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Multiscale Modelling Of Brain Networks And The Analysis Of Dynamic Processes In Neurodegenerative Disorders, Hina Shaheen 2024 Wilfrid Laurier University

Multiscale Modelling Of Brain Networks And The Analysis Of Dynamic Processes In Neurodegenerative Disorders, Hina Shaheen

Theses and Dissertations (Comprehensive)

The complex nature of the human brain, with its intricate organic structure and multiscale spatio-temporal characteristics ranging from synapses to the entire brain, presents a major obstacle in brain modelling. Capturing this complexity poses a significant challenge for researchers. The complex interplay of coupled multiphysics and biochemical activities within this intricate system shapes the brain's capacity, functioning within a structure-function relationship that necessitates a specific mathematical framework. Advanced mathematical modelling approaches that incorporate the coupling of brain networks and the analysis of dynamic processes are essential for advancing therapeutic strategies aimed at treating neurodegenerative diseases (NDDs), which afflict millions of …


Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia 2023 Brigham Young University

Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia

Journal of Nonprofit Innovation

Urban farming can enhance the lives of communities and help reduce food scarcity. This paper presents a conceptual prototype of an efficient urban farming community that can be scaled for a single apartment building or an entire community across all global geoeconomics regions, including densely populated cities and rural, developing towns and communities. When deployed in coordination with smart crop choices, local farm support, and efficient transportation then the result isn’t just sustainability, but also increasing fresh produce accessibility, optimizing nutritional value, eliminating the use of ‘forever chemicals’, reducing transportation costs, and fostering global environmental benefits.

Imagine Doris, who is …


Differentiation Of Human, Dog, And Cat Hair Fibers Using Dart Tofms And Machine Learning, Laura Ahumada, Erin R. McClure-Price, Chad Kwong, Edgard O. Espinoza, John Santerre 2023 Southern Methodist University

Differentiation Of Human, Dog, And Cat Hair Fibers Using Dart Tofms And Machine Learning, Laura Ahumada, Erin R. Mcclure-Price, Chad Kwong, Edgard O. Espinoza, John Santerre

SMU Data Science Review

Hair is found in over 90% of crime scenes and has long been analyzed as trace evidence. However, recent reviews of traditional hair fiber analysis techniques, primarily morphological examination, have cast doubt on its reliability. To address these concerns, this study employed machine learning algorithms, specifically Linear Discriminant Analysis (LDA) and Random Forest, on Direct Analysis in Real Time time-of-flight mass spectra collected from human, cat, and dog hair samples. The objective was to develop a chemistry- and statistics-based classification method for unbiased taxonomic identification of hair. The results of the study showed that LDA and Random Forest were highly …


Analyzing The Efficacy Of Covid-19 Travel Bans: A Regression Analysis Approach, Mallory Kochanek 2023 Bowling Green State University

Analyzing The Efficacy Of Covid-19 Travel Bans: A Regression Analysis Approach, Mallory Kochanek

Honors Projects

Some might associate the term ‘public health’ with the pandemic that occurred in 2020. COVID-19 spread like most have never seen in their lifetime. It is useful to look at the effectiveness of the travel re- strictions in mitigating the spread of the global pandemic. Using linear regression and network regression, we obtain parameter estimates to determine the relation of predictors, such as network effect, percentage of urban population and GDP, on the COVID-19 incidence rate for the months January to April of 2020. Linear regression does not ac- count for the correlation structure of the data. Network regression, on …


The Private Pilot Check Ride: Applying The Spacing Effect Theory To Predict Time To Proficiency For The Practical Test, Michael Scott Harwin 2023 Florida Institute of Technology - Melbourne

The Private Pilot Check Ride: Applying The Spacing Effect Theory To Predict Time To Proficiency For The Practical Test, Michael Scott Harwin

