Biological Psychology Commons^™

Effects Of Foster Children’S Epigenetics In Abusive Environments, Shamika Ellis, Theresa Moore

Undergraduate Research Symposium

Abstract: Effects of Foster Children’s Epigenetics in Abusive Environments

Shamika Ellis, Theresa A. Moore, Hannah B. White, PhD

This presentation will review the literature on the epigenetics of abused foster children, and the subsequent acute, delayed, and long-term physiological, cognitive, and behavioral effects. One study experimentally investigated the effects of sexual and physical abuse on 150 foster children from 8 to 19 years of age and found post-traumatic stress disorder (PTSD) was diagnosed in 64% of children who experienced sexual abuse and 42% of children who experienced physical abuse Further, of the foster children who had not experienced either form …

Proteomic Profiles Of Cytokines And Chemokines In Moderate To Severe Depression: Implications For Comorbidities And Biomarker Discovery, Kathleen T. Watson, Jennifer Keller, Caleb M. Spiro, Isaac B. Satz, Samantha V. Goncalves, Heather Pankow, Idit Kosti, Benoit Lehallier, Adolfo Sequeira, William E. Bunney, Natalie L. Rasgon, Alan F. Schatzberg

Psychology Division Scholarship

Objective: This study assessed the proteomic profiles of cytokines and chemokines in individuals with moderate to severe depression, with or without comorbid medical disorders, compared to healthy controls. Two proteomic multiplex platforms were employed for this purpose. Metods: An immunofluorescent multiplex platform and an aptamer-based method were used to evaluate 32 protein analytes from 153 individuals with moderate to severe major depressive disorder (MDD) and healthy controls (HCs). The study focused on determining the level of agreement between the two platforms and evaluating the ability of individual analytes and principal components (PCs) to differentiate between the MDD and HC groups. …

The Power Of Polish: Exploring The Impact Of Nail Adornments On Perceptions Of Attraction, Sara Demichele

Honors Theses

Understanding the significance of nail adornments in shaping perceptions of attractiveness and mate value provides insights into human behavior and preferences. In the current investigation, participants rated human nail length and color on physical attractiveness and partner desirability measures. Results revealed significant effects of nail length and color across different demographic groups. Medium-length nails consistently received higher ratings for physical attractiveness, cuteness, and partner desirability compared to short and long nails. White-colored nails were generally rated most attractive, while blue and black nails received the lowest ratings. Additionally, participants reported a moderate association between having manicured nails and feelings of …

Sympathetic-Cardiovascular Stress Reactivity In Adults With Major Depressive Disorder, Ashley Darling

Kinesiology Dissertations - Archive

Major depressive disorder (MDD) is a mood disorder characterized by persistently depressed mood and/or anhedonia that causes significant functional impairment in daily life. MDD affects nearly 15% of adults in their lifetime, and since 2019, prevalence estimates have increased up to ~30% in young adults (18-25 years old). In addition to its debilitating effects on daily functioning, epidemiological studies link MDD to ~3 times greater risk of cardiovascular disease (CVD), followed by accelerated CVD progression and mortality. Although the mechanisms contributing to MDD-CVD comorbidity are unclear, there is evidence of stress system dysfunction in adults with MDD.

Accordingly, the aim …

The Effects Of Early Developmental Co-Exposure To Alcohol And Nicotine Via E-Cigarettes On Anxiety- And Motor-Related Behaviors In Mice, Carley Cirafesi

West Chester University Master’s Theses

Thirty percent of people who report consumption of alcohol while pregnant simultaneously report consuming nicotine. Prenatal co-exposure to alcohol and nicotine has increased with the popularity of electronic cigarettes due to their presumed safety, yet e-cigarette use may have a greater impact on fetal development than traditional cigarettes. Prenatal exposure to alcohol or nicotine is associated with increased anxiety-related behaviors and impaired motor coordination later in life, yet it is unknown whether prenatal co-exposure to alcohol and nicotine exacerbates these effects, particularly via e-cigarettes. This project examined the effects of co-exposure to alcohol and nicotine via e-cigarettes during early development …

