Genetic Effects Mediated Through Epistatic Networks Onto Metabolic Traits,
2021
Washington University in St. Louis
Genetic Effects Mediated Through Epistatic Networks Onto Metabolic Traits, Juan Francisco Macias-Velasco
Arts & Sciences Electronic Theses and Dissertations
Predicting variation in complex traits from DNA sequence is a major public health goal, but our understanding of the genotype-to-phenotype relationship is incomplete. It will remain so unless we can adequately integrate genetic, epigenetic, and environmental information into a systems level framework. In a step towards that goal, quantitative trait mapping studies have attempted to account for environmental factors such as sex and diet, and epigenetic factors such as allelic parent-of-origin effects. Several studies used an advanced intercross of the LG/J and SM/J inbred mouse strains to unravel the genetic architecture of multiple metabolic traits. These studies found that parent-of-origin …
The Art Of Amphibian Conservation: Linking In-Situ And Ex-Situ Populations Of Endangered Species Through Genome Banking,
2021
Mississippi State University
The Art Of Amphibian Conservation: Linking In-Situ And Ex-Situ Populations Of Endangered Species Through Genome Banking, Isabella Joann Burger
Theses and Dissertations
Limited breeding success in captive breeding programs has necessitated the development of assisted reproductive technologies (ART) to preserve and increase genetic variation and population numbers of both captive and wild amphibian groups. ART has been shown to be successful in numerous anuran species, and current studies focus on the application of ART in ex-situ populations. The focus of this project is to show that linking in-situ and ex-situ amphibian populations through sperm cryopreservation, genome banking, and in-vitro fertilization is possible, with the goal of increasing gene diversity throughout groups in order to produce self-sustaining, wild populations in the future. Specific …
Relationship Of Winter Hair Coat Shedding Ability Of Purebred Angus Dams With Mineral Status, Apparent Forage Digestibility, Uterine Artery Hemodynamics, And Calf Growth And Development,
2021
Mississippi State University
Relationship Of Winter Hair Coat Shedding Ability Of Purebred Angus Dams With Mineral Status, Apparent Forage Digestibility, Uterine Artery Hemodynamics, And Calf Growth And Development, Randy Hunter Burnett
Theses and Dissertations
Winter hair coat shedding ability in southern U.S. cattle production has previously been associated with differences in adjusted birth and weaning weights of calves from dams that shed by June or later (Gray et al., 2011; Cauble et al., 2019). This study was developed to research possible avenues of why these relationships exist with winter hair coat shedding ability. The primary objectives of the following experiments were to: 1) evaluate how mineral status relates to winter hair coat shedding ability, 2) evaluate how winter hair coat shedding ability relates to apparent digestibility of forage, 3) evaluate winter hair coat shedding …
Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy,
2021
University of Kentucky
Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan J. Vechetti Jr.
Physiology Faculty Publications
Many of the molecular and cellular mechanisms discovered to regulate skeletal muscle hypertrophy were first identified using the rodent synergist ablation model. This model reveals the intrinsic capability and necessary pathways of skeletal muscle growth in response to mechanical overload (MOV). Reminiscent of the rapid cellular growth observed with cancer, we hypothesized that in response to MOV, skeletal muscle would undergo metabolic programming to sustain increased demands to support hypertrophy. To test this hypothesis, we analyzed the gene expression of specific metabolic pathways taken from transcriptomic microarray data of a MOV time course. We found an upregulation of genes involved …
Alterations In Glycemic Variability, Vascular Health, And Oxidative Stress Following A 12-Week Aerobic Exercise Intervention-A Pilot Study,
2021
Pennington Biomedical Research Center
Alterations In Glycemic Variability, Vascular Health, And Oxidative Stress Following A 12-Week Aerobic Exercise Intervention-A Pilot Study, Joshua R. Sparks, Mark A. Sarzynski, J. Mark Davis, Peter W. Grandjean, Xuewen Wang
International Journal of Exercise Science
International Journal of Exercise Science 14(3): 1334-1353, 2021. The state of being overweight or obese leads to an increased risk of development of cardiometabolic disease. Increases in glycemic variability have been associated with greater induction of oxidative stress and declined vascular health, which may be exacerbated by higher weight status and improved through exercise. The purpose of this study was to examine the impact of a twelve-week aerobic exercise intervention on continuous glucose monitor (CGM) assessed glucose concentrations and glycemic variability, and biomarkers of vascular health and oxidative stress in overweight or obese adults. Eight adults (Age = 48.9 ± …
