Neuroscience and Neurobiology Commons^™

Designing For The Brain: Neuroarchitecture, Isabella Schutte

Hospitality Design Graduate Student Capstones

This capstone explores how principles from neuroscience can inform the design of micro-scale architectural environments to support emotional well-being and cognitive clarity. Through research, sensory analysis, immersive VR testing, and physiological and perceptual data collection, the project investigates how elements such as light, materiality, form, and atmosphere influence human experience. By comparing existing, aesthetic, and neuroscience-informed environments, the study suggests that intentional sensory design may better support restoration, stress regulation, and overall well-being within everyday spaces.

Postural And Load Dependent Modulation Of Lower Limb H-Reflex Excitability After Stroke, Daniel Bamiro, Matthew Berdiago, Ethan Hunter, Tia Nguyen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis

Leg stiffness is regulated by reflexive, intrinsic, and passive mechanisms, which are influenced by posture, body weight loading, and motor task demands. After a stroke, the capacity to modulate these mechanisms is often compromised. The H-reflex is a widely used electrophysiological tool to assess the excitability of the Ia afferent pathway within spinal circuitry. Although prior studies in healthy individuals have examined limb loading effects, results have been variable, and the role of postural and loading changes during standing remains underexplored, particularly in individuals post-stroke. This study investigated how different postural and limb loading conditions, specifically prone, standing, and …

Effectiveness Of Cognitive Stimulation Therapy On The Quality Of Life Of Adults With Dementia: A Secondary Analysis, Evelyn Airam

UNLV Theses, Dissertations, Professional Papers, and Capstones

This secondary analysis study evaluated the effectiveness of Cognitive Stimulation Therapy (CST) on quality of life (QoL), depressive symptoms, and cognitive function in 108 community-dwelling older adults with cognitive impairments, including dementia. Outcomes involved Quality of Life (QoL) measured by the Quality of Life in Alzheimer’s Disease (QoL-AD), symptoms of depression by the Cornell Scale for Depression in Dementia (CSDD), and cognitive function using the Saint Louis University Mental Status (SLUMS). After the CST, significant improvements were observed in QoL (p = .004), depressive symptoms (p = .002), and cognitive function (p < .001), with small effect sizes. Additionally, a significant interaction between sex and dementia diagnosis status was found in predicting cognitive changes, suggesting that the relationship between dementia diagnosis and cognitive improvement differs by sex. No between-group differences were found for QoL or depression. Findings support CST as a multidimensional, non-pharmacological intervention that improves cognitive, psychological, and social outcomes. Although effects were small, consistent improvements are clinically meaningful given the progressive nature of dementia. This study extends existing literature by demonstrating CST’s effectiveness in a community-based setting and reinforces its alignment with occupational therapy’s emphasis on participation and holistic care. Results highlight the need for early intervention and expanded access to CST programs to enhance quality of life in this population.

Delineating Differences In Firing Rate Estimates Of Healthy And Parkinsonian Single-Unit Basal Ganglia Recordings, Richard R. Foster, Cheng Ly

Biology and Medicine Through Mathematics Conference

No abstract provided.

Gap Junction Architecture And Synchronization Clusters In The Thalamic Reticular Nuclei, Alex Norwood

Biology and Medicine Through Mathematics Conference

No abstract provided.

Understanding Behavioral And Representational Divergences Of Humans And Machines, Thomas Lasman Botch

Dartmouth College Ph.D Dissertations

Human behavior and cognition are strikingly variable: people differ from one another in their preferences and abilities, and even from themselves across situations. Yet this diversity arises from common neural machinery shaped by the complex environments humans inhabit. A central objective of cognitive neuroscience is to understand how this varied experience emerges from interactions between brains, agents, and environments. In this dissertation, I argue that comparing behavior and neural computation across humans, artificial systems, and contexts is essential for understanding the flexibility of human cognition. Across three chapters, I use this comparative approach to examine how the rich, multimodal contexts …

The Brain Breakdown: Bringing Neuroscience To A Broader Audience, Katharine Buehrig

Undergraduate Honors Theses

Neuroscience is a rapidly growing field, which needs to continue becoming more accessible and understandable to younger generations. Expanding access to neuroscience through different modes, such as podcasts, brings the discipline to a broader audience. Podcasts allow listeners to follow an outlined learning path they can pursue on their personal timeline. High school students often do not have access to neuroscience specific materials within their standard science curriculum. To address this knowledge gap, I collected questions about neuroscience from high school students across four schools in the United States to develop an understanding about what they are interested in learning. …

The Legacy Of Lead: Lead Exposure's Harmful Effects And Its Concentration In Poc Communities, Layla Sophronia Barber

Student Theses 2015-Present

This thesis examines the disproportionate burden of lead exposure carried by low income, POC communities. The systemic nature of this problem is a symptom of a longstanding legacy of environmental injustice in the United States. Decades of federal neglect are reflected in the higher statistics of lead exposure and poisoning in predominantly black communities. While it is understood that lead exposure poses a serious threat to physical health and early cognitive development, there is a discouraging lack of urgency to remove the toxin from non-wealthy communities. The material covered by this thesis aims to identify and correct the discriminatory social …

