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Full-Text Articles in Data Science

Optimizing Malaria Control: Granular And Cost-Effective Mosquito Habitat Index In Endemic Areas Through Satellite Imagery, Nur Ainun Daulay, Salwa Rizqina Putri, Arie Wahyu Wijayanto, Ika Yuni Wulansari Apr 2024

Optimizing Malaria Control: Granular And Cost-Effective Mosquito Habitat Index In Endemic Areas Through Satellite Imagery, Nur Ainun Daulay, Salwa Rizqina Putri, Arie Wahyu Wijayanto, Ika Yuni Wulansari

Knowledge Engineering and Data Science

Malaria, classified as a tropical disease under the Sustainable Development Goals (SDGs) indicator 3.3, remains a significant global health challenge. In this study, by taking advantage of multiple spectral composite indexes of multisource satellite imagery to capture various geospatial features relevant to the suitability of marsh mosquito habitat, we introduced the Mosquito Habitat Suitability Index (MHSI) to assess potential Anopheles mosquito breeding sites in terms of the vegetation density, water bodies, environment temperature, and humidity in any particular areas. The MHSI integrates the publicly accessible granular level of the normalized difference vegetation index, water index, land surface temperature, and moisture …


Docker Optimization Of An Automotive Sector Virtual Server Infrastructure, Leonel Hernandez, Carlos Eduardo Uc Rios Apr 2024

Docker Optimization Of An Automotive Sector Virtual Server Infrastructure, Leonel Hernandez, Carlos Eduardo Uc Rios

Knowledge Engineering and Data Science

Server virtualization is a powerful strategy for optimizing network infrastructure. It allows multiple virtual servers to run on a single physical server, maximizing resource utilization and improving efficiency. Deploying server virtualization using Docker technology offers a lightweight and flexible approach to optimizing network infrastructure. Docker contains package applications and their dependencies, enabling consistent and efficient deployment across various environments. Specifically, optimizing virtual server infrastructure using Docker Technology in the automotive sector focuses on improving the efficiency and management of the company's virtual server resources. By implementing Docker technology, a container platform that allows the packaging and running of applications in …


Timbre Style Transfer For Musical Instruments Acoustic Guitar And Piano Using The Generator-Discriminator Model, Widean Nagari, Joan Santoso, Esther Irawati Setiawan Apr 2024

Timbre Style Transfer For Musical Instruments Acoustic Guitar And Piano Using The Generator-Discriminator Model, Widean Nagari, Joan Santoso, Esther Irawati Setiawan

Knowledge Engineering and Data Science

Music style transfer is a technique for creating new music by combining the input song's content and the target song's style to have a sound that humans can enjoy. This research is related to timbre style transfer, a branch of music style transfer that focuses on using the generator-discriminator model. This exciting method has been used in various studies in the music style transfer domain to train a machine learning model to change the sound of instruments in a song with the sound of instruments from other songs. This work focuses on finding the best layer configuration in the generator- …


Unveiling Gene Interactions In Alzheimer's Disease By Integrating Genetic And Epigenetic Data With A Network-Based Approach, Keith L Sanders, Astrid M Manuel, Andi Liu, Boyan Leng, Xiangning Chen, Zhongming Zhao Apr 2024

Unveiling Gene Interactions In Alzheimer's Disease By Integrating Genetic And Epigenetic Data With A Network-Based Approach, Keith L Sanders, Astrid M Manuel, Andi Liu, Boyan Leng, Xiangning Chen, Zhongming Zhao

Faculty, Staff and Student Publications

Alzheimer’s Disease (AD) is a complex disease and the leading cause of dementia in older people. We aimed to uncover aspects of AD’s pathogenesis that may contribute to drug repurposing efforts by integrating DNA methylation and genetic data. Implementing the network-based tool, a dense module search of genome-wide association studies (dmGWAS), we integrated a large-scale GWAS dataset with DNA methylation data to identify gene network modules associated with AD. Our analysis yielded 286 significant gene network modules. Notably, the foremost module included the BIN1 gene, showing the largest GWAS signal, and the GNAS gene, the most significantly hypermethylated. We conducted …