Theses and Dissertations

This study examined the relationship between a set of targeted factors and the total flight time students needed to become ready to take the private pilot check ride. The study was grounded in Ebbinghaus’s (1885/1913/2013) forgetting curve theory and spacing effect, and Ausubel’s (1963) theory of meaningful learning. The research factors included (a) training time to proficiency, which represented the number of training days needed to become check-ride ready; (b) flight training program (Part 61 vs. Part 141); (c) organization offering the training program (2- or 4-year college/university vs. FBO); (d) scheduling policy (mandated vs. student-driven); and demographical variables, which …


Radiation Exposure Calibration Of The Al2o3:C With Radium-226 And Cesium-137 Using The Osl Method, Selma Tepeli Aydin 2023 Clemson University

Radiation Exposure Calibration Of The Al2o3:C With Radium-226 And Cesium-137 Using The Osl Method, Selma Tepeli Aydin

All Theses

Optically stimulated luminescence (OSL) dosimetry was utilized to calibrate Al2O3:C powder dosimeters, available commercially as the nanoDot® from Landauer Inc., and compare the dosimeter response to radium-226 (226Ra) and cesium-137 (137Cs). The signal from the OSL was quantified using a microSTARii® OSL reader also produced by Landauer Inc. Dose-response curves were developed for 226Ra and 137Cs experiments (5 dosimeters each) at thirteen absorbed doses. Individual dosimeter response was tracked by serial number. Linear regression analysis was performed to determine if there were significant differences between the intercepts of the …


The Impacts Of The Covid-19 Pandemic On Mental Health Across Different Genders And Sexualities, Jiale Zhu, Jonas Katona 2023 Miss Porter's School

The Impacts Of The Covid-19 Pandemic On Mental Health Across Different Genders And Sexualities, Jiale Zhu, Jonas Katona

Undergraduate Research Journal for the Human Sciences

Current studies report an increase in psychological distress as a result of the COVID-19 pandemic. This study is interested in examining mental health disparities and how the COVID-19 pandemic has disproportionately impacted marginalized groups—and more specifically, those identified by sex, gender, and sexuality—compared with the general population. This study also considers the effects and ramifications of different policy measures taken during the course of the pandemic. We perform exploratory data modeling and analysis on several important and publicly available datasets taken during the pandemic on mental health and COVID-19 infection data across various identity groups to look for significant disparities, …


Nonparametric Derivative Estimation Using Penalized Splines: Theory And Application, Bright Antwi Boasiako 2023 University of Massachusetts Amherst

Nonparametric Derivative Estimation Using Penalized Splines: Theory And Application, Bright Antwi Boasiako

Doctoral Dissertations

This dissertation is in the field of Nonparametric Derivative Estimation using
Penalized Splines. It is conducted in two parts. In the first part, we study the L2
convergence rates of estimating derivatives of mean regression functions using penalized splines. In 1982, Stone provided the optimal rates of convergence for estimating derivatives of mean regression functions using nonparametric methods. Using these rates, Zhou et. al. in their 2000 paper showed that the MSE of derivative estimators based on regression splines approach zero at the optimal rate of convergence. Also, in 2019, Xiao showed that, under some general conditions, penalized spline estimators …


Predicting Dengue Incidence In Central Argentina Using Google Trends Data, Sahil Chindal 2023 Illinois State University

Predicting Dengue Incidence In Central Argentina Using Google Trends Data, Sahil Chindal

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


The Double Edged Sword Of The Pandemic: Exploring Associations Between Covid-19 And Social Isolation In The Usa, Alexander Fulk 2023 University of Kansas

The Double Edged Sword Of The Pandemic: Exploring Associations Between Covid-19 And Social Isolation In The Usa, Alexander Fulk

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Langevin Dynamic Models For Smfret Dynamic Shift, David Frost, Keisha Cook Dr, Hugo Sanabria Dr 2023 Clemson University

Langevin Dynamic Models For Smfret Dynamic Shift, David Frost, Keisha Cook Dr, Hugo Sanabria Dr

