Statistics and Probability Commons^™

Normal Mixture And Contaminated Model With Nuisance Parameter And Applications, Qian Fan

Theses and Dissertations--Statistics

This paper intend to find the proper hypothesis and test statistic for testing existence of bilaterally contamination when there exists nuisance parameter. The test statistic is based on method of moments estimators. Union-Intersection test is used for testing if the distribution of population can be implemented by a bilaterally contaminated normal model with unknown variance. This paper also developed a hierarchical normal mixture model (HNM) and applied it to birth weight data. EM algorithm is employed for parameter estimation and a singular Bayesian information criterion (sBIC) is applied to choose the number components. We also proposed a singular flexible information …

Value Of Mendelian Laws Of Segregation In Families: Data Quality Control, Imputation, And Beyond, Elizabeth M. Blue, Lei Sun, Nathan L. Tintle, Ellen M. Wijsman

Faculty Work Comprehensive List

When analyzing family data, we dream of perfectly informative data, even whole-genome sequences (WGSs) for all family members. Reality intervenes, and we find that next-generation sequencing (NGS) data have errors and are often too expensive or impossible to collect on everyone. The Genetic Analysis Workshop 18 working groups on quality control and dropping WGSs through families using a genome-wide association framework focused on finding, correcting, and using errors within the available sequence and family data, developing methods to infer and analyze missing sequence data among relatives, and testing for linkage and association with simulated blood pressure. We found that single-nucleotide …

Pathway Analysis Approaches For Rare And Common Variants: Insights From Genetic Analysis Workshop 18, Stella Aslibekyan, Marcio Almeida, Nathan L. Tintle

Faculty Work Comprehensive List

Pathway analysis, broadly defined as a group of methods incorporating a priori biological information from public databases, has emerged as a promising approach for analyzing high-dimensional genomic data. As part of Genetic Analysis Workshop 18, seven research groups applied pathway analysis techniques to whole-genome sequence data from the San Antonio Family Study. Overall, the groups found that the potential of pathway analysis to improve detection of causal variants by lowering the multiple-testing burden and incorporating biologic insight remains largely unrealized. Specifically, there is a lack of best practices at each stage of the pathway approach: annotation, analysis, interpretation, and follow-up. …

Statistical Analysis Of Sleep Patterns In Drosophila Melanogaster, Luyang Wang

Masters Theses

“Sleep is one of the most preserved and restorative behaviors of animals and is important in human health. Lack of sleep may cause numerous diseases. So the study of sleep rhythms is very essential and complicated. In order to simplify the process of studying sleep, the fruit fly Drosophila melanogaster, is utilized as a model organism for several reasons. Some of the molecular mechanisms that contribute to the circadian clock in the fruit fly were also found to generate similar cycles in mammals. In order to study sleep patterns in the fruit fly, experiments were designed and performed to …

Assessment Of Contributing Factors To The Reduction Of Diarrhea In Rural Communities Of Para, Brazil, Lee Voth-Gaeddert

Masters Theses

"In developing communities the occurrence of diarrhea has been reported at elevated levels as compared to those communities in more developed regions. Diarrheal diseases were linked to over one million deaths in 2012 throughout the world. While multiple pathways are present for the transmission of diarrheal diseases, water has been the focus for many aid organizations. Point-of-use (POU) water treatment methods are a common tool used by aid organizations in efforts to provide potable water. The CAWST biosand filter is a POU tool that has shown removal effectiveness of pathogenic microorganisms ranging from 90-99%. However, minimal literature was found that …

Evaluating The Impact Of Genotype Errors On Rare Variant Tests Of Association, Kaitlyn Cook, Alejandra Benitez, Casey Fu, Nathan Tintle

Statistical and Data Sciences: Faculty Publications

The new class of rare variant tests has usually been evaluated assuming perfect genotype information. In reality, rare variant genotypes may be incorrect, and so rare variant tests should be robust to imperfect data. Errors and uncertainty in SNP genotyping are already known to dramatically impact statistical power for single marker tests on common variants and, in some cases, inflate the type I error rate. Recent results show that uncertainty in genotype calls derived from sequencing reads are dependent on several factors, including read depth, calling algorithm, number of alleles present in the sample, and the frequency at which an …

Statistical Analysis Of Depression And Social Support Change In Arab Immigrant Women In Usa, Hazhar Blbas

