quadrupole Lcms Instrument For Cocaine And Amphetamines, Isabel R. Nichols 2024 University of Mississippi

Validation Of A Triple Quadrupole Lcms Instrument For Cocaine And Amphetamines, Isabel R. Nichols

Honors Theses

Despite the opioid crisis taking headlines, the abuse of cocaine and amphetamines remains rampant and laboratory instruments must be able to effectively and reliably handle the overwhelming case load. In this study, an Agilent 6475 Triple Quadrupole (QQQ) LCMS, recently acquired by the Tarrant County Medical Examiner’s Office (TCMEO) in Fort Worth, Texas, was validated for identifying and quantifying CocAmps. Results show that the instrument was fit-for-purpose and that the instrument passed all validation tests. Reproducibility was ≤ 20% RSD for 12 QC replicates, 6 of blood and 6 of urine. Accuracy was ± 20%. A 98.9% recovery was yielded …


Mechanistic Study Of Photochemical And Advanced Oxidation Processes For Degradation Of Pharmaceuticals In Water, Melissa J. Chisholm 2024 University of Maine

Mechanistic Study Of Photochemical And Advanced Oxidation Processes For Degradation Of Pharmaceuticals In Water, Melissa J. Chisholm

Electronic Theses and Dissertations

Pharmaceuticals and personal care products (PPCPs) are contaminants in water worldwide and the effects of the accumulation of these contaminants in the environment are a growing concern. Current water treatment methods involve chlorination and chloramination, which have the potential to create chlorinated by-products that are possibly more harmful than the starting material that was the target of decomposition. Alternative methods to chlorination are advanced oxidation processes (AOP). Previous studies of AOPs often focused on the rate at which the target compound is removed, but neglect to evaluate the by-products.

The compounds of interest in this study were chosen because of …


Determining Perfluorooctanesulfonic Acid Adsorption On Nanoparticles Using Liquid Chromatography – Mass Spectrometry, Iqra Shakoor 2024 Missouri State University

Determining Perfluorooctanesulfonic Acid Adsorption On Nanoparticles Using Liquid Chromatography – Mass Spectrometry, Iqra Shakoor

MSU Graduate Theses

The contamination of perfluorooctanesulfonic acid (PFOS, C8F17SO3H) in water is considered a threat to humans and the environment. The strength of carbon and fluorine bond is responsible for its high stability in the environment. Therefore, it can be transferred from the environment to food sources and eventually humans. This study assessed the ability of nanoparticles to adsorb PFOS from water. The experiment was performed by preparing suspensions of PFOS (10 ppm) and different concentrations (1000 ppm, 500 ppm, 250 ppm) of cerium oxide nanoparticles (CeO2-NPs) or magnesium oxide nanoparticles (MgO-NPs). The suspensions …


The Biobehavioral Effects Of Embryonic Exposure To Neural Inflammation And Oxidative Stress In Zebrafish, Dalton J. Anderson 2024 Georgia Southern University

The Biobehavioral Effects Of Embryonic Exposure To Neural Inflammation And Oxidative Stress In Zebrafish, Dalton J. Anderson

Honors College Theses

The purpose of this research is to improve understanding of the neurodevelopmental effects of embryonic exposure to elevated inflammation and oxidative stress induced by the antipyretic drug acetaminophen (APAP). Our study was the first to examine the interactive effects of APAP and inflammation in zebrafish embryos and how the treatments affect brain development and larval behavior. Experimental groups of zebrafish larvae were exposed to lipopolysaccharide (LPS) to induce inflammation, APAP, or LPS + APAP and larval behavior was analyzed using Ethovision automated behavioral tracking software. We also measured changes in whole-brain Glycogen Synthase Kinase 3 Beta (GSK3B) and GSK3B phosphorylation, …


Implementation Of Prognosticator Algorithm For Initiation Of Serious Illness Discussions And Improving The Rate Of Palliative And Hospice Referrals, Joy Isebor 2024 University of Texas at Arlington

Implementation Of Prognosticator Algorithm For Initiation Of Serious Illness Discussions And Improving The Rate Of Palliative And Hospice Referrals, Joy Isebor

Doctor of Nursing Practice (DNP) Scholarly Projects

Context: Early serious illness conversations related to end-of-life and goals of care with seriously ill patients have been associated with improving patients' outcomes and quality of care (Bernacki et al., 2015). However, initiating these serious illness discussions has been challenging in the home-based primary care setting.