Cognitive Functioning In Well-Controlled Asthma, Erin Walsh

West Chester University Doctoral Projects

Asthma is a common lung disease that impacts lung functioning through inflammatory based mechanisms. Past research suggests that decreased blood oxygenation due to asthma attacks may impair cognitive capabilities (Irani et al., 2017). Moreover, the observed differences in cognition between those with and without asthma may be associated with disease severity or asthma control respectively in asthma populations. The current study explored differences in cognitive functioning between college students with and without self-reported asthma. Sociodemographic data, self-reported asthma severity, and measures of asthma control were collected. The current study did not find significant differences in measures of cognitive efficiency between …

The Behavioral Origins Of Phylogenic Responses And Ontogenic Habits, W. David Stahlman, Kenneth J. Leising

Psychological Science Articles

An examination of innate behavior and its possible origins suggests parallels with the formation of habitual behavior. Inflexible but adaptive responses-innate reflexive behavior, Pavlovian conditioned responses, and operant habits-may have evolved from variable behavior in phylogeny and ontogeny. This form of "plasticity-first" scientific narrative was unpopular post-Darwin but has recently gained credibility in evolutionary biology. The present article seeks to identify originating events and contingencies contributing to such inflexible but adaptive behavior at both phylogenic and ontogenic levels of selection. In ontogeny, the development of inflexible performance (i.e., habit) from variable operant behavior is reminiscent of the genetic accommodation of …

Electrophysiological And Clinical Fundamentals Of Qtc Prolongation Induced By Antipsychotic Medications, Zaid Naseer, Minaal Khan, Najeeb Manalai, Allison Foroobar, Patricia Harrison, Charles Scercy, Beth Yanoff, Partam Manalai

Department Surgery Faculty Publications

Patients with psychiatric disorders undergoing antipsychotic treatment are at an elevated risk for adverse cardiovascular events, including arrhythmias and sudden cardiac death. While the precise mechanisms linking cardiovascular diseases and psychiatric conditions remain unclear, QTc prolongation is suspected to be a contributing factor. The human ether-à-go-go-related gene (hERG, or KCNH2), which affects potassium channels, is implicated in the cardiotoxicity of various medications, including antipsychotics. This gene plays a critical role in determining whether a drug will be approved for market use. This paper elucidates the electrophysiological basis of QTc prolongation and reviews the evidence concerning which antipsychotics may exacerbate QTc …

Simulated Effects Of Postpartum Depression On Maternal-Infant Bonding: Mediated By Reward-Related Responses To Infant Facial Cuteness, Caitlin Harp

Cal Poly Humboldt theses and projects

Infant cuteness (facial cuteness in particular) is linked to evolutionary adaptations to motivate caretaking and protective behaviors (Kringelbach et al., 2008). Previous neuroimaging work has demonstrated that infant cuteness activates reward-related regions in the brain (Glocker et al., 2009) and behavioral work suggests that the reward value of cuteness is linked to maternal tendencies (Hahn et al., 2015). It is estimated that 15% of new mothers experience postpartum depression (PPD) (Wisner et al., 2013), which impacts the mesolimbic system and is linked to anhedonia (i.e., reduced ability to experience pleasure). Based on the above literature, this study used a simulated …

A Comparison Of Symptom Profiles In Probands With 16p11.2 Deletion And Duplication Syndromes: Repetitive Behavior And Psychosis Proneness, Adrianna Rakauskas