Acute Changes In Arterial Function Post High-Intensity Lower Extremity Cycling,
2021
University of Southern Indiana
Acute Changes In Arterial Function Post High-Intensity Lower Extremity Cycling, Alyssa Weatherholt, William R. Vanwye, Jeffery L. Short, Alyssa A. Andreis, Guoyuan Huang
International Journal of Exercise Science
International Journal of Exercise Science 14(2): 1363-1374, 2021. The purpose of this study was to assess the acute arterial blood flow velocity of the lower extremity (LE) immediately after a bout of high-intensity LE cycling exercise. Twenty-eight healthy males (n = 14) and females (n = 14) aged 20.9 ± 1.7 years participated in this study. All subjects performed a single bout of high-intensity cycling (70% of HRR) for 45 min. The subjects' LE blood flow velocity, heart rate (HR), systolic blood pressure (SBP), and oxygen saturation (SpO2) were measured at rest, immediately post-, post-15 min., …
Remote Ischemic Preconditioning Does Not Improve The Six Minutes Walk Test Performance In Chronic Heart Failure Patients: A Randomised Pilot Trial,
2021
University of Quebec in Montreal
Remote Ischemic Preconditioning Does Not Improve The Six Minutes Walk Test Performance In Chronic Heart Failure Patients: A Randomised Pilot Trial, Sarah-Maude Martin, Francois Lalonde, Elise Legault, Paula Ribeiro, Alain Steve Comtois, François Tournoux
International Journal of Exercise Science
International Journal of Exercise Science 14(2): 1354-1362, 2021. Cycles of ischemia and reperfusion induced with a pressure cuff on a skeletal muscle, also know as remote ischemic preconditioning (RIPC), appears to improve performance in different time-trial events in healthy individuals. Our primary goal was to assess the effect of RIPC in heart failure (HF) patients’ functional capacity using the six-minute walk test (6MWT). A randomized crossover design comparing RIPC (4 x five-minutes of upper arm ischemia) to the SHAM procedure was done in 15 patients prior to a 6MWT. The primary outcome measure was the total distance walked in a …
Ketone Body Metabolism In The Ischemic Heart,
2021
Ursinus College
Ketone Body Metabolism In The Ischemic Heart, Stephen C. Kolwicz Jr.
Health Sciences Faculty Publications
Ketone bodies have been identified as an important, alternative fuel source in heart failure. In addition, the use of ketone bodies as a fuel source has been suggested to be a potential ergogenic aid for endurance exercise performance. These findings have certainly renewed interest in the use of ketogenic diets and exogenous supplementation in an effort to improve overall health and disease. However, given the prevalence of ischemic heart disease and myocardial infarctions, these strategies may not be ideal for individuals with coronary artery disease. Although research studies have clearly defined changes in fatty acid and glucose metabolism during ischemia …
Lactose Intolerance: The Comic,
2021
Illinois Mathematics and Science Academy
Lactose Intolerance: The Comic, Natali Chung '22, Apurva Reddy '22
Human Diseases Graphic Novels
No abstract provided.
Will Power,
2021
Illinois Mathematics and Science Academy
Will Power, Piere Joyner '23, Andrew Zhang '22, Ethan Brazelton '22, Akhil Vytla '22
Human Diseases Graphic Novels
No abstract provided.
Bobby And Marv: The Asthma Attack,
2021
Illinois Mathematics and Science Academy
Bobby And Marv: The Asthma Attack, Vidhi Shah '23, Joanna Menendie '22
Human Diseases Graphic Novels
No abstract provided.
The Misadventures Of Dirty Dan,
2021
Illinois Mathematics and Science Academy Academy
The Misadventures Of Dirty Dan, Ethan Brazelton '22, Akhil Vytla '22, Andrew Zhang '22, Piere Joyner '23
Human Diseases Graphic Novels
No abstract provided.
Chronic Bronchitis,
2021
Illinois Mathematics and Science Academy
Chronic Bronchitis, Siddharth Tiwari '22, Edward Ning '23, Avery Hedican '23
Human Diseases Graphic Novels
No abstract provided.
Acute Consumption Of A Sugar-Sweetened Beverage Impairs Microvascular Function In Midwestern Hispanic Males,
2021
University of Dayton
Acute Consumption Of A Sugar-Sweetened Beverage Impairs Microvascular Function In Midwestern Hispanic Males, Emma Hirshman, Anne R. Crecelius
Health and Sport Science Faculty Publications
Hispanic males are at risk for cardiovascular disease and consume high levels of sugar-sweetened beverages (SSB); yet, their acute vascular response to SSBs is unknown. Ten healthy Hispanic men (18-45 years old) consumed a SSB and reactive hyperemia was performed prior to, immediately following, and 1-hr post-consumption. Both peak and total (area under the curve) forearm blood flow were attenuated immediately following consumption but returned to at or above pre-consumption levels at the 1-hr test.