Evaluating And Improving The Usability Of A Mhealth Platform To Assess Postoperative Dental Pain, Ana M Ibarra-Noriega, Alfa Yansane, Joanna Mullins, Kristen Simmons, Nicholas Skourtes, David Holmes, Joel White, Elsbeth Kalenderian, Muhammad F Walji Apr 2024

Evaluating And Improving The Usability Of A Mhealth Platform To Assess Postoperative Dental Pain, Ana M Ibarra-Noriega, Alfa Yansane, Joanna Mullins, Kristen Simmons, Nicholas Skourtes, David Holmes, Joel White, Elsbeth Kalenderian, Muhammad F Walji

Faculty, Staff and Student Publications

OBJECTIVES: The use of interactive mobile health (mHealth) applications to monitor patient-reported postoperative pain outcomes is an emerging area in dentistry that requires further exploration. This study aimed to evaluate and improve the usability of an existing mHealth application.

MATERIALS AND METHODS: The usability of the application was assessed iteratively using a 3-phase approach, including a rapid cognitive walkthrough (Phase I), lab-based usability testing (Phase II), and

RESULTS: The rapid cognitive walkthrough identified 23 potential issues that could negatively impact user experience, with the majority classified as system issues. The lab-based usability testing yielded 141 usability issues.; 43% encountered by …


Identification Of Novel F2-Isoprostane Metabolites By Specific Udp-Glucuronosyltransferases, Ginger L Milne, Marina S Nogueira, Benlian Gao, Stephanie C Sanchez, Warda Amin, Sarah Thomas, Camille Oger, Jean-Marie Galano, Harvey J Murff, Gong Yang, Thierry Durand Apr 2024

Identification Of Novel F2-Isoprostane Metabolites By Specific Udp-Glucuronosyltransferases, Ginger L Milne, Marina S Nogueira, Benlian Gao, Stephanie C Sanchez, Warda Amin, Sarah Thomas, Camille Oger, Jean-Marie Galano, Harvey J Murff, Gong Yang, Thierry Durand

Faculty, Staff and Student Publications

UDP-glucuronosyltransferases (UGTs) catalyze the conjugation of glucuronic acid with endogenous and exogenous lipophilic small molecules to facilitate their inactivation and excretion from the body. This represents approximately 35 % of all phase II metabolic transformations. Fatty acids and their oxidized eicosanoid derivatives can be metabolized by UGTs. F2-isoprostanes (F2-IsoPs) are eicosanoids formed from the free radical oxidation of arachidonic acid. These molecules are potent vasoconstrictors and are widely used as biomarkers of endogenous oxidative damage. An increasing body of evidence demonstrates the efficacy of measuring the β-oxidation metabolites of F2-IsoPs rather than the unmetabolized F2-IsoPs to quantify oxidative damage in …


Transcriptional Signature Of Durable Effector T Cells Elicited By A Replication Defective Hcmv Vaccine, Xiaohua Ye, David J H Shih, Zhiqiang Ku, Junping Hong, Diane F Barrett, Richard E Rupp, Ningyan Zhang, Tong-Ming Fu, W Jim Zheng, Zhiqiang An Apr 2024

Transcriptional Signature Of Durable Effector T Cells Elicited By A Replication Defective Hcmv Vaccine, Xiaohua Ye, David J H Shih, Zhiqiang Ku, Junping Hong, Diane F Barrett, Richard E Rupp, Ningyan Zhang, Tong-Ming Fu, W Jim Zheng, Zhiqiang An

Faculty, Staff and Student Publications

Human cytomegalovirus (HCMV) is a leading infectious cause of birth defects and the most common opportunistic infection that causes life-threatening diseases post-transplantation; however, an effective vaccine remains elusive. V160 is a live-attenuated replication defective HCMV vaccine that showed a 42.4% efficacy against primary HCMV infection among seronegative women in a phase 2b clinical trial. Here, we integrated the multicolor flow cytometry, longitudinal T cell receptor (TCR) sequencing, and single-cell RNA/TCR sequencing approaches to characterize the magnitude, phenotype, and functional quality of human T cell responses to V160. We demonstrated that V160 de novo induces IE-1 and pp65 specific durable polyfunctional …


