Physiology Commons^™

Identifying New Treatment Options And Risk Factors For Type 2 Diabetes: The Potential Role Of Thymoquinone And Persistent Organic Pollutants, Shpetim Karandrea

USF Tampa Graduate Theses and Dissertations

Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia, which develops as a consequence of peripheral insulin resistance and defective insulin secretion from pancreatic β-cells. A high calorie diet coupled with physical inactivity are known risk factors for the development of T2DM; however, these alone fail to account for the rapid rise of the disease. Recent attention has turned to the role of environmental pollutants in the development of metabolic diseases. PBDEs (polybrominated diphenyl ethers) are environmental pollutants that have been linked to the development of type 2 diabetes (T2D), however, the precise mechanisms are not …

Effects Of Heat Exposure On Body Water Assessed Using Single-Frequency Bioelectrical Impedance Analysis And Bioimpedance Spectroscopy, Brett S. Nickerson, Michael R. Esco, Phillip A. Bishop, Brian M. Kliszczewicz, Henry N. Williford, Kyung-Shin Park, Bailey A. Welborn, Ronald L. Snarr, Danilo V. Tolusso

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1085-1093, 2017. The purpose of this study was to determine if heat exposure alters the measures of total body water (TBW), extracellular water (ECW), and intracellular water (ICW) in both single-frequency bioelectrical impedance analysis (BIA) and bioimpedance spectroscopy (BIS). Additionally, we sought to determine if any differences exist between the BIA and BIS techniques before and after brief exposure to heat. Body water was evaluated for twenty men (age=24±4 years) in a thermoneutral environment (22°C) before (PRE) and immediately after (POST) 15 min of passive heating (35°C) in an environmental chamber. The mean difference …

Repeated Plyometric Exercise Attenuates Blood Glucose In Healthy Adults, Saldiam R. Barillas, Casey M. Watkins, Megan A. Wong, Ian J. Dobbs, David C. Archer, Cameron N. Munger, Andrew J. Galpin, Jared W. Coburn, Lee E. Brown

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1076-1084, 2017. Plyometric exercise is popular in commercial exercise programs aiming to maximize energy expenditure for weight loss. However, the effect of plyometric exercise on blood glucose is unknown. The purpose of this study was to investigate the effect of relatively high intensity plyometric exercise on blood glucose. Thirteen subjects (6 females age= 21.8 ± 1.0 yrs.; height= 163.7 ± 7.8 cm; mass= 60.8 ± 6.7 kg and 7 males age= 22.0 ± 2.6 yrs.; height= 182.3 ± 3.6 cm; mass= 87.4 ± 12.5 kg) volunteered to participate. Subjects completed two random conditions on …

Is The Relationship Between Stride Length, Frequency, And Velocity Influenced By Running On A Treadmill Or Overground?, Joshua Paul Bailey, Tiffany Mata, John Mercer Dr.

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1067-1075, 2017. The purpose of the study was to compare the relationship between stride length (SL), stride frequency (SF), and velocity while running on a treadmill and overground. Participants (n=10; 22.3±2.6 yrs; 1.71±.08 m; 71.4±15.5 kg) completed a total of 14 runs (7 treadmill, 7 overground) with each run at a different velocity. SL, SF, and velocity data were recorded using wearable technology (Garmin, Fenix2). The outdoor trials occurred first. The treadmill velocities were selected to match the range of velocities used overgroud. SL vs. velocity plots were generated for treadmill and overground data …

The Effects Of Resistance Training Volume On Skeletal Muscle Proteome, Ramires A. Tibana, Octávio L. Franco, Gabriel V. Cunha, Nuno M. F Sousa, Ivo V. Sousa Neto, Márcia M. Carvalho, Jeeser Alves De Almeida, James W. Navalta, Mariana O. Lobo, Fabricio A. Voltarelli, Rita C. Marqueti, João L.Q Durigan, Jonato Prestes

