Open Access. Powered by Scholars. Published by Universities.®

Pharmacology, Toxicology and Environmental Health Commons

Open Access. Powered by Scholars. Published by Universities.®

3,153 Full-Text Articles 6,307 Authors 677,081 Downloads 207 Institutions

All Articles in Pharmacology, Toxicology and Environmental Health

Faceted Search

3,153 full-text articles. Page 3 of 115.

Carbon Neutral, Spring/Summer 2018, Issue 38, 2019 University of Louisville

Carbon Neutral, Spring/Summer 2018, Issue 38

Sustain Magazine

No abstract provided.


Political Will, Fall/Winter 2018, Issue 37, 2019 University of Louisville

Political Will, Fall/Winter 2018, Issue 37

Sustain Magazine

No abstract provided.


Our Envirome, Spring/Summer 2019, Issue 40, 2019 University of Louisville

Our Envirome, Spring/Summer 2019, Issue 40

Sustain Magazine

No abstract provided.


Plastic Pollution, Fall/Winter 2019, Issue 39.3, 2019 University of Louisville

Plastic Pollution, Fall/Winter 2019, Issue 39.3

Sustain Magazine

No abstract provided.


Plastic Pollution, Fall/Winter 2019, Issue 39.2, 2019 University of Louisville

Plastic Pollution, Fall/Winter 2019, Issue 39.2

Sustain Magazine

No abstract provided.


Plastic Pollution, Fall/Winter 2019, Issue 39, 2019 University of Louisville

Plastic Pollution, Fall/Winter 2019, Issue 39

Sustain Magazine

No abstract provided.


Mechanism For Apobec3g Catalytic Exclusion Of Rna And Non-Substrate Dna, William C. Solomon, Wazo Myint, Shurong Hou, Tapan Kanai, Rashmi Tripathi, Nese Kurt Yilmaz, Celia A. Schiffer, Hiroshi Matsuo 2019 University of Minnesota

Mechanism For Apobec3g Catalytic Exclusion Of Rna And Non-Substrate Dna, William C. Solomon, Wazo Myint, Shurong Hou, Tapan Kanai, Rashmi Tripathi, Nese Kurt Yilmaz, Celia A. Schiffer, Hiroshi Matsuo

Schiffer Lab Publications

The potent antiretroviral protein APOBEC3G (A3G) specifically targets and deaminates deoxycytidine nucleotides, generating deoxyuridine, in single stranded DNA (ssDNA) intermediates produced during HIV replication. A non-catalytic domain in A3G binds strongly to RNA, an interaction crucial for recruitment of A3G to the virion; yet, A3G displays no deamination activity for cytidines in viral RNA. Here, we report NMR and molecular dynamics (MD) simulation analysis for interactions between A3Gctd and multiple substrate or non-substrate DNA and RNA, in combination with deamination assays. NMR ssDNA-binding experiments revealed that the interaction with residues in helix1 and loop1 (T201-L220) distinguishes the binding mode of ...


Screening Of Microbial Volatile Organic Compounds For Detection Of Disease In Cattle: Development Of Lab-Scale Method, Devin L. Maurer, Christine K. Ellis, Tyler C. Thacker, Somchai Rice, Jacek A. Koziel, Pauline Nol, Kurt C. VerCauteren 2019 Iowa State University

Screening Of Microbial Volatile Organic Compounds For Detection Of Disease In Cattle: Development Of Lab-Scale Method, Devin L. Maurer, Christine K. Ellis, Tyler C. Thacker, Somchai Rice, Jacek A. Koziel, Pauline Nol, Kurt C. Vercauteren

Agricultural and Biosystems Engineering Publications

The primary hurdle for diagnosis of some diseases is the long incubation required to culture and confirm the presence of bacteria. The concept of using microbial VOCs as “signature markers” could provide a faster and noninvasive diagnosis. Finding biomarkers is challenging due to the specificity required in complex matrices. The objectives of this study were to (1) build/test a lab-scale platform for screening of microbial VOCs and (2) apply it to Mycobacterium avium paratuberculosis; the vaccine strain of M. bovis Bacillus Calmette-Guérin; and M. kansasii to demonstrate detection times greater those typically required for culture. SPME-GC-MS was used for ...


