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Contributions Of The Women Groups Of West Bengal, India For Solving Rural Water Challenges, Mina Das 2021 Nishtha, India

Contributions Of The Women Groups Of West Bengal, India For Solving Rural Water Challenges, Mina Das

wH2O: The Journal of Gender and Water

Poor rural communities suffer from many socio-economic issues; however, the availability of clean and safe water is the fundamental challenge amongst all other hindrances confronted by these communities. This article focuses on the non-profit organization, Nishtha (meaning dedication) and their intervention in women empowerment for better water accessibility in rural communities of West Bengal, India. The paper will further highlight the so-called “rural ignorant women’s endeavour” in innovative thought and strategy to protect their own families and the community. The article also discusses Nishtha’s intervention during water crises and disasters using a participatory approach involving women.


Community Effort For Drinking Water Management Near India- China Border At Jamak Village District Uttarkashi, Uttarakhand, India, Kamlesh Gururani 2021 Reliance Foundation, India

Community Effort For Drinking Water Management Near India- China Border At Jamak Village District Uttarkashi, Uttarakhand, India, Kamlesh Gururani

wH2O: The Journal of Gender and Water

In Uttarakhand, drinking water is a major problem and a burning issue for the last decade. Many natural springs that dotted the hillside have been damaged due to the climate conditions and other unplanned or illegal activities such as deforestation and human-made forest fires have affected spring catchments, resulting in reduced discharge from springs. To tackle this major problem of drinking water security, the community of mountain village Jamak, district Uttarkashi came together for community-led drinking water supply by adopting participatory planning and ownership. The village community’s participation and ownership improved the village’s drinking water situation, and villagers ...


Modeling Of Co Accumulation In The Headspace Of The Bioreactor During Organic Waste Composting, Karolina Sobieraj, Sylwia Stegenta-Dabrowska, Jacek A. Koziel, Andrzej Białowiec 2021 Wrocław University of Environmental and Life Sciences

Modeling Of Co Accumulation In The Headspace Of The Bioreactor During Organic Waste Composting, Karolina Sobieraj, Sylwia Stegenta-Dabrowska, Jacek A. Koziel, Andrzej Białowiec

Agricultural and Biosystems Engineering Publications

Advanced technologies call for composting indoors for minimized impact on the surrounding environment. However, enclosing compost piles inside halls may cause the accumulation of toxic pollutants, including carbon monoxide (CO). Thus, there is a need to assess the occupational risk to workers that can be exposed to CO concentrations > 300 ppm at the initial stage of the process. The objectives were to (1) develop a model of CO accumulation in the headspace of the bioreactor during organic waste composting and (2) assess the impact of headspace ventilation of enclosed compost. The maximum allowable CO level inside the bioreactor headspace for ...


Evaluating A Commercially Available In-Duct Bipolar Ionization Device For Pollutant Removal And Potential Byproduct Formation, Yicheng Zeng, Prashik Manwatkar, Aurelie Laguerre, Marina Beke, Insung Kang, Akram S. Ali, Delphine K. Farmer, Elliott T. Gall, Mohammad Heidarinejad, Brent Stephens 2021 Illinois Institute of Technology

Evaluating A Commercially Available In-Duct Bipolar Ionization Device For Pollutant Removal And Potential Byproduct Formation, Yicheng Zeng, Prashik Manwatkar, Aurelie Laguerre, Marina Beke, Insung Kang, Akram S. Ali, Delphine K. Farmer, Elliott T. Gall, Mohammad Heidarinejad, Brent Stephens

Mechanical and Materials Engineering Faculty Publications and Presentations

We conducted a series of experiments to evaluate the gas and particle removal effectiveness and potential for byproduct formation resulting from the operation of a commercially available in-duct bipolar ionization device. Laboratory tests were conducted with the ionizer installed in a small air handler serving a large semi-furnished chamber. Chamber experiments were conducted under (i) normal operating conditions to characterize the impact of the ionizer on concentrations of particles (0.01–10 μm), ozone (O3), nitrogen dioxide (NO2), volatile organic compounds (VOCs), and aldehydes, and (ii) particle injection and decay conditions to characterize the impact of the ionizer operation on ...


