Statistics and Probability Commons^™

Mengukur Kualitas Hidup Anak, Toha Muhaimin

Kesmas

Kata kualitas hidup sering dihubungkan dengan pembangunan, khususnya pembangunan manusia, yang sering dikaitkan dengan kondisi seseorang baik dalam keadaan sehat maupun sakit, untuk menunjukkan aktivitas fisik, atau kondisi seseorang dalam hidup sehari-harinya. Sebagian orang mengkaitkan istilah kualitas hidup dengan kondisi sejauh mana terpenuhinya kebutuhan dasar untuk hidup seperti sandang, pangan, papan dan pendidikan pada seseorang. Oleh karena itu, banyak penelitian mengukur kualitas hidup dengan instrumen yang berbeda-beda, termasuk mengukur kualitas hidup anak dan banyak instrumen yang telah dikembangkan. Tulisan ini mencoba membahas pengertian kualitas hidup dan cara mengukurnya, terutama pada anak. Belum ada konsensus mengukur atau menggambarkan definisi konseptual kualitas …

Assessment Of Acgh Clustering Methodologies, Serena F. Baker

Theses and Dissertations

Array comparative genomic hybridization (aCGH) is a technique for identifying duplications and deletions of DNA at specific locations across a genome. Potential objectives of aCGH analysis are the identification of (1) altered regions for a given subject, (2) altered regions across a set of individuals, and (3) clinically relevant clusters of hybridizations. aCGH analysis can be particularly useful when it identifies previously unknown clusters with clinical relevance. This project focuses on the assessment of existing aCGH clustering methodologies. Three methodologies are considered: hierarchical clustering, weighted clustering of called aCGH data, and clustering based on probabilistic recurrent regions of alteration within …

Modeling Functional Data With Spatially Heterogeneous Shape Characteristics, Ana-Maria Staicu, Ciprian M. Crainiceanu, Daniel S. Reich, David Ruppert

Johns Hopkins University, Dept. of Biostatistics Working Papers

We propose a novel class of models for functional data exhibiting skewness or other shape characteristics that vary with spatial or temporal location. We use copulas so that the marginal distributions and the dependence structure can be modeled independently. Dependence is modeled with a Gaussian or t-copula, so that there is an underlying latent Gaussian process. We model the marginal distributions using the skew t family. The mean, variance, and shape parameters are modeled nonparametrically as functions of location. A computationally tractable inferential framework for estimating heterogeneous asymmetric or heavy-tailed marginal distributions is introduced. This framework provides a new set …

A Maximum Pseudo-Likelihood Approach For Estimating Species Trees Under The Coalescent Model, Liang Liu, Lili Yu, Scott V. Edwards

Biostatistics: Faculty Publications

Background

Several phylogenetic approaches have been developed to estimate species trees from collections of gene trees. However, maximum likelihood approaches for estimating species trees under the coalescent model are limited. Although the likelihood of a species tree under the multispecies coalescent model has already been derived by Rannala and Yang, it can be shown that the maximum likelihood estimate (MLE) of the species tree (topology, branch lengths, and population sizes) from gene trees under this formula does not exist. In this paper, we develop a pseudo-likelihood function of the species tree to obtain maximum pseudo-likelihood estimates (MPE) of species trees, …

Non-Invasive Prenatal Detection Of Trisomy 21 Using Tandem Single Nucleotide Polymorphisms, Sujana Ghanta, Michael Mitchell, Mary Ames, Mats Hidestrand, Pippa Simpson, Mary Goetsch, William Thilly, Craig Struble, Aoy Tomita-Mitchell

Mathematics, Statistics and Computer Science Faculty Research and Publications

Background: Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely performed for the majority of pregnant women. However, current tests rely on either evaluating non-specific markers, which lead to false negative and false positive results, or on invasive tests, which while highly accurate, are expensive and carry a risk of fetal loss. We outline a novel, rapid, highly sensitive, and targeted approach to non-invasively detect fetal T21 using maternal plasma DNA.