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1051-1066, 2017. Studies are conflicting to whether low volume resistance training (RT) is as effective as high-volume RT protocols with respect to promoting morphological and molecular adaptations. Thus, the aim of the present study was to compare, using a climbing a vertical ladder, the effects of 8 weeks, 3 times per week, resistance training with 4 sets (RT4), resistance training with 8 sets (RT8) and without resistance training control (CON) on gastrocnemius muscle proteome using liquid chromatography mass spectrometry (LC-MS/MS) and cross sectional area (CSA) of rats. Fifty-two proteins were identified by LC-MS/MS, …

Energy Cost Of Active And Sedentary Music Video Games: Handheld Gaming Vs. Walking And Sitting, Edwin Miranda, Brittany S. Overstreet, William A. Fountain, Vincent Gutierrez, Michael Kolankowski, Matthew L. Overstreet, Ryan M. Sapp, Christopher A. Wolff, Scott A. Mazzetti Ph.D.

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1038-1050, 2017. To compare energy expenditure during and after active and handheld video game drumming compared to walking and sitting. Ten experienced, college-aged men performed four protocols (one per week): no-exercise seated control (CTRL), virtual drumming on a handheld gaming device (HANDHELD), active drumming on drum pads (DRUM), and walking on a treadmill at ~30% of VO_2max (WALK). Protocols were performed after an overnight fast, and expired air was collected continuously during (30min) and after (30min) exercise. DRUM and HANDHELD song lists, day of the week, and time of day were identical for …

A Pre-Exercise Dose Of Melatonin Can Alter Substrate Use During Exercise, Cardyl P. Trionfante, Greggory R. Davis, Tyler M. Farney, Ryan W. Miskowiec, Arnold G. Nelson

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1029-1037, 2017. Notwithstanding the lack of exercise research, several reviews have championed the use of melatonin to combat metabolic syndrome. Therefore, this study compared substrate utilization during a 30-minute (min) graded exercise protocol following the ingestion of either 6 mg melatonin (M) or a placebo (P). Participants (12 women, 12 men) performed stages 1-5 of the Naughton graded exercise protocol (6 min per stage). The protocol was repeated 4 times (2x M, 2x P) at the same time of day with one week separating each session. Expired gases were monitored, VO₂ and respiratory …

Nutrient Intake Of Elite Canadian And American Athletes With Spinal Cord Injury, Heather R. Gerrish, Elizabeth Broad, Melissa Lacroix, Dana Ogan, Robert C. Pritchett, Kelly Pritchett

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1018-1028, 2017. The nutrient needs of athletes with Spinal Cord Injury (SCI) are dependent on their physiological alterations and training status. Limited research is available regarding dietary intake of elite athletes with SCI and possible nutrient deficiencies. Therefore, the purpose of this study was to examine dietary intake of elite athletes with SCI, and determine dietary intake inadequacies based on the Estimated Average Requirement (EAR) comparisons. Additionally, the average energy and macronutrient (carbohydrate, protein, and fat) intake was compared based on level of injury (C level, T1-T6, T7-T12, Lumbar). A total of 39 athletes …

College Student Work Habits Are Related To Physical Activity And Fitness, Jesse Calestine, Melissa Bopp, Christopher M. Bopp, Zack Papalia

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1009-1017, 2017. Despite the known benefits of regular physical activity, research shows a significant decline in physical activity participation and an increase in sedentary behavior during young adulthood during the college years. Studies examining the relationship between academic outcomes and fitness/physical activity have not extensively examined this among college students. Therefore, the purpose of this study was to examine the relationship between fitness measures (cardiovascular endurance, muscular endurance, flexibility and body composition), physical activity, and academic outcomes in college students. This cross-sectional study had college students complete a one-time fitness assessment and survey examining …

A Pre-Exercise Dose Of Muscle Sentry® Has No Effect On Performing Repeated Leg Press Sets To Failure, Trezlyn M. Bartschi, David C. Sanders, Tyler M. Farney, Joke Kokkonen, Arnold G. Nelson

