Statistics and Probability Commons^™

A Novel Device For Cell-Cell Electrofusion, Justin T. Stewart

USF Tampa Graduate Theses and Dissertations

Cell transplantation therapy is a potentially powerful tool and can be used to replace defective cells with healthy cells. This offers the possibility of alleviating the destructive symptoms for many diseases such as Parkinson's disease, Alzheimer's disease, stroke, spinal cord trauma, Type I diabetes and many more. While there are many diseases that could be positively impacted from cell transplantation therapy, the focus of this research is insulin dependent, Type I Diabetes.

The Islets of Langerhans are composed of various types of cells located in the pancreas and are responsible for a variety of biochemical functions. Specifically, the beta Islet …

Statistical Models For Environmental And Health Sciences, Yong Xu

USF Tampa Graduate Theses and Dissertations

Statistical analysis and modeling are useful for understanding the behavior of different phenomena. In this study we will focus on two areas of applications: Global warming and cancer research. Global Warming is one of the major environmental challenge people face nowadays and cancer is one of the major health problem that people need to solve.

For Global Warming, we are interest to do research on two major contributable variables: Carbon dioxide (CO2) and atmosphere temperature. We will model carbon dioxide in the atmosphere data with a system of differential equations. We will develop a differential equation for each of six …

Alternative Statistical Methods For Analyzing Geological Phenomena: Bridging The Gap Between Scientific Disciplines, Joseph Frank Van Gaalen

USF Tampa Graduate Theses and Dissertations

When we consider the nature of the scientific community in conjunction with a sense of typical economic circumstances we find that there are two distinct paths for development. One path involves hypothesis testing and evolution of strategies that are linked with iterations in equipment advances. A second, more complicated scenario, can involve external influences whether economic, political, or otherwise, such as the government closure of NASA's space program in 2011 which will no doubt influence research in associated fields. The following chapters are an account of examples of two statistical techniques and the importance of both on the two relatively …

Gender Differences In Lung Cancer Treatment And Survival, Margaret Anne Kowski

USF Tampa Graduate Theses and Dissertations

The objectives of this research were to test treatment and survival differences between women and men with lung cancer as there is minimal investigation in the literature. Three research questions were developed with statistical testing for gender differences based on similar cancer type, stage, treatment assignment and survival. Data for 44,863 primary lung cancer cases were collected from eight U.S. state-based cancer registries to investigate the research questions. The lung cancer incidence data included the morphological cell-types of adenocarcinoma (AC); squamous cell carcinoma (SCC); large cell carcinoma (LCC) and small cell carcinoma (SCC). Stage, grade, treatment type, as well as, …

Parametric And Bayesian Modeling Of Reliability And Survival Analysis, Carlos A. Molinares

USF Tampa Graduate Theses and Dissertations

The objective of this study is to compare Bayesian and parametric approaches to determine the best for estimating reliability in complex systems. Determining reliability is particularly important in business and medical contexts. As expected, the Bayesian method showed the best results in assessing the reliability of systems.

In the first study, the Bayesian reliability function under the Higgins-Tsokos loss function using Jeffreys as its prior performs similarly as when the Bayesian reliability function is based on the squared-error loss. In addition, the Higgins-Tsokos loss function was found to be as robust as the squared-error loss function and slightly more efficient. …

Statistician Recommends A Dose Of Skepticism, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Neath Studies, Teaches The Uncertainties Of Life, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Approximate Vs. Monte Carlo Critical Values For The Winsorized T-Test, Michael Lance

Wayne State University Dissertations

Historically, it has been accepted practice for critical values for the Winsorized t test for independent samples to be based on adjusted degrees of freedom depending on the number of total non-Winsorized (approximate) values. Recently, a new such table of Winsorized critical values has been developed via approximate randomization by Monte Carlo simulation.

Based on eight common data distributions estimated from Psychology and Education along with the normal and five Mathematical distributions, these two tables of values were compared with respect to robustness to types I and II errors through Monte Carlo simulations for one and 10% Winsorized values per …

A Comparison Of The Effects Of Non-Normal Distributions On Tests Of Equivalence, Linda Ellington

Wayne State University Dissertations

Statistical theory and its application provide the foundation to modern systematic inquiry in the behavioral, physical and social sciences disciplines (Fisher, 1958; Wilcox, 1996). It provides the tools for scholars and researchers to operationalize constructs, describe populations, and measure and interpret the relations between populations and variables (Weinbach & Grinnell, 1997; Wilcox, 1996). Given that the majority of real data analysis in the behavioral and social sciences is comprised of non-normally distributed data, it is important that researchers be aware of the effects of non-normal distributions on the probability of detecting equivalence between populations.

The present study examined the effects …

On The Use Of Log-Transformation Vs. Nonlinear Regression For Analyzing Biological Power-Laws, Xiao Xiao

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Power-law relationships are among the most well-studied functional relationships in biology . Recently the common practice of fitting power-laws using linear regression on log-transformed data (LR) has been criticized, calling into question the conclusions of hundreds of studies. It has been suggested that nonlinear regression (NLR) is preferable, but no rigorous comparison of these two methods has been conducted. Using Monte Carlo simulations we demonstrate that the error distribution determines which method performs better, with LR better characterizing data with multiplicative lognormal error and NLR better characterizing data with additive normal error. Analysis of 471 biological power-laws shows that both …

