Pyridine Nucleotide Redox Potential In Coronary Smooth Muscle Couples Myocardial Blood Flow To Cardiac Metabolism.,
2021
University of Louisville
Pyridine Nucleotide Redox Potential In Coronary Smooth Muscle Couples Myocardial Blood Flow To Cardiac Metabolism., Marc Matthew Dwenger
Electronic Theses and Dissertations
The maintenance of myocardial oxygen supply during stress is essential for sustaining cardiac health. Enhancement of coronary blood flow upon increases in myocardial oxygen demand (i.e., hyperemia) relies on regulation of voltage-gated K+ (Kv) channels by their intracellular β subunits (i.e., Kvβ proteins). Considering that, Kvβ proteins are aldo-keto reductases (AKRs) and regulate Kv channel gating, we tested the hypothesis that elevation of myocardial oxygen demand modifies intracellular NAD(H) in arterial myocytes. Furthermore, we tested whether the resultant change in the redox state of the pyridine nucleotide pool directly regulates coronary Kv1 channel activity. High-resolution imaging mass spectrometry and …
Role Of Ataxia Telangiectasia Mutated Kinase In Western-Type Diet-Induced Cardiac Outcomes Under Basal And Ischemic Conditions,
2021
East Tennessee State University
Role Of Ataxia Telangiectasia Mutated Kinase In Western-Type Diet-Induced Cardiac Outcomes Under Basal And Ischemic Conditions, Mary Wingard
Electronic Theses and Dissertations
Ataxia-telangiectasia mutated kinase (ATM), a serine/threonine kinase, plays a role in DNA damage repair, redox sensing, and metabolism. In the heart, ATM contributes significantly in the myocardial infarction (MI)-induced cardiac remodeling with effects on fibrosis, hypertrophy, apoptosis and inflammation. This study investigates the role of ATM deficiency in 14 weeks Western-type diet (WD)-induced cardiac outcomes prior to and 1-day post-MI in a sex-specific manner using wild-type (WT) and ATM heterozygous knockout (hKO) mice. In male mice, ATM deficiency induced rapid body weight gain and preload-associated dysfunction, while WT mice displayed afterload-associated dysfunction 14 weeks post-WD. Myocyte apoptosis and hypertrophy were …
Effects Of Exogenous Ketone Therapy On Performance, Cardiorespiration, And Seizure Genesis During Exposure To Hbo2 In The Sprague Dawley Rat,
2021
University of South Florida
Effects Of Exogenous Ketone Therapy On Performance, Cardiorespiration, And Seizure Genesis During Exposure To Hbo2 In The Sprague Dawley Rat, Nicole M. Stavitzski
USF Tampa Graduate Theses and Dissertations
Hyperbaric oxygen (HBO2) is used for clinical HBO2 therapy and in undersea and aerospace medicine. HBO2 is a humanmade extreme environment and protracted exposures can cause several adverse physiological effects on the body. For example, HBO2 increases the partial pressure of oxygen (PO2) in the body leading to redox stress. Redox stress is, in part, a cause of oxygen toxicity that manifests as seizures in its most severe form (central nervous system oxygen toxicity, CNS-OT). This dissertation focuses on strategies to be employed specifically for the warfighter breathing HBO2. Currently, the only way to prevent CNS-OT is to lower the …
Rapid And Direct Action Of Lipopolysaccharide (Lps) On Skeletal Muscle Of Larval Drosophila,
2021
University of Kentucky
Rapid And Direct Action Of Lipopolysaccharide (Lps) On Skeletal Muscle Of Larval Drosophila, Rachel Potter, Alexis Meade, Samuel Potter, Robin L. Cooper
Biology Faculty Publications
The endotoxin lipopolysaccharide (LPS) from Gram-negative bacteria exerts a direct and rapid effect on tissues. While most attention is given to the downstream actions of the immune system in response to LPS, this study focuses on the direct actions of LPS on skeletal muscle in Drosophila melanogaster. It was noted in earlier studies that the membrane potential rapidly hyperpolarizes in a dose-dependent manner with exposure to LPS from Pseudomonas aeruginosa and Serratia marcescens. The response is transitory while exposed to LPS, and the effect does not appear to be due to calcium-activated potassium channels, activated nitric oxide synthase …
Boosting Brain Waves Improves Memory,
2021
Florida Institute of Technology - Melbourne
Boosting Brain Waves Improves Memory, Richard J. Addante, Mairy Yousif, Rosemarie Valencia, Constance Greenwood, Raechel Marino
Psychology Student Publications
Have you ever wanted to improve your memory? Or have you struggled to remember what you studied? Memory uses special patterns of activity in the brain. This experiment tested a new way to create brain wave patterns that help with memory. We wanted to see if we could improve memory by using lights and sounds that teach the brain waves to be in sync. People wore special goggles that made flashes of light and headphones that made beeping noises. This trained the brain through a process called entrainment. The entrainment put the brain in sync at a specific brain wave …