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1000-1008, 2017. This study compared the number of bilateral leg presses done at 150% of body mass while on either Muscle Sentry^® (MS) or placebo (PL). Participants (16 women, 14 men, college students 19-26 years) performed 2 sets of leg press to failure using 150% of their body mass with 5 min rest separating the 2 sets. Each exercise was performed twice (1x MS, 1x PL) at the same time of day with 48 h separating each exercise. Both MS and PL were ingested 30 min prior to performing the exercise. Just prior …

The Effect Of A Single Bout Of Surfing On Exercise Induced Affect, Ryan Pittsinger, Jeff Kress, Jill Crussemeyer

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 989-999, 2017. Exercise-induced affect (EIA) has been well documented and is often composed of positive affect, negative affect, tranquility, and fatigue. Research on EIA has focused on mainstream sports such as running, walking, or cycling; however, no research has evaluated the influence of action sports participation in activities such surfing on EIA. The current study examined the effect of a single 30-min surfing bout on EIA in 107 adult volunteers. An additional purpose was if change in affect was similar based on surfing history, surfing frequency, and surfing skill level. To assess EIA, each …

Validity Of Arm-To-Arm Bia Devices Compared To Dxa For Estimating %Fat In College Men And Women, Rebecca A. Rockamann, Emily K. Dalton, Jana L. Arabas, Liz Jorn, Jerry L. Mayhew

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 977-988, 2017. Bioelectric impedance analysis (BIA) devices are commonly used to estimate percent body fat (%fat), although validation of their accuracy varies widely. The purpose of this study was to assess the validity of four commonly used BIA devices compared to dual-energy X-ray absorptiometry (DXA). College-aged men (n = 29, age = 19.7 ± 1.2 y, weight = 76.9 ± 12.5 kg) and women (n = 31, age = 20.5 ± 0.8 y, weight = 61.5 ± 9.2 kg) were evaluated for %fat using four single-frequency (50 mHz) BIA devices and DXA. A gender …

Effects Of The Boy Scouts Of America Personal Fitness Merit Badge On Cardio-Metabolic Risk, Health Related Fitness And Physical Activity In Adolescents Boys, Justin Maxwell, Ryan D. Burns, Timothy A. Brusseau

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 964-976, 2017. A growing number of adolescents are more sedentary and have fewer formal opportunities to participate in physical activity. With the mounting evidence that sedentary time has a negative impact on cardio-metabolic profiles, health related fitness and physical activity, there is a pressing need to find an affordable adolescent physical activity intervention. One possible intervention that has been overlooked in the past is Boy Scouts of America. There are nearly 900,000 adolescent boys who participate in Boy Scouts in the United States. The purpose of this research study was to evaluate the effect …

Effects Of Flexibility And Balance On Driving Distance And Club Head Speed In Collegiate Golfers, Kelsey J. Marshall

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 954-963, 2017. Good balance, flexibility, and strength are all required to maintain a steady stance during the kinematic chain to produce successful golf shots. When the body can produce more power, more club head speed is generated. This formation of power translates into greater distance and accuracy. Athletes today are seeking exercise programs to enhance these qualities of their golf swing. The purpose of this study is to investigate the correlations between flexibility and balance with club head speed and driving distance in the golf swing of male and female collegiate golfers. Five male …

Speed- And Circuit-Based High-Intensity Interval Training On Recovery Oxygen Consumption, Lindsay N. Schleppenbach, Andreas B. Ezer, Sarah A. Gronemus, Katelyn R. Widenski, Saori Braun, Jeffery Janot