Identifying Rare Variants From Exome Scans: The Gaw17 Experience, Saurabh Ghosh, Heike Bickeboller, Julia Bailey, Joan E. Bailey-Wilson, Rita Cantor, Robert Culverhouse, Warwick Daw, Anita L. Destefano, Corinne D. Engelman, Anthony Hinrichs, Jeanine Houwing-Duistermaat, Inke R. Konig, Jack Kent, Nan Laird, Nathan Pankratz, Andrew Paterson, Elizabeth Pugh, Brian Suarez, Yan Sun, Alun Thomas, Nathan L. Tintle, Xiaofeng Zhu, Andreas Ziegler, Jean W. Maccluer, Laura Almasy

Faculty Work Comprehensive List

Genetic Analysis Workshop 17 (GAW17) provided a platform for evaluating existing statistical genetic methods and for developing novel methods to analyze rare variants that modulate complex traits. In this article, we present an overview of the 1000 Genomes Project exome data and simulated phenotype data that were distributed to GAW17 participants for analyses, the different issues addressed by the participants, and the process of preparation of manuscripts resulting from the discussions during the workshop

An Analog Experiment Comparing Goal-Free Evaluation And Goal Achievement Evaluation Utility, Brandon W. Youker

Dissertations

Goal-free evaluation (GFE) is the process of determining the merit of an evaluand independent of the stated or implied goals and objectives, whereas goal achievement evaluation (GAE), as the most rudimentary form of goal-based evaluation, determines merit according to the evaluand’s level of accomplishment with regard to its goals. This study examines the utility of GAE and GFE from the perspective of the evaluation’s intended users. In the study, two evaluation teams, goal achievement and goal-free, independently and simultaneously evaluate the same human service program. Each team produced a final evaluation report, which was read by the evaluation’s users, who …

Class Discovery And Prediction Of Tumor With Microarray Data, Bo Liu

All Graduate Theses, Dissertations, and Other Capstone Projects

Current microarray technology is able take a single tissue sample to construct an Affymetrix oglionucleotide array containing (estimated) expression levels of thousands of different genes for that tissue. The objective is to develop a more systematic approach to cancer classification based on Affymetrix oglionucleotide microarrays. For this purpose, I studied published colon cancer microarray data. Colon cancer, with 655,000 deaths worldwide per year, has become the fourth most common form of cancer in the United States and the third leading cause of cancer - related death in the Western world. This research has been focuses in two areas: class discovery, …

Neurological And Cardiovascular Outcomes After Cardiac Arrest At Six Regional Interventional Cardiology Centers In The United States 2007-2011, David B. Seder Md, Nainesh Patel Md, John Mcpherson Md, Paul W. Mcmullan Md, Karl B. Kern Md, Barbara Unger Rn, J Browning, Sudip Nanda Md, Facp, Melkon Hacobian Md, Michael B. Kelley Md, Niklas Nielsen Md, Phd, Michael R. Mooney Md

Department of Medicine

No abstract provided.

Post-Resuscitation Care Practices Following Cardiac Arrest At Six Regional Interventional Cardiology Centers In The United States 2007-2011, David B. Seder Md, Nainesh Patel Md, John A. Mcpherson Md, Paul W. Mcmullan Md, Karl B. Kern Md, Barbara T. Unger Rn, J Browning, Sudip Nanda Md, Facp, Melkon Hacobian Md, Michael B. Kelley Md, Niklas Nielsen Md, Phd, Michael R. Mooney Md

Department of Medicine

No abstract provided.

Bayesian Computational Methods For Hidden Markov Models, Samson Laine Ghebremariam

Open Access Theses & Dissertations

Hidden Markov Models (HMMs) have been applied to many real-world problems. Hidden Markov modeling has recently become increasingly important and popular among researchers,and many software tools are based on them. Given that the models are rich in mathematical structure, they can form theoretical foundation for use in a wide range of applications. Hidden Markov models provide a universal configuration for statistical analysis of a large variety of DNA sequences containing symbols A, C, G, T. In a HMM, it is impossible to figure out what state the model is in by just having a look at the symbol generated.

A …

Gamma And Generalized Gamma Distributions, Victor Hugo Jiménez Nava

Open Access Theses & Dissertations

We present the Generalized Gamma Distribution, study its properties and derive the estimators of the parameters. This distribution includes many standard forms, like: Gamma, Exponential, Weibull, Half Normal and others. Sum and ratios of independent generalized gamma lead to intractable forms. However approximation works well. In particular two-moment gamma and three moment normal approximations are shown to approximate the sum of k independent gamma as well as generalized gamma distributions.

Computational Methods Of Hidden Markov Models With Respect To Cpg Island Prediction In Dna Sequences, Roberto Angel Ortega

Open Access Theses & Dissertations

Hidden Markov models (HMM's) are a specific case of Markov models where, contrary to Markov chains, the observer is unaware of what state the model was in when the symbol is observed. Like Markov chains, HMM's assume that the future state of a sequence is dependent only on the current state of the sequence. The parameters associated with HMM's are transition and emission probabilities, where transition probabilities are associated with the probability of transitioning from one state to another, and emission probabilities are the probabilities associated with observing a symbol given it came from a specific state.

The structure of …

Estimating The Effect Of Dust And Low Wind Events On Hospitalizations For Asthma While Adjusting For Hourly Levels Of Air Pollutants, Priyangi Kanchana Bulathsinhala

Open Access Theses & Dissertations

El Paso, Texas is known as one of the dust hotspots in North America. We explore the effect of dust and low wind events on asthma admissions in El Paso, Texas between 2000 and 2005. Conditional logistic regression with a case-crossover design was used to estimate the probability of hospitalization after dust and low wind events while controlling for pollutants with hourly monitor measurements, and weather. The historical functional linear model is used to incorporate the hourly pollutant measures into the regression model with a continuous lag, as an alternative to a distributed lag model based on daily averages. The …

Fact Sheet, Yale University Office Of Institutional Research

Fact Sheets

No abstract provided.