Honors Theses

The present study examines two classes of behavior in probands with the 16p11.2 duplication and deletion: repetitive behavior and psychosis spectrum behavior. It was hypothesized that 1.) deletion and duplication cases will differ significantly in the means and profiles of repetitive behaviors across five subscales and 2.)16p11.2 duplication cases will exhibit more schizotypal traits than the deletion cases. Data on 94 total participants was obtained from the Simmons Variation Individuals Project. Three scales were used to measure behavior: the Childhood Routines Inventory-Revised, the Childhood Oxford-Liverpool Inventory of Feelings and Experiences, and the Child Behavior Checklist. Data analysis was conducted using …

Emotional Throwing: Decision Making And Emotion In The Dual-Process Theory, Eve Wasil

Honors Program Theses

The dual process theory of decision-making describes system 1 as automatic and system 2 as controlled (Frankish & Evans, 2009). While much research has been conducted on system 2 and emotional arousal, little is known about how arousal affects the more automatic, gut-feeling processes of system 1. Through galvanic skin response (GSR), a system 1 ball throwing task, and a system 2 trolley problem survey, this study measured emotional arousal’s effect on both systems in conjunction with one another. Results revealed minimal effects of emotion on system 1 and system 2, leaving room for speculation as to the robustness of …

Understanding The Application Of Evolutionary Psychology In Consumer Behavior: A Review And Future Research Agenda, Faegheh Taheran, Veronica L. Thomas, Kendra Fowler, Abdolati Mortazavi

Marketing Faculty Publications

This paper is the first to offer a comprehensive literature review of the role of evolutionary psychology (EP) in marketing and consumer behavior. This study takes a holistic approach, combining techniques of a systematic review with bibliometric analysis, to provide a performance analysis and identify theories and methodologies used in the literature. Most importantly, by studying the current state of EP, we elucidate six major themes: the role of gender in families, the role of affect in consumer behavior, food preferences and shopping behavior, motivations for and consequences of status signaling, the impact of ovulation on consumer motives and behaviors, …

Synthetic Neuroactive Steroids Targeting Gaba-A Receptors As A Potential Therapy For Contraceptive-Associated Mood Disorders, Alexandria A. Davis

Scripps Senior Theses

4-10% of women who use hormonal oral contraceptives (HOCs) discontinue use after experiencing symptoms of anxiety, irritability, and depression in the first 3 months of administration. Previous studies have acknowledged a relationship between HOCs and emotional dysregulation but have not identified mechanisms by which HOCs have this effect. As a result, effective treatment options for HOC-induced mood disorders are lacking. Current theories implicate combined-HOCs, particularly those containing ethinyl estradiol and levonorgestrel (EE-LNG), in reducing neuroactive steroid levels. Specifically, HOC users show decreases in allopregnanolone, a positive allosteric modulator associated with neuronal inhibition and emotional regulation. The objective of this study …

Differences In The Neurological Functioning Of Females And Males During The Human Sexual Response Cycle: A Quantitative Systematic Review, Zachary Larson

Theses and Dissertations

The psychology field recognizes differences between females and males. Yet, there is a lack of research examining neurobiological sex differences, and a sophisticated understanding of neurobiological contributors that explain these sex differences related to sexuality is lacking. An integrative systematic review of the literature examined differences in the neurological functioning between females and males during the human sexual response cycle (SRC). This study investigated sex differences and commonalities in regional neural activation during the four stages of the human SRC (i.e., excitement, plateau, orgasm, and resolution). The main result of this study is that the differences between females and males …

Opioid System's Potential Involvement In Ketamine's Cognitive And Antidepressant-Like Effects In Rats, Fan Zhang

Theses and Dissertations

Depression stands as one of the most pervasive mental health challenges worldwide, including the United States. Conventional antidepressants typically display a delayed onset of therapeutic action (4-8 weeks) and lack efficacy in a substantial portion of patients (over 40% of depressed patients are treatment-resistant). The dissociative anesthetic ketamine, which is a glutamatergic N-methyl-D-aspartate (NMDA) antagonist, has emerged as a promising novel treatment due to its rapid and prolonged antidepressant effects, and it is especially beneficial for treatment-resistant depression. Nevertheless, the precise neurochemical mechanisms underlying ketamine’s antidepressant properties remain elusive, hampering the development of safer and more efficacious treatments. The present …

Effects Of The Cb1 Receptor Antagonist, Am251, On Maternal Behavior In Long-Evans Rat Dams, Jennifer Aguilera-Fonseca, Karla Colley, Eddie Galarza, Atoria Hamm, Joe Morse, Rachel Ntor, Destiny Pichardo, Vincent P. Markowski

McNair Scholars Program

No abstract provided.

