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Articles 841 - 870 of 1200

Full-Text Articles in Biological Psychology

Exploring The Impact Of Meditation On Attentional Allocation To Emotion, Sychopathology, And Acute Stress, In A Community Sample With Mixed Anxiety And Depression, Nicholas Thomas Van Dam Jan 2013

Exploring The Impact Of Meditation On Attentional Allocation To Emotion, Sychopathology, And Acute Stress, In A Community Sample With Mixed Anxiety And Depression, Nicholas Thomas Van Dam

Legacy Theses & Dissertations (2009 - 2024)

Attempts to define mindfulness in the clinical and psychological sciences have been marred by contradictions, inconsistencies, and controversies. In this wait-list (WL) controlled mindfulness meditation training (MMT) study, the efficacy and potential mechanisms of MMT was tested in a community sample with undiagnosed, but significant, symptoms of anxiety, depression, and stress. In a pre/post design, which also included 3 month follow-up, participants completed self-report measures, participated in a psychosocial stress task (before and after which they completed self-report mood questionnaires and had physiological and salivary neuroendocrine markers collected), and completed an emotional attentional blink paradigm. Compared to WL (n = …

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The Role Of Pubertal Timing And Temperamental Vulnerability In Adolescents’ Internalizing Symptoms, Lisa J. Crockett, Gustavo Carlo, Jennifer M. Wolff, Meredith O. Hope Jan 2013

The Role Of Pubertal Timing And Temperamental Vulnerability In Adolescents’ Internalizing Symptoms, Lisa J. Crockett, Gustavo Carlo, Jennifer M. Wolff, Meredith O. Hope

Department of Psychology: Faculty Publications

This longitudinal study examined the joint role of pubertal timing and temperament variables (emotional reactivity and self-regulation) in predicting adolescents’ internalizing symptoms. The multiethnic sample included 1,025 adolescent girls and boys followed fromage 11 to age 15 (Mage¼11.03 years at Time 1). In structural equation models, age 11 measures of pubertal timing, emotional reactivity, and self-regulation and their interactions were used to predict adolescents’ internalizing behavior concurrently and at age 15. Results indicated that, among girls, early pubertal timing, higher emotional reactivity, and lower self-regulation predicted increased internalizing behavior. In addition, self-regulation moderated the effect of pubertal timing such that …

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Olanzapine Sensitization And Clozapine Tolerance: From Adolescence To Adulthood In The Conditioned Avoidance Response Model, Jing Qiao, Hong Li, Ming Li Jan 2013

Olanzapine Sensitization And Clozapine Tolerance: From Adolescence To Adulthood In The Conditioned Avoidance Response Model, Jing Qiao, Hong Li, Ming Li

Department of Psychology: Faculty Publications

Disruption of conditioned avoidance response (CAR) in rodents is one trademark feature of many antipsychotic drugs. In adult rats, repeated olanzapine (OLZ) treatment causes an enhanced disruption of avoidance response (sensitization), whereas repeated clozapine (CLZ) treatment causes a decreased disruption (tolerance). The present study addressed (1) whether OLZ sensitization and CLZ tolerance can be induced in adolescent rats, and (2) the extent to which OLZ sensitization and CLZ tolerance induced in adolescence persists into adulthood. Male adolescent Sprague–Dawley rats (approximate postnatal days (BP) 43–47) were first treated with OLZ (1.0 or 2.0 mg/kg, subcutaneously (sc)) or CLZ (10 or 20 …

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The Interface Between Morphology And Action Planning: A Comparison Of Two Species Of New World Monkeys, Stacey L. Zander, Dan J. Weiss, Peter G. Judge Jan 2013

The Interface Between Morphology And Action Planning: A Comparison Of Two Species Of New World Monkeys, Stacey L. Zander, Dan J. Weiss, Peter G. Judge

Faculty Journal Articles

Recent research with several species of nonhuman primates suggests sophisticated motor-planning abilities observed in human adults may be ubiquitous among primates. However, there is considerable variability in the extent to which these abilities are expressed across primate species. In the present experiment, we explore whether the variability in the expression of anticipatory motor-planning abilities may be attributed to cognitive differences (such as tool use abilities) or whether they may be due to the consequences of morphological differences (such as being able to deploy a precision grasp). We compared two species of New World monkeys that differ in their tool use …