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Mathematical Modeling Of The Impact Of Lobbying On Climate Policy, Andrew Jacoby, Claire Hannah, James Hutchinson, Jasmine Narehood, Aditi Ghosh, Padmanabhan Seshaiyer 2023 Jack M Barrack Hebrew Academy

Mathematical Modeling Of The Impact Of Lobbying On Climate Policy, Andrew Jacoby, Claire Hannah, James Hutchinson, Jasmine Narehood, Aditi Ghosh, Padmanabhan Seshaiyer

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Decentralized Science (Desci): A New Paradigm For Diverse And Sustainable Scientific Development, Feiyue WANG, Wenwen DING 2023 The State Key Laboratory for Management and Control of Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China Faculty of Innovation Engineering, Macau University of Science and Technology, Macao 999078, China

Decentralized Science (Desci): A New Paradigm For Diverse And Sustainable Scientific Development, Feiyue Wang, Wenwen Ding

Bulletin of Chinese Academy of Sciences (Chinese Version)

The rise of artificial intelligence for science (AI4S) has made it particularly important and urgent to ensure the openness, fairness, impartiality, diversity, and sustainability of scientific systems. This is significant to the discourse power and leadership of countries in global innovation and industrial revolution, and also affects the security, stability, and sustainable development of a community with a shared future for mankind. To address these challenges, AI4S needs to adopt new scientific organizational and operational methods. Decentralized science (DeSci) has emerged to vitalize AI4S and provide strong support, effectively addressing issues such as information silos, biases, unfair distribution, and monopolies …


Deep Q-Learning Framework For Quantitative Climate Change Adaptation Policy For Florida Road Network Due To Extreme Precipitation, Orhun Aydin 2023 Saint Louis University

Deep Q-Learning Framework For Quantitative Climate Change Adaptation Policy For Florida Road Network Due To Extreme Precipitation, Orhun Aydin

I-GUIDE Forum

Climate change-induced extreme weather and increasing population are increasing the pressure on the global aging road networks. Adaptation requires designing interventions and alterations to the road networks that consider future dynamics of flooding and increased traffic due to the growing population. This paper introduces a reinforcement learning approach to designing interventions for Florida's road network under future traffic and climate projections. Three climate models and a tide and surge model are used to create flooding and coastal inundation projections, respectively. The optimal sequence of decisions for adapting Florida's road network to minimize flooding-related disruptions is solved by using a graph-based …


Bayesian Statistical Modeling Of Spatially Resolved Transcriptomics Data, Xi Jiang 2023 Southern Methodist University

Bayesian Statistical Modeling Of Spatially Resolved Transcriptomics Data, Xi Jiang

Statistical Science Theses and Dissertations

Spatially resolved transcriptomics (SRT) quantifies expression levels at different spatial locations, providing a new and powerful tool to investigate novel biological insights. As experimental technologies enhance both in capacity and efficiency, there arises a growing demand for the development of analytical methodologies.

One question in SRT data analysis is to identify genes whose expressions exhibit spatially correlated patterns, called spatially variable (SV) genes. Most current methods to identify SV genes are built upon the geostatistical model with Gaussian process, which could limit the models' ability to identify complex spatial patterns. In order to overcome this challenge and capture more types …


Parameter Estimation For Normally Distributed Grouped Data And Clustering Single-Cell Rna Sequencing Data Via The Expectation-Maximization Algorithm, Zahra Aghahosseinalishirazi 2023 Western University

Parameter Estimation For Normally Distributed Grouped Data And Clustering Single-Cell Rna Sequencing Data Via The Expectation-Maximization Algorithm, Zahra Aghahosseinalishirazi