Effect Of Crohn's Disease On Villous Length And Cyp3a4 Expression In The Pediatric Small Intestine., Carrie A. Vyhlidal, Brian D. Chapron, Atif Ahmed, Vivekanand Singh, Rebecca Casini, Valentina Shakhnovich 2021 Children's Mercy Hospital

Effect Of Crohn's Disease On Villous Length And Cyp3a4 Expression In The Pediatric Small Intestine., Carrie A. Vyhlidal, Brian D. Chapron, Atif Ahmed, Vivekanand Singh, Rebecca Casini, Valentina Shakhnovich

Manuscripts, Articles, Book Chapters and Other Papers

Changes in absorptive capacity and first-pass metabolism in the small intestine affect oral drug bioavailability. Characterization of such changes as a consequence of inflammation is important for developing physiologically-based pharmacokinetic (PBPK) models for inflammatory bowel disease. We sought to elucidate the impact of small intestinal Crohn's disease (CD) on villous length and CYP3A4 expression in children. Freshly frozen duodenal and terminal ileum (TI) biopsies from 107 children (1-19 years) with and without CD were evaluated for active inflammation. Villous length and CYP3A4 mRNA/protein expression were compared among regions of active and inactive inflammation in CD and controls. A ...


How A Low-Cost Method For Cumulative Water-Sampling Shows Need For Improvement Of Legal Public-Contact Standards In The United States, Samuel Kessler 2021 University of Louisville

How A Low-Cost Method For Cumulative Water-Sampling Shows Need For Improvement Of Legal Public-Contact Standards In The United States, Samuel Kessler

Grawemeyer Colloquium Papers

Across the world, it is estimated that 4.5 billion people live near water sources “impaired” for use or contact. Standards for human-interaction are established by international organizations such as the WHO, and legislative bodies from national to local levels with jurisdiction over the quality of our waterways to ensure public & environmental health. Standards are often assessed from “grab-samples” taken from a waterbody at a certain time, with a minimum number analyzed. Water-quality standards in the United States are enforced under the Clean Water Act (CWA) via the Environmental Protection Agency (EPA), applying to “waters of the United States” (WOTUS ...


Quantifying And Mitigating Motor Phenotypes Induced By Antisense Oligonucleotides In The Central Nervous System [Preprint], Michael P. Moazami, Julia M. Rembetsy-Brown, Feng Wang, Pranathi Meda Krishnamurthy, Alexandra Weiss, Miklos G. Marosfoi, Robert M. King, Mona Motwani, Heather L. Gray-Edwards, Katherine A. Fitzgerald, Robert H. Brown Jr., Jonathan K. Watts 2021 University of Massachusetts Medical School

Quantifying And Mitigating Motor Phenotypes Induced By Antisense Oligonucleotides In The Central Nervous System [Preprint], Michael P. Moazami, Julia M. Rembetsy-Brown, Feng Wang, Pranathi Meda Krishnamurthy, Alexandra Weiss, Miklos G. Marosfoi, Robert M. King, Mona Motwani, Heather L. Gray-Edwards, Katherine A. Fitzgerald, Robert H. Brown Jr., Jonathan K. Watts

University of Massachusetts Medical School Faculty Publications

Antisense oligonucleotides (ASOs) are emerging as a promising class of therapeutics for neurological diseases. When injected directly into the cerebrospinal fluid, ASOs distribute broadly across brain regions and exert long-lasting therapeutic effects. However, many phosphorothioate (PS)-modified gapmer ASOs show transient motor phenotypes when injected into the cerebrospinal fluid, ranging from reduced motor activity to ataxia or acute seizure-like phenotypes. The effect of sugar and phosphate modifications on these phenotypes has not previously been systematically studied. Using a behavioral scoring assay customized to reflect the timing and nature of these effects, we show that both sugar and phosphate modifications influence ...


Environmentally Marginalized Populations: The "Perfect Storm" For Infectious Disease Pandemics, Including Covid-19, Gabriella Y. Meltzer, Oyemwenosa Avenbuan, Christina Awada, Oluwakemi B. Oyetade, Tricia Blackman, Simona Kwon DrPH, MPH, Esther Erdei PhD, Judith T. Zelikoff PhD 2021 New York University School of Global Public Health

Environmentally Marginalized Populations: The "Perfect Storm" For Infectious Disease Pandemics, Including Covid-19, Gabriella Y. Meltzer, Oyemwenosa Avenbuan, Christina Awada, Oluwakemi B. Oyetade, Tricia Blackman, Simona Kwon Drph, Mph, Esther Erdei Phd, Judith T. Zelikoff Phd

Journal of Health Disparities Research and Practice

COVID-19 has exacted a severe toll on the United States population’s physical and mental health and its effects have been felt most severely among people of color and low socioeconomic status. Using illustrative case studies, this commentary argues that in addition to COVID-19 health disparities created by psychosocial stressors such as the inability to socially distance and access quality healthcare, environmental justice communities have the additional burden of disproportionate exposure to toxic contaminants that contribute to their higher risk of COVID-19. Environmental contaminants including heavy metals and persistent organic pollutants found contaminating their nearby environments can alter the immune ...


