Open Access. Powered by Scholars. Published by Universities.®

Behavioral Neurobiology Commons

Open Access. Powered by Scholars. Published by Universities.®

868 Full-Text Articles 1,340 Authors 347,593 Downloads 116 Institutions

All Articles in Behavioral Neurobiology

Faceted Search

868 full-text articles. Page 1 of 36.

Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor 2023 West Virginia University

Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor

Graduate Theses, Dissertations, and Problem Reports

The blood-brain barrier (BBB) is a critical interface between the systemic circulation and the brain. It is a specialized multicellular unit composed of brain microvascular endothelial cells (BMECs), pericytes, a basement membrane, and astrocytic end foot processes. BMECs are a principal component of the BBB that provide the structural framework needed for the stringent transport of molecules into the brain. BMEC dysfunction permits the trafficking of neurotoxins from systemic circulation into the brain, which ultimately exacerbates BBB dysfunction and neuroinflammation. Studies have shown that BBB dysfunction is a key determinant of cognitive decline in sepsis. However, there are critical knowledge ...


Belonging Amidst Bias: Embracing Difference On The Path To Common Humanity, Alyssia Sheikh 2022 Lesley University

Belonging Amidst Bias: Embracing Difference On The Path To Common Humanity, Alyssia Sheikh

Mindfulness Studies Theses

The mindfulness community prioritizes self-awareness and common humanity, but is often entrapped by the idea that oneness is equivalent to sameness. This inclination for objectivity is rooted in the same neural propensities that facilitate bias; the brain is a subjective organ, however, and so neurologically speaking, bias is inevitable. This paper asks: Is striving for sameness separating us from interconnectedness? A human experience is a subjective, diverse, and variable one. The path to shared humanity and social justice co-occurs with increasing cultural humility through mindful awareness and acknowledging our subjective nature. Exploring our neurological tendency to make assumptions, we can ...


Assessing The Impact Of Lipopolysaccharide On Learning And Memory In Rats, Anahat Luthra 2022 Western University

Assessing The Impact Of Lipopolysaccharide On Learning And Memory In Rats, Anahat Luthra

Undergraduate Student Research Internships Conference

The immune system and the central nervous system (CNS) have a bi-direction relationship, modulating one another.4 Proinflammatory cytokines released from CNS immune cells have an impact on cognitive processes such as learning and memory.1 Liposaccharide (LPS), a cell wall component of Gram-negative bacteria, which is used to activate proinflammatory cytokine release has been found to impact learning and memory processes, such as in the anticipatory nausea paradigm (ANP).2 Anticipatory nausea and vomiting is that which may occur before a chemotherapy treatment session begins in a patient who has had chemotherapy before. It is caused by triggers like ...


The Effects Of Prenatal Cannabis Exposure On The Basolateral Amygdala, Karen KW Wong 2022 Western University

The Effects Of Prenatal Cannabis Exposure On The Basolateral Amygdala, Karen Kw Wong

Undergraduate Student Research Internships Conference

No abstract provided.


Stimulus Duration Alters Temporal Sensitivity In Rat Model Of Audiovisual Perception, Juwairiya F. Ahmad 2022 Western University

Stimulus Duration Alters Temporal Sensitivity In Rat Model Of Audiovisual Perception, Juwairiya F. Ahmad

Undergraduate Student Research Internships Conference

The aim of this experiment was to investigate the effect of stimulus duration on the perceived temporal order judgement in Long Evans rats.


The Distinction Of Logical Decision According To The Model Of The Analysis Of Brain Signals (Eeg), Akeel Abdulkareem Al-Sakaa, Zaid H. Nasralla, Mohsin Hasan Hussein, Saif A. Abd, Hazim Alsaqaa, Kesra Nermend, Anna Borawska 2022 College of Computer Science & Information Technology, University of Kerbala - Iraq

The Distinction Of Logical Decision According To The Model Of The Analysis Of Brain Signals (Eeg), Akeel Abdulkareem Al-Sakaa, Zaid H. Nasralla, Mohsin Hasan Hussein, Saif A. Abd, Hazim Alsaqaa, Kesra Nermend, Anna Borawska

Karbala International Journal of Modern Science

Recently, brain signal patterns have been recruited by researchers in different life activities. Researchers have studied each life activity and how brain signal patterns appear. These patterns could then be generalised and used in different disciplines. In this paper, we study the brain state during decision making in a lottery experiment. An EEG device is used to capture brain signals during an experiment to extract the optimal state for logical decision making. After collecting data, extracting useful information and then processing it, the proposed method is able to identify rational decisions from irrational ones with a success rate of 67%.