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The Lives Of Others: Social Rationality In Animals, Jeffrey R. Stevens, Andrew J. King Jan 2013

The Lives Of Others: Social Rationality In Animals, Jeffrey R. Stevens, Andrew J. King

Jeffrey Stevens Publications

Darwin (1871) boldly claimed that humans and other animals differ very little in their cognition; a statement that has raised the ire of many scientists (Bolhuis & Wynne, 2009; Penn, Holyoak, & Povinelli, 2008). Rather than stating this continuity as a fact, we will explore the similarities and differences between humans and animals in the social rationality of their decision making. We find this a fruitful exercise because it can profit researchers of both humans and animals. Our purpose here is to provide an evolutionary background of social rationality: Why do animals attend to the lives of others? To this …

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Rats Acquire Stronger Preference For Flavors Consumed Towards The End Of A High-Fat Meal, Kevin P. Myers Jan 2013

Rats Acquire Stronger Preference For Flavors Consumed Towards The End Of A High-Fat Meal, Kevin P. Myers

Faculty Journal Articles

Rats learn to prefer flavors associated with postingestive effects of nutrients. The physiological signals underlying this postingestive reward are unknown. We have previously shown that rats readily learn to prefer a flavor that was consumed early in a multi-flavored meal when glucose is infused intragastrically (IG), suggesting rapid postingestive reward onset. The present experiments investigate the timing of postingestive fat reward, by providing distinctive flavors in the first and second halves of meals accompanied by IG fat infusion. Learning stronger preference for the earlier or later flavor would indicate when the rewarding postingestive effects are sensed. Rats consumed sweetened, calorically-dilute …

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Capuchin Monkeys Exercise Self-Control By Choosing Token Exchange Over An Immediate Reward, Peter G. Judge, Jennifer L. Essler Jan 2013

Capuchin Monkeys Exercise Self-Control By Choosing Token Exchange Over An Immediate Reward, Peter G. Judge, Jennifer L. Essler

Faculty Journal Articles

Self-control is a prerequisite for complex cognitive processes such as cooperation and planning. As such, comparative studies of self-control may help elucidate the evolutionary origin of these capacities. A variety of methods have been developed to test for self-control in non-human primates that include some variation of foregoing an immediate reward in order to gain a more favorable reward. We used a token exchange paradigm to test for self-control in capuchin monkeys (Cebus apella). Animals were trained that particular tokens could be exchanged for food items worth different values. To test for self-control, a monkey was provided with …

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Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney Jan 2013

Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney

McNair Poster Presentations

Schizophrenia is a chronic debilitating brain disorder, which affects approximately one per­cent of the adult population worldwide. The symptoms of schizophrenia are commonly divided into three broad classes: positive symptoms, negative symptoms, and cognitive disturbances (Kay, et al., 1987). The positive symptoms of schizophrenia include hallucinations, delusions, and dis­organized thinking, while the negative symptoms include affective flattening, social withdrawal, and an inability to plan and carry out future activities. The cognitive disturbances exhibited in schizophrenia include deficits in spatial reference and working memory as well as difficulties with focus and attention (Lewis et. al., 2007). Several models have been proposed …

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Untangling Cultural Differences In Behavioral, Physiological, And Psychological Symptoms Of Dementia And Alzheimer’S Disease, John S. Avant Jan 2013

Untangling Cultural Differences In Behavioral, Physiological, And Psychological Symptoms Of Dementia And Alzheimer’S Disease, John S. Avant

Calvert Undergraduate Research Awards

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; 4th ed. Revised; American Psychiatric Association) and (BPSD) there are many behavioral, physiological, and psychological issues that have been correlated with the progression of the Alzheimer’s disease and other dementias. Examples of these issues include; emotional regulation problems, variations in eating behavior, and an advancing decline in memory. Though certain symptoms of the disease seem to be widely universal, current literature shows that a number of disparities do exist. There are several differences between and within populations suffering from Alzheimer’s disease and dementia that are influenced by various …

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Placental Corticotropin-Releasing Hormone Mediates The Association Between Prenatal Social Support And Postpartum Depression, Jennifer Hahn-Holbrook, Christine Dunkel Schetter, Chander Arora, Calvin J. Hobel Jan 2013