Neurophysiological Signatures Of Perceived Control In The Human Brain: An Electroencephalography Study, Megan Staehling

Honors Theses

Perceived control is defined as the belief that one’s actions can influence the outcomes in the environment. It plays an important role in decision-making, motivation, and emotional regulation. Previous studies suggest that perceived control shapes how the brain processes both reward and punishment stimuli. However, the neural mechanisms underlying this process are still unclear. The present study examined the neurophysiological correlates of perceived control during a decision-making task. Electroencephalography (EEG) was used to record the neural activity of twenty-nine undergraduate students while they completed the Choice Task. Participants associated visual cues with different levels of control over trials involving monetary …

From Stranger To Self: The Role Of Familiarity In Modulating The N170 And N250 Erp Components, Tabish Gul

Dissertations

This study investigated how varying levels of face familiarity modulate the N170 and N250 event-related potential (ERP) components, two neural markers of face perception and recognition. While the N250 is widely considered familiarity-sensitive, the N170 has traditionally been linked to the structural encoding stage of face perception. However, recent research suggests that face familiarity may also influence N170 amplitude and latency. While most previous studies have compared up to three familiarity levels, the present study examined five levels of familiarity: own face, friend’s face, famous face, experimentally familiar face, and unfamiliar face. Twenty-six participants viewed face images while completing a …

Neuroprotective Effects Of Estradiol And Genistein And Interactions With Aromatase Inhibitions Post Cerebellar Lesion In Male Zebra Finches, Grace E. Thompson, Anthony P. Irovic

Honors Theses

Across vertebrates, peripheral and brain-derived estradiol (E₂) promotes neuroplasticity. After injury, E₂ can be derived locally from testosterone via aromatase (AROM), an enzyme that is upregulated in glia at the site of neural injury. E₂disrupts testicular function and elevates cancer and stroke risk, primarily via binding to estrogen receptor alpha (ER α). Genistein (GEN), a phytoestrogen, is similar to E₂ but binds preferentially to estrogen receptor beta (ER β). It may offer neuroprotection without adverse effects of E₂. We used adult male zebra finches (ZF) to model neuroprotective effects of E_{2 …}

Invisible Shipwrecks And Neurological Endangerment: The Trade-Off In Seeking Asylum - Reframing The Neurobiological Cost Of Forced Migration, Eisha Giran

CISLA Senior Integrative Projects

Forced migration along the Spain–Morocco route represents one of the most visible humanitarian crises of the twenty-first century, yet its neurological dimensions remain insufficiently examined. This paper investigates how prolonged displacement and trauma reshape neural systems involved in stress regulation, memory, and emotional processing. It introduces the concept of neurological endangerment, defined as a condition of prolonged and inescapable threat exposure during forced migration in which stress-response systems remain chronically activated, opportunities for recovery are structurally constrained, and cumulative neurobiological risk persists beyond the period of immediate danger.

To address the gap between biological measurement and lived experience, this paper …

Neural Mechanisms Underlying Jung’S Active Imagination: A Review And Hypothesis, Charles R. Fox

Journal of Conscious Evolution

Active imagination is a key technique of Jungian analysis. Despite its centrality, and its potential importance beyond Jungian psychology to the area of systems neuroscience, psychology, and consciousness studies, there are no known neurological mechanisms underlying this psychological phenomenon. There is a history of using the types of mental imagery used in active imagination to explore consciousness. The development and use of active imagination is briefly reviewed, and a case is developed that the neurology underlying active imagination would be fruitfully explored by considering it a special case of mystical experience. Active imagination primarily uses the right hemisphere processing of …

Stromal Interaction Molecule (Stim) Proteins In Microglia And The Impact On Store-Operated Calcium Entry (Soce) And Spinal Cord Injury Recovery, Norah G. Hill

College of Arts & Sciences Senior Theses

In spinal cord injury (SCI), worsening functional outcomes are largely because of secondary injury processes and prolonged chronic inflammation. A major contributor of secondary injury is overload of intracellular calcium, causing neuronal overexcitation and persistent inflammatory responses. One of the primary mediators of calcium entry into the cell is store-operated calcium entry (SOCE). In SOCE, sensors detecting calcium depletion from the endoplasmic reticulum stores are called STIM proteins (1-2). When calcium is low in the cell, STIM proteins will activate Orai channels to open, allowing for the influx of calcium into the cell. The purpose of this study was to …

The Influence Of Valence On Action Control: A Comparison Of Simon Effects In The Extrinsic Affective Simon Task (East) And The Spatial Simon Task, Yaara Aleissa

College of Arts & Sciences Senior Theses

People adjust their thoughts and actions in response to a changing environment every day and emotions may influence these actions. Understanding how emotion impacts action control in situations where emotion is central to the action (task-relevant) compared to when it is present in the environment as distracting information (task-irrelevant) is essential. Currently it is unclear when emotion most significantly modulates action control. This study seeks to compare how valence (positive versus negative emotion) impacts action control performance when valence is task-relevant and task-irrelevant by using two modified versions of the Simon conflict task.