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 942-953, 2017. Due to the current obesity epidemic in the United States, there is growing interest in efficient, effective ways to increase energy expenditure and weight loss. Research has shown that high-intensity exercise elicits a higher Excess Post-Exercise Oxygen Consumption (EPOC) throughout the day compared to steady-state exercise. Currently, there is no single research study that examines the differences in Recovery Oxygen Consumption (ROC) resulting from high-intensity interval training (HIIT) modalities. The purpose of this study is to review the impact of circuit training (CT) and speed interval training (SIT), on ROC in both …

Students’ Perceptions Of An Applied Research Experience In An Undergraduate Exercise Science Course, Regis C. Pearson, K. Jason Crandall, Kathryn Dispennette, Jill M. Maples

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 926-941, 2017. Applied research experiences can provide numerous benefits to undergraduate students, however few studies have assessed the perceptions of Exercise Science (EXS) students to an applied research experience. The purpose of this study was two-fold: 1) to describe the rationale and implementation of an applied research experience into an EXS curriculum and 2) to evaluate EXS undergraduate students’ perceptions of an applied research experience. An EXS measurement course was chosen for implementation of an applied research experience. The applied research experience required groups of students to design, implement, and evaluate a student-led research …

Functional Neuroplasticity In The Nucleus Tractus Solitarius And Increased Risk Of Sudden Death In Mice With Acquired Temporal Lobe Epilepsy, Isabel D. Derera, Brian P. Delisle, Bret N. Smith

Physiology Faculty Publications

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in individuals with refractory acquired epilepsy. Cardiorespiratory failure is the most likely cause in most cases, and central autonomic dysfunction has been implicated as a contributing factor to SUDEP. Neurons of the nucleus tractus solitarius (NTS) in the brainstem vagal complex receive and integrate vagally mediated information regarding cardiorespiratory and other autonomic functions, and GABAergic inhibitory NTS neurons play an essential role in modulating autonomic output. We assessed the activity of GABAergic NTS neurons as a function of epilepsy development in the pilocarpine-induced status epilepticus (SE) model of …

Deletion Of The Nr4a Nuclear Receptor Nor1 In Hematopoietic Stem Cells Reduces Inflammation But Not Abdominal Aortic Aneurysm Formation, Hua Qing, Karrie L. Jones, Elizabeth B. Heywood, Hong Lu, Alan Daugherty, Dennis Bruemmer

Pharmacology and Nutritional Sciences Faculty Publications

Background: The NR4A3 orphan nuclear hormone receptor, NOR1, functions as a constitutively active transcription factor to regulate inflammation, proliferation, and cell survival during pathological vascular remodeling. Inflammatory processes represent key mechanisms leading to abdominal aortic aneurysm (AAA) formation. However, a role of NOR1 in AAA formation has not been investigated previously.

Methods: Inflammatory gene expression was analyzed in bone marrow-derived macrophages isolated from NOR1-deficient mice. Low-density lipoprotein receptor-deficient (LDLr^−/−) mice were irradiated and reconstituted with hematopoietic stem cells obtained from NOR1−/− or wild-type littermate mice. Animals were infused with angiotensin II and fed a diet enriched in saturated …

Maximum Strength, Rate Of Force Development, Jump Height, And Peak Power Alterations In Weightlifters Across Five Months Of Training, W. Guy Hornsby, Jeremy A. Gentles, Christopher J. Macdonald, Satoshi Mizuguchi, Michael W. Ramsey, Michael H. Stone

ETSU Faculty Works

The purpose of this monitoring study was to investigate how alterations in training affect changes in force-related characteristics and weightlifting performance. Subjects: Seven competitive weightlifters participated in the study. Methods: The weightlifters performed a block style periodized plan across 20 weeks. Force plate data from the isometric mid-thigh pull and static jumps with 0 kg, 11 kg, and 20 kg were collected near the end of each training block (weeks 1, 6, 10, 13, 17, and 20). Weightlifting performance was measured at weeks 0, 7, 11, and 20. Results: Very strong correlations were noted between weightlifting performances and isometric rate …