Placental Corticotropin-Releasing Hormone Mediates The Association Between Prenatal Social Support And Postpartum Depression, Jennifer Hahn-Holbrook, Christine Dunkel Schetter, Chander Arora, Calvin J. Hobel

Psychology Faculty Articles and Research

Three decades of research point to both biological and psychological risk factors for postpartum depression, but very little research integrates the two. This study bridged this gap by testing whether prenatal social support predicted depressive symptoms at 8 weeks postpartum in a multiethnic sample of 210 women and whether the stress hormone placental corticotropinreleasing hormone (pCRH), measured at 19, 29, and 37 weeks’ gestation, mediated this relationship. We found that prenatal family support predicted significantly fewer depressive symptoms postpartum and more gradual increases in pCRH from 29 to 37 weeks’ gestation. Furthermore, steeper increases in pCRH during this same period …

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Examining The Interaction Of Neonatal Alcohol And Hypoxia In Vitro, Megan L. Carter Jan 2013

Examining The Interaction Of Neonatal Alcohol And Hypoxia In Vitro, Megan L. Carter

Theses and Dissertations--Psychology

Exposure to ethanol (ETOH) during fetal development results in a range of cognitive/behavioral deficits. There are differences in sensitivity to the effects of ETOH that could be explained by other factors, such as hypoxia. Similar mechanisms of damage underlie both ETOH, more specifically ETOH withdrawal, and hypoxia. Based on this overlap, it was hypothesized that sub threshold levels of these insults may interact to produce increased damage in sensitive brain regions. This study used a rodent organotypic hippocampal slice culture model to investigate the interaction of hypoxia and ETOH withdrawal and to determine possible developmental differences in the sensitivity to …

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Expression Of Borderline Personality Disorder Symptoms Across The Ovulatory Cycle: A Multilevel Investigation, Tory A. Eisenlohr-Moul Jan 2013

Expression Of Borderline Personality Disorder Symptoms Across The Ovulatory Cycle: A Multilevel Investigation, Tory A. Eisenlohr-Moul

Theses and Dissertations--Psychology

Borderline Personality Disorder (BPD) is a disabling condition characterized by chronic emotion dysregulation and behavioral impulsivity. Prospective studies that test proposed mechanisms of within-person change in BPD hold the key to improving symptom predictability and control in this disorder. A small body of evidence suggests that fluctuations in estradiol such as those occurring naturally at ovulation during the monthly female reproductive cycle may increase symptoms in women with BPD (DeSoto et al., 2003). Furthermore, there is preliminary evidence that both self-esteem and feelings of social rejection are highest at ovulation, when estradiol peaks (Durante and Hill, 2009; Eisenlohr-Moul et al., …

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Characterizing Consumption, Dependence, And The Role Of Glucocorticoids In An Animal Model Of Voluntary Ethanol Consumption, Lynda Sharrett-Field Jan 2013

Characterizing Consumption, Dependence, And The Role Of Glucocorticoids In An Animal Model Of Voluntary Ethanol Consumption, Lynda Sharrett-Field

Theses and Dissertations--Psychology

Alcohol abuse disorders (AUD) represent a serious worldwide health problem with far reaching social, financial, and interpersonal implications. One of the most devastating facets of these disorders is the propensity to relapse following periods of abstinence. Ethanol withdrawal (EWD) is believed to promote relapse by increasing anxiety and craving, and may contribute to the development of cognitive decline associated with long-term dependence. Clinical data suggest that stress also plays a main role in both the development of AUD as well as relapse to drinking. As a physiological stressor, EtOH elevates levels of stress hormones (cortisol in humans, corticosterone (CORT) in …

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The Psychophysiology Of Novelty Processing: Do Brain Responses To Deviance Predict Recall, Recognition And Response Time?, Siri-Maria Kamp Jan 2013

The Psychophysiology Of Novelty Processing: Do Brain Responses To Deviance Predict Recall, Recognition And Response Time?, Siri-Maria Kamp

USF Tampa Graduate Theses and Dissertations

Events that violate expectations are biologically significant and accordingly elicit various physiological responses. We investigated the functional relationship between three of these responses: the P300, the Novelty P3 and the pupil dilation response (PDR), with a particular focus on their co-variance with reaction time and measures of subsequent memory. In a modified Novelty P3 oddball paradigm, participants semantically categorized a sequence of stimuli including (1) words of a frequent category, (2) words of an infrequent category (14% of the trials) and (3) pictures of the frequent category (14% of the trials). The Novelty P3 oddball task was followed by a …