The Simon task is a paradigm to …

Beat Behind The Bark: Investigating The Effects Of Music Tempo On Canine Physiological And Psychological States, Marley Lanier

Honors Theses

This study explores how the tempo of music, measured in beats per minute (BPM), affects dogs' heart rate and oxytocin levels, adding to past research that shows that music affects physiological and behavioral states in dogs. Being able to understand these effects holds practical implications for improving overall well-being in canines in environments such as homes, shelters, and clinical environments. Using a within-subjects design, the dogs were exposed to slow and fast versions of one instrumental track, along with a white noise baseline condition before each randomized condition. Heart rate was recorded continuously throughout the session, and oxytocin saliva samples …

Clinical And Demographic Characteristics Of Hospitalized Patients With Xylazine-Related Wounds, Elizabeth Novick, Nikhil Seval, Dagan Coppock, Mollie Tucker, Daniel Taupin, John Zurlo, Carolyn Kramer

Department of Medicine Faculty Papers

OBJECTIVES: Little is known about the demographic and clinical features of patients with xylazine-related wounds. We sought to characterize hospitalized patients with substance use disorder (SUD) and xylazine-related wounds seen for infectious diseases consultation.

METHODS: We retrospectively reviewed the medical records of 193 patients diagnosed with SUD at 3 Philadelphia hospitals between October 2023 and January 2024. Patients were identified as either being diagnosed with (n=73) or without (n=120) xylazine-related wounds. We compared the demographic and clinical features between the 2 groups.

RESULTS: Patients diagnosed with wounds were younger ( P < 0.001), more likely to be White or Hispanic and less likely to be Black/AA ( P < 0.001), more likely to have tested positive for fentanyl ( P < 0.001), amphetamines ( P < 0.001), and cocaine ( P 0.001), more likely to acknowledge injection ( P < 0.001), and more likely to leave the hospital by patient-directed discharge (PDD) ( P < 0.001). Most patients had multiple wounds (75%), and more than half (53%) had at least one wound greater than 10 cm at its widest dimension. Although most patients diagnosed with wounds received antibiotics, many did not have symptoms or signs of infection.

CONCLUSIONS: Xylazine-related wounds are highly associated with illicitly manufactured …

Expanding Access To Noninvasive Spinal Neuromodulation For Pediatric Spinal Cord Injury Rehabilitation: A Comparative Device Study, Alice E C Palmer

College of Arts & Sciences Senior Theses

Paralysis following spinal cord injury (SCI) has traditionally been considered permanent due to the disruption of supraspinal input to spinal motor circuits. However, growing evidence suggests that spinal networks below the level of injury retain intrinsic motor-generating capabilities through central pattern generators. Transcutaneous spinal cord stimulation (scTS) is a noninvasive neuromodulation technique that delivers electrical stimulation through the skin to reactivate these spinal networks. Although prior studies demonstrate that scTS delivered through research-grade devices is safe and effective in adults and children with chronic SCI, clinical translation remains limited by lack of FDA-approved systems, high costs, and restricted access to …

Using A Toxic Aging Coin To Assess Hexavalent Chromium Neurotoxicity: Impact Of Cr(Vi) On The Blood-Brain Barrier, Liam Buchanan

College of Arts & Sciences Senior Theses

The US population faces simultaneous public health threats from both aging and environmental pollutants. Chief among these is hexavalent chromium [Cr(VI)], whose toxic effects in peripheral tissues are well-established but its effects on the brain are still understudied. Following previous results indicating hippocampal metals dyshomeostasis after Cr(VI) exposure, we aim to assess Cr(VI)’s impact on the blood-brain barrier (BBB), a key structure for brain protection. We exposed young, middle-aged, and geriatric rats of both sexes to low levels of Cr(VI) in their drinking water for 90 days, after which we used immunofluorescence and confocal microscopy to analyze tissues for evidence …

Revised - The Role Of Gad67/65 In The Therapeutic Effects Of Ketamine And Fluoxetine In Fear-Conditioned Mice, Alex G. Ottimer

All NMU Master's Theses

Post-traumatic stress disorder (PTSD) is a chronic psychiatric disorder and the most common disorder following exposure to a traumatic event. The most commonly used drugs in PTSD treatment are selective serotonin reuptake inhibitors (SSRIs), though only about 50% of patients respond to this treatment. Previous work in our lab demonstrated the combination of chronic fluoxetine (FLX) and acute ketamine treatment decreased fear response in a contextual fear paradigm in male C57/BL mice. In rodents, fear conditioning (FC) is commonly used in the literature to induce behaviors related to PTSD. The mammalian central fear memory circuit involves a dynamic interplay between …