Objectives: To train and support home-based primary care clinicians in integrating best practices in serious illness discussions and decision-making engagement among patients sixty-five and older with serious illnesses, optimize the alignment between patient goals and the medical care they receive, improving their quality of life and the rate of palliative care and hospice referrals. …


Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee 2023 University of Louisville

Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee

Electronic Theses and Dissertations

We are facing an aging crisis, with 20% of the U.S. population projected to be geriatric (65+) by 2030 and live another 40+ years. Age-related diseases accompany a growing geriatric population, emphasizing the need to understand their etiology. Environmental pollutants compound this crisis by: 1) geriatrics are more susceptible, exacerbating age-related diseases and comorbidities, and 2) they accelerate biological aging, inducing age-related diseases at younger ages. We address this crisis using a ‘toxic aging coin’ approach; heads examines how age impacts toxicity, tails examines how chemicals accelerate aging. This thesis applies the heads side for Cr(VI)-induced neurotoxicity across ages. We …


Piperine Encourages Apoptosis In Human Cervical Adenocarcinoma Cells Through Ros Generation, Dna Fragmentation, Caspase-3 Activation And Cell Cycle Arrest, Asif Jafri, Juhi Rais, Sudhir Kumar, Md Arshad 2023 University of Lucknow

Piperine Encourages Apoptosis In Human Cervical Adenocarcinoma Cells Through Ros Generation, Dna Fragmentation, Caspase-3 Activation And Cell Cycle Arrest, Asif Jafri, Juhi Rais, Sudhir Kumar, Md Arshad

Research Symposium

Background: Cancer is one of the most common destructive diseases and the second leading cause of death in humans. Among cancer, cervical cancer is the second most common malignancy among women globally. Thus, there is a continuous need to search for chemotherapeutic chemicals or naturally occurring drugs to resolve this global health problem. Piperine (1-piperoylpeperdine) is present in the fruits of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). It possesses several pharmacological properties and in the present study we have evaluated its anti-cancer potential on human cervical adenocarcinoma (HeLa) cells.

Methods: The anti-proliferative effect …


International Conference On Cancer Health Disparities, Juhi Rais, Asif Jafri, Neelam Shivnath, Habiba Khan, Md Arshad 2023 Sanjay Gandhi Postgraduate lnstitute of Medical Sciences

International Conference On Cancer Health Disparities, Juhi Rais, Asif Jafri, Neelam Shivnath, Habiba Khan, Md Arshad

Research Symposium

Background: Biochanin A, an isoflavone that is mainly present in red clover, has potent chemopreventive properties against many cancers. Ovarian carcinoma is fifth most common and deadliest gynaecological malignancy that causes the highest mortality in females worldwide. Hence a substantial need for new therapies for combating this gynaecological malignancy arises.

Methods: The present study aimed to investigate anti-cancerous potentials of biochanin A on cultured human ovarian carcinoma PA-1 cells through the cell viability assay, cellular apoptosis, disruption of mitochondrial membrane potential (MMP), involvement of ROS, cell cycle kinetics, and expression of apoptosis-related genes namely, p53, Bax, Bcl-2, Noxa and Puma. …


Effect Of Authentic Kefir And Nigella Sativa On Broilers Challenged By Coccidia And Clostridium Perfringens, Julian E. Nixon 2023 Clemson University

Effect Of Authentic Kefir And Nigella Sativa On Broilers Challenged By Coccidia And Clostridium Perfringens, Julian E. Nixon

All Dissertations

Black seed oil concentrations of 0%, 0.1%, 1% and 5% were added to milk inoculated with kefir grains and incubated at 25°C for 22 h. The pH and microbial count indicated 1% black seed oil caused low inhibition (P > 0.05) of fermentation, but 5% black seed oil caused significant inhibition of the kefir microorganisms (P < 0.05).