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Prenatal Stress, Depression, And Herpes Viral Titers, Pao-Chu Hsu Jan 2013

Prenatal Stress, Depression, And Herpes Viral Titers, Pao-Chu Hsu

USF Tampa Graduate Theses and Dissertations

Recent studies suggest that some cases of prenatal depression may be associated with reactivation of latent infections of the herpesvirus family. The possible relationships among stress, prenatal depression, and herpes viral reactivation in pregnancy are understudied and the molecular pathways such as the neuroimmune biogenic amine pathway are unidentified. Chronic stress shifts the T helper-1 cell (Th1) cytokine profile to a Th2 profile, which favors virus induced pathogenesis and survival. Pregnancy is also associated with a similar Th2 dominance. In non-pregnant individuals, exposure to psychological or physical stress may be associated with latent herpes viral reactivation and could result in …

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Effects Of Neonatal Hypoxic Ischemic Brain Injury On Spatial Working Memory, Amanda L. Smith Dec 2012

Effects Of Neonatal Hypoxic Ischemic Brain Injury On Spatial Working Memory, Amanda L. Smith

Master's Theses

Children born prematurely or at very low birth weight (VLBW) have an increased risk for hypoxic ischemic brain injury (HI). HI refers to a lack of adequate blood and oxygen flow in the brain. HI can also occur in the term infant due to birth complications such as prolonged labor, placental dysfunction, or cord prolapse. In both populations (though exact patterns of neuropathology vary) brain damage is likely to occur in the form of decreased hippocampal and cortical volume, and enlargement of the ventricles (Kesler et al., 2004, Nagy et al., 2009). Resulting neuropathology can in turn lead to cognitive …

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Autonomic And Behavioral Reactivity To An Acute Laboratory Stressor, Jeremy C. Peres Dec 2012

Autonomic And Behavioral Reactivity To An Acute Laboratory Stressor, Jeremy C. Peres

LSU New Orleans Theses and Dissertations

Stress has been widely shown to directly influence people’s emotional and behavioral processing as well as their underlying biological systems. This project examined physiological and behavioral responses as indicators of stress and coping in the context of a psychosocial stressor in a controlled laboratory setting. We examined the association between indicators of behavioral coping and underlying physiological reactivity within participants while experiencing stress. Participants included 68 emerging adults. Physiological measures include autonomic biomarkers (e.g., heart-rate, skin conductance) at rest and during the stressor while behavioral indicators that were coded include acute verbal and non-verbal actions exhibited by participants during the …

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Asymmetry In Resting Alpha Activity: Effects Of Handedness, Ruth E. Propper, Jenna Pierce, Mark W. Geisler, Stephen D. Christman, Nathan Bellorado Oct 2012

Asymmetry In Resting Alpha Activity: Effects Of Handedness, Ruth E. Propper, Jenna Pierce, Mark W. Geisler, Stephen D. Christman, Nathan Bellorado

Department of Psychology Faculty Scholarship and Creative Works

Frontal electroencephalographic (EEG) alpha band power during rest shows increased right, and/or decreased left, hemisphere activity under conditions of state or trait withdrawal-associated effect. Non-right-handers (NRH) are more likely to have mental illnesses and dispositions that involve such withdrawal-related effect. The aim of the study was to examine whether NRH might be characterized by increased right, relative to left, hemisphere activity during rest. Methods: The present research investigated that hypothesis by examining resting EEG alpha power in consistently-right-handed (CRH) and NRH individuals. Results: In support of the hypothesis, NRH demonstrated decreased right hemisphere alpha power, and therefore increased right hemisphere …

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Distinct Retinohypothalamic Innervation Patterns Predict The Developmental Emergence Of Species-Typical Circadian Phase Preference In Nocturnal Norway Rats And Diurnal Nile Grass Rats, William D. Todd, Andrew J. Gall, Joshua A. Weiner, Mark S. Blumberg Oct 2012

Distinct Retinohypothalamic Innervation Patterns Predict The Developmental Emergence Of Species-Typical Circadian Phase Preference In Nocturnal Norway Rats And Diurnal Nile Grass Rats, William D. Todd, Andrew J. Gall, Joshua A. Weiner, Mark S. Blumberg