Social And Behavior Factors Of Alzheimer's Disease And Related Dementias: A National Study In The Us, David Ciciora, Elizabeth Vásquez, Edward Valachovic, Lifang Hou, Yinan Zheng, Hua Xu, Xiaoqian Jiang, Kun Huang, Kelley Pettee Gabriel, Hong-Wen Deng, Mary P Gallant, Kai Zhang Apr 2024

Social And Behavior Factors Of Alzheimer's Disease And Related Dementias: A National Study In The Us, David Ciciora, Elizabeth Vásquez, Edward Valachovic, Lifang Hou, Yinan Zheng, Hua Xu, Xiaoqian Jiang, Kun Huang, Kelley Pettee Gabriel, Hong-Wen Deng, Mary P Gallant, Kai Zhang

Faculty, Staff and Student Publications

Introduction: Considerable research has linked many risk factors to Alzheimer's Disease and Related Dementias (ADRD). Without a clear etiology of ADRD, it is advantageous to rank the known risk factors by their importance and determine if disparities exist. Statistical-based ranking can provide insight into which risk factors should be further evaluated.

Methods: This observational, population-based study assessed 50 county-level measures and estimates related to ADRD in 3,155 counties in the U.S. using data from 2010 to 2021. Statistical analysis was performed in 2022-2023. The machine learning method, eXtreme Gradient Boosting, was utilized to rank the importance of these variables by …


Optimising The Fashion E-Commerce Journey: A Data-Driven Approach To Customer Retention, Hasna Luthfiana Fadhila, Vynska Amalia Permadi, Sylvert Prian Tahalea Apr 2024

Optimising The Fashion E-Commerce Journey: A Data-Driven Approach To Customer Retention, Hasna Luthfiana Fadhila, Vynska Amalia Permadi, Sylvert Prian Tahalea

Knowledge Engineering and Data Science

A fashion e-commerce company offers a wide range of products from domestic and international brands that are popular with young people. However, there has been an increase in non-organically acquired customers, many of whom do not return to make repeat purchases. This has led to a higher customer churn rate, with a significant proportion of non-organically sourced customers failing to become repeat purchasers. Consequently, a churn analysis and prediction model were developed to address this issue. This paper employs the Recency, Frequency, and Monetary (RFM) framework for churn analysis and prediction. The framework is underpinned by three key dimensions: last …


Random Forest Algorithm To Measure The Air Pollution Standard Index, Ariyono Setiawan, Untung Lestari Wibowo, Ahmad Mubarok, Khoirunnisa Larasati Apr 2024

Random Forest Algorithm To Measure The Air Pollution Standard Index, Ariyono Setiawan, Untung Lestari Wibowo, Ahmad Mubarok, Khoirunnisa Larasati

Knowledge Engineering and Data Science

This study uses the Random Forest algorithm to measure and predict the Air Pollution Standard Index (APSI) at Blimbing Banyuwangi Airport. Air pollution data, including concentrations of O3, CO, NO2, SO2, PM2.5, and PM10, were collected from air monitoring stations at the airport from April 15-30, 2024. APSI measurement followed established formulas by relevant authorities. Data analysis utilized statistical approaches and computational algorithms. The findings reveal that air quality at the airport is generally "Moderate," with occasional "Good" days. The Random Forest algorithm effectively predicts APSI based on existing pollution data. These results provide insights for improving air pollution management …


A Novel Approach To Defect Detection In Arabica Coffee Beans Using Deep Learning: Investigating Data Augmentation And Model Optimization, Yusriel Ardian, Novta Danyel Irawan, Sutoko Sutoko, I Nyoman Gede Arya Astawa Apr 2024