Defining The Developmental Toxicity Of The Herbicide Dicamba Using The Zebrafish Model System, Lucas W. Turner 2019 Purdue University

Defining The Developmental Toxicity Of The Herbicide Dicamba Using The Zebrafish Model System, Lucas W. Turner

The Journal of Purdue Undergraduate Research

No abstract provided.


Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes, Kaushal Arvind Prasad 2019 Purdue University

Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes, Kaushal Arvind Prasad

The Journal of Purdue Undergraduate Research

No abstract provided.


Whole-Brain Approaches For Investigating Iron Accumulation By Mri Show No Excess From Occupational Exposure To Welding Fumes, Jennifer Davis 2019 Purdue University

Whole-Brain Approaches For Investigating Iron Accumulation By Mri Show No Excess From Occupational Exposure To Welding Fumes, Jennifer Davis

The Journal of Purdue Undergraduate Research

No abstract provided.


Toxicity Interaction Of The Two Most Common Agricultural Herbicides In The United States: Glyphosate And Atrazine, Lauren E. Brulinski 2019 Purdue University

Toxicity Interaction Of The Two Most Common Agricultural Herbicides In The United States: Glyphosate And Atrazine, Lauren E. Brulinski

The Journal of Purdue Undergraduate Research

No abstract provided.


Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer 2019 Purdue University

Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer

The Journal of Purdue Undergraduate Research

No abstract provided.


Evaluation Of Biodegradability Characteristics Of Cellulose-Based Film As Per Is/Iso 14855-1, Narayan C. Saha Dr, Gaurav Madhu Dr, Diksha B. Kadu Ms 2019 Indian Institute of Packaging, Mumbai

Evaluation Of Biodegradability Characteristics Of Cellulose-Based Film As Per Is/Iso 14855-1, Narayan C. Saha Dr, Gaurav Madhu Dr, Diksha B. Kadu Ms

Journal of Applied Packaging Research

Biodegradable polymers (especially those derived from plant sources) begin their lifecycle as renewable resources, usually in the form of starch or cellulose. In this paper, the evaluation of biodegradability of cellulose-based polymer film under controlled composting conditions as per the guidelines of IS/ISO 14855 (Part-1) standard has been described. Microcrystalline cellulose (MCC) powder was taken as positive-control polymer. The apparatus used to analyse the degree and rate of biodegradation was developed indigenously. The validation of the biodegradability testing apparatus was also performed as per the prescribed test method given in IS/ISO 14855-1.


Spatiotemporal Patterns Of Small For Gestational Age And Low Birth Weight Births And Associations With Land Use And Socioeconomic Status, Charlene Nielsen, Carl Amrhein, Prakesh S Shah, Khalid Aziz, Alvaro R Osornio-Vargas 2019 University of Alberta

Spatiotemporal Patterns Of Small For Gestational Age And Low Birth Weight Births And Associations With Land Use And Socioeconomic Status, Charlene Nielsen, Carl Amrhein, Prakesh S Shah, Khalid Aziz, Alvaro R Osornio-Vargas

Office of the Provost

In addition to small for gestational age (SGA) and low birth weight at term (LBWT), critically ill cases of SGA/LBWT are significant events from outcomes and economic perspectives that require further understanding of risk factors. We aimed to assess the spatiotemporal distribution of locations where there were consistently higher numbers of critically ill SGA/LBWT (hot spots) in comparison with all SGA/LBWT and all births. We focused on Edmonton (2008-2010) and Calgary (2006-2010), Alberta, and used a geographical information system to apply emerging hot spot analysis, as a new approach for understanding SGA, LBWT, and the critically ill ...


Evaluating The Presence Of The Endocrine Disruptor 4-Nonylphenol In California Glaciers, Jonah Lay 2019 University of Redlands

Evaluating The Presence Of The Endocrine Disruptor 4-Nonylphenol In California Glaciers, Jonah Lay

MS GIS Program Major Individual Projects

The use of GIS in addressing environmental problems is evident in its application to the Sierra Nevada mountain range glaciers in California. The presence of 4-nonylphenol (4NP) in pesticides used in agriculture has led to its accumulation in California glaciers through onshore wind deposition. As an endocrine disruptor, 4NP poses a threat to human health because it can interrupt and alter physiological processes such as human development and metabolism, and lead to ovarian and prostate cancer at higher concentrations. To evaluate the mass of 4NP in the glacier, GIS analysis is conducted with considerations of wind direction, topographic features, and ...