Cobb 500 male chicks (n = 256) were distributed in a randomized block design and received one of four treatments: CTRL1 (Non-medicated, no kefir, no Clostridium perfringens), CTRL2 (Non-medicated, no kefir, C. perfringens inoculated), CTRL3 (BMD medicated, no kefir, C. perfringens inoculated), KTRT (Non-medicated, …


An Exploratory Study On Strategies Adopted By Parents Who Use E-Cigarettes To Negotiate Risk Perceptions Of Their Children's Secondhand Exposure And Parental Role Modeling, Joon Kyung Nam, Jesse P Zatloff, Su-Wei Wong, Hsien-Chang Lin, Wei-Chung Su, Anne Buu 2023 The Texas Medical Center Library

An Exploratory Study On Strategies Adopted By Parents Who Use E-Cigarettes To Negotiate Risk Perceptions Of Their Children's Secondhand Exposure And Parental Role Modeling, Joon Kyung Nam, Jesse P Zatloff, Su-Wei Wong, Hsien-Chang Lin, Wei-Chung Su, Anne Buu

Faculty, Staff and Student Publications

Existing health messages mainly targeted youth susceptible to vaping or parents who do not have much knowledge about e-cigarettes. This study makes a unique contribution by conducting the first in-depth investigation of e-cigarette-using parents' risk perceptions and parental role modeling and how these two factors affect their vaping behaviors at home or implementation of any strategies to reduce their children's risk. Fifteen parents who used e-cigarettes participated in a semi-structured interview. Interview transcripts were coded and analyzed through a deductive approach of thematic analysis. This study demonstrates the need to develop and disseminate future health messages for e-cigarette-using parents who …


The Opioid Epidemic: How Genetics Play A Role In Addiction And Treatment, Kirsten Houston 2023 Murray State University

The Opioid Epidemic: How Genetics Play A Role In Addiction And Treatment, Kirsten Houston

Honors College Theses

The opioid epidemic is an issue within the pharmaceutical industry in the United States of America due to prescription and non-prescription substances being made available to the population. Opioids include chemical substances that affect the body and brain through opioid receptors, including the mu, kappa, and delta receptors. These substances are derived and synthesized from the poppy plant. Multiple causes have been linked to opioid abuse disorder, including but not limited to employment, income, housing, nutrition, mental health disorders, and genetics. By gathering information from previous literature, genetics may be the main cause of narcotic analgesic tolerance and abuse. Specific …


Improving Traumatic Brain Injury Outcomes: Early Identification And Management Of Paroxysmal Sympathetic Hyperactivity, Randi Rockwell 2023 Southern Illinois University Edwardsville

Improving Traumatic Brain Injury Outcomes: Early Identification And Management Of Paroxysmal Sympathetic Hyperactivity, Randi Rockwell

Doctor of Nursing Practice Projects

Abstract

Background: Paroxysmal sympathetic hyperactivity (PSH) can occur in patients with acutely acquired brain injury and is associated with mortality, poor clinical outcomes, prolonged hospitalizations, physical disability, and increased healthcare costs. The most common cause of PSH syndrome is traumatic brain injury (TBI). Symptoms consist of hyperthermia, diaphoresis, arterial hypertension, tachycardia, tachypnea, and extremity motor dystonic posturing, often in response to evoked stimuli and occurs in 8% to 33% of TBI patients. Critical care nurses are at the forefront of providing direct patient care to TBI patients and are often the first to identify PSH.

Purpose: The objective of this …


Map The System: Presence And Impact Of Ppcps In Water, Emma VanderMeulen, Ruby Mitchell 2023 Portland State University

Map The System: Presence And Impact Of Ppcps In Water, Emma Vandermeulen, Ruby Mitchell

OHSU-PSU School of Public Health Annual Conference

In a changing climate, there is growing emphasis on protecting our water sources and developing systems for conserving and reusing water. While many contaminants of concern are monitored and addressed by water treatment systems, pharmaceuticals and personal care products (PPCPs) are generally not accounted for. PPCPs in water systems have been an increasing concern as detection of these products has increased over the last few decades. Studies have been exploring the impact of antibiotics, antidepressants, contraceptives, and other anthropogenic products on our water system and how these substances interact with local ecosystems. Our main research questions are to understand what …


Exploring The Potential Of Intranasally Administered Naturally Occurring Quercetin Loaded Into Polymeric Nanocapsules As A Novel Platform For The Treatment Of Anxiety, Shady Swidan, Khaled Younis Mahmoud, Nahla Ahmed Elhesaisy, Abdelrahman Rashed, Ebram Mikhael, Mahmoud Fadl, Mahmoud Elsadek, Merna Mohamed, Merna Mostafa, Mohamed Hassan, Omar Halema, Youssef Elnemer 2023 The British University in Egypt