A Novel Approach To Defect Detection In Arabica Coffee Beans Using Deep Learning: Investigating Data Augmentation And Model Optimization, Yusriel Ardian, Novta Danyel Irawan, Sutoko Sutoko, I Nyoman Gede Arya Astawa

Knowledge Engineering and Data Science

Arabica coffee beans have valuable market worth because of their taste and quality, and there are defects like wholly and partially black beans that can lower the standards of a product, especially in the premium coffee sector. However, the manual processes used to detect the defects take an inordinate amount of time and are inefficient. This study aims to bridge the knowledge gap on the automated detection and recognition of the defects present in the Arabica coffee beans by creating and optimizing a CNN model based on a modified VGG16 architecture. The model applies data augmentation, rotation, cropping, and Bayesian …


Digital Health Technologies For High-Risk Pregnancy Management: Three Case Studies Using Digilego Framework, Sahiti Myneni, Alexandra Zingg, Tavleen Singh, Angela Ross, Amy Franklin, Deevakar Rogith, Jerrie Refuerzo Apr 2024

Digital Health Technologies For High-Risk Pregnancy Management: Three Case Studies Using Digilego Framework, Sahiti Myneni, Alexandra Zingg, Tavleen Singh, Angela Ross, Amy Franklin, Deevakar Rogith, Jerrie Refuerzo

Faculty, Staff and Student Publications

OBJECTIVE: High-risk pregnancy (HRP) conditions such as gestational diabetes mellitus (GDM), hypertension (HTN), and peripartum depression (PPD) affect maternal and neonatal health. Patient engagement is critical for effective HRP management (HRPM). While digital technologies and analytics hold promise, emerging research indicates limited and suboptimal support offered by the highly prevalent pregnancy digital solutions within the commercial marketplace. In this article, we describe our efforts to develop a portfolio of digital products leveraging advances in social computing, data science, and digital health.

METHODS: We describe three studies that leverage core methods from

RESULTS: Scalable social computing models using deep learning classifiers …


Elevating Academic Administration: A Comprehensive Faculty Dashboard For Tracking Student Evaluations And Research, Musa M. Azeem Apr 2024

Elevating Academic Administration: A Comprehensive Faculty Dashboard For Tracking Student Evaluations And Research, Musa M. Azeem

Senior Theses

The USC Faculty Dashboard is a web application designed to revolutionize how department heads, professors, and instructors monitor progress and make decisions, providing a centralized hub for efficient data storage and analysis. Currently, there’s a gap in tools tailored for department heads to concisely manage the performance of their department, which our platform aims to fill. The USC Faculty Dashboard offers easy access to upload and view student evaluation and research information, empowering department heads to evaluate the performance of faculty members and seamlessly track their research grants, publications, and expenditures. Furthermore, professors and instructors gain personalized performance analysis tools, …


Learning From Data In Dentistry: Summary Of The Third Annual Openwide Conference, Elsbeth Kalenderian, Kawtar Zouaidi, Jan Yeager, Janelle Urata, Alfa Yansane, Bunmi Tokede, D Brad Rindal, Heiko Spallek, Joel White, Muhammad Walji Apr 2024

Learning From Data In Dentistry: Summary Of The Third Annual Openwide Conference, Elsbeth Kalenderian, Kawtar Zouaidi, Jan Yeager, Janelle Urata, Alfa Yansane, Bunmi Tokede, D Brad Rindal, Heiko Spallek, Joel White, Muhammad Walji

Faculty, Staff and Student Publications

The overarching goal of the third scientific oral health symposium was to introduce the concept of a learning health system to the dental community and to identify and discuss cutting-edge research and strategies using data for improving the quality of dental care and patient safety. Conference participants included clinically active dentists, dental researchers, quality improvement experts, informaticians, insurers, EHR vendors/developers, and members of dental professional organizations and dental service organizations. This report summarizes the main outputs of the third annual OpenWide conference held in Houston, Texas, on October 12, 2022, as an affiliated meeting of the American Dental Association (ADA) …