Electronic Theses and Dissertations

Arab Muslim immigrant women encounter many stressors and are at risk for depression. Social supports from husbands, family and friends are generally considered mitigating resources for depression. However, changes in social support over time and the effects of such supports on depression at a future time period have not been fully addressed in the literature This thesis investigated the relationship between demographic characteristics, changes in social support, and depression in Arab Muslim immigrant women to the USA. A sample of 454 married Arab Muslim immigrant women provided demographic data, scores on social support variables and depression at three time periods …

Markov Chain Theory With Applications To Baseball, Cal D. Thomay

Senior Independent Study Theses

The applications of Markov chains span a wide range of fields to which models have been designed and implemented to simulate random processes. Markov chains are stochastic processes that are characterized by their memoryless property, where the probability of the process being in the next state of the system depends only on the current state and not on any of the previous states. This property is known as the Markov property. This thesis paper will first introduce the theory of Markov chains, along with explaining two types of Markov chains that will be beneficial in creating a model for analyzing …

Introduction To Neutrosophic Statistics, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

Neutrosophic Statistics means statistical analysis of population or sample that has indeterminate (imprecise, ambiguous, vague, incomplete, unknown) data. For example, the population or sample size might not be exactly determinate because of some individuals that partially belong to the population or sample, and partially they do not belong, or individuals whose appurtenance is completely unknown. Also, there are population or sample individuals whose data could be indeterminate.

In this book, we develop the 1995 notion of neutrosophic statistics. We present various practical examples. It is possible to define the neutrosophic statistics in many ways, because there are various types of …

The Efficient Use Of Supplementary Information In Finite Population Sampling, Florentin Smarandache, Rajesh Singh

Branch Mathematics and Statistics Faculty and Staff Publications

The purpose of writing this book is to suggest some improved estimators using auxiliary information in sampling schemes like simple random sampling, systematic sampling and stratified random sampling. This volume is a collection of five papers, written by nine co-authors (listed in the order of the papers): Rajesh Singh, Mukesh Kumar, Manoj Kr. Chaudhary, Cem Kadilar, Prayas Sharma, Florentin Smarandache, Anil Prajapati, Hemant Verma, and Viplav Kr. Singh. In first paper dual to ratio-cum-product estimator is suggested and its properties are studied. In second paper an exponential ratio-product type estimator in stratified random sampling is proposed and its properties are …

Fusion Of Masses Defined On Infinite Countable Frames Of Discernment, Florentin Smarandache, Arnaud Martin

Branch Mathematics and Statistics Faculty and Staff Publications

In this paper we introduce for the first time the fusion of information on infinite discrete frames of discernment and we give general results of the fusion of two such masses using the Dempster’s rule and the PCR5 rule for Bayesian and non-Bayesian cases.

A General Procedure Of Estimating Population Mean Using Information On Auxiliary Attribute, Sachin Malik, Rajesh Singh, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

This paper deals with the problem of estimating the finite population mean when some information on auxiliary attribute is available. It is shown that the proposed estimator is more efficient than the usual mean estimator and other existing estimators. The results have been illustrated numerically by taking empirical population considered in the literature.

A Generalized Family Of Estimators For Estimating Population Mean Using Two Auxiliary Attributes, Sachin Malik, Rajesh Singh, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

This paper deals with the problem of estimating the finite population mean when some information on two auxiliary attributes are available. A class of estimators is defined which includes the estimators recently proposed by Malik and Singh (2012), Naik and Gupta (1996) and Singh et al. (2007) as particular cases. It is shown that the proposed estimator is more efficient than the usual mean estimator and other existing estimators. The study is also extended to two-phase sampling. The results have been illustrated numerically by taking empirical population considered in the literature.

Testing Longitudinal Data By Logarithmic Quantiles, Manfred Denker, Lucia Tabacu

Mathematics & Statistics Faculty Publications

The shoulder tip pain study of Lumley [13] is re-investigated. It is shown that the new logarithmic quantile estimation (LQE) technique in [9] applies and behaves well under singular covariance structure and small sample sizes as in the shoulder tip pain study. The findings in [6] can be assured under weaker assumptions using a combination of LQE and an ANOVA type statistic. © 2014, Institute of Mathematical Statistics.