Physiological, Musculoskeletal & Anthropometric Characteristics & Performance Between Competitive & Recreational Surfers: A Scoping Review,
2021
Bond University
Physiological, Musculoskeletal & Anthropometric Characteristics & Performance Between Competitive & Recreational Surfers: A Scoping Review, Harrison Stone, Lucy Douglas, James Furness, Kevin Kemp-Smith, Mike Climstein, Sean Newcomer
International Journal of Exercise Science
International Journal of Exercise Science 14(6): 1277-1293, 2021. Surfing is the ability to ride a surfboard along the unbroken section, wall or face of a wave, as it moves closer towards the shore. The purpose of this review is to provide an overview of the physiological, musculoskeletal and anthropometric characteristics that can differentiate between paddling and wave riding performance in competitive and recreational surfing populations. The eligibility criteria for this scoping review included articles that distinguished between multiple surfing ability groups, identified physiological, musculoskeletal or anthropometric characteristics, were peer reviewed, and directly related to the sport of surfing. The databases …
Impact Of Social Support On The Physical Activity Behaviors Of International College Students In The United States,
2021
Al-Baha University, Saudi Arabia
Impact Of Social Support On The Physical Activity Behaviors Of International College Students In The United States, Mohammed A. Alshehri, Aaron Kruse-Diehr, Justin Tyler Mcdaniel, Julie Partridge, Dawn Christina Null
International Journal of Exercise Science
International Journal of Exercise Science 14(5): 1305-1319, 2021. Research has suggested that international students’ transition to the United States is often correlated with less physical activity after arriving in the U.S). One reason might be related to reduced social support when living in a foreign environment. The purpose of this cross-sectional study was to assess the impact of social support on international college students’ physical activity behaviors. Participants (N = 318) from five public universities in one Midwest state completed an electronic survey assessing self-reported physical activity behaviors and perceived social support for exercise (SSE). Data analyses included multiple …
Tactical Circuit Training Improves Blood Pressure And Vascular Health More Than Resistance Training,
2021
Drexel University
Tactical Circuit Training Improves Blood Pressure And Vascular Health More Than Resistance Training, Kelly C. Mclaughlin, Avery N. Perez, Stephanie Donahue, Deborah L. Feairheller
International Journal of Exercise Science
International Journal of Exercise Science 14(3): 1320-1333, 2021. Exercise training is known to reduce CVD risk factors; however, in tactical populations, like veterans and firefighters, the effects of different forms of exercise such as tactical circuit training (CT) or conventional resistance training (RT) is unclear. Thus, the purpose of this study was to compare changes in various CVD risk measures after 4-week tactical CT or RT programs. Thirty-seven firefighters (20 CT, 17 RT), 35% of whom were veterans, participated. Pre- and post-intervention measures included body fat (BF%), carotid artery intima media thickness (IMT), central and brachial BP, and indices of …
Exercise Variability Did Not Affect Muscle Thickness And Peak Force For Elbow Flexors After A Resistance Training Session In Recreationally-Trained Subjects,
2021
California State University, Northridge
Exercise Variability Did Not Affect Muscle Thickness And Peak Force For Elbow Flexors After A Resistance Training Session In Recreationally-Trained Subjects, Ethan Smith, Andre Sepulveda, Vincent G.F. Martinez, Ashley Samaniego, Priscyla N. Marchetti, Paulo H. Marchetti
International Journal of Exercise Science
International Journal of Exercise Science 14(3): 1294-1304, 2021. The purpose of this study is to measure the acute effects of exercise variability on muscle thickness and physical performance after two resistance training (RT) protocols using the same or different exercises in recreationally-trained subjects. Fifteen resistance-trained men (23.1 ± 2.6 years, 83.4 ± 16.6 kg, 173.5 ± 8.3cm) performed one of two RT protocols: SINGLE: six sets of 10RM/two-minutes rest of the unilateral biceps curl exercise using cables or MIX: six sets of 10RM/two-minutes rest for the unilateral biceps curl exercises (cable: three sets and dumbbells: three sets, randomly). Muscle thickness …