Measuring Jury Perception Of Explainable Machine Learning And Demonstrative Evidence, Rachel Edie Sparks Rogers Apr 2024

Measuring Jury Perception Of Explainable Machine Learning And Demonstrative Evidence, Rachel Edie Sparks Rogers

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Subjective pattern comparison has been subject to increased scrutiny by the courts and by the general public, resulting in an increased interest in pattern comparison algorithms that provide quantitative assessments of similarity for use by forensic scientists. While these algorithms would mark an improvement over current subjective comparison methods, individuals without a statistical background may struggle with the statistical concepts and language necessary for describing algorithmic methods. If algorithms are to be used, examiners must be able to testify about their use in a way that is accessible to the jury. In a series of studies, we conduct an assessment …


Improving Educational Delivery And Content In Juvenile Detention Centers, Yomna Elmousalami Mar 2024

Improving Educational Delivery And Content In Juvenile Detention Centers, Yomna Elmousalami

Undergraduate Research Symposium

Students in juvenile detention centers have the greatest need to receive improvements in educational delivery and content; however, they are one of the “truly disadvantaged” populations in terms of receiving those improvements. This work presents a qualitative data analysis based on a focus group meeting with stakeholders at a local Juvenile Detention Center. The current educational system in juvenile detention centers is based on paper worksheets, single-room style teaching methods, outdated technology, and a shortage of textbooks and teachers. In addition, detained students typically have behavioral challenges that are deemed "undesired" in society. As a result, many students miss classes …


Accurate Estimation Of Ethanol Content In Fruit Juices Using Cielab Color Space And Chemometrics Via Smartphone-Based Digital Image Colorimetry, Chairul Ichsan, Yasir Amrulloh, Desti Erviana Mar 2024

Accurate Estimation Of Ethanol Content In Fruit Juices Using Cielab Color Space And Chemometrics Via Smartphone-Based Digital Image Colorimetry, Chairul Ichsan, Yasir Amrulloh, Desti Erviana

Makara Journal of Science

This study aims to investigate the optimal color space and chemometric technique for digital image colorimetry to determine ethanol content (% v/v) in apple, orange, and grape juices, using potassium dichromate (K2Cr2O7) under acidic conditions. The accuracy of colorimetric–chemometric integration across various color spaces (RGB, HSV, CIELab, CMYK, CIELuv, CIEXYZ, and CIELch) was benchmarked against UV–Vis spectrophotometry using metrics such as coefficient of determination (R²), mean absolute percentage error (MAPE), and root–mean–squared error (RMSE). Various chemometric techniques (PLS, PCR, MLR, multivariable–SVR, and multivariable NN regression) were evaluated. Results demonstrate that combining the CIELab color …


High Dietary Folic Acid Supplementation Reduced The Composition Of Fatty Acids And Amino Acids In Fortified Eggs, Ao-Chuan Yu, Yu-Han Deng, Cheng Long, Xi-Hui Sheng, Xiang-Guo Wang, Long-Fei Xiao, Xue-Ze Lv, Xiang-Ning Chen, Li Chen, Xiao-Long Qi Mar 2024

High Dietary Folic Acid Supplementation Reduced The Composition Of Fatty Acids And Amino Acids In Fortified Eggs, Ao-Chuan Yu, Yu-Han Deng, Cheng Long, Xi-Hui Sheng, Xiang-Guo Wang, Long-Fei Xiao, Xue-Ze Lv, Xiang-Ning Chen, Li Chen, Xiao-Long Qi

Faculty, Staff and Student Publications

AIMS: The study aimed to evaluate the effects of dietary folic acid (FA) on the production performance of laying hens, egg quality, and the nutritional differences between eggs fortified with FA and ordinary eggs.