Behavioral And Histological Inflammatory Analysis Of A Single, Mild Traumatic Brain Injury And Repeated Subconcussive Brain Injury Using A Rodent Model., Anna Marie Clay 2022 Mississippi State University

Behavioral And Histological Inflammatory Analysis Of A Single, Mild Traumatic Brain Injury And Repeated Subconcussive Brain Injury Using A Rodent Model., Anna Marie Clay

Theses and Dissertations

Subconcussive (SC) impacts have become a growing concern within the neuroscience community regarding the immediate and long-lasting effects of sports-related injuries. While a single low-level impact, i.e., a subconcussion, may not cause cerebral perturbations, it has been increasingly recognized that repeated SC exposure can induce deleterious effects. Therefore, determining the lower limits of systematic perturbation resulting from multiple SC impacts is of critical importance in expanding our understanding of cerebral vulnerability and recovery. Currently, there is a lack of correlation between a mild traumatic brain injury (mTBI) and repeated SC impacts with respect to injury biomechanics. Moreover, the cumulative ...


Analysis Of The Distributed Representation Of Operant Memory In Aplysia, Renan Murillo Costa 2022 The Texas Medical Center Library

Analysis Of The Distributed Representation Of Operant Memory In Aplysia, Renan Murillo Costa

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)

Operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior, engages a high-dimensional neuronal population space spanning multiple brain regions. A complete characterization of an operant memory remains elusive. Some sites of plasticity participating in the engram underlying an example of operant memory in Aplysia have been previously uncovered. Three studies are described here that sought to draw closer to a thorough characterization of this memory. The first study used a computational model to examine the ways in which sites of plasticity (individually and in combination) contribute to memory expression. Each site of plasticity ...


Non-Photic Mechanisms Of Entrainment In Bmal1 Deficient Conditions, Jamie Tran 2022 The Texas Medical Center Library

Non-Photic Mechanisms Of Entrainment In Bmal1 Deficient Conditions, Jamie Tran

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)

Maintaining our internal circadian (i.e. 24 -hour) clock is imperative to our daily biological and mental well-being. Large epidemiological studies have shown that disruptions of our circadian rhythms can lead to poor mental health, metabolic diseases, and various types of cancer. Various external cues that have become a part of the modern times such as electricity, shift -work, rapid travel across various time zones, easier access to nutritionally unbalanced food items, and various rigid social demands have deleterious effects on our internal clock, and generally reduce robustness of the circadian clock. The two following projects aim to examine two ...


Mirnas Levels In A Streptozocin Model Of Alzheimer’S Disease, Nada Moustafa 2022 American University in Cairo

Mirnas Levels In A Streptozocin Model Of Alzheimer’S Disease, Nada Moustafa

Theses and Dissertations

Dementia entails a progressive decrease in cognitive functions, with 50%-75% of cases attributed to Alzheimer’s disease (AD); an aging-associated condition characterized by the build-up of tangled phosphorylated Tau (p-Tau) protein and beta-amyloid (Aβ) depositions. Sporadic AD (sAD) is multifactorial in nature, resulting from a combination of environmental and genetic predisposing factors. Type 2 diabetes mellitus (T2DM) is a leading risk factor for dementia, and deregulation of brain glucose metabolism is associated with early cognitive affection in sAD. Thus, the diabetogenic agent Streptozotocin (STZ) is used to experimentally create an AD model in animals (STZ-induced sAD), in which abnormalities ...