Osmr Signaling Induces Tamp-Specific Bbb Dysfunction Following Autoimmune-Mediated Neutrophil Recruitment,
2021
Boise State University
Osmr Signaling Induces Tamp-Specific Bbb Dysfunction Following Autoimmune-Mediated Neutrophil Recruitment, Travis Scott Wertz
Boise State University Theses and Dissertations
Integrity of the brain microvessels that form the blood-brain barrier (BBB) is maintained through fine-tuned regulation of endothelial tight junction proteins, chiefly represented by claudin 5 and the tight junction-associated MARVEL protein (TAMP) occludin. Under proinflammatory conditions in autoimmune-mediated multiple sclerosis (MS), autoreactive effector T cells are activated in white matter regions of the brain and spinal cord and release cytokines to recruit circulating neutrophils that, in turn, release neurotoxic substances. Lack of tight junctions in peripheral blood vessels allows neutrophils to exit blood vessels unhindered, but BBB tight junctions must first be downregulated before neutrophils can transmigrate into the …
Effects Of Maternal And Neonatal Hypoxia On The Future Life History Of Daphnia Magna,
2021
East Tennessee State University
Effects Of Maternal And Neonatal Hypoxia On The Future Life History Of Daphnia Magna, Rachael Lowman
Undergraduate Honors Theses
Early exposure to hypoxia is related to a variety of physiological and metabolic changes that have lasting effects on organisms’ physiology and life history. We measured the effects of maternal and embryonic mild, intermittent hypoxia on the life history of four clones of microcrustacean Daphnia magna, an emerging model organism for the studies of senescence and longevity. Daphnia individuals were produced parthenogenically, maintained in individual vials, and fed standard algal concentration daily. The cohort consisted of 189 individuals. We measured body size at first reproduction, fecundity (including late-life fecundity peak), offspring sex ratio, and longevity. We found no effect …
The Impact Of Muscular Strength On Cardiovascular Disease Risk Factors,
2021
Old Dominion University
The Impact Of Muscular Strength On Cardiovascular Disease Risk Factors, Joel Ernest Harden
Human Movement Studies & Special Education Theses & Dissertations
The purpose of this study was to determine the associations between isokinetic leg muscular strength and cardiovascular disease (CVD) risk factor characterizations in Americans aged 50 and older. Using a publicly available dataset from the National Health and Nutrition Examination Survey (NHANES), a secondary analysis was conducted on participants (males ≥50 yrs; females ≥55 yrs; N=10,858) pooled from 1999 to 2002. CVD risk factors were determined using the American College of Sports Medicine (ACSM) cutoff values, with all nine ACSM risk factors analyzed. CVD risk factor characterization was determined by creating CVD risk factor profiles (i.e., the total number of …
Effects Of Varying Warmup Stimuli On Running Economy,
2021
Stephen F Austin State University
Effects Of Varying Warmup Stimuli On Running Economy, Connor Bigenho
Electronic Theses and Dissertations
Purpose: The purpose of this study was to determine the effects of two potentiating warm-up stimuli (weighted-vest strides and plyometrics) on running economy (RE) over short (5-10 minutes) and longer durations (30+ minutes) of exercise in trained distance runners. Methods: Five recreationally trained male runners were recruited to participate in this study. Each trial consisted of a 10-min self-paced warm-up on the treadmill followed by baseline RE test and baseline leg-stiffness. This was immediately followed by one of two intervention warmup protocols. The protocols consisted of either a series of plyometric movements, 6 x 10-sec strides with a …
Role Of Meibum And Tear Phospholipids In The Evaporative Water Loss Associated With Dry Eye.,
2021
University of Louisville
Role Of Meibum And Tear Phospholipids In The Evaporative Water Loss Associated With Dry Eye., Samiyyah M. Sledge
Electronic Theses and Dissertations
It is generally believed that the tear film lipid surface film inhibits the rate of evaporation (Revap) of the underlying tear aqueous. It is also generally believed that changes in the composition of the tear film lipid layer is responsible for an increase in Revap in patients with dry eye. Both of these ideas have never been proven. The purpose of the current studies was to test these ideas. Revap was measured in vitro gravimetrically. Lipid spreading was measured using Raman spectroscopy and microscopy. The influence of the following surface films on the Revap of the sub phase of physiologically …
Genome-Wide Analyses Of Genomic Variation Regulating Differential Stress Responses In Japanese Quail,
2021
University of Arkansas, Fayetteville
Genome-Wide Analyses Of Genomic Variation Regulating Differential Stress Responses In Japanese Quail, Steven Anthony Shumaker
Graduate Theses and Dissertations
As consumer demands for poultry grow, producers work to improve bird productivity in both meat and egg production. This endeavor is multifaceted, as many different factors play a part in influencing the productivity of birds, including environmental conditions, overall health, and genetic potential. One aspect controlled for in all aspects of poultry production optimization is stress management. Mitigation of stress is of primary concern to producers, as improper stress management can have many deleterious effects on chickens. Stress management requires an understanding of poultry stress responses and their physiological mechanisms, which can be more deeply understood through genomic analysis. Chapter …