METHODS: A total of 288 26-week-old Hy-Line Brown laying hens (initial body weights 1.65 ± 0.10 kg) with a similar weight and genetic background were used. A completely randomized design divided the birds into a control group and three treatment groups. Each group consisted of six replicates, with twelve chickens per replicate. Initially, all birds were fed a basal diet for 1 week. Subsequently, they were …


Multi-Modality Transformer For E-Commerce: Inferring User Purchase Intention To Bridge The Query-Product Gap, Srivatsa Mallapragada Mar 2024

Multi-Modality Transformer For E-Commerce: Inferring User Purchase Intention To Bridge The Query-Product Gap, Srivatsa Mallapragada

Dissertations

The rapid growth of e-commerce has necessitated the development of sophisticated product retrieval systems that can effectively match user queries with relevant products. However, the semantic gap between queries and products remains a significant challenge, as traditional retrieval methods often fail to capture the nuances of user purchase intentions. E-commerce click-stream data and product catalogs offer critical user behavior insights and product knowledge that are untapped in the current product search algorithms. This dissertation presents learning strategies that leverage the query-product transaction logs to enrich the pipeline of our proposed multi-modal transformer model, which transforms initial user queries into pseudo …


Investigation Of Gas Dynamics In Water And Oil-Based Muds Using Das, Dts, And Dss Measurements, Temitayo S. Adeyemi Mar 2024

Investigation Of Gas Dynamics In Water And Oil-Based Muds Using Das, Dts, And Dss Measurements, Temitayo S. Adeyemi

LSU Master's Theses

Reliable prediction of gas migration velocity, void fraction, and length of gas-affected region in water and oil-based muds is essential for effective planning, control, and optimization of drilling operations. However, there is a gap in our understanding of gas behavior and dynamics in water and oil-based muds. This is a consequence of the use of experimental systems that are not representative of field-scale conditions. This study seeks to bridge the gap via the well-scale deployment of distributed fiber-optic sensors for real-time monitoring of gas behavior and dynamics in water and oil-based mud. The aforementioned parameters were estimated in real-time using …


Machine Learning Prediction Of Photoluminescence In Mos2: Challenges In Data Acquisition And A Solution Via Improved Crystal Synthesis, Ethan Swonger, John Mann, Jared Horstmann, Daniel Yang Mar 2024

Machine Learning Prediction Of Photoluminescence In Mos2: Challenges In Data Acquisition And A Solution Via Improved Crystal Synthesis, Ethan Swonger, John Mann, Jared Horstmann, Daniel Yang

Seaver College Research And Scholarly Achievement Symposium

Transition metal dichalcogenides (TMDCs) like molybdenum disulfide (MoS2) possess unique electronic and optical properties, making them promising materials for nanotechnology. Photoluminescence (PL) is a key indicator of MoS2 crystal quality. This study aimed to develop a machine-learning model capable of predicting the peak PL wavelength of single MoS2 crystals based on micrograph analysis. Our limited ability to consistently synthesize high-quality MoS2 crystals hampered our ability to create a large set of training data. The project focus shifted towards improving MoS2 crystal synthesis to generate improved training data. We implemented a novel approach utilizing low-pressure chemical vapor deposition (LPCVD) combined with …


Deep Learning Can Be Used To Classify And Segment Plant Cell Types In Xylem Tissue, Reem Al Dabagh, Benjamin Shin, Sean Wu, Fabien Scalzo, Helen Holmlund, Jessica Lee, Chris Ghim, Samuel Fitzgerald, Marinna Grijalva Mar 2024

Deep Learning Can Be Used To Classify And Segment Plant Cell Types In Xylem Tissue, Reem Al Dabagh, Benjamin Shin, Sean Wu, Fabien Scalzo, Helen Holmlund, Jessica Lee, Chris Ghim, Samuel Fitzgerald, Marinna Grijalva

Seaver College Research And Scholarly Achievement Symposium

Studies of plant anatomical traits are essential for understanding plant physiological adaptations to stressful environments. For example, shrubs in the chaparral ecosystem of southern California have adapted various xylem anatomical traits that help them survive drought and freezing. Previous studies have shown that xylem conduits with a narrow diameter allows certain chaparral shrub species to survive temperatures as low as -12 C. Other studies have shown that increased cell wall thickness of fibers surrounding xylem vessels improves resistance to water stress-induced embolism formation. Historically, these studies on xylem anatomical traits have relied on hand measurements of cells in light micrographs, …