Isometric Exercise Training: A Review Of Hypothesized Mechanisms And Protocol Application In Persons With Hypertension,
2021
Smith College
Isometric Exercise Training: A Review Of Hypothesized Mechanisms And Protocol Application In Persons With Hypertension, Jacquelyn Rickson, Stephen A. Maris, Samuel A.E. Headley
International Journal of Exercise Science
International Journal of Exercise Science 14(2): 1261-1276, 2021. According to the American Heart Association 116.4 million, or 46% of US adults are estimated to have hypertension. Although, traditional moderate intensity aerobic exercise training is associated with reducing blood pressure by 5-8 mmHg, barriers to this modality of exercise training exist. Thus, the purpose of this review is to evaluate the mechanisms and incorporation of isometric exercise training (IET) as an adjunctive mode of exercise in a population with HTN. Based upon the articles reviewed from the years 2000-2020 which incorporated IET and provided clear protocols lasting 4 or more weeks, …
One Step At A Time: Robotics Lab Team Combines Talents In Quest For The Perfect Synthetic Tendon,
2021
Colby College
One Step At A Time: Robotics Lab Team Combines Talents In Quest For The Perfect Synthetic Tendon, Laura Meader
Colby Magazine
When Caitrin Eaton arrived at Colby a year ago, she named her new robotics lab C3PO. The name grabs students’ attention, but they’re drawn to the lab for another reason: Eaton’s cutting-edge research unites engineering and animal physiology to help robots walk more smoothly than Hollywood’s stiff-legged C-3PO robot.
Race And Drug Toxicity: A Study Of Three Cardiovascular Drugs With Strong Pharmacogenetic Recommendations.,
2021
George Washington University
Race And Drug Toxicity: A Study Of Three Cardiovascular Drugs With Strong Pharmacogenetic Recommendations., Travis J. O'Brien, Kevin Fenton, Alfateh Sidahmed, April Barbour, Arthur F Harralson
Pharmacology and Physiology Faculty Publications
No abstract provided.
Effect Of Estrogen Pretreatment On Glial-Like Cell Viability Following Stress Response Hormone Treatment,
2021
Columbus State University
Effect Of Estrogen Pretreatment On Glial-Like Cell Viability Following Stress Response Hormone Treatment, Bridget N. Smith, Kevin S. Burgess, Kathleen S. Hughes
Georgia Journal of Science
The role of steroid hormones is critical in cellular function. Previous studies have found a positive correlation between the endogenous estrogen 17β-estradiol and cellular protection. Conversely, exogenous conjugated equine estrogens provide less protective mechanisms than endogenous hormones, and little is known about the role of estrogens in cellular protection during a stress response. In the present study, we compare the effects of short-term estrogen pretreatments (alone and in combination) on cell viability when cells with glial cell morphology are exposed to either epinephrine or cortisol. Results showed that 1 µM 17β-estradiol resulted in decreased cell viability following the epinephrine treatment; …
Adult Spiny Mice (Acomys) Exhibit Endogenous Cardiac Recovery In Response To Myocardial Infarction,
2021
University of Kentucky
Adult Spiny Mice (Acomys) Exhibit Endogenous Cardiac Recovery In Response To Myocardial Infarction, Hsuan Peng, Kazuhiro Shindo, Renée R. Donahue, Erhe Gao, Brooke M. Ahern, Bryana M. Levitan, Himi Tripathi, David Powell, Ahmed Noor, Garrett A. Elmore, Jonathan Satin, Ashley W. Seifert, Ahmed K. Abdel-Latif
Physiology Faculty Publications
Complex tissue regeneration is extremely rare among adult mammals. An exception, however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While Acomys species exhibit the remarkable ability to heal complex tissue with minimal scarring, little is known about their cardiac structure and response to cardiac injury. In this study, we first examined baseline Acomys cardiac anatomy and function in comparison with commonly used inbred and outbred laboratory Mus strains (C57BL6 and CFW). While our results demonstrated comparable cardiac anatomy and function between Acomys and Mus, Acomys exhibited a higher percentage of cardiomyocytes displaying …
Editorial: Perturbations In Metabolic Cues: Implications For Adverse Cardiac Function Leading To Sudden Cardiac Death,
2021
University of Kentucky
Editorial: Perturbations In Metabolic Cues: Implications For Adverse Cardiac Function Leading To Sudden Cardiac Death, Brian P. Delisle, Ademuyiwa S. Aromolaran
Physiology Faculty Publications
No abstract provided.