Exploring The Potential Of Intranasally Administered Naturally Occurring Quercetin Loaded Into Polymeric Nanocapsules As A Novel Platform For The Treatment Of Anxiety, Shady Swidan, Khaled Younis Mahmoud, Nahla Ahmed Elhesaisy, Abdelrahman Rashed, Ebram Mikhael, Mahmoud Fadl, Mahmoud Elsadek, Merna Mohamed, Merna Mostafa, Mohamed Hassan, Omar Halema, Youssef Elnemer

Pharmacy

Anxiety is one of the most prevalent forms of psychopathology that afects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/beneft ratio resulting in a shift toward active ingredients with better safety profle such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best …


Chemical, Microbial And Safety Profiling Of A Standardized Withania Somnifera (Ashwagandha) Extract And Withaferin A, A Potent Novel Phytotherapeutic Of The Millennium, Pawan Kumar, Samudra P. Banik, Apurva Goe, Sanjoy Chakraborty, Manashi Bagchi, Debasis Bagchi 2023 Chemical Resources (CHERESO)

Chemical, Microbial And Safety Profiling Of A Standardized Withania Somnifera (Ashwagandha) Extract And Withaferin A, A Potent Novel Phytotherapeutic Of The Millennium, Pawan Kumar, Samudra P. Banik, Apurva Goe, Sanjoy Chakraborty, Manashi Bagchi, Debasis Bagchi

Publications and Research

Background:Withania somnifera (L.) Dunal, popularly known as Ashwagandha, is an ethnomedicinal plant with multiple pharmacotherapeutic applications. The diverse medicinal properties of the plant are largely due to the presence of withanolides, a group of C28 ergostane based steroidal lactones, with several sites of unsaturation and oxygenation. Withaferin A, a major with anolide present in Ashwagandha plant accounts for its emerging new roles to treat cancer, arthritis, inflammatory responses, immunomodulatory properties, and neuronal disorders. The root and leaf extracts are specifically important constituent materials for the development of phytotherapeutics, mostly intended for oral consumption. Several studies have been carried out …


The Impact Of Hiv-1 Tat And Morphine On Spatial Distribution Of Drugs In The Brain., Austin M. Jones 2023 Virginia Commonwealth University

The Impact Of Hiv-1 Tat And Morphine On Spatial Distribution Of Drugs In The Brain., Austin M. Jones

Theses and Dissertations

Despite combination antiretroviral therapy effectively suppressing HIV within the periphery, the central nervous system (CNS) remains affected by the virus. Approximately half of people living with HIV will experience HIV-associated neurocognitive disorders (HAND) or neuroHIV. Concurrent opioid use exacerbates neuroHIV by promoting neuroinflammation, viral replication, and potentially altering the antiretroviral concentrations within the brain.

Using a transgenic mouse that expresses the HIV-1 Tat protein, we examined the effects of Tat and morphine on antiretroviral accumulation and distribution and the effects of Tat on morphine accumulation within the brain using infrared matrix-assisted laser desorption electrospray ionization with mass spectrometry imaging (IR-MALDESI-MSI). …


Antibacterial, Antioxidant, And Repellency Potential Of The Essential Oil From Spartium Junceum L. Grown In Lebanon, Hawraa Zahrddin, Mahmoud Khalil, Akram Hijazi 2022 Department of Biology, Faculty of Science, Beirut Arab University

Antibacterial, Antioxidant, And Repellency Potential Of The Essential Oil From Spartium Junceum L. Grown In Lebanon, Hawraa Zahrddin, Mahmoud Khalil, Akram Hijazi

BAU Journal - Science and Technology

The goal of our present study is to assess the pharmacological potential of essential oil extracted from Spartium junceum cultivated in Lebanon. This oil was obtained by hydrodistillation using the Clevenger apparatus. Then, an organoleptic characterization and an evaluation of its antioxidant, repellent/insecticidal, and antibacterial activities have been evaluated. The obtained results showed that this oil had an antioxidant activity reaching 82 % dependent on the dilution used. In addition, it showed an insecticidal effect and an antibacterial effect.


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