Mate Choice And The Evolutionary Stability Of A Fixed Threshold In A Sequential Search Strategy, Raymond Cheng, Steven M. Seubert, Daniel D. Wiegmann

Mathematics & Statistics Faculty Publications

The sequential search strategy is a prominent model of searcher behavior, derived as a rule by which females might sample and choose a mate from a distribution of prospective partners. The strategy involves a threshold criterion against which prospective mates are evaluated. The optimal threshold depends on the attributes of prospective mates, which are likely to vary across generations or within the lifetime of searchers due to stochastic environmental events. The extent of this variability and the cost to acquire information on the distribution of the quality of prospective mates determine whether a learned or environmentally canalized threshold is likely …

Building A Predictive Model For Baseball Games, Jordan Robertson Tait

All Graduate Theses, Dissertations, and Other Capstone Projects

In this paper, we will discuss a method of building a predictive model for Major League Baseball Games. We detail the reasoning for pursuing the proposed predictive model in terms of social popularity and the complexity of analyzing individual variables. We apply a coarse-grain outlook inspired by Simon Dedeos' work on Human Social Systems, in particular the open source website Wikipedia [2] by attempting to quantify the influence of winning and losing streaks instead of analyzing individual performance variables. We will discuss initial findings of data collected from the LA Dodgers and Colorado Rockies and apply further statistical analysis to …

A Statistical Fmri Model For Differential T2* Contrast Incorporating T1 And T2* Of Gray Matter, M. Muge Karaman, Iain P. Bruce, Daniel B. Rowe

Mathematics, Statistics and Computer Science Faculty Research and Publications

Relaxation parameter estimation and brain activation detection are two main areas of study in magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI). Relaxation parameters can be used to distinguish voxels containing different types of tissue whereas activation determines voxels that are associated with neuronal activity. In fMRI, the standard practice has been to discard the first scans to avoid magnetic saturation effects. However, these first images have important information on the MR relaxivities for the type of tissue contained in voxels, which could provide pathological tissue discrimination. It is also well-known that the voxels located in gray matter …

Trivial Meet And Join Within The Lattice Of Monotone Triangles, John Engbers, Adam Hammett

Mathematics, Statistics and Computer Science Faculty Research and Publications

The lattice of monotone triangles (�_n, ≼) ordered by entry-wise comparisons is studied. Let τ_min denote the unique minimal element in this lattice, and τ_max the unique maximum. The number of r-tuples of monotone triangles (τ₁...,τ_r) with minimul infimum τ_min (maximul supremum τ_max, resp.) is shown to asymptotically approach r|�_n|^r-1 as n→ ∞. Thus, with high probability this even implies that one of the τ_i is τ_min (τ_max, resp.). Higher-order error terms are also discussed.

Master Regulators, Regulatory Networks, And Pathways Of Glioblastoma Subtypes, Serdar Bozdag, Aiguo Li, Mehmet Baysan, Howard A. Fine

Mathematics, Statistics and Computer Science Faculty Research and Publications

Glioblastoma multiforme (GBM) is the most common malignant brain tumor. GBM samples are classified into subtypes based on their transcriptomic and epigenetic profiles. Despite numerous studies to better characterize GBM biology, a comprehensive study to identify GBM subtype-specific master regulators, gene regulatory networks, and pathways is missing. Here, we used FastMEDUSA to compute master regulators and gene regulatory networks for each GBM subtype. We also ran Gene Set Enrichment Analysis and Ingenuity Pathway Analysis on GBM expression dataset from The Cancer Genome Atlas Project to compute GBM- and GBM subtype-specific pathways. Our analysis was able to recover some of the …

Hp-Daemon: HIgh PErformance DIstributed ADaptive ENergy-Efficient MAtrix-MultiplicatiOn, Li Tan, Longxiang Chen, Zizhong Chen, Ziliang Zong, Rong Ge, Dong Li

Mathematics, Statistics and Computer Science Faculty Research and Publications

The demands of improving energy efficiency for high performance scientific applications arise crucially nowadays. Software-controlled hardware solutions directed by Dynamic Voltage and Frequency Scaling (DVFS) have shown their effectiveness extensively. Although DVFS is beneficial to green computing, introducing DVFS itself can incur non-negligible overhead, if there exist a large number of frequency switches issued by DVFS. In this paper, we propose a strategy to achieve the optimal energy savings for distributed matrix multiplication via algorithmically trading more computation and communication at a time adaptively with user-specified memory costs for less DVFS switches, which saves 7.5% more energy on average than …