Growing On A Scar: Genetic Variation Of Achillea Millefolium Near Meeker, Colorado, Ace Spitzer 2019 University of Northern Colorado

Growing On A Scar: Genetic Variation Of Achillea Millefolium Near Meeker, Colorado, Ace Spitzer

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Mining operations deposit high concentrations of heavy metals such as lead, cadmium, arsenic, and vanadium into the topsoil of an ecosystem. These toxic metals can affect plant health and behavior, causing local extinction and shifts in ecosystem dynamics. However, genetic analyses of some plants growing on toxic soil conditions indicate higher genetic diversity than would be expected in that environment. Determining the effects of soil pollution on plants is important to determine a species’ utility in conservation and restoration. This investigation compared the genetic diversity of western yarrow (Achillea millefolium, Asteraceae), growing near a mine with vanadium and arsenic contamination ...


A Permethrin Metabolite Is Associated With Adaptive Immune Responses In Gulf War Illness, Utsav Joshi, Lawrence J. Stern, Laila Abdullah 2019 The Open University

A Permethrin Metabolite Is Associated With Adaptive Immune Responses In Gulf War Illness, Utsav Joshi, Lawrence J. Stern, Laila Abdullah

Open Access Articles

Gulf War Illness (GWI), affecting 30% of veterans from the 1991 Gulf War (GW), is a multi-symptom illness with features similar to those of patients with autoimmune diseases. The objective of the current work is to determine if exposure to GW-related pesticides, such as permethrin (PER), activates peripheral and central nervous system (CNS) adaptive immune responses. In the current study, we focused on a PER metabolite, 3-phenoxybenzoic acid (3-PBA), as this is a common metabolite previously shown to form adducts with endogenous proteins. We observed the presence of 3-PBA and 3-PBA modified lysine of protein peptides in the brain, blood ...


Systems Approach Reveals Photosensitivity And Per2 Level As Determinants Of Clock-Modulator Efficacy, Dae Wook Kim, Cheng Chang, Xian Chen, Angela C. Doran, Francois Gaudreault, Travis Wager, George J. DeMarco, Jae Kyoung Kim 2019 Korea Advanced Institute of Science and Technology

Systems Approach Reveals Photosensitivity And Per2 Level As Determinants Of Clock-Modulator Efficacy, Dae Wook Kim, Cheng Chang, Xian Chen, Angela C. Doran, Francois Gaudreault, Travis Wager, George J. Demarco, Jae Kyoung Kim

Open Access Articles

In mammals, the master circadian clock synchronizes daily rhythms of physiology and behavior with the day-night cycle. Failure of synchrony, which increases the risk for numerous chronic diseases, can be treated by phase adjustment of the circadian clock pharmacologically, for example, with melatonin, or a CK1delta/epsilon inhibitor. Here, using in silico experiments with a systems pharmacology model describing molecular interactions, and pharmacokinetic and behavioral experiments in cynomolgus monkeys, we find that the circadian phase delay caused by CK1delta/epsilon inhibition is more strongly attenuated by light in diurnal monkeys and humans than in nocturnal mice, which are common preclinical ...


Hexavalent Chromium-Induced Cytotoxicity And Mutagenicity: A Study Of Protection By Ascorbic Acid And Epigallocatechin Gallate, Timothy P. Mayotte 2019 Olivet Nazarene University

Hexavalent Chromium-Induced Cytotoxicity And Mutagenicity: A Study Of Protection By Ascorbic Acid And Epigallocatechin Gallate, Timothy P. Mayotte

Honors Program Projects

Hexavalent chromium, or Cr(VI), is a potent oxidizer and known carcinogen, that is found at varying levels in the water sources of more than 200 million Americans. However, the exact mechanism of carcinogenicity remains unknown, and though the government currently regulates total chromium levels, they have yet to determine a permissible exposure limit for Cr(VI). Moreover, there is currently no preventative treatment for Cr(VI). Because of Cr(VI)’s strong oxidative power, we hypothesized that it causes DNA mutation and cell death via oxidation and that antioxidants could prevent this from occurring. To test this, we first ...


Digital Commons powered by bepress