Methods and Findings: Highly heterozygous tandem Single Nucleotide Polymorphism (SNP) sequences on chromosome 21 were analyzed using High-Fidelity PCR and Cycling Temperature Capillary …

Population Value Decomposition, A Framework For The Analysis Of Image Populations, Ciprian M. Crainiceanu, Brian S. Caffo, Sheng Luo, Vadim Zipunnikov

Johns Hopkins University, Dept. of Biostatistics Working Papers

Images, often stored in multidimensional arrays are fast becoming ubiquitous in medical and public health research. Analyzing populations of images is a statistical problem that raises a host of daunting challenges. The most severe challenge is that data sets incorporating images recorded for hundreds or thousands of subjects at multiple visits are massive. We introduce the population value decomposition (PVD), a general method for simultaneous dimensionality reduction of large populations of massive images. We show how PVD can seamlessly be incorporated into statistical modeling and lead to a new, transparent and fast inferential framework. Our methodology was motivated by and …

Multilevel Functional Principal Component Analysis For High-Dimensional Data, Vadim Zipunnikov, Brian Caffo, Ciprian Crainiceanu, David M. Yousem, Christos Davatzikos, Brian S. Schwartz

Johns Hopkins University, Dept. of Biostatistics Working Papers

We propose fast and scalable statistical methods for the analysis of hundreds or thousands of high dimensional vectors observed at multiple visits. The proposed inferential methods avoid the difficult task of loading the entire data set at once in the computer memory and use sequential access to data. This allows deployment of our methodology on low-resource computers where computations can be done in minutes on extremely large data sets. Our methods are motivated by and applied to a study where hundreds of subjects were scanned using Magnetic Resonance Imaging (MRI) at two visits roughly five years apart. The original data …

Analysis Of Nonlinear Spectral Eddy-Viscosity Models Of Turbulence, Max Gunzburger, Eunjung Lee, Yuki Saka, Catalin Trenchea, Xiaoming Wang

Mathematics and Statistics Faculty Research & Creative Works

Fluid turbulence is commonly modeled by the Navier-Stokes equations with a large Reynolds number. However, direct numerical simulations are not possible in practice, so that turbulence modeling is introduced. We study artificial spectral viscosity models that render the simulation of turbulence tractable. We show that the models are well posed and have solutions that converge, in certain parameter limits, to solutions of the Navier-Stokes equations. We also show, using the mathematical analyses, how effective choices for the parameters appearing in the models can be made. Finally, we consider temporal discretizations of the models and investigate their stability. © 2009 Springer …

Targeted Bayesian Learning, Ivan Diaz Munoz, Alan E. Hubbard, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Targeted maximum likelihood estimation (van der Laan & Rubin 2006) is a loss-based semi-parametric estimation method that yields a substitution estimator of a target parameter of the probability distribution of the data that solves the efficient influence curve estimating equation, and thereby yields a double robust locally efficient estimator of the parameter of interest, under regularity conditions. The Bayesian paradigm is concerned with including the researcher’s prior uncertainty about the parameter through a prior distribution, which combined with the likelihood yields a posterior distribution for the parameter that reflects the researcher’s posterior uncertainty. In this paper, we present a way …

The Pathways To Mental Health Care Of First-Episode Psychosis Patients: A Systematic Review., Kelly K. Anderson, Rebecca Fuhrer, Ashok K. Malla

Epidemiology and Biostatistics Publications

BACKGROUND: Although there is agreement on the association between delay in treatment of psychosis and outcome, less is known regarding the pathways to care of patients suffering from a first psychotic episode. Pathways are complex, involve a diverse range of contacts, and are likely to influence delay in treatment. We conducted a systematic review on the nature and determinants of the pathway to care of patients experiencing a first psychotic episode.

METHOD: We searched four databases (Medline, HealthStar, EMBASE, PsycINFO) to identify articles published between 1985 and 2009. We manually searched reference lists and relevant journals and used forward citation …

Student Fact Book, Fall 2010, Thirty-Fourth Annual Edition, Wright State University, Office Of Student Information Systems, Wright State University

Wright State University Student Fact Books

The student fact book has general demographic information on all students enrolled at Wright State University for Fall Quarter, 2010.

Missing Pieces: A New Report To Congress Details Biases And Gaps In Economic Statistics Resulting From Globalization, Susan N. Houseman

Employment Research Newsletter

No abstract provided.

The Statistical Properties Of The Survivor Interaction Contrast, Joseph W. Houpt, James T. Townsend

Psychology Faculty Publications

The Survivor Interaction Contrast (SIC) is a powerful tool for assessing the architecture and stopping rule of a model of mental processes. Despite its demonstrated utility, the methodology has lacked a method for statistical testing until now. In this paper we briefly describe the SIC then develop some basic statistical properties of the measure. These developments lead to a statistical test for rejecting certain classes of models based on the SIC. We verify these tests using simulated data, then demonstrate their use on data from a simple cognitive task.