No Difference In Myosin Kinetics And Spatial Distribution Of The Lever Arm In The Left And Right Ventricles Of Human Hearts, Divya Duggal, S. Requena, Janhavi Nagwekar, Sangram Raut, Ryan Rich, Hriday Das, Vipul Patel, Ignacy Gryczynski, Rafal Fudala, Zygmunt Gryczynski, Cheavar Blair, Kenneth S. Campbell, Julian Borejdo

Physiology Faculty Publications

The systemic circulation offers larger resistance to the blood flow than the pulmonary system. Consequently, the left ventricle (LV) must pump blood with more force than the right ventricle (RV). The question arises whether the stronger pumping action of the LV is due to a more efficient action of left ventricular myosin, or whether it is due to the morphological differences between ventricles. Such a question cannot be answered by studying the entire ventricles or myocytes because any observed differences would be wiped out by averaging the information obtained from trillions of myosin molecules present in a ventricle or myocyte. …

Heads And Tails, Julie Simons

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Decreased Triple Network Connectivity In Patients With Recent Onset Post-Traumatic Stress Disorder After A Single Prolonged Trauma Exposure, Yang Liu, Liang Li, Baojuan Li, Na Feng, Lihong Li, Xi Zhang, Hongbing Lu, Hong Yin

Publications and Research

The triple network model provides a common framework for understanding affective and neurocognitive dysfunctions across multiple disorders, including central executive network (CEN), default mode network (DMN), and salience network (SN). Considering the effect of traumatic experience on post-traumatic stress disorder (PTSD), this study aims to explore the alteration of triple network connectivity in a specific PTSD induced by a single prolonged trauma exposure. With an arterial spin labeling sequence, three networks were first identified using independent component analysis among 10 PTSD patients and 10 healthy survivors, who experienced the same coal mining flood disaster. Then, the triple network connectivity was …

What’S Food Got To Do With It?: The Host Mother’S Role In The Cultural Education Of Students Studying Abroad In The Rabat Medina, Isabel Bonhomme

Independent Study Project (ISP) Collection

The dynamic between studentsstudying abroad and the host families with whom they stay is significant to both the study abroad experience and the way people in receiving countries view those fromthe West. Through my research, my goal was to explore and reachafundamental comprehension of this global dynamic from the Moroccan perspective.Specifically, the purpose of this study is to gain a deeper understanding of the process of cultural exchange and absorption which occurs through the use of food. I draw conclusions from information attained through formal interviews of mothers who host American students studying abroad in Rabat, and supplement this with …

Direct Antioxidant Properties Of Methotrexate: Inhibition Of Malondialdehyde-Acetaldehyde-Protein Adduct Formation And Superoxide Scavenging., Matthew C. Zimmerman, Dahn L. Clemens, Michael J. Duryee, Cleofes Sarmiento, Andrew Chiou, Carlos D. Hunter, Jun Tian, Lynell W. Klassen, James R. O'Dell, Geoffrey M. Thiele, Ted R. Mikuls, Daniel R. Anderson

Journal Articles: Cellular & Integrative Physiology

Methotrexate (MTX) is an immunosuppressant commonly used for the treatment of autoimmune diseases. Recent observations have shown that patients treated with MTX also exhibit a reduced risk for the development of cardiovascular disease (CVD). Although MTX reduces systemic inflammation and tissue damage, the mechanisms by which MTX exerts these beneficial effects are not entirely known. We have previously demonstrated that protein adducts formed by the interaction of malondialdehyde (MDA) and acetaldehyde (AA), known as MAA-protein adducts, are present in diseased tissues of individuals with rheumatoid arthritis (RA) or CVD. In previously reported studies, MAA-adducts were shown to be highly immunogenic, …

Associative Learning Contributes To The Increased Water Intake Observed After Daily Injections Of Angiotensin Ii, Maggie Postolache, Jessica Santollo, Derek Daniels