Nobody's Perfect: Examining The Relationship Between Parenting Traits And Perfectionism And The Impact Of Maladaptive Versus Adaptive Perfectionism On Cortisol Regulation After Receiving Criticism, Olivia G. Baron

Graduate Theses/Dissertations

The trait of perfectionism has been related to both internalizing and externalizing psychopathology. Parenting traits, and attachment tendencies affect how children develop relationships and impact them into their adult lives. Parents have a large impact on their child’s personality traits, coping styles, and modeling reactions to outward criticism. Criticism, especially criticism delivered by parents, has been linked to perfectionism. Perfectionism often involves a self-critical component, though perfectionists have not been studied to examine stress responses (e.g. cortisol change) when receiving criticism. This study examined the relationships between parenting traits (positive and negative) and perfectionism (adaptive and maladaptive). Cortisol change scores …

An Ewas Of Dementia Biomarkers And Their Associations With Age, African Ancestry, And Ptsd, Mark W. Miller, Erika J. Wolf, Xiang Zhao, Mark W. Logue, Sage E. Hawn

Psychology Faculty Publications

Background

Large-scale cohort and epidemiological studies suggest that PTSD confers risk for dementia in later life but the biological mechanisms underlying this association remain unknown. This study examined this question by assessing the influences of PTSD, APOE ε4 genotypes, DNA methylation, and other variables on the age- and dementia-associated biomarkers Aβ40, Aβ42, GFAP, NfL, and pTau-181 measured in plasma. Our primary hypothesis was that PTSD would be associated with elevated levels of these markers.

Methods

Analyses were based on data from a PTSD-enriched cohort of 849 individuals. We began by performing factor analyses of the biomarkers, the results of which …

Mental Workload Modulates The Effects Of Baroreceptor Afferents On Sensorimotor Processing, Xiao Yang, Katie Herberlein, Anthony Reid, Dongfang Jiao, Fang Fang

Psychology Faculty Publications

The heart–brain interaction is the main mechanism for maintaining normative physiological processes, and its dysregulation underlies the somatic symptoms of various mental disorders. Cortical inhibition, triggered by afferent signals from baroreceptor activation, induces systematic variations in sensorimotor responses within a cardiac cycle, with reaction times (RTs) slower at cardiac systole compared to diastole (known as cardiac cycle time effects). However, recent data suggest that baroreceptor afferents not only inhibit simple responses but also facilitate complex sensorimotor responses during cardiac systole. The mental workload that is implicated in complex responses may modulate the cardiac cycle time effects. The current study aimed …

Short-Term Blood Pressure Variability Among Young Adults At High Or Low Risk For Depression, Balázs Bence Nyárády, Miklós Vértes, Edit Dósa, Xiao Yang, Charles J. George, Enikõ Kiss, Iidiko Baji, Krisztina Kapornai, Maria Kovacs

Psychology Faculty Publications

Background: Depression has been shown to have adverse effects on blood pressure (BP) and is associated with high blood pressure variability (BPV). In turn, high short-term BPV has been related to eventual cardiovascular risk. But it is not clear how early in adulthood the detrimental effects of depression on BPV may be discerned, if being at high risk for depression also compromises BPV, and whether the clinical features of depression moderate its adverse effects. We investigated these three issues among young adults using an office-like setting. Methods: In total, 218 subjects with a history of childhood-onset major depressive episodes (probands), …