Design And Testing Of Mobile Laboratory For Mitigation Of Gaseous Emissions From Livestock Agriculture With Photocatalysis, Myeongseong Lee, Jacek A. Koziel, Wyatt Murphy, William S. Jenks, Blake Fonken, Ryan Storjohann, Baitong Chen, Peiyang Li, Chumki Banik, Landon Wahe, Heekwon Ahn 2021 Iowa State University

Design And Testing Of Mobile Laboratory For Mitigation Of Gaseous Emissions From Livestock Agriculture With Photocatalysis, Myeongseong Lee, Jacek A. Koziel, Wyatt Murphy, William S. Jenks, Blake Fonken, Ryan Storjohann, Baitong Chen, Peiyang Li, Chumki Banik, Landon Wahe, Heekwon Ahn

Agricultural and Biosystems Engineering Publications

Livestock production systems generate nuisance odor and gaseous emissions affecting local communities and regional air quality. There are also concerns about the occupational health and safety of farmworkers. Proven mitigation technologies that are consistent with the socio-economic challenges of animal farming are needed. We have been scaling up the photocatalytic treatment of emissions from lab-scale, aiming at farm-scale readiness. In this paper, we present the design, testing, and commissioning of a mobile laboratory for on-farm research and demonstration of performance in simulated farm conditions before testing to the farm. The mobile lab is capable of treating up to 1.2 ...


Simultaneous Chemical And Sensory Analysis Of Domestic Cat Urine And Feces With Headspace Solid-Phase Microextraction And Gc-Ms-Olfactometry, Chumki Banik, Jacek A. Koziel, James Z. Li 2021 Iowa State University

Simultaneous Chemical And Sensory Analysis Of Domestic Cat Urine And Feces With Headspace Solid-Phase Microextraction And Gc-Ms-Olfactometry, Chumki Banik, Jacek A. Koziel, James Z. Li

Agricultural and Biosystems Engineering Publications

The association between humans and cats (Felis catus) is well known. This domestic animal is also known for its malodorous urine and feces. The complexity of the odorous urine and feces impacts human life by triggering the human sensory organ in a negative way. The objective of this research was to identify the volatile organic chemicals (VOCs) and associated odors in cat urine and feces using gas chromatography–mass spectrometry and simultaneous sensory analysis of fresh and aged samples. The solid-phase microextraction (SPME) technique was used to preconcentrate the VOCs emitted from urine or feces samples. Twenty-one compounds were identified ...


Unique Structural Solution From A Vh3-30 Antibody Targeting The Hemagglutinin Stem Of Influenza A Viruses, Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, Wayne A Marasco 2021 Dana-Farber Cancer Institute

Unique Structural Solution From A Vh3-30 Antibody Targeting The Hemagglutinin Stem Of Influenza A Viruses, Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, Wayne A Marasco

Schiffer Lab Publications

Broadly neutralizing antibodies (bnAbs) targeting conserved influenza A virus (IAV) hemagglutinin (HA) epitopes can provide valuable information for accelerating universal vaccine designs. Here, we report structural details for heterosubtypic recognition of HA from circulating and emerging IAVs by the human antibody 3I14. Somatic hypermutations play a critical role in shaping the HCDR3, which alone and uniquely among VH3-30 derived antibodies, forms contacts with five sub-pockets within the HA-stem hydrophobic groove. 3I14 light-chain interactions are also key for binding HA and contribute a large buried surface area spanning two HA protomers. Comparison of 3I14 to bnAbs from several defined ...


Crystal Structure Of Sars-Cov-2 Main Protease In Complex With The Non-Covalent Inhibitor Ml188, Gordon J. Lockbaum, Archie C. Reyes, Jeong Min Lee, Ronak Tilvawala, Ellen A. Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Paul R. Thompson, Celia A. Schiffer 2021 University of Massachusetts Medical School

Crystal Structure Of Sars-Cov-2 Main Protease In Complex With The Non-Covalent Inhibitor Ml188, Gordon J. Lockbaum, Archie C. Reyes, Jeong Min Lee, Ronak Tilvawala, Ellen A. Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Paul R. Thompson, Celia A. Schiffer

COVID-19 Publications by UMMS Authors

Viral proteases are critical enzymes for the maturation of many human pathogenic viruses and thus are key targets for direct acting antivirals (DAAs). The current viral pandemic caused by SARS-CoV-2 is in dire need of DAAs. The Main protease (M(pro)) is the focus of extensive structure-based drug design efforts which are mostly covalent inhibitors targeting the catalytic cysteine. ML188 is a non-covalent inhibitor designed to target SARS-CoV-1 M(pro), and provides an initial scaffold for the creation of effective pan-coronavirus inhibitors. In the current study, we found that ML188 inhibits SARS-CoV-2 M(pro) at 2.5 microM, which is ...