Application Of The Fractional Diffusion Equation For Predicting Market Behaviour, Jonathan Blackledge

Articles

Most Financial modelling system rely on an underlying hypothesis known as the Eficient Market Hypothesi (EMH) including the famous BlackScholes formula for placing an option. However, the EMH has a fundamental flaw: it is based on the assumption that economic processes are normally distributed and it has long been known that this is not the case. This fundamental assumption leads to a number of shortcomings associated with using the EMH to analyse financial data which includes failure to predict the future volatility of a market share value. This paper introduces a new financial risk assessment model based on Levy statistics …

Estimating Temporal Associations In Electrocorticographic (Ecog) Time Series With First Order Pruning, Haley Hedlin, Dana Boatman, Brian Caffo

Johns Hopkins University, Dept. of Biostatistics Working Papers

Granger causality (GC) is a statistical technique used to estimate temporal associations in multivariate time series. Many applications and extensions of GC have been proposed since its formulation by Granger in 1969. Here we control for potentially mediating or confounding associations between time series in the context of event-related electrocorticographic (ECoG) time series. A pruning approach to remove spurious connections and simultaneously reduce the required number of estimations to fit the effective connectivity graph is proposed. Additionally, we consider the potential of adjusted GC applied to independent components as a method to explore temporal relationships between underlying source signals. Both …

Journal Usage By Subject For Fiscal Year 2010, Michael A. Cerbo Ii

Technical Services Reports and Statistics

Journal holdings for the University Libraries are listed alphabetically by subject than authority title. Usage statistics for the fiscal year are included along with a cost per use where available. The information is taken from each vendor and incorporated in Serials Solutions 360 Counter.

Landmark Prediction Of Survival, Layla Parast, Tianxi Cai

Harvard University Biostatistics Working Paper Series

No abstract provided.

Weakly Positioned Nucleosomes Enhance The Transcriptional Competency Of Chromatin, Yaakov Belch, Jingyi Yang, Yang Liu, Sridhar A. Malkaram, Rong Liu, Jean-Jack M. Riethoven, Istvan Ladunga

Department of Statistics: Faculty Publications

Background: Transcription is affected by nucleosomal resistance against polymerase passage. In turn, nucleosomal resistance is determined by DNA sequence, histone chaperones and remodeling enzymes. The contributions of these factors are widely debated: one recent title claims ‘‘… DNA-encoded nucleosome organization…’’ while another title states that ‘‘histone-DNA interactions are not the major determinant of nucleosome positions.’’ These opposing conclusions were drawn from similar experiments analyzed by idealized methods. We attempt to resolve this controversy to reveal nucleosomal competency for transcription.

Methodology/Principal Findings: To this end, we analyzed 26 in vivo, nonlinked, and in vitro genome-wide nucleosome maps/replicates by new, rigorous …

Diagnosing And Responding To Violations In The Positivity Assumption, Maya L. Petersen, Kristin Porter, Susan Gruber, Yue Wang, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

The assumption of positivity or experimental treatment assignment requires that observed treatment levels vary within confounder strata. This article discusses the positivity assumption in the context of assessing model and parameter-specific identifiability of causal effects. Positivity violations occur when certain subgroups in a sample rarely or never receive some treatments of interest. The resulting sparsity in the data may increase bias with or without an increase in variance and can threaten valid inference. The parametric bootstrap is presented as a tool to assess the severity of such threats and its utility as a diagnostic is explored using simulated data. Several …

Net Impact Evaluation Of Moving Men And Women To Economic Independence In Michigan, Within Reach Program: Year 1 And Year 2 Cohorts, Randall W. Eberts, Jason M. Preuss

Presentations

The authors completed a net impact evaluation of the “Within Reach” component of the Goodwill Industries of Greater Detroit program (Moving Men and Women to Economic Independence). This program provided employment-related support services to disadvantaged adults as coordinated by WorkFirst. The net impact evaluation estimated the contribution of the program to the employment outcomes of the participants. It constructed comparison groups of individuals who were similar to the program participants, but who did not participate in the program. The net impact analysis focused on three employment-related outcomes: finding a job, retaining a job (workforce attachment), and earnings.