Norepinephrine Regulation Of Spatial Memory Using The Barnes Maze In Male And Female Rats, Serena Simpson, Ali Gheidi PhD, Nareen Sadik, Cameron J. Davidson PhD, Shane A. Perrine PhD 2022 Wayne State University

Norepinephrine Regulation Of Spatial Memory Using The Barnes Maze In Male And Female Rats, Serena Simpson, Ali Gheidi Phd, Nareen Sadik, Cameron J. Davidson Phd, Shane A. Perrine Phd

Medical Student Research Symposium

The role of norepinephrine (NE) in learning and memory has been extensively studied, yet its contribution remains to be clarified. This study aimed to investigate the role of NE on spatial learning and memory in female and male rats using a Barnes maze assay. We used N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), a specific noradrenergic neurotoxin that can cross the blood brain barrier, to deplete NE stores. We hypothesized that brain NE ablation would attenuate spatial learning and memory in rats. Loss of NE by DSP-4 was determined by measuring NE (and dopamine and serotonin) levels in several brain regions using HPLC ...


The Effects Of Floral Attributes And Conspecifics On Bumble Bee Forager Memory, Lucas Lauter, Tiffany Dinh 2022 University of Missouri, St. Louis

The Effects Of Floral Attributes And Conspecifics On Bumble Bee Forager Memory, Lucas Lauter, Tiffany Dinh

Undergraduate Research Symposium

What do bees remember about flowers? These memories are important for both bees and flowers. The bees have better foraging success and gain more nectar and pollen from flowers when they remember the most rewarding flower types. More memorable flowers will be visited more frequently, resulting in more successful pollination for the plant. At the same time, bees can also learn about flowers from other bees and may remember this information differently. We are training and testing three floral cues and a single social cue to see how the different types of cues affect their learning and memory of rewarding ...


Withdrawal From Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities To Behavioral Deficits And Neurochemical Perpetuators Of Neurotoxicity And Drug Seeking Behavior, Nicoletta K. Memos 2022 The Graduate Center, City University of New York

Withdrawal From Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities To Behavioral Deficits And Neurochemical Perpetuators Of Neurotoxicity And Drug Seeking Behavior, Nicoletta K. Memos

Dissertations, Theses, and Capstone Projects

MA is a potent, highly addictive psychomotor stimulant known to produce neurotoxic effects on the brain leading to neurological impairments1-6 characterized by neurodegeneration of dopaminergic fibers, cell bodies and pathways, as well as brain regions such as the hippocampus, frontal cortex, and midbrain1,5.

In MA addiction, women are more vulnerable to the behavioral and cognitive effects of MA compared to men. Adult human literature reveals gender differences in usage patterns and women demonstrate increased vulnerability to the neurotoxic effects and health effects of MA use. Women begin drug use at an earlier age, escalate drug use quicker ...


Regulation Of Activity Patterns In Astyanax Mexicanus Cavefish, Udodirim Nwosu 2022 New Jersey Institute of Technology

Regulation Of Activity Patterns In Astyanax Mexicanus Cavefish, Udodirim Nwosu

Theses

Organisms commonly modulate their behavioral activity in relation to the 24-hour solar cycle. This modulation of behavior is driven by a combination of responses to external cues in the environment, such as light/dark visual signals, and internal pattern generators that can persist in the absence of external cues. However, there are animals that live in caves or in the deep sea that are isolated from solar circadian cues. How these animals regulate their behavioral activity in relation to external and internal rhythms is an open question in neuroscience that may help us to understand the mechanisms that other animals ...


The Effects Of Astrocytic Derived Insulin-Like Growth Factor (Igf-1) On Cognition And Astrocytes, Destiny Wilson 2022 University of Mississippi

The Effects Of Astrocytic Derived Insulin-Like Growth Factor (Igf-1) On Cognition And Astrocytes, Destiny Wilson

Honors Theses

Insulin-like growth factor 1 (IGF-1) is a neuroendocrine signaling hormone that plays a vital role in growth and development, as well as learning and memory. Inhibition of this hormone results in cognitive impairments like those seen with age-related decline. While a majority of research has focused on the role of IGF-1 on neurons, the role of astrocytes still needs to be explored. Our research investigates how astrocytes and cognition are affected as a result of direct regulation of localized IGF-1 production in early development and after puberty. Preliminary studies in our laboratory established a connection between IGF-1 and glial fibrillary ...


