Statistics and Probability Commons^™

Decision Aid Models For Resource Sharing Strategies During Global Influenza Pandemics, Alfredo Santana Reynoso

USF Tampa Graduate Theses and Dissertations

Pandemic influenza outbreaks have historically entailed significant societal and economic disruptions. Today, our quality of life is threatened by our inadequate preparedness for the imminent pandemic. The key challenges we are facing stem from a significant uncertainty in virus epidemiology, limited response resources, inadequate international collaboration, and the lack of appropriate science-based decision support tools. The existing literature falls short of comprehensive models for global pandemic spread and mitigation which incorporate the heterogeneity of the world regions and realistic travel networks. In addition, there exist virtually no studies which quantify the impact of resource sharing strategies among multiple countries. This …

Outlier Detection In Circular Data And Circular-Circular Regression Model., Adzhar Rambli

Student Works (2010-2019)

This study focuses on studying several numerical methods used to detect outliers in circular data and circular-circular regression models. Firstly, we will look at different distributions for circular variable and different regression models involving bivariate circular data. The parameters that describe each circular distribution will be explained in detail and illustrated using real data sets. As for the circular regression, we will consider the DM circular regression model proposed by Down and Mardia (2002). We employ the maximum likelihood estimation method to estimate the parameters of the model. Secondly, we consider the occurrence of outliers in circular data generated from …

Some Contributions To The Censored Empirical Likelihood With Hazard-Type Constraints, Yanling Hu

University of Kentucky Doctoral Dissertations

Empirical likelihood (EL) is a recently developed nonparametric method of statistical inference. Owen’s 2001 book contains many important results for EL with uncensored data. However, fewer results are available for EL with right-censored data. In this dissertation, we first investigate a right-censored-data extension of Qin and Lawless (1994). They studied EL with uncensored data when the number of estimating equations is larger than the number of parameters (over-determined case). We obtain results similar to theirs for the maximum EL estimator and the EL ratio test, for the over-determined case, with right-censored data. We employ hazard-type constraints which are better able …

Analysis Of Differential Gene Expression And Alternative Splicing In The Liver And Gastrointestinal Tract In The Lactating Rat, Antony Thomas Athippozhy

University of Kentucky Doctoral Dissertations

Rat exon microarrays were utilized to detect changes in mRNA expression and alternative splicing in the liver, duodenum, jejunum, and ileum of the lactating rat when compared to age-matched virgin controls. Analysis of data at the level of gene expression revealed differential expression of genes involved in cholesterol biosynthesis in each tissue examined, suggesting increased Sterol Response Element Binding Protein activity. We also detected decreased mRNA from components of the T-cell signaling pathway in the jejunum and ileum. We characterized expression of solute carrier and adenosine triphosphate binding cassette proteins. In addition to characterizing genes by pathway, we have also …

Bayesian Semiparametric Generalizations Of Linear Models Using Polya Trees, Angela Schoergendorfer

University of Kentucky Doctoral Dissertations

In a Bayesian framework, prior distributions on a space of nonparametric continuous distributions may be defined using Polya trees. This dissertation addresses statistical problems for which the Polya tree idea can be utilized to provide efficient and practical methodological solutions.

One problem considered is the estimation of risks, odds ratios, or other similar measures that are derived by specifying a threshold for an observed continuous variable. It has been previously shown that fitting a linear model to the continuous outcome under the assumption of a logistic error distribution leads to more efficient odds ratio estimates. We will show that deviations …

Autonomous Entropy-Based Intelligent Experimental Design, Nabin Kumar Malakar

Legacy Theses & Dissertations (2009 - 2024)

The aim of this thesis is to explore the application of probability and information theory in experimental design, and to do so in a way that combines what we know about inference and inquiry in a comprehensive and consistent manner.

Computational Network Analysis Of The Anatomical And Genetic Organizations In The Mouse Brain, Shuiwang Ji

Computer Science Faculty Publications

Motivation: The mammalian central nervous system (CNS) generates high-level behavior and cognitive functions. Elucidating the anatomical and genetic organizations in the CNS is a key step toward understanding the functional brain circuitry. The CNS contains an enormous number of cell types, each with unique gene expression patterns. Therefore, it is of central importance to capture the spatial expression patterns in the brain. Currently, genome-wide atlas of spatial expression patterns in the mouse brain has been made available, and the data are in the form of aligned 3D data arrays. The sheer volume and complexity of these data pose significant challenges …