Electronic Thesis and Dissertation Repository

The Expectation-Maximization (EM) algorithm is an iterative algorithm for finding the maximum likelihood estimates in problems involving missing data or latent variables. The EM algorithm can be applied to problems consisting of evidently incomplete data or missingness situations, such as truncated distributions, censored or grouped observations, and also to problems in which the missingness of the data is not natural or evident, such as mixed-effects models, mixture models, log-linear models, and latent variables. In Chapter 2 of this thesis, we apply the EM algorithm to grouped data, a problem in which incomplete data are evident. Nowadays, data confidentiality is of …


Dynamic Influence Diagram-Based Deep Reinforcement Learning Framework And Application For Decision Support For Operators In Control Rooms, Joseph Mietkiewicz, Ammar N. Abbas, Chidera Winifred Amazu, Anders L. Madsen, Gabriele Baldissone 2023 Technological University Dublin

Dynamic Influence Diagram-Based Deep Reinforcement Learning Framework And Application For Decision Support For Operators In Control Rooms, Joseph Mietkiewicz, Ammar N. Abbas, Chidera Winifred Amazu, Anders L. Madsen, Gabriele Baldissone

Articles

In today’s complex industrial environment, operators are often faced with challenging situations that require quick and accurate decision-making. The human-machine interface (HMI) can display too much information, leading to information overload and potentially compromising the operator’s ability to respond effectively. To address this challenge, decision support models are needed to assist operators in identifying and responding to potential safety incidents. In this paper, we present an experiment to evaluate the effectiveness of a recommendation system in addressing the challenge of information overload. The case study focuses on a formaldehyde production simulator and examines the performance of an improved Human-Machine Interface …


Modelling Long-Term Security Returns, XINGHAN ZHU 2023 Western University

Modelling Long-Term Security Returns, Xinghan Zhu

Electronic Thesis and Dissertation Repository

This research focuses on the concerns of Canadian investors regarding portfolio diversification and preparedness for unexpected risks in retirement planning. It models market crashes and two main financial instruments as independent components to simulate clients’ portfolios. Initially exploring single distributions on mutual funds such as Laplace and t distributions, the research finds limited success. Instead, a normal-Weibull spliced distribution is introduced to model log returns. The Geometric Brownian Motion (GBM) model is employed to predict and evaluate returns on common stocks using the Maximum Likelihood Estimator (MLE), assuming that daily log returns follow a normal distribution. Additionally, the Merton Jump …


Using Geographic Information To Explore Player-Specific Movement And Its Effects On Play Success In The Nfl, Hayley Horn, Eric Laigaie, Alexander Lopez, Shravan Reddy 2023 Southern Methodist University

Using Geographic Information To Explore Player-Specific Movement And Its Effects On Play Success In The Nfl, Hayley Horn, Eric Laigaie, Alexander Lopez, Shravan Reddy

SMU Data Science Review

American Football is a billion-dollar industry in the United States. The analytical aspect of the sport is an ever-growing domain, with open-source competitions like the NFL Big Data Bowl accelerating this growth. With the amount of player movement during each play, tracking data can prove valuable in many areas of football analytics. While concussion detection, catch recognition, and completion percentage prediction are all existing use cases for this data, player-specific movement attributes, such as speed and agility, may be helpful in predicting play success. This research calculates player-specific speed and agility attributes from tracking data and supplements them with descriptive …


Forecasting Covid-19 With Temporal Hierarchies And Ensemble Methods, Li Shandross 2023 University of Massachusetts Amherst

Forecasting Covid-19 With Temporal Hierarchies And Ensemble Methods, Li Shandross

Masters Theses

Infectious disease forecasting efforts underwent rapid growth during the COVID-19 pandemic, providing guidance for pandemic response and about potential future trends. Yet despite their importance, short-term forecasting models often struggled to produce accurate real-time predictions of this complex and rapidly changing system. This gap in accuracy persisted into the pandemic and warrants the exploration and testing of new methods to glean fresh insights.

In this work, we examined the application of the temporal hierarchical forecasting (THieF) methodology to probabilistic forecasts of COVID-19 incident hospital admissions in the United States. THieF is an innovative forecasting technique that aggregates time-series data into …


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