Historical Perspectives In Volatility Forecasting Methods With Machine Learning, Zhiang Qiu, Clemens Kownatzki, Fabien Scalzo, Eun Sang Cha Mar 2024

Historical Perspectives In Volatility Forecasting Methods With Machine Learning, Zhiang Qiu, Clemens Kownatzki, Fabien Scalzo, Eun Sang Cha

Seaver College Research And Scholarly Achievement Symposium

Volatility forecasting in the financial market plays a pivotal role across a spectrum of disciplines, such as risk management, option pricing, and market making. However, volatility forecasting is challenging because volatility can only be estimated, and different factors influence volatility, ranging from macroeconomic indicators to investor sentiments. While recent works suggest advances in machine learning and artificial intelligence for volatility forecasting, a comprehensive benchmark of current statistical and learning-based methods for such purposes is lacking. Thus, this paper aims to provide a comprehensive survey of the historical evolution of volatility forecasting with a comparative benchmark of key landmark models. We …


Mechanistic Investigation Of C—C Bond Activation Of Phosphaalkynes With Pt(0) Complexes, Roberto M. Escobar, Abdurrahman C. Ateşin, Christian Müller, William D. Jones, Tülay Ateşin Mar 2024

Mechanistic Investigation Of C—C Bond Activation Of Phosphaalkynes With Pt(0) Complexes, Roberto M. Escobar, Abdurrahman C. Ateşin, Christian Müller, William D. Jones, Tülay Ateşin

Research Symposium

Carbon–carbon (C–C) bond activation has gained increased attention as a direct method for the synthesis of pharmaceuticals. Due to the thermodynamic stability and kinetic inaccessibility of the C–C bonds, however, activation of C–C bonds by homogeneous transition-metal catalysts under mild homogeneous conditions is still a challenge. Most of the systems in which the activation occurs either have aromatization or relief of ring strain as the primary driving force. The activation of unstrained C–C bonds of phosphaalkynes does not have this advantage. This study employs Density Functional Theory (DFT) calculations to elucidate Pt(0)-mediated C–CP bond activation mechanisms in phosphaalkynes. Investigating the …


Research On Boundary Reconstruction And Government Supervision Strategy For Digital Platform, Jichang Dong, Feiyang Zhan, Wei Li, Jinlu Guo, Ying Liu Mar 2024

Research On Boundary Reconstruction And Government Supervision Strategy For Digital Platform, Jichang Dong, Feiyang Zhan, Wei Li, Jinlu Guo, Ying Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Digital platform is the most important form of organization in the digital era. How to clarify the boundary between platform autonomy and government regulation so as to exert the order maintenance function of platforms effectively is the key issue in the region of the digital economy governance. This study firstly introduces the basic model of platform autonomy and the regulatory challenges it faces, basing on the background of the emergence of digital platform autonomy. Secondly, through a comparative analysis of the regulatory theories and legal policies of the digital platform autonomy in the European Union and the United States, this …


Research On Chinese Data Sovereignty Policy Based On Lda Model And Policy Instruments, Han Qiao, Junru Xu Mar 2024

Research On Chinese Data Sovereignty Policy Based On Lda Model And Policy Instruments, Han Qiao, Junru Xu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Data sovereignty has become an important component of national sovereignty in the dual context of the digital economy development and the overall national security concept. Major countries and regions are actively carrying out data sovereignty strategic deployment and engaging in fierce competition in data resources, data technology, and data rules. This work adopts the policy text analysis method to study China’s data sovereignty policy, and employs the LDA model and policy instruments to quantitatively analyze the process evolution and thematic characteristics of China’s data sovereignty policy. Drawing on these findings, this study comprehensively considers the global data sovereignty policy and …


Algorithmic Harms In Child Welfare: Uncertainties In Practice, Organization, And Street-Level Decision-Making, Devansh Saxena, Shion Guha Mar 2024