Faculty Publications

How does the brain develop differently to support nocturnality in some mammals, but diurnality in others? To answer this question, one might look to the suprachiasmatic nucleus (SCN), which is entrained by light via the retinohypothalamic tract (RHT). However, because the SCN is more active during the day in all mammals studied thus far, it alone cannot determine circadian phase preference. In adult Norway rats (Rattus norvegicus), which are nocturnal, the RHT also projects to the ventral subparaventricular zone (vSPVZ), an adjacent region that expresses an in-phase pattern of SCN-vSPVZ neuronal activity. In contrast, in adult Nile grass rats (Arvicanthis …

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Development Of Scn Connectivity And The Circadian Control Of Arousal: A Diminishing Role For Humoral Factors?, Andrew J. Gall, William D. Todd, Mark S. Blumberg Sep 2012

Development Of Scn Connectivity And The Circadian Control Of Arousal: A Diminishing Role For Humoral Factors?, Andrew J. Gall, William D. Todd, Mark S. Blumberg

Faculty Publications

The suprachiasmatic nucleus (SCN) is part of a wake-promoting circuit comprising the dorsomedial hypothalamus (DMH) and locus coeruleus (LC). Although widely considered a "master clock," the SCN of adult rats is also sensitive to feedback regarding an animal's behavioral state. Interestingly, in rats at postnatal day (P)2, repeated arousing stimulation does not increase neural activation in the SCN, despite doing so in the LC and DMH. Here we show that, by P8, the SCN is activated by arousing stimulation and that selective destruction of LC terminals with DSP-4 blocks this activational effect. We next show that bidirectional projections among the …

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The Relationship Between Suicide Ideation And Parasuicide: An Electrophysiological Investigation Using The Loudness Dependence Of Auditory Evoked Potential, Angelika Marsic Aug 2012

The Relationship Between Suicide Ideation And Parasuicide: An Electrophysiological Investigation Using The Loudness Dependence Of Auditory Evoked Potential, Angelika Marsic

Dissertations

The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a promising valid and a non-invasive indicator of behaviorally relevant central 5-HT functioning. There is limited research on the utility of the LDAEP in discriminating individuals who engage in various degrees of suicidal behavior. The primary purpose of the present study was to examine if the LDAEP, as a measure of central serotonergic functioning, can be useful in distinguishing groups of individuals who: (a) solely experience suicidal ideation (SI group); (b) experience suicidal ideation and have engaged in deliberate self-harm acts (SH group); and (c) individuals with …

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The Effects Of An Online Sleep Hygiene Intervention On Students' Sleep Quality, Giuliana Farias Jul 2012

The Effects Of An Online Sleep Hygiene Intervention On Students' Sleep Quality, Giuliana Farias

Psychology Theses & Dissertations

Students in college or in their first year of medical school undergo increased educational and social pressure. To cope, students may sacrifice sleep to meet demands. Poor sleep affects learning, performance, and health. Studies have been successful at improving sleep quality through the use of in-person recruitment or cognitive-behavioral therapy delivered over the internet (Trockel, Manber, Chang, Thurston, & Tailor, 2011). The purpose of the current study was to investigate whether an online sleep hygiene intervention could improve sleep quality. One hundred thirty-eight students from one undergraduate institution in Southeast Virginia completed this study. Students were divided into groups; one …

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Physiological Politics: Stress And Dominance Responses To Political News, Erin Strauts May 2012

Physiological Politics: Stress And Dominance Responses To Political News, Erin Strauts

Master's Theses

No abstract provided.

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Effect Of Nicotine On Body Composition, Laura O'Dell May 2012

Effect Of Nicotine On Body Composition, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

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Effect Of Nicotine On Body Composition, Laura O'Dell May 2012

Effect Of Nicotine On Body Composition, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

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The Effects Of Rhes, A Striatal Specific Protein, On The Expression Of Behavioral And Neuropathological Symptoms In A Transgenic Mouse Model Of Huntington's Disease, Brandon A. Baiamonte May 2012

The Effects Of Rhes, A Striatal Specific Protein, On The Expression Of Behavioral And Neuropathological Symptoms In A Transgenic Mouse Model Of Huntington's Disease, Brandon A. Baiamonte