Refining The Scope Of Genetic Influences On Alcohol Misuse Through Environmental Stratification And Gene-Environment Interaction, Jeanne E. Savage, Christiaan A. De Leeuw, Josefin Werme, Spit For Science Working Group, Danielle M. Dick, Danielle Posthuma, Sophie Van Der Sluis

Psychology Faculty Publications

Background

Gene-environment interaction (G X E) is likely an important influence shaping individual differences in alcohol misuse (AM), yet it has not been extensively studied in molecular genetic research. In this study, we use a series of genome-wide gene-environment interaction (GWEIS) and in silico annotation methods with the aim of improving gene identification and biological understanding of AM.

Methods

We carried out GWEIS for four AM phenotypes in the large UK Biobank sample (N = 360,314), with trauma exposure and socioeconomic status (SES) as moderators of the genetic effects. Exploratory analyses compared stratified genome-wide association (GWAS) and GWEIS modeling approaches. …

Effect Of A Brief Coping Intervention On Activity Of Target Organs Of The Sympathetic And Parasympathetic Nervous Systems During Stress, Kyle P. Rawn

Theses and Dissertations--Psychology

Stress is a critical aspect of the human experience and how an individual responds to stress can shape future outcomes, such as physical and mental health, as well as shape the patterns of stress responding that persist throughout one’s lifespan. Coping is a central element of stress responding and can strongly influence the outcome of the stress process. Successful coping can alleviate stress, but ineffective coping may lead to less-than-optimal responding. For example, aspects of the biological stress response, such as activity of target organs for the sympathetic and parasympathetic nervous systems, have important implications for future susceptibility to health …

Identifying Patterns For Neurological Disabilities By Integrating Discrete Wavelet Transform And Visualization, Soo Yeon Ji, Sampath Jayarathna, Anne M. Perrotti, Katrina Kardiasmenos, Dong Hyun Jeong

Computer Science Faculty Publications

Neurological disabilities cause diverse health and mental challenges, impacting quality of life and imposing financial burdens on both the individuals diagnosed with these conditions and their caregivers. Abnormal brain activity, stemming from malfunctions in the human nervous system, characterizes neurological disorders. Therefore, the early identification of these abnormalities is crucial for devising suitable treatments and interventions aimed at promoting and sustaining quality of life. Electroencephalogram (EEG), a non-invasive method for monitoring brain activity, is frequently employed to detect abnormal brain activity in neurological and mental disorders. This study introduces an approach that extends the understanding and identification of neurological disabilities …

Direct Relationships Between The Five Internal Senses: The Extremes And In-Between Of The Inner Experience, Sydnie Hoyt, Camryn O'Neal, Miranda Brannum, Sara Bagley

The Confluence

Inner experience of all 5 modalities were investigated to determine if there were correlations amongst them and how visual mental imagery and internal hearing were used in an applied story. Our sample (N = 137) completed the Vividness of Visual Imagery Questionnaire (VVIQ; Marks, 1973) and the Plymouth Sensory Imagery Questionnaire (Psi-Q; Andrade et al., 2013) to obtain trait measures of the different modalities within the inner experience. Results showed statistically significant positive correlations between each of the trait measures of the 5 sensory modalities (visual mental imagery, inner hearing, taste, smell, and touch). Based on their VVIQ total scores, …

Examining The Hormonal Underpinnings Of Affiliation Motivation In Oral Contraceptive Users, Hormonal Iud Users, And Naturally Cycling Women, Mikayla Tolliver

Graduate Theses and Dissertations

Affiliation is important for women during times of stress. Although, affiliation has been linked to women’s hormones across the menstrual cycle, many women use hormonal contraceptives which disrupt the links between hormones, psychology, and behavior. This study examined how hormonal contraceptives (hormonal IUD vs. the oral contraceptive pill) and menstrual cycle phase (follicular vs. luteal) are associated with affiliative motivations following the Trier Social Stress Test (TSST). Further, this study examined women’s cortisol reactivity and whether cortisol reactivity mediated affiliative motivation following the stressor. I found that oral contraceptive pill users projected more stress and rejection onto others’ faces and …