Utilization Of The Naranjo Scale To Evaluate Adverse Drug Reactions At A Free-Standing Children's Hospital., Madhavi Murali, Sarah Suppes, Keith Feldman, Jennifer Goldman 2021 Children's Mercy Hospital

Utilization Of The Naranjo Scale To Evaluate Adverse Drug Reactions At A Free-Standing Children's Hospital., Madhavi Murali, Sarah Suppes, Keith Feldman, Jennifer Goldman

Manuscripts, Articles, Book Chapters and Other Papers

The relationship between the Naranjo scaling system and pediatric adverse drug reactions (ADR) is poorly understood. We performed a retrospective review of 1,676 pediatric ADRs documented at our hospital from 2014-2018. We evaluated patient demographics, implicated medication, ADR severity, calculated Naranjo score, associated symptoms, and location within the hospital in which the ADR was documented. ADR severity was poorly correlated with Naranjo interpretation. Out of the 10 Naranjo scale questions, 4 had a response of "unknown" greater than 85% of the time. Cardiovascular and oncological/immunologic agents were more likely to have a probable or definite Naranjo interpretation compared ...


Mitigation Of Gaseous Emissions From Stored Swine Manure With Biochar: Effect Of Dose And Reapplication On A Pilot-Scale, Baitong Chen, Jacek A. Koziel, Chumki Banik, Hantian Ma, Myeongseong Lee, Samuel C. O'Brien, Peiyang Li, Daniel S. Andersen, Andrzej Białowiec, Robert C. Brown 2021 Iowa State University

Mitigation Of Gaseous Emissions From Stored Swine Manure With Biochar: Effect Of Dose And Reapplication On A Pilot-Scale, Baitong Chen, Jacek A. Koziel, Chumki Banik, Hantian Ma, Myeongseong Lee, Samuel C. O'Brien, Peiyang Li, Daniel S. Andersen, Andrzej Białowiec, Robert C. Brown

Agricultural and Biosystems Engineering Publications

Rural communities are affected by gaseous emissions from intensive livestock production. Practical mitigation technologies are needed to minimize emissions from stored manure and improve air quality inside barns. In our previous research, the one-time surficial application of biochar to swine manure significantly reduced emissions of NH3 and phenol. We observed that the mitigation effect decreased with time during the 30-day trials. In this research, we hypothesized that bi-weekly reapplication of biochar could improve the mitigation effect on a wider range of odorous compounds using a larger scale and longer trials. The objective was to evaluate the effectiveness of biochar ...


Assessment Of Monochloramine Toxicity On Three Small Coastal Organisms, Ashley K. Le 2021 Nova Southeastern University

Assessment Of Monochloramine Toxicity On Three Small Coastal Organisms, Ashley K. Le

All HCAS Student Capstones, Theses, and Dissertations

Monochloramine ( is a secondary disinfectant used by water treatment facilities to eliminate lingering bacteria in basins, filters, and pipelines. While an effective disinfectant, monochloramine can have negative effects on aquatic organisms. Organis ms affected by the chemical can include species whose environment is near to effluent sites and aquaculture facilities that use tap water lines or has water intake pipes near to effluent sites. Three species commonly found in south Florida that are lik ely exposed to MCA by effluent sites or aquaculture facilities are mosquitofish Gambusia affinis pink shrimp Farfantepenaeus duorarum and the hard clam Mercenaria mercenaria These species ...