Does Anodal Tdcs Over The Left Prefrontal Cortex Using The C3-Rso Montage Improve Cognitive Control?, Jhoan Rodriguez 2022 University of Connecticut

Does Anodal Tdcs Over The Left Prefrontal Cortex Using The C3-Rso Montage Improve Cognitive Control?, Jhoan Rodriguez

Honors Scholar Theses

Executive function is the ability to change one’s behavior in order to achieve a goal, which is supported by the prefrontal cortex (for review, Abdullah et al., 2021). Transcranial Direct Current Stimulation (tDCS) is a noninvasive brain stimulation technique that changes the likelihood of neuronal firing by sending current through at least two electrodes on the scalp. Prior work in our lab found no enhancement of executive function on healthy participants when at- tempting to stimulate the dorsolateral prefrontal cortex using anodal tDCS with the F3-RSO montage (Darling et al., 2020). However, current modeling suggests that the C3-RSO montage ...


Regaining Effort-Based Food Motivation: The Drug Methylphenidate Reverses The Depressive Effects Of Tetrabenazine In Female Rats, Deanna Pietrorazio 2022 University of Connecticut

Regaining Effort-Based Food Motivation: The Drug Methylphenidate Reverses The Depressive Effects Of Tetrabenazine In Female Rats, Deanna Pietrorazio

Honors Scholar Theses

Tetrabenazine (TBZ), a vesicular monoamine transporter type 2 (VMAT-2) inhibitor, depletes dopamine and induces motivational deficits and other depressive symptoms in humans. Methylphenidate (MPH) is a dopamine transport blocker that is used to enhance motivational function. Previous studies have shown that in male rats, TBZ induces a shift in effort-related choice such that a low-effort bias is induced. In male rats this occurs at a dose range of 0.75-1.0 mg/kg TBZ, and this effect is reversible with co-administration of MPH. Recent studies have shown that females need a higher dose of TBZ (2.0 mg/kg) to ...


Case Study: Effects Of Ultrasonic Vocalizations On Rat Behavior And Place Cell Remapping In The Hippocampus, Qingli Hu 2022 University of Connecticut

Case Study: Effects Of Ultrasonic Vocalizations On Rat Behavior And Place Cell Remapping In The Hippocampus, Qingli Hu

Honors Scholar Theses

Spatial information is known to be encoded in the hippocampus, and small changes in the environment can alter the way that it is represented by our hippocampal place cells in a process called remapping. Hearing is an important sense that can be used to orient ourselves and react to the environment accordingly. In this case study, a rat model is used to test the effects of emotional auditory stimuli, behaviorally significant ultrasonic vocalizations (USVs) (50 kHz, emitted during play; 22 kHz, emitted during danger), on rat behavior on a linear track and place cell remapping in the hippocampus. Behaviorally, it ...


Use Of Intramodal Odor Cues In Shelter Recognition By An Amblypygid, Nathan Bostelman 2022 Bowling Green State University

Use Of Intramodal Odor Cues In Shelter Recognition By An Amblypygid, Nathan Bostelman

Honors Projects

Amblypygids are nocturnal arthropods which live in cluttered habitats and possess the ability to navigate home after displacements of up to ten meters. Homing amblypygids rely on olfactory and tactile information gathered by their antenniform legs to navigate successfully. Given that odor signals encountered in nature are complex and dynamic, navigation via olfaction presents unique challenges related to signal uncertainty. To understand how amblypygids perceive perceive complex odors and what they learn from them, individuals of the subtropical amblypygid P. marginemaculatus were trained to associate a blend of two odors with a shelter and tested on three treatments: the reinforced ...


Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert 2022 University of Tennessee, Knoxville

Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert

Select or Award-Winning Individual Scholarship

Buprenorphine, a semi-synthetic opioid prescribed for the treatment of opioid use disorder (OUD), has been suggested as a potential pharmacological treatment for anxiety. Some preclinical and clinical studies provide support for the anxiolytic effects of buprenorphine, but research in this area is scarce, and findings to date have been mixed. The present study was designed to test the hypothesis that buprenorphine alters anxiety-like behavior in C57BL/IJ (B6) mice measured using the elevated zero maze (EZM). Adult, male mice (n=10) were given subcutaneous injections of saline (control) and three doses of buprenorphine (0.3, 1, and 10 mg/kg ...


Digital Commons powered by bepress