Cerebrospinal Fluid Biomarkers Not Associated With Neurologic Compromise Among Mild Cognitively Impaired Reverters With Parkinson's Disease, Cameron Ryczek

Electronic Theses, Projects, and Dissertations

Parkinson's Disease (PD) is a neurodegenerative disease characterized by motor (e.g. tremors) and non-motor symptoms (e.g. cognitive impairment). PD patients' change in cognitive functioning can be observed using the following classifications: cognitively intact, mild cognitive impairment (MCI), or dementia (PDD). MCI has many subtypes, one of which is MCI reversion which is defined as those with MCI at one time point reverting to cognitively intact later. While there is limited research into the utility of MCI reversion and its relationship with cerebrospinal fluid (CSF) biomarkers in PD, this study will begin to elucidate this relationship. To this end, data from …

Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor

Electronic Theses, Projects, and Dissertations

Serotonin has been found to regulate several cognitive and physiological functions, and its role in depression and other neuropsychiatric disorders has been a focus of research. More specifically, a wealth of research regarding serotonin focuses on serotonergic medications in the treatment of neuropsychiatric disorders, such as depression and anxiety, and stimulates the 5-HT_1A and 5-HT_1B receptors. Within the last decade, there has been an increase in prescriptions of psychotropic medication for children, however, the efficacy and adverse effects of these drugs have not been evaluated in younger populations. While antidepressants reduce symptoms of depression in adults, they are …

Identifying Trauma Related Predictors Of Dissociation In Maltreated Youth, Amanda L. Mraz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maltreated youth who experience traumatic dissociation are at an increased risk for various psychopathological difficulties. Much is still unknown about the machinations behind experiences of dissociation post-trauma. This study aimed to identify variables that place maltreated youth at risk for experiencing traumatic dissociation (e.g., dissociative amnesia, absorption and imaginative involvement, passive influence, depersonalization and derealization, and total adolescent dissociative experiences symptoms (A-DES)). Investigatory variables included demographic (e.g., age, gender, and racial identity), cognitive (e.g., resiliency and posttraumatic cognitions), and psychological (e.g., posttraumatic stress disorder symptoms (PTSD) and anxiety) factors. Classification and regression tree (CART) analysis was utilized to observe the …

What’S In A Word? A Study Of Emotional Valence, Trisha Patel, Cameron Smith, Olivia Williams, Raul Rodriguez-Calva

Science University Research Symposium (SURS)

Cognitive stress affects humans mentally and physically, and specifically may impact emotional recognition. Previous studies have focused on the perceived emotional valence of nouns vs. adjectives and the emotional recognition of photographs. While this has led to the creation of an emotional valence database, there has yet to be a study to explore how stress can change perceived emotional valence. Using data from the Affective Norms for English Words (ANEW), the Portland Arithmetic Stress Test (PAST), and the Montreal Imaging Stress Task (MIST), a study was created to explore how participants emotional valence of words would change after being placed …

Book Review: Kings, Conquerors, Psychopaths: From Alexander To Hitler To The Corporation, Tim Bakken

Genocide Studies and Prevention: An International Journal

The book Kings, Conquerors, Psychopaths is a survey of a vast amount of human wrongdoing. It lays bare the motivations of aggressors who wish to subjugate nations or groups of people and corporate executives and government bureaucrats who make discretionary decisions that harm people. Along with cataloging mass killings by despots and soldiers, the book includes stories about Ponzi-schemers and the deaths of automobile drivers and passengers who were killed by vehicle defects known to the manufacturer. The book posits that “[p]owerful, elite forces are trying to force us backward toward a non-democratic state, one where power, wealth, and prerogative …