Site-Specific Incorporation Of Citrulline Into Proteins In Mammalian Cells, Santanu Mondal, Shu Wang, Yunan Zheng, Sudeshna Sen, Abhishek Chatterjee, Paul R. Thompson 2021 University of Massachusetts Medical School

Site-Specific Incorporation Of Citrulline Into Proteins In Mammalian Cells, Santanu Mondal, Shu Wang, Yunan Zheng, Sudeshna Sen, Abhishek Chatterjee, Paul R. Thompson

University of Massachusetts Medical School Faculty Publications

Citrullination is a post-translational modification (PTM) of arginine that is crucial for several physiological processes, including gene regulation and neutrophil extracellular trap formation. Despite recent advances, studies of protein citrullination remain challenging due to the difficulty of accessing proteins homogeneously citrullinated at a specific site. Herein, we report a technology that enables the site-specific incorporation of citrulline (Cit) into proteins in mammalian cells. This approach exploits an engineered E. coli-derived leucyl tRNA synthetase-tRNA pair that incorporates a photocaged-citrulline (SM60) into proteins in response to a nonsense codon. Subsequently, SM60 is readily converted to Cit with light in vitro and in ...


Propranolol Sensitizes Vascular Sarcoma Cells To Doxorubicin By Altering Lysosomal Drug Sequestration And Drug Efflux, Jhuma Saha, Jong Hyuk Kim, Clarissa N. Amaya, Caleb M. Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Erin B. Dickerson 2021 University of Minnesota - St. Paul

Propranolol Sensitizes Vascular Sarcoma Cells To Doxorubicin By Altering Lysosomal Drug Sequestration And Drug Efflux, Jhuma Saha, Jong Hyuk Kim, Clarissa N. Amaya, Caleb M. Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Erin B. Dickerson

Faculty Publications

Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance. We previously identified a subset of doxorubicin-resistant cells in human angiosarcoma and canine hemangiosarcoma cell lines that exhibit high lysosomal accumulation of doxorubicin. Hydrophobic, weak base chemotherapeutics, like doxorubicin, are known to sequester within lysosomes, promoting resistance by limiting drug accessibility to cellular targets. Drug synergy between the beta adrenergic receptor (β-AR) antagonist, propranolol, and multiple chemotherapeutics has been documented in vitro, and ...


The Carbon Price Equivalent: A Metric For Comparing Climate Change Mitigation Efforts Across Jurisdictions, Gabriel Weil 2021 Climate Leadership Council & Georgetown University Law Center

The Carbon Price Equivalent: A Metric For Comparing Climate Change Mitigation Efforts Across Jurisdictions, Gabriel Weil

Dickinson Law Review

Climate change presents a global commons problem: Emissions reductions on the scale needed to meet global targets do not pass a domestic cost-benefit test in most countries. To give national governments ample incentive to pursue deep decarbonization, mutual interstate coercion will be necessary. Many proposed tools of coercive climate diplomacy would require a onedimensional metric for comparing the stringency of climate change mitigation policy packages across jurisdictions. This article proposes and defends such a metric: the carbon price equivalent. There is substantial variation in the set of climate change mitigation policy instruments implemented by different countries. Nonetheless, the consequences of ...


Achieving Better Care In Pennsylvania By Allowing Pharmacists To Practice Pharmacy, Travis Murray 2021 Penn State Dickinson Law

Achieving Better Care In Pennsylvania By Allowing Pharmacists To Practice Pharmacy, Travis Murray

Dickinson Law Review

Traditionally, state legislatures implemented Prescription Drug Monitoring Programs (“PDMPs”) to assist prescribers, pharmacists, and law enforcement in identifying patients likely to misuse, abuse, or divert controlled substances. PDMP databases contain a catalog of a patient’s recent controlled substances that pharmacies have filled, including the date, location, the quantity of medication filled, and the prescribing health care provider. Prescribers in Pennsylvania have a duty to query the PDMP before prescribing controlled substances in most clinical settings. Pharmacists have a similar duty in Pennsylvania to dispense safe and effective medication therapy to patients and to screen patients for potential signs of ...


Network And Cellular Effects Of The Mu Opioid Receptor In Cortical Interneurons, Adrian Dutkiewicz 2021 University of Vermont

Network And Cellular Effects Of The Mu Opioid Receptor In Cortical Interneurons, Adrian Dutkiewicz

Graduate College Dissertations and Theses

The µ opioid receptor (µOR) exerts a powerful excitatory effect in cortical circuits and cultured neurons by promoting glutamatergic activity after binding endogenous or exogenous opioids. While most research indicates that the receptor does this by decreasing activity or output of GABAergic interneurons that inhibit glutamate-releasing Pyramidal Neurons, other experiments suggest that the µOR directly upregulates excitatory Pyramidal Neurons instead. Thus, the cellular target of cortical opioid agonists remains unclear, and the µOR’s net excitatory mechanisms are not fully understood. Consequently, utilizing electrophysiology to detect µOR responses to the specific agonist [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin (DAMGO) has yielded incomplete ...


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