LSU New Orleans Theses and Dissertations

Huntington's disease (HD) is a neuropsychiatric disorder characterized by choreiform movement of the limbs, cognitive disability, psychosis and dementia. It is untreatable, incurable, and ultimately fatal. HD is invariably associated with an abnormally long CAG expansion within the IT15 gene on human chromosome 4. Although the mutant huntingtin protein (mHtt) is ubiquitously expressed in HD patients, cellular degeneration occurs only in neurons within the striatum and cerebral cortex. The Ras homolog Rhes is expressed very selectively in the precise brain areas affected by HD. Recent work using cultured cells suggests that Rhes may be a co-factor with mHtt in cell …

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A Multigroup Analysis Of The Psychological Factors That Contribute To Persisting Working Attention Problems In Mild Traumatic Brain Injury And Chronic Pain, Kelly L. Curtis May 2012

A Multigroup Analysis Of The Psychological Factors That Contribute To Persisting Working Attention Problems In Mild Traumatic Brain Injury And Chronic Pain, Kelly L. Curtis

LSU New Orleans Theses and Dissertations

A significant subset of mild traumatic brain injury (mild TBI) and chronic pain (CP) patients report, and sometimes show objective evidence of, persisting cognitive problems. Despite differences in injury mechanisms, there is considerable overlap in the types of persisting cognitive symptoms that are reported by the two populations. Psychogenic, rather than physiogenic, factors are thought to play an important role in the maintenance of these persisting symptoms. The current investigation examined the contributions somatization, depression, and anxiety had on an objective measure of “working attention.” In order to best elucidate the influences these psychological factors had on attentional performance, only …

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Sleep Deprivation And Delusion Proneness: Influence On Dream Bizarreness, Anna Leigh Lezon May 2012

Sleep Deprivation And Delusion Proneness: Influence On Dream Bizarreness, Anna Leigh Lezon

Undergraduate Honors Thesis Collection

While evidence for many types of psychotic experience exists in the general population, dreams have been a particularly prominent model for hallucinations and delusions in otherwise healthy individuals. This definition of "bizarreness" in dreams mirrors the description of psychosis in schizophrenia patients when their psychosis remits (Colace, 2003). Babkoff et al, (1989) found a linear association - less sleep caused more waking-state hallucinations. While the relationship between psychotic symptoms and sleep deprivation is well established, most existing data regard waking-state psychotic symptomology. The relationship between sleep deprivation and dream-state psychotic symptomology has not been investigated. Further, no sleep deprivation study …

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Ketamine Can Disrupt Episodic Memory (Hours To Days) Consolidation: Effects Of Varying Dose And Retention Intervals, Ryan Darius Tabtabai May 2012

Ketamine Can Disrupt Episodic Memory (Hours To Days) Consolidation: Effects Of Varying Dose And Retention Intervals, Ryan Darius Tabtabai

Honors Scholar Theses

Memory consolidation is the process wherein short-term, episodic memories are converted into stable, long-term representations. Forebrain N-methy-d-aspartate receptors (NMDARs), particularly frontal cortical and hippocampal receptors, are thought to play a key role in neuronal plasticity and memory consolidation. Ketamine is an NMDA antagonist that disrupts memory, particularly encoding and retrieval processes. Previously we have observed no effect of post-acquisition ketamine treatment (50-100 mg/kg) on memory consolidation in rats performing a delayed-match-to place radial water maze task. The current study reexamined the effects of ketamine (25-100 mg/kg) on memory consolidation in this task over varying retention intervals (4, 24, and 48 …

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Adenosine-Dopamine Interactions In The Open Field Arena: Studies Related To Locomotion And Anxiety, Rothem Kovner May 2012

Adenosine-Dopamine Interactions In The Open Field Arena: Studies Related To Locomotion And Anxiety, Rothem Kovner

Honors Scholar Theses

Nucleus accumbens dopamine (DA) is an important regulator of locomotion. The neuromodulator adenosine also has a role in regulating locomotion. The adenosine A2A receptor subtype is colocalized with DA D2 receptors on medium spiny neurons in the striatum and nucleus accumbens. Interactions between adenosine A2A and DA D2 receptor antagonists are significant for regulating various aspects of motor and motivational function. The adenosine A2A antagonist MSX-3 has been shown to reverse the suppression of locomotion induced by the DA D2 antagonist eticlopride. The structure of MSX-3 was modified to produce the prodrug MSX-4 which has high oral …

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