Algorithmic Harms In Child Welfare: Uncertainties In Practice, Organization, And Street-Level Decision-Making, Devansh Saxena, Shion Guha

Health Services and Informatics Research

Algorithms in public services such as child welfare, criminal justice, and education are increasingly being used to make high-stakes decisions about human lives. Drawing upon findings from a two-year ethnography conducted at a child welfare agency, we highlight how algorithmic systems are embedded within a complex decision-making ecosystem at critical points of the child welfare process. Caseworkers interact with algo rithms in their daily lives where they must collect information about families and feed it to algorithms to make critical decisions. We show how the interplay between systemic mechanics and algorithmic decision making can adversely impact the fairness of the …


A Self-Supervised Learning Approach For Registration Agnostic Imaging Models With 3d Brain Cta, Yingjun Dong, Samiksha Pachade, Xiaomin Liang, Sunil A Sheth, Luca Giancardo Mar 2024

A Self-Supervised Learning Approach For Registration Agnostic Imaging Models With 3d Brain Cta, Yingjun Dong, Samiksha Pachade, Xiaomin Liang, Sunil A Sheth, Luca Giancardo

Faculty, Staff and Student Publications

Deep learning-based neuroimaging pipelines for acute stroke typically rely on image registration, which not only increases computation but also introduces a point of failure. In this paper, we propose a general-purpose contrastive self-supervised learning method that converts a convolutional deep neural network designed for registered images to work on a different input domain, i.e., with unregistered images. This is accomplished by using a self-supervised strategy that does not rely on labels, where the original model acts as a teacher and a new network as a student. Large vessel occlusion (LVO) detection experiments using computed tomographic angiography (CTA) data from 402 …


Label-Aware Distance Mitigates Temporal And Spatial Variability For Clustering And Visualization Of Single-Cell Gene Expression Data, Shaoheng Liang, Jinzhuang Dou, Ramiz Iqbal, Ken Chen Mar 2024

Label-Aware Distance Mitigates Temporal And Spatial Variability For Clustering And Visualization Of Single-Cell Gene Expression Data, Shaoheng Liang, Jinzhuang Dou, Ramiz Iqbal, Ken Chen

Faculty, Staff and Student Publications

Clustering and visualization are essential parts of single-cell gene expression data analysis. The Euclidean distance used in most distance-based methods is not optimal. The batch effect, i.e., the variability among samples gathered from different times, tissues, and patients, introduces large between-group distance and obscures the true identities of cells. To solve this problem, we introduce Label-Aware Distance (LAD), a metric using temporal/spatial locality of the batch effect to control for such factors. We validate LAD on simulated data as well as apply it to a mouse retina development dataset and a lung dataset. We also found the utility of our …


An Exposome Atlas Of Serum Reveals The Risk Of Chronic Diseases In The Chinese Population, Lei You, Jing Kou, Mengdie Wang, Guoqin Ji, Xiang Li, Chang Su, Fujian Zheng, Mingye Zhang, Yuting Wang, Tiantian Chen, Ting Li, Lina Zhou, Xianzhe Shi, Chunxia Zhao, Xinyu Liu, Surong Mei, Guowang Xu Mar 2024

An Exposome Atlas Of Serum Reveals The Risk Of Chronic Diseases In The Chinese Population, Lei You, Jing Kou, Mengdie Wang, Guoqin Ji, Xiang Li, Chang Su, Fujian Zheng, Mingye Zhang, Yuting Wang, Tiantian Chen, Ting Li, Lina Zhou, Xianzhe Shi, Chunxia Zhao, Xinyu Liu, Surong Mei, Guowang Xu

Faculty, Staff and Student Publications

Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical exposures and related risks. For this study, we collected serum samples from 5696 healthy people and patients, including those with 12 chronic diseases, in China and completed serum biomonitoring including 267 chemicals via gas and liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected exposures were used for exposure characterization and risk analysis. The results show that region is the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances are associated with multiple chronic diseases, …