Biology Faculty Publications

Daily injections of angiotensin II (AngII) cause a progressive increase of water intake that resembles a classically ascribed non-associative sensitization. Consistent with the presumption that the observed increase in intake was sensitization, we hypothesized that it resulted from a pharmacological interaction between AngII and its receptor. To test this hypothesis, and remove the influence of drinking itself, we implemented a delay in water access after injection of AngII (icv) on four consecutive ‘induction days,’ and then measured intake on the next day (‘test day’) when rats were allowed to drink immediately after AngII. The delay in water access effectively reduced …

Psychosocial Functioning And The Cortisol Awakening Response: Meta-Analysis, P-Curve Analysis, And Evaluation Of The Evidential Value In Existing Studies, Ian Andres Boggero, Camelia E. Hostinar, Eric A. Haak, Michael L. M. Murphy, Suzanne C. Segerstrom

Psychology Faculty Publications

Cortisol levels rise immediately after awakening and peak approximately 30-45 minutes thereafter. Psychosocial functioning influences this cortisol awakening response (CAR), but there is considerable heterogeneity in the literature. The current study used p-curve and metaanalysis on 709 findings from 212 studies to test the evidential value and estimate effect sizes of four sets of findings: those associating worse psychosocial functioning with higher or lower cortisol increase relative to the waking period (CARi) and to the output of the waking period (AUCw). All four sets of findings demonstrated evidential value. Psychosocial predictors explained 1%-3.6% of variance in CARi and AUCw …

Adipose Tissue As A Site Of Toxin Accumulation, Erin Jackson, Robin C. Shoemaker, Nika Larian, Lisa A. Cassis

Pharmacology and Nutritional Sciences Faculty Publications

We examine the role of adipose tissue, typically considered an energy storage site, as a potential site of toxicant accumulation. Although the production of most persistent organic pollutants (POPs) was banned years ago, these toxicants persist in the environment due to their resistance to biodegradation and widespread distribution in various environmental forms (e.g., vapor, sediment, and water). As a result, human exposure to these toxicants is inevitable. Largely due to their lipophilicity, POPs bioaccumulate in adipose tissue, resulting in greater body burdens of these environmental toxicants with obesity. POPs of major concern include polychlorinated biphenyls (PCBs), polychlorinated dibenzo‐p‐dioxins and furans …

Effects Of Winter And Summer Thermal Variability Regimes On Growth And Metabolism In Brook Trout (Salvelinus Fontinalis), Spenser Chicoine

All NMU Master's Theses

Brook trout (Salvelinus fontinalis) is a cold-water species with a narrow range of thermal tolerance. Climate change projections show that in addition to increases in average temperatures worldwide, daily thermal variability is increasing. Such conditions could prove challenging for brook trout and other ectotherms that are adapted to small temperature ranges. This research investigates how the growth and metabolic capacities of brook trout respond to long-term exposure to thermal variation. Groups of fish were reared under three thermal regimes: constant baily temperature, a 4°C daily range, and an 8°C daily range in a controlled lab setting. This was …

Nutrients, Infectious And Inflammatory Diseases, Helieh S. Oz

Physiology Faculty Publications

No abstract provided.

There’S More Than One Way To Climb A Tree: Limb Length And Microhabitat Use In Lizards With Toe Pads, Travis J. Hagey, Scott Hart, Matthew Vickers, Luke J. Harmon, Lin Schwarzkopf

Biology

Ecomorphology links microhabitat and morphology. By comparing ecomorphological associations across clades, we can investigate the extent to which evolution can produce similar solutions in response to similar challenges. While Anolis lizards represent a well-studied example of repeated convergent evolution, very few studies have investigated the ecomorphology of geckos. Similar to anoles, gekkonid lizards have independently evolved adhesive toe pads and many species are scansorial. We quantified gecko and anole limb length and microhabitat use, finding that geckos tend to have shorter limbs than anoles. Combining these measurements with microhabitat observations of geckos in Queensland, Australia, we observed geckos using similar …