Evaluating Methods For The Analysis Of Rare Variants In Sequence Data, Alexander Luedtke, Scott Powers, Ashley Petersen, Alexandra Sitarik, Airat Bekmetjev, Nathan L. Tintle

Faculty Work Comprehensive List

A number of rare variant statistical methods have been proposed for analysis of the impending wave of next-generation sequencing data. To date, there are few direct comparisons of these methods on real sequence data. Furthermore, there is a strong need for practical advice on the proper analytic strategies for rare variant analysis. We compare four recently proposed rare variant methods (combined multivariate and collapsing, weighted sum, proportion regression, and cumulative minor allele test) on simulated phenotype and next-generation sequencing data as part of Genetic Analysis Workshop 17. Overall, we find that all analyzed methods have serious practical limitations on identifying …

Inflated Type I Error Rates When Using Aggregation Methods To Analyze Rare Variants In The 1000 Genomes Project Exon Sequencing Data In Unrelated Individuals: Summary Results From Group 7 At Genetic Analysis Workshop 17, Nathan L. Tintle, Hugues Aschard, Inchi Hu, Nora Nock, Haitian Wang, Elizabeth Pugh

Faculty Work Comprehensive List

As part of Genetic Analysis Workshop 17 (GAW17), our group considered the application of novel and standard approaches to the analysis of genotype-phenotype association in next-generation sequencing data. Our group identified a major issue in the analysis of the GAW17 next-generation sequencing data: type I error and false-positive report probability rates higher than those expected based on empirical type I error levels (as high as 90%). Two main causes emerged: population stratification and long-range correlation (gametic phase disequilibrium) between rare variants. Population stratification was expected because of the diverse sample. Correlation between rare variants was attributable to both random causes …

Identification Of Genetic Association Of Multiple Rare Variants Using Collapsing Methods, Yan V. Sun, Yun Ju Sung, Nathan L. Tintle, Andreas Ziegler

Faculty Work Comprehensive List

Next-generation sequencing technology allows investigation of both common and rare variants in humans. Exomes are sequenced on the population level or in families to further study the genetics of human diseases. Genetic Analysis Workshop 17 (GAW17) provided exomic data from the 1000 Genomes Project and simulated phenotypes. These data enabled evaluations of existing and newly developed statistical methods for rare variant sequence analysis for which standard statistical methods fail because of the rareness of the alleles. Various alternative approaches have been proposed that overcome the rareness problem by combining multiple rare variants within a gene. These approaches are termed collapsing …

Evaluating Methods For Combining Rare Variant Data In Pathway-Based Tests Of Genetic Association, Ashley Petersen, Alexandra Sitarik, Alexander Luedtke, Scott Powers, Airat Bekmetjev, Nathan L. Tintle

Faculty Work Comprehensive List

Analyzing sets of genes in genome-wide association studies is a relatively new approach that aims to capitalize on biological knowledge about the interactions of genes in biological pathways. This approach, called pathway analysis or gene set analysis, has not yet been applied to the analysis of rare variants. Applying pathway analysis to rare variants offers two competing approaches. In the first approach rare variant statistics are used to generate p-values for each gene (e.g., combined multivariate collapsing [CMC] or weighted-sum [WS]) and the gene-level p-values are combined using standard pathway analysis methods (e.g., gene set enrichment analysis or …

Adjusted Empirical Likelihood Models With Estimating Equations For Accelerated Life Tests, Ni Wang, Jye-Chyi Lu, Di Chen, Paul H. Kvam

Department of Math & Statistics Faculty Publications

This article proposes an adjusted empirical likelihood estimation (AMELE) method to model and analyze accelerated life testing data. This approach flexibly and rigorously incorporates distribution assumptions and regression structures by estimating equations within a semiparametric estimation framework. An efficient method is provided to compute the empirical likelihood estimates, and asymptotic properties are studied. Real-life examples and numerical studies demonstrate the advantage of the proposed methodology.

Adjusted Hazard Rate Estimator Based On A Known Censoring Probability, Ülkü Gürler, Paul H. Kvam

Department of Math & Statistics Faculty Publications

In most reliability studies involving censoring, one assumes that censoring probabilities are unknown. We derive a nonparametric estimator for the survival function when information regarding censoring frequency is available. The estimator is constructed by adjusting the Nelson–Aalen estimator to incorporate censoring information. Our results indicate significant improvements can be achieved if available information regarding censoring is used. We compare this model to the Koziol–Green model, which is also based on a form of proportional hazards for the lifetime and censoring distributions. Two examples of survival data help to illustrate the differences in the estimation techniques.