Moving In Fluid: Exploring How Fishes Manipulate Water To Swim Efficiently,
2021
University of South Florida
Moving In Fluid: Exploring How Fishes Manipulate Water To Swim Efficiently, Nils B. Tack
USF Tampa Graduate Theses and Dissertations
Moving through a dense fluid such as water presents some unique challenges to minimizing energy use and maximizing performance (i.e., speed). Due to animal-fluid interactions during swimming (drag and thrust production) fish have evolved a variety of morphological structures and locomotor mechanisms. For instance, fish rely on body bending and/or fins to interact with the surrounding water such that energy can be transferred to generate thrust. Typically, this synergy promotes morphologies and behaviors aimed at enhancing propulsive efficiency and/or minimizing metabolic activity to lessen the cost of transport (COT). This work focuses on quantifying the energetic and hydromechanical benefits of …
Fibroblast Growth Factor 19 Increases The Excitability Of Pre-Motor Glutamatergic Dorsal Vagal Complex Neurons From Hyperglycemic Mice,
2021
University of Kentucky
Fibroblast Growth Factor 19 Increases The Excitability Of Pre-Motor Glutamatergic Dorsal Vagal Complex Neurons From Hyperglycemic Mice, Jordan B. Wean, Bret N. Smith
Physiology Faculty Publications
Intracerebroventricular administration of the protein hormone fibroblast growth factor 19 (FGF19) to the hindbrain produces potent antidiabetic effects in hyperglycemic mice that are likely mediated through a vagal parasympathetic mechanism. FGF19 increases the synaptic excitability of parasympathetic motor neurons in the dorsal motor nucleus of the vagus (DMV) from hyperglycemic, but not normoglycemic, mice but the source of this synaptic input is unknown. Neurons in the area postrema (AP) and nucleus tractus solitarius (NTS) express high levels of FGF receptors and exert glutamatergic control over the DMV. This study tested the hypothesis that FGF19 increases glutamate release in the DMV …
Editorial: Recent Advances In Cardiotoxicity Testing,
2021
University of Louisville
Editorial: Recent Advances In Cardiotoxicity Testing, Tamer M. A. Mohamed, Javid Moslehi, Jonathan Satin
Physiology Faculty Publications
No abstract provided.
Scaling Of Computed Tomography Body Composition To Height: Relevance Of Height-Normalized Indices In Patients With Colorectal Cancer,
2021
LSU Health Sciences Center - New Orleans
Scaling Of Computed Tomography Body Composition To Height: Relevance Of Height-Normalized Indices In Patients With Colorectal Cancer, Justin C. Brown, Steven B. Heymsfield, Bette J. Caan
School of Medicine Faculty Publications
Background: Body weight scales to height with a power of ≈2 (weight/height2), forming the basis of body mass index (BMI). The corresponding scaling of body composition measured by abdominal computed tomography (CT) to height has not been established. The objective of this analysis was to quantify the scaling of body composition measured by a single-slice axial abdominal CT image (skeletal muscle, and visceral, subcutaneous, and total adipose tissue) to height in patients with colorectal cancer (CRC). Methods: This cross-sectional study included non-Hispanic white males and females, aged 18–80 years, who were diagnosed with stage I–III CRC at an integrated health …
Editorial: The Metabolism Of The Neuron-Glia Unit,
2021
Albany Medical College
Editorial: The Metabolism Of The Neuron-Glia Unit, Yannick Poitelon, Lance A. Johnson, Marie-Ève Tremblay
Physiology Faculty Publications
No abstract provided.