Multi-Cause Degradation Path Model: A Case Study On Rubidium Lamp Degradation, Sun Quan, Paul H. Kvam

Department of Math & Statistics Faculty Publications

At the core of satellite rubidium standard clocks is the rubidium lamp, which is a critical piece of equipment in a satellite navigation system. There are many challenges in understanding and improving the reliability of the rubidium lamp, including the extensive lifetime requirement and the dearth of samples available for destructive life tests. Experimenters rely on degradation experiments to assess the lifetime distribution of highly reliable products that seem unlikely to fail under the normal stress conditions, because degradation data can provide extra information about product reliability. Based on recent research on the rubidium lamp, this article presents a multi‐cause …

On The First-Order Expressibility Of Lattice Properties To Unicoherence In Continua, Paul Bankston

Mathematics, Statistics and Computer Science Faculty Research and Publications

Many properties of compacta have “textbook” definitions which are phrased in lattice-theoretic terms that, ostensibly, apply only to the full closed-set lattice of a space. We provide a simple criterion for identifying such definitions that may be paraphrased in terms that apply to all lattice bases of the space, thereby making model-theoretic tools available to study the defined properties. In this note we are primarily interested in properties of continua related to unicoherence; i.e., properties that speak to the existence of “holes” in a continuum and in certain of its subcontinua.

Detecting Temporal Patterns Using Reconstructed Phase Space And Support Vector Machine In The Dynamic Data System, Wenjing Zhang, Xin Feng

Mathematics, Statistics and Computer Science Faculty Research and Publications

In this paper we present a method for detecting dynamic temporal patterns that are characteristic and predictive of significant events in a dynamic data system. We employ the Gaussian Mixture Model (GMM) to cluster the data sequence into three categories of signals, e.g. normal, patterns and events. The data sequence is then embedded into a Reconstructed Phase Space (RPS) which is topologically equivalent to the dynamics of the original system. We apply a hybrid method using Support Vector Machines (SVM) and Maximum a Posterior (MAP) to classify temporal pattern signals based on the event function. We performed two experimental applications …

Impact Of Curriculum Reform: Evidence Of Change In Classroom Instruction In The United States, John Moyer, Jinfa Cai, Ning Wang, Bikai Nie

Mathematics, Statistics and Computer Science Faculty Research and Publications

The purpose of the study reported in this article is to examine the impact of curriculum on instruction. Over a three-year period, we observed 579 algebra-related lessons in grades 6–8. Approximately half the lessons were taught in schools that had adopted a Standards-based mathematics curriculum called the Connected Mathematics Program (CMP), and the remainder of the lessons were taught in schools that used more traditional curricula (non-CMP). We found many significant differences between the CMP and non-CMP lessons. The CMP lessons, emphasized the conceptual aspects of instruction to a greater extent than the non-CMP lessons and the non-CMP lessons …

On The Distributions Of Certain Spacings, Gholamhossein Hamedani, Hans Volkmer

Mathematics, Statistics and Computer Science Faculty Research and Publications

A characterization of the uniform distribution based on distributions of spacings is presented which extends the existing result in this direction. Also, a result on the distribution of spacings for distributions close to the uniform one is discussed.

Weighted Scores Method For Regression Models With Dependent Data, Aristidis K. Nikoloulopoulos, Harry Joe, N. Rao Chaganty

Mathematics & Statistics Faculty Publications

There are copula-based statistical models in the literature for regression with dependent data such as clustered and longitudinal overdispersed counts, for which parameter estimation and inference are straightforward. For situations where the main interest is in the regression and other univariate parameters and not the dependence, we propose a "weighted scores method", which is based on weighting score functions of the univariate margins. The weight matrices are obtained initially fitting a discretized multivariate normal distribution, which admits a wide range of dependence. The general methodology is applied to negative binomial regression models. Asymptotic and small-sample efficiency calculations show that our …

Essays On Hedge Fund Replication: Methodological Assessment And Development Of The Factor Approach, Nonlinear Modeling And Policy Perspectives, Guillaume Weisang

2011

This dissertation is concerned with hedge fund replication, a subject of a practical and theoretical importance, both from an investment and a risk management point of view. One of our goals is to extend known methodologies in order to enhance our understanding of an industry that is known for its secrecy and its lack of transparency. A second goal is to contribute to the quantitative finance literature with improved techniques for hedge fund replication. Hedge fund replication (HFR) is approached from the methodological as well as from practical and regulatory perspectives. The first